Mutagenesis of 16 S rRNA C1409-G1491 base-pair differentiates between 6′OH and 6′NH3+ aminoglycosides

Journal of Molecular Biology

Volumn 346, Issue 2, 2005, Pages 467-475

  Pfister, P ^a   Hobbie, S ^a   Brull C ^a   Corti, N ^a   Vasella, A ^b   Westhof, E ^c   Bottger E C ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

aminoglycosides; mutagenesis; resistance; ribosome; structure

Indexed keywords

2 DEOXYSTREPTAMINE; AMINOGLYCOSIDE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMMONIUM DERIVATIVE; ANTIBIOTIC G 418; GENTAMICIN; HYDROXYL GROUP; NEOMYCIN; PAROMOMYCIN; RNA; TOBRAMYCIN; ANTIINFECTIVE AGENT; HEXOSAMINE; RNA 16S; STREPTAMINE;

ALLELE; ARTICLE; DRUG RESISTANCE; HYDROGEN BOND; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY; BASE PAIRING; BINDING SITE; CHEMISTRY; CYTOLOGY; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENETICS; MYCOBACTERIUM SMEGMATIS; SITE DIRECTED MUTAGENESIS;

POSIBACTERIA;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BASE PAIRING; BINDING SITES; DRUG RESISTANCE; ESCHERICHIA COLI; HEXOSAMINES; HYDROGEN BONDING; MUTAGENESIS, SITE-DIRECTED; MYCOBACTERIUM SMEGMATIS; RNA, RIBOSOMAL, 16S; SUBSTRATE SPECIFICITY;

EID: 12544252978     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.11.073     Document Type: Article

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