N6′, N6′′′, and O4′ Modifications to Neomycin Affect Ribosomal Selectivity without Compromising Antibacterial Activity

ACS Infectious Diseases

Volumn 3, Issue 5, 2017, Pages 368-377

  Sati, Girish C ^a   Shcherbakov, Dimitri ^b   Hobbie, Sven N ^b   Vasella, Andrea ^c   Böttger, Erik C ^b   Crich, David ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c ETH ZURICH   (Switzerland)

Author keywords

aminoglycosides; cell free translation assay; decoding A site; multidrug resistant infectious diseases; ototoxicity; synthesis

Indexed keywords

4' O ETHYL NEOMYCIN B; AMINOGLYCOSIDE ANTIBIOTIC AGENT; FRAMYCETIN; GENTAMICIN C; KANAMYCIN A; NEOMYCIN; NEOMYCIN DERIVATIVE; PAROMOMYCIN; TOBRAMYCIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ACINETOBACTER BAUMANNII; ALKYLATION; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CELL; CONTROLLED STUDY; DERIVATIZATION; DRUG SELECTIVITY; DRUG SYNTHESIS; ENTEROBACTER CLOACAE; ESCHERICHIA COLI; HYDROGEN BOND; IC50; KLEBSIELLA PNEUMONIAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MITOCHONDRIAL RIBOSOME; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RIBOSOME; RNA TRANSLATION; STAPHYLOCOCCUS AUREUS; ANALOGS AND DERIVATIVES; BASE PAIRING; CELL FRACTIONATION; CONFORMATION; DRUG EFFECTS; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIAL SENSITIVITY TEST; NUCLEOTIDE SEQUENCE; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACINETOBACTER BAUMANNII; ANTI-BACTERIAL AGENTS; BASE PAIRING; BASE SEQUENCE; CARBOHYDRATE CONFORMATION; ENTEROBACTER CLOACAE; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; NEOMYCIN; PAROMOMYCIN; PROTEIN BIOSYNTHESIS; RIBOSOMES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS;

EID: 85019181591     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.6b00214     Document Type: Article

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