Influence of linker length and composition on enzymatic activity and ribosomal binding of neomycin dimers

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 7, 2015, Pages 3899-3905

  Watkins, Derrick ^a   Kumar, Sunil ^b,d   Green, Keith D ^c   Arya, Dev P ^a,b   Garneau Tsodikova, Sylvie ^c  

^a NUBAD LLC   (United States)

^b CLEMSON UNIVERSITY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE DERIVATIVE; AMINOGLYCOSIDE MODIFYING ENZYME; BENZENE DERIVATIVE; DIMER; FRAMYCETIN; HYDROXYL GROUP; RIBOSOME RNA; THIOUREA DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE; ANTIINFECTIVE AGENT; NEOMYCIN; THIOUREA; UREA;

ACETYLATION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; ESCHERICHIA COLI; HUMAN; HUMAN CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN STRUCTURE; RIBOSOME; STAPHYLOCOCCUS AUREUS; BACTERIUM; BINDING COMPETITION; BIOSYNTHESIS; CHEMISTRY; DIMERIZATION; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MICROBIAL SENSITIVITY TEST; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BACTERIA; BINDING SITES; BINDING, COMPETITIVE; DIMERIZATION; HUMANS; MICROBIAL SENSITIVITY TESTS; NEOMYCIN; PROTEIN CONFORMATION; RIBOSOMES; RNA, RIBOSOMAL; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; TRIAZOLES; UREA;

EID: 84931275150     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00861-15     Document Type: Article

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