Toxicity modulation, resistance enzyme evasion, and A-site X-ray structure of broad-spectrum antibacterial neomycin analogs

ACS Chemical Biology

Volumn 9, Issue 9, 2014, Pages 2067-2073

  Maianti, Juan Pablo ^a   Kanazawa, Hiroki ^b   Dozzo, Paola ^c   Matias, Rowena D ^c   Feeney, Lee Ann ^c   Armstrong, Eliana S ^c   Hildebrandt, Darin J ^c   Kane, Timothy R ^c   Gliedt, Micah J ^c   Goldblum, Adam A ^c   Linsell, Martin S ^c   Aggen, James B ^c   Kondo, Jiro ^b   Hanessian, Stephen ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b SOPHIA UNIVERSITY   (Japan)

^c Achaogen Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE MODIFYING ENZYME; CASPASE 3; CASPASE 7; ENZYME; FLUORIDE; GENTAMICIN; N1 HYDROXYAMINOBUTYRYL ACYL; NEOMYCIN; PAROMOMYCIN; TARTARIC ACID DERIVATIVE; TETRADEOXYNEOMYCIN; UNCLASSIFIED DRUG; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; RNA;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; APOPTOSIS; ARTICLE; ASYMMETRIC SYNTHESIS; BACTERIAL STRAIN; BENZYLATION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; CELL VIABILITY ASSAY; COLUMN CHROMATOGRAPHY; CRYSTAL STRUCTURE; CYTOTOXICITY; DEOXYGENATION; DIASTEREOISOMER; DRUG POTENCY; ENANTIOMER; FLUORINE NUCLEAR MAGNETIC RESONANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; KIDNEY CELL; MINIMUM INHIBITORY CONCENTRATION; NEPHROTOXICITY; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; RNA BINDING; SHARPLESS EPOXIDATION; SILICA GEL COLUMN CHROMATOGRAPHY; STEREOCHEMISTRY; WILD TYPE; X RAY CRYSTALLOGRAPHY; ANALOGS AND DERIVATIVES; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; DRUG SCREENING; KIDNEY; METABOLISM; MICROBIAL SENSITIVITY TEST; PROCEDURES; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; CELL LINE; CHEMISTRY TECHNIQUES, SYNTHETIC; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, BACTERIAL; HUMANS; KIDNEY; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NEOMYCIN; RNA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84912567413     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb5003416     Document Type: Article

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