4′-O-substitutions determine selectivity of aminoglycoside antibiotics

Nature Communications

Volumn 5, Issue , 2014, Pages

  Perez Fernandez, Déborah ^a   Shcherbakov, Dmitri ^b   Matt, Tanja ^b   Leong, Ng Chyan ^c,d   Kudyba, Iwona ^a   Duscha, Stefan ^b   Boukari, Heithem ^b   Patak, Rashmi ^a   Dubbaka, Srinivas Reddy ^a   Lang, Kathrin ^c   Meyer, Martin ^b   Akbergenov, Rashid ^b   Freihofer, Pietro ^b   Vaddi, Swapna ^e   Thommes, Pia ^e   Ramakrishnan, V ^c   Vasella, Andrea ^a   Böttger, Erik C ^b  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^d UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^e Euprotec Limited   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 DEOXYSTREPTAMINE; ACETAL DERIVATIVE; AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; APRAMYCIN; CYCLOPHOSPHAMIDE; ETHER DERIVATIVE; GENTAMICIN; KANAMYCIN; LINEZOLID; NEOMYCIN; PAROMOMYCIN; RNA 16S; TOBRAMYCIN; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT;

AMMONIUM COMPOUND; ANTIBIOTICS; ANTIMICROBIAL ACTIVITY; BACTERIUM; CHEMICAL ALTERATION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIMICROBIAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; DRUG BINDING SITE; DRUG SELECTIVITY; DRUG TARGETING; MALE; MOUSE; NONHUMAN; POINT MUTATION; RIBOSOME; ANIMAL; CELL FREE SYSTEM; CHEMISTRY; CONFORMATION; DISEASE MODEL; DRUG EFFECTS; DRUG INTERACTION; ESCHERICHIA COLI; GENETICS; HUMAN; IC50; ISOLATION AND PURIFICATION; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR GENETICS; MYCOBACTERIUM SMEGMATIS; NUCLEOTIDE SEQUENCE; PROTEIN SYNTHESIS; SEPSIS; STAPHYLOCOCCUS AUREUS; X RAY CRYSTALLOGRAPHY;

AMINOGLYCOSIDES; ANIMALS; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; CELL-FREE SYSTEM; CRYSTALLOGRAPHY, X-RAY; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; ESCHERICHIA COLI; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM SMEGMATIS; NUCLEIC ACID CONFORMATION; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA, RIBOSOMAL, 16S; SEPSIS; STAPHYLOCOCCUS AUREUS;

EID: 84893267937     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4112     Document Type: Article

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