Binding of neomycin-class aminoglycoside antibiotics to mutant ribosomes with alterations in the A site of 16S rRNA

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 4, 2006, Pages 1489-1496

  Hobbie, Sven N ^a   Pfister, Peter ^a   Bruell, Christian ^a   Sander, Peter ^a   François, Boris ^b   Westhof, Eric ^b   Böttger, Erik C ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b INST DE BIOL MOLEC ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 DEOXYSTREPTAMINE; ADENINE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; CYTOSINE; GLYCOPYRANOSIDE; GUANINE; LIVIDOMYCIN; NEAMINE; NEOMYCIN; PAROMOMYCIN; RIBOSTAMYCIN; RNA 16S; URACIL;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM MUTANT; BASE PAIRING; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG BINDING SITE; DRUG CLASSIFICATION; DRUG INTERACTION; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM SMEGMATIS; NONHUMAN; PRIORITY JOURNAL; RIBOSOME; RNA SEQUENCE;

ANTI-BACTERIAL AGENTS; BINDING SITES; MUTAGENESIS, SITE-DIRECTED; NEOMYCIN; RIBOSOMES; RNA, RIBOSOMAL, 16S; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33645757767     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.50.4.1489-1496.2006     Document Type: Article

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