Designer aminoglycosides that selectively inhibit cytoplasmic rather than mitochondrial ribosomes show decreased ototoxicity a strategy for the treatment of genetic diseases

Journal of Biological Chemistry

Volumn 289, Issue 4, 2014, Pages 2318-2330

  Shulman, Eli ^a   Belakhov, Valery ^a   Wei, Gao ^a   Kendall, Ann ^a   Meyron Holtz, Esther G ^b   Ben Shachar, Dorit ^a   Schacht, Jochen ^a   Baasov, Timor ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDES; CYTOPLASMIC PROTEINS; GENETIC DISEASE; HUMAN GENETIC DISEASE; MITOCHONDRIAL RIBOSOMES; OTOTOXICITY;

BIOSYNTHESIS;

MACROMOLECULES;

ACONITATE HYDRATASE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; CYTOPLASM PROTEIN; DESIGNER DRUG; FERROUS GLUCONATE; FERROUS ION; NB 74; NB 84; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BIOACCUMULATION; CELL DAMAGE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG EFFECT; DRUG SAFETY; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; MALE; MAMMAL CELL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OTOTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL;

AMINOGLYCOSIDES; ANTIBIOTICS ACTION; CYTOPLASMIC PROTEIN SYNTHESIS INHIBITION; GENETIC DISEASES; MITOCHONDRIAL APOPTOSIS; MITOCHONDRIAL PROTEIN SYNTHESIS INHIBITION; OTOTOXICITY; OXIDATIVE STRESS; RIBOSOME FUNCTION;

AMINOGLYCOSIDES; ANIMALS; APOPTOSIS; COCHLEA; CYTOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; GENETIC DISEASES, INBORN; GUINEA PIGS; HELA CELLS; HUMANS; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXYGEN CONSUMPTION; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; REACTIVE OXYGEN SPECIES; RIBOSOMES;

EID: 84893141493     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.533588     Document Type: Article

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