Rational design and synthesis of potent aminoglycoside antibiotics against resistant bacterial strains

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 1, 2011, Pages 30-40

  Yan, Ri Bai ^a   Yuan, Min ^b   Wu, Yanfen ^a   You, Xuefu ^b   Ye, Xin Shan ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

Aminoglycoside; Antibiotics; Chemical modification; Drug design; Drug resistance

Indexed keywords

1,3 DIAZIDO 5 O BENZYL 6 O (3 DEOXY 3 AZIDO 2,4,6 TRI O BENZYL ALPHA DEXTRO GLUCOPYRANOSYL) 2 DEOXYSTREPTAMINE; 3',4' O ISOPROPYLIDENE 5,2'',4'',6'' O TETRA O BENZYL PENTAAZIDOKANAMYCIN B; 3',4' O ISOPROPYLIDENE 6'' O TERT BUTYLDIPHENYLSILYL PENTAAZIDOKANAMYCIN B; 4 TOLYL 2 DEOXY 2 AZIDO 3 O BENZYL 4,6 O BENZYLIDENE 1 THIO ALPHA DEXTRO GLUCOPYRANOSIDE; 4 TOLYL 2,6 DIDEOXY 2,6 DIAZIDO 3 O BENZYL 1 THIO ALPHA DEXTRO GALACTOPYRANOSIDE; 4 TOLYL 2,6 DIDEOXY 2,6 DIAZIDO 3 O BENZYL 1 THIO ALPHA DEXTRO GLUCOPYRANOSIDE; 4 TOLYL 2,6 DIDEOXY 2,6 DIAZIDO 3 O BENZYL 4 DEOXY 4 (2,2,2 TRICHLOROETHOXYCARBONYLAMINO) 1 THIO ALPHA DEXTRO GLUCOPYRANOSIDE; 4' DEOXY 4' (2 (2 METHYLBENZAMIDO)ACETAMIDO) 5,3',2'',4'',6'' PENTA O BENZYL PENTAAZIDO KANAMYCIN B; 4' DEOXY 4' (2,2,2 TRICHLOROETHOXYCARBONYLAMINO) 5,3',2'',4'',6'' PENTA O BENZYL PENTAAZIDO KANAMYCIN B; 4' DEOXY 4' (4 AMINO BUTANOYLAMINO)KANAMYCIN B; 4' DEOXY 4' (4 AZIDOBUTOYLAMINO) 5,3',2'',4'',6'' PENTA O BENZYL PENTAAZIDO KANAMYCIN B; 4' DEOXY 4' (N BENZOXYCARBONYL PIPERIDINYL) 4 CARBONYLAMINO 5,3',2'',4'',6'' PENTA O BENZYL PENTAAZIDO KANAMYCIN B; 4' DEOXY 4' ACETAMIDO 5,3',2'',4'',6'' PENTA O BENZYL PENTAAZIDO KANAMYCIN B; 4' DEOXY 4' ACETAMIDO KANAMYCIN B; 4' DEOXY 4' AMINO 5,3',2'',4'',6'' PENTA O BENZYL PENTAAZIDO KANAMYCIN B; 4' DEOXY 4' CYCLOHEXYLCARBONYLAMINO 5,3',2'',4'',6'' PENTA O BENZYL PENTAAZIDO KANAMYCIN B; 4' DEOXY 4' CYCLOHEXYLCARBONYLAMINO KANAMYCIN B; 4' DEOXY 4' DIMETHYLAMINO 5,3',2'',4'',6'' PENTA O BENZYL PENTAAZIDO KANAMYCIN B; 4' DEOXY 4' DIMETHYLAMINO KANAMYCIN B; 5,2'',4'',6'' TETRA O BENZYL PENTAAZIDOKANAMYCIN B; 6'' O TERT BUTYLDIPHENYLSILYL PENTAAZIDOKANAMYCIN B; AMINOGLYCOSIDE ANTIBIOTIC AGENT; APRAMYCIN; FRAMYCETIN; KANAMYCIN A; KANAMYCIN B; NEAMINE; PAROMOMYCIN; TOBRAMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MORTIERELLA ALPINA; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIA; CARBOHYDRATE SEQUENCE; DRUG DESIGN; DRUG RESISTANCE, MICROBIAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA;

BACTERIA (MICROORGANISMS);

EID: 78650727992     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.11.065     Document Type: Article

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