Designer aminoglycosides prevent cochlear hair cell loss and hearing loss

Journal of Clinical Investigation

Volumn 125, Issue 2, 2015, Pages 583-592

  Huth, Markus E ^a,b   Han, Kyu Hee ^a   Sotoudeh, Kayvon ^a   Hsieh, Yi Ju ^a,c   Effertz, Thomas ^a   Vu, Andrew A ^a   Verhoeven, Sarah ^a   Hsieh, Michael H ^a,c   Greenhouse, Robert ^a   Cheng, Alan G ^a   Ricci, Anthony J ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BERN   (Switzerland)

^c BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; AMINOGLYCOSIDE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; CIPROFLOXACIN; EXTENDED SPECTRUM BETA LACTAMASE; GENTAMICIN; IMIPENEM; N1MS AMINE; SISOMICIN; TOBRAMYCIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; BLADDER; COCHLEAR HAIR CELL LOSS; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; HEARING; HEARING IMPAIRMENT; INNER EAR HEARING LOSS; INNER HAIR CELL; KIDNEY FUNCTION; KLEBSIELLA PNEUMONIAE; MOUSE; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RAT; RIBOSOME; STAPHYLOCOCCUS AUREUS; URINALYSIS; URINARY TRACT; URINARY TRACT INFECTION; ANIMAL; BACTERIAL INFECTIONS; BACTERIUM; CHEMICALLY INDUCED; CHEMISTRY; DRUG DESIGN; DRUG SCREENING; GROWTH, DEVELOPMENT AND AGING; HAIR CELL; HEARING LOSS, SENSORINEURAL; HUMAN; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; SYNTHESIS;

AMINOGLYCOSIDES; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HAIR CELLS, AUDITORY; HEARING LOSS, SENSORINEURAL; HUMANS; MICE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84961290086     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI77424     Document Type: Article

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