Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 52, 2008, Pages 20888-20893

  Hobbie, Sven N ^a   Akshay, Subramanian ^a   Kalapala, Sarath K ^a   Bruell, Christian M ^a   Shcherbakov, Dmitry ^a   Böttger, Erik C ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Decoding; Mitochondria; Ribosomes; Toxicity; Translation

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE; FRAMYCETIN; GENTAMICIN; KANAMYCIN A; NETILMICIN; PAROMOMYCIN; TOBRAMYCIN;

ARTICLE; BACTERIAL CHROMOSOME; CONTROLLED STUDY; DRUG BINDING; DRUG SENSITIVITY; GENE FREQUENCY; GENE MUTATION; GENETIC ANALYSIS; MOLECULAR INTERACTION; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA STRUCTURE;

AMINOGLYCOSIDES; DEAFNESS; DRUG RESISTANCE, MICROBIAL; HUMANS; MITOCHONDRIA; MYCOBACTERIUM SMEGMATIS; POINT MUTATION; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA, RIBOSOMAL;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 58549117857     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0811258106     Document Type: Article

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