Structural Analysis of the Tobramycin and Gentamicin Clinical Resistome Reveals Limitations for Next-generation Aminoglycoside Design

ACS Chemical Biology

Volumn 11, Issue 5, 2016, Pages 1339-1346

  Bassenden, Angelia V ^a   Rodionov, Dmitry ^a   Shi, Kun ^a   Berghuis, Albert M ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GENTAMICIN; TOBRAMYCIN; ADENOSINE TRIPHOSPHATE; ALPHA,BETA-METHYLENEADENOSINE 5'-TRIPHOSPHATE; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; GENTAMICIN 2''-NUCLEOTIDYLTRANSFERASE; MANGANESE; NUCLEOTIDYLTRANSFERASE;

ANTIBIOTIC RESISTANCE; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME MODIFICATION; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; RIBOSOME; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; ENZYMOLOGY; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR DOCKING; MOLECULAR MODEL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

ADENOSINE TRIPHOSPHATE; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; GENTAMICINS; HUMANS; MANGANESE; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; NUCLEOTIDYLTRANSFERASES; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; TOBRAMYCIN;

EID: 84971241605     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b01070     Document Type: Article

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