Design and synthesis of new aminoglycoside antibiotics containing neamine as an optimal core structure: Correlation of antibiotic activity with in vitro inhibition of translation

Journal of the American Chemical Society

Volumn 121, Issue 28, 1999, Pages 6527-6541

  Greenberg, William A ^a   Priestley, E Scott ^a   Sears, Pamela S ^a   Alper, Phil B ^a   Rosenbohm, Christoph ^a   Hendrix, Martin ^a   Hung, Shang Cheng ^a   Wong, Chi Huey ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AZIDO 2 DEOXY 3,4,6 TRI O BENZYL 1 PHENYLTHIO BETA DEXTRO GLUCOPYRANOSIDE; 2 DEOXY 1,3 DIAZIDO 4,5,6 TRI O ACETYLSTREPTAMINE; 2 DEOXYSTREPTAMINE; 3 AZIDO 3 DEOXY 2,4,6 TRI O BENZYL 1 PHENYLTHIO BETA DEXTRO GLUCOPYRANOSIDE; 4 AZIDO 4 DEOXY 2,3,6 TRI O BENZYL 1 PHENYLTHIO BETA DEXTRO GLUCOPYRANOSIDE; 4 O (3 AMINO 3 DEOXY ALPHA DEXTRO GLUCOPYRANOSYL) 2 DEOXYSTREPTAMINE; 4 O (4 AMINO 4 DEOXY ALPHA DEXTRO GLUCOPYRANOSYL) 2 DEOXYSTREPTAMINE; 4 O (6 AMINO 6 DEOXY ALPHA DEXTRO GLUCOPYRANOSYL) 2 DEOXYSTREPTAMINE; 4 O (ALPHA DEXTRO GLUCOPYRANOSYL) 2 DEOXYSTREPTAMINE; 6 AZIDO 6 DEOXY 2,3,4 TRI O BENZYL 1 PHENYLTHIO BETA DEXTRO GLUCOPYRANOSIDE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; DISACCHARIDE; FRAMYCETIN; GENTAMICIN; NEAMINE; PAROMAMINE; RIBOSOME RNA; RIBOSTAMYCIN; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; PROTEIN SYNTHESIS INHIBITION; RIBOSOME; RNA BINDING; RNA CONFORMATION; STRUCTURE ACTIVITY RELATION; TRANSLATION REGULATION;

EID: 0033591922     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9910356     Document Type: Article

References (18)

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