Synthesis and Antiribosomal Activities of 4′-O-, 6′-O-, 4″-O-, 4′,6′-O- and 4″,6″-O-Derivatives in the Kanamycin Series Indicate Differing Target Selectivity Patterns between the 4,5- and 4,6-Series of Disubstituted 2-Deoxystreptamine Aminoglycoside Antibiotics

ACS Infectious Diseases

Volumn 1, Issue 10, 2016, Pages 479-486

  Kato, Takayuki ^a   Yang, Guanyu ^a   Teo, Youjin ^b   Juskeviciene, Reda ^b   Perez Fernandez, Déborah ^c   Shinde, Harish M ^c   Salian, Sumanth ^c   Bernet, Bruno ^c   Vasella, Andrea ^c   Böttger, Erik C ^b   Crich, David ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c ETH ZURICH   (Switzerland)

Author keywords

antibacterial activity; decoding A site; mitochondrial rRNA; ototoxicity; ribosomal selectivity

Indexed keywords

6' HYDROXYKANAMYCIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; KANAMYCIN A; KANAMYCIN B; KANAMYCIN C; KANAMYCIN DERIVATIVE; PAROMOMYCIN; UNCLASSIFIED DRUG;

ALKYLATION; ANTIBACTERIAL ACTIVITY; ANTIRIBOSOMAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; DRUG SYNTHESIS; HUMAN; OTOTOXICITY; PRIORITY JOURNAL;

EID: 84966427974     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.5b00069     Document Type: Article

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