Surprising alteration of antibacterial activity of 5″-modified neomycin against resistant bacteria

Journal of Medicinal Chemistry

Volumn 51, Issue 23, 2008, Pages 7563-7573

  Zhang, Jianjun ^a   Chiang, Fang I ^a   Wu, Long ^b   Czyryca, Przemyslaw Greg ^c   Li, Ding ^b   Chang, Cheng Wei Tom ^a  

^a UTAH STATE UNIVERSITY   (United States)

^b CITY UNIVERSITY OF HONG KONG   (Hong Kong)

^c Allosterix Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE; FRAMYCETIN; FRAMYCETIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANTI-BACTERIAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENTEROCOCCUS; ENZYME INHIBITORS; FRAMYCETIN; KANAMYCIN KINASE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VANCOMYCIN RESISTANCE;

EID: 57349085030     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800997s     Document Type: Article

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