Molecular recognition of aminoglycoside antibiotics by ribosomal RNA and resistance enzymes: An analysis of x-ray crystal structures

Biopolymers

Volumn 70, Issue 1, 2003, Pages 42-57

  Vicens, Quentin ^a   Westhof, Eric ^a  

^a INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Aminoglycoside antibiotic; Aminoglycoside modifying enzyme; Resistance mechanism; Ribosomal RNA; X ray crystal structure

Indexed keywords

ANTIBIOTICS; MOLECULAR STRUCTURE; PROTEINS; X RAY CRYSTALLOGRAPHY;

MOLECULAR RECOGNITION;

RNA;

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC G 418; ENZYME; GENTAMICIN C; KANAMYCIN A; KANAMYCIN B; NEAMINE; NEOMYCIN; PAROMOMYCIN; RIBOSOME RNA; RIBOSTAMYCIN; TOBRAMYCIN;

ANTIMICROBIAL ACTIVITY; BACTERIAL CELL; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG BINDING; DRUG BINDING SITE; DRUG DESIGN; DRUG TARGETING; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN RNA BINDING; RECEPTOR BINDING; REVIEW; RNA BINDING; STRUCTURE ANALYSIS; X RAY ANALYSIS;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MICROBIAL; ENZYMES; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN BINDING; RIBOSOMES; RNA; RNA, RIBOSOMAL;

BACTERIA (MICROORGANISMS);

EID: 0042337397     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.10414     Document Type: Review

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