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Volumn 120, Issue 9, 1998, Pages 1965-1978

Probing the specificity of aminoglycoside-ribosomal RNA interactions with designed synthetic analogs

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; FRAMYCETIN; NEAMINE; PAROMOMYCIN; RIBOSOME RNA; RIBOSTAMYCIN;

EID: 0032507263     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja972599h     Document Type: Article
Times cited : (190)

References (70)
  • 1
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    • Mechanism of Action of Ammoglycoside Antibiotics
    • Springer-Verlag: New York
    • (a) Tanaka, N. Mechanism of Action of Ammoglycoside Antibiotics. Handbook of Experimental Pharmacology; Springer-Verlag: New York, 1982; Vol. 62, p 221.
    • (1982) Handbook of Experimental Pharmacology , vol.62 , pp. 221
    • Tanaka, N.1
  • 2
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    • Recognition Sites for Antibiotics Within rRNA
    • Hill, W. E., et al. Eds.; American Society of Microbiology: Washington, DC
    • (b) Cundliffe, E. Recognition Sites for Antibiotics Within rRNA. In The Ribosome; Hill, W. E., et al. Eds.; American Society of Microbiology: Washington, DC, 1990; p 479.
    • (1990) The Ribosome , pp. 479
    • Cundliffe, E.1
  • 35
    • 0002087668 scopus 로고
    • Disk testing protocols
    • Garrod, L., Ed.; Churchill Livingstone Press: Edinburgh
    • For antibiotic testing protocols, see: (a) Disk testing protocols: Phillips. I.; Williams, D. In Laboratory Methods in Antimicrobial Chemotherapy; Garrod, L., Ed.; Churchill Livingstone Press: Edinburgh, 1978: pp 3-30. (b) MIC determination: Waterworth, P. M. In Laboratory Methods in Antimicrobial Chemotherapy; Garrod, L., Ed.; Churchill Livingstone Press: Edinburgh, 1978; pp 31-40, Barry, A. L. The Antimicrobic Susceptibility Test: Principles and Practice; Lea and Febiger: Philadelphia, 1976. (c) Standards: Lorian, V. Antibiotics in Laboratory Medicine, 2nd ed.; Williams and Wilkins: Baltimore, 1986.
    • (1978) Laboratory Methods in Antimicrobial Chemotherapy , pp. 3-30
    • Phillips, I.1    Williams, D.2
  • 36
    • 0003022415 scopus 로고
    • MIC determination
    • Garrod, L., Ed.; Churchill Livingstone Press: Edinburgh
    • For antibiotic testing protocols, see: (a) Disk testing protocols: Phillips. I.; Williams, D. In Laboratory Methods in Antimicrobial Chemotherapy; Garrod, L., Ed.; Churchill Livingstone Press: Edinburgh, 1978: pp 3-30. (b) MIC determination: Waterworth, P. M. In Laboratory Methods in Antimicrobial Chemotherapy; Garrod, L., Ed.; Churchill Livingstone Press: Edinburgh, 1978; pp 31-40, Barry, A. L. The Antimicrobic Susceptibility Test: Principles and Practice; Lea and Febiger: Philadelphia, 1976. (c) Standards: Lorian, V. Antibiotics in Laboratory Medicine, 2nd ed.; Williams and Wilkins: Baltimore, 1986.
    • (1978) Laboratory Methods in Antimicrobial Chemotherapy , pp. 31-40
    • Waterworth, P.M.1
  • 37
    • 0003446418 scopus 로고
    • Lea and Febiger: Philadelphia
    • For antibiotic testing protocols, see: (a) Disk testing protocols: Phillips. I.; Williams, D. In Laboratory Methods in Antimicrobial Chemotherapy; Garrod, L., Ed.; Churchill Livingstone Press: Edinburgh, 1978: pp 3-30. (b) MIC determination: Waterworth, P. M. In Laboratory Methods in Antimicrobial Chemotherapy; Garrod, L., Ed.; Churchill Livingstone Press: Edinburgh, 1978; pp 31-40, Barry, A. L. The Antimicrobic Susceptibility Test: Principles and Practice; Lea and Febiger: Philadelphia, 1976. (c) Standards: Lorian, V. Antibiotics in Laboratory Medicine, 2nd ed.; Williams and Wilkins: Baltimore, 1986.
    • (1976) The Antimicrobic Susceptibility Test: Principles and Practice
    • Barry, A.L.1
  • 38
    • 2642701628 scopus 로고
    • Standards
    • Williams and Wilkins: Baltimore
    • For antibiotic testing protocols, see: (a) Disk testing protocols: Phillips. I.; Williams, D. In Laboratory Methods in Antimicrobial Chemotherapy; Garrod, L., Ed.; Churchill Livingstone Press: Edinburgh, 1978: pp 3-30. (b) MIC determination: Waterworth, P. M. In Laboratory Methods in Antimicrobial Chemotherapy; Garrod, L., Ed.; Churchill Livingstone Press: Edinburgh, 1978; pp 31-40, Barry, A. L. The Antimicrobic Susceptibility Test: Principles and Practice; Lea and Febiger: Philadelphia, 1976. (c) Standards: Lorian, V. Antibiotics in Laboratory Medicine, 2nd ed.; Williams and Wilkins: Baltimore, 1986.
    • (1986) Antibiotics in Laboratory Medicine, 2nd Ed.
    • Lorian, V.1
  • 39
    • 0023264965 scopus 로고
    • For the total synthesis of neomycin B, see: (a) Usui, T.; Umezawa, S. J. Antibiot. 1987, 1464. (b) Usui, T.; Umezawa, S. Carbohydr. Res. 1987, 133.
    • (1987) J. Antibiot. , pp. 1464
    • Usui, T.1    Umezawa, S.2
  • 40
    • 2642610200 scopus 로고
    • For the total synthesis of neomycin B, see: (a) Usui, T.; Umezawa, S. J. Antibiot. 1987, 1464. (b) Usui, T.; Umezawa, S. Carbohydr. Res. 1987, 133.
    • (1987) Carbohydr. Res. , pp. 133
    • Usui, T.1    Umezawa, S.2
  • 61
    • 2642643627 scopus 로고    scopus 로고
    • note
    • The desired β anomer featured no coupling to H2″ whereas the a anomer had a coupling constant of 4 Hz.
  • 68
    • 2642709956 scopus 로고    scopus 로고
    • note
    • 4 led to the decomposition of the azide prior to liberation of the anomeric center.
  • 69
    • 2642681563 scopus 로고    scopus 로고
    • note
    • Use of benzyl bromide instead of allyl bromide as an electrophile led to decomposition under conditions necessary for reaction while Lewis acid promoted benzylation with benzyl 2,2,2-trichloroacetimidate led to reclosure to 28.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.