메뉴 건너뛰기




Volumn 2, Issue 2, 2015, Pages

Growth hormone secretagogue receptor dimers: A new pharmacological target

Author keywords

G protein coupled receptor; Ghrelin; Growth hormone secretagogue receptor; Pharmacology; Receptor dimerization

Indexed keywords


EID: 85016630584     PISSN: None     EISSN: 23732822     Source Type: Journal    
DOI: 10.1523/ENEURO.0053-14.2015     Document Type: Review
Times cited : (68)

References (132)
  • 1
    • 69249105958 scopus 로고    scopus 로고
    • Ghrelin and dopamine: New insights on the peripheral regulation of appetite
    • Cross-Ref Medline
    • Abizaid A (2009) Ghrelin and dopamine: new insights on the peripheral regulation of appetite. J Neuroendocrinol 21:787-793. Cross-Ref Medline
    • (2009) J Neuroendocrinol , vol.21 , pp. 787-793
    • Abizaid, A.1
  • 2
    • 48849107624 scopus 로고    scopus 로고
    • Brain circuits regulating energy homeostasis
    • Abizaid A, Horvath TL (2008) Brain circuits regulating energy homeostasis. Regul Pept 149:3-10. CrossRef Medline
    • (2008) Regul Pept , vol.149 , pp. 3-10
    • Abizaid, A.1    Horvath, T.L.2
  • 5
    • 0029417035 scopus 로고
    • Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera
    • Abramowski D, Rigo M, Duc D, Hoyer D, Staufenbiel M (1995) Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera. Neuropharmacology 34:1635-1645. Medline
    • (1995) Neuropharmacology , vol.34 , pp. 1635-1645
    • Abramowski, D.1    Rigo, M.2    Duc, D.3    Hoyer, D.4    Staufenbiel, M.5
  • 6
    • 33846426067 scopus 로고    scopus 로고
    • Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission
    • Alex KD, Pehek EA (2007) Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol Ther 113:296-320. CrossRef Medline
    • (2007) Pharmacol Ther , vol.113 , pp. 296-320
    • Alex, K.D.1    Pehek, E.A.2
  • 8
    • 4644249772 scopus 로고    scopus 로고
    • Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin
    • Archer ZA, Dieguez C, Mitchell SE, Nogueiras R, Rayner DV, Tovar S, Williams LM (2004) Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin. Diabetes 53:2552-2558. CrossRef
    • (2004) Diabetes , vol.53 , pp. 2552-2558
    • Archer, Z.A.1    Dieguez, C.2    Mitchell, S.E.3    Nogueiras, R.4    Rayner, D.V.5    Tovar, S.6    Williams, L.M.7
  • 9
    • 0038304457 scopus 로고    scopus 로고
    • Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
    • Asakawa A, Inui A, Kaga T, Katsuura G, Fujimiya M, Fujino MA, Kasuga M (2003) Antagonism of ghrelin receptor reduces food intake and body weight gain in mice. Gut 52:947-952. Medline
    • (2003) Gut , vol.52 , pp. 947-952
    • Asakawa, A.1    Inui, A.2    Kaga, T.3    Katsuura, G.4    Fujimiya, M.5    Fujino, M.A.6    Kasuga, M.7
  • 10
    • 0036073405 scopus 로고    scopus 로고
    • Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure
    • Banks WA, Tschöp M, Robinson SM, Heiman ML (2002) Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther 302:822-827. CrossRef Medline
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 822-827
    • Banks, W.A.1    Tschöp, M.2    Robinson, S.M.3    Heiman, M.L.4
  • 12
    • 33845972656 scopus 로고    scopus 로고
    • The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors
    • Breit A, Wolff K, Kalwa H, Jarry H, Büch T, Gudermann T (2006) The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors. J Biol Chem 281:37447-37456. CrossRef Medline
    • (2006) J Biol Chem , vol.281 , pp. 37447-37456
    • Breit, A.1    Wolff, K.2    Kalwa, H.3    Jarry, H.4    Büch, T.5    Gudermann, T.6
  • 14
    • 0037111181 scopus 로고    scopus 로고
    • Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamus
    • Brunetti L, Recinella L, Orlando G, Michelotto B, Di Nisio C, Vacca M (2002) Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamus. Eur J Pharmacol 454: 189-192. Medline
    • (2002) Eur J Pharmacol , vol.454 , pp. 189-192
    • Brunetti, L.1    Recinella, L.2    Orlando, G.3    Michelotto, B.4    Di Nisio, C.5    Vacca, M.6
  • 16
    • 84885197226 scopus 로고    scopus 로고
    • Analysis of brain nuclei accessible to ghrelin present in the cerebrospinal fluid
    • Cabral A, Fernandez G, Perello M (2013) Analysis of brain nuclei accessible to ghrelin present in the cerebrospinal fluid. Neuroscience 253:406-415. CrossRef Medline
    • (2013) Neuroscience , vol.253 , pp. 406-415
    • Cabral, A.1    Fernandez, G.2    Perello, M.3
  • 17
    • 34548487757 scopus 로고    scopus 로고
    • Stimulation by ghrelin of p42/p44 mitogen-activated protein kinase through the GHS-R1a receptor: Role of G-proteins and β-arrestins
    • Camiña JP, Lodeiro M, Ischenko O, Martini AC, Casanueva FF (2007) Stimulation by ghrelin of p42/p44 mitogen-activated protein kinase through the GHS-R1a receptor: role of G-proteins and β-arrestins. J Cell Physiol 213:187-200. CrossRef Medline
    • (2007) J Cell Physiol , vol.213 , pp. 187-200
    • Camiña, J.P.1    Lodeiro, M.2    Ischenko, O.3    Martini, A.C.4    Casanueva, F.F.5
  • 18
    • 0022360214 scopus 로고
    • The role of food deprivation in the maintenance and reinstatement of cocaine-seeking behavior in rats
    • Carroll ME (1985) The role of food deprivation in the maintenance and reinstatement of cocaine-seeking behavior in rats. Drug Alcohol Depend 16:95-109. Medline
    • (1985) Drug Alcohol Depend , vol.16 , pp. 95-109
    • Carroll, M.E.1
  • 22
    • 84896319848 scopus 로고    scopus 로고
    • Differential role of D1 and D2 receptors in the perifornical lateral hypothalamus in controlling ethanol drinking and food intake: Possible interaction with local orexin neurons
    • Chen YW, Morganstern I, Barson JR, Hoebel BG, Leibowitz SF (2014) Differential role of D1 and D2 receptors in the perifornical lateral hypothalamus in controlling ethanol drinking and food intake: possible interaction with local orexin neurons. Alcohol Clin Exp Res 38:777-786. CrossRef
    • (2014) Alcohol Clin Exp Res , vol.38 , pp. 777-786
    • Chen, Y.W.1    Morganstern, I.2    Barson, J.R.3    Hoebel, B.G.4    Leibowitz, S.F.5
  • 25
    • 0033200153 scopus 로고    scopus 로고
    • Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat
    • Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD (1999) Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24:155-163. Medline
    • (1999) Neuron , vol.24 , pp. 155-163
    • Cowley, M.A.1    Pronchuk, N.2    Fan, W.3    Dinulescu, D.M.4    Colmers, W.F.5    Cone, R.D.6
  • 27
    • 77957749960 scopus 로고    scopus 로고
    • Hypothalamic paraventricular 5-hydroxytryptamine inhibits the effects of ghrelin on eating and energy substrate utilization
    • Currie PJ, John CS, Nicholson ML, Chapman CD, Loera KE (2010) Hypothalamic paraventricular 5-hydroxytryptamine inhibits the effects of ghrelin on eating and energy substrate utilization. Pharmacol Biochem Behav 97:152-155. CrossRef
    • (2010) Pharmacol Biochem Behav , vol.97 , pp. 152-155
    • Currie, P.J.1    John, C.S.2    Nicholson, M.L.3    Chapman, C.D.4    Loera, K.E.5
  • 30
    • 79952483790 scopus 로고    scopus 로고
    • Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice
    • Davis JF, Choi DL, Clegg DJ, Benoit SC (2011) Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice. Physiol Behav 103:39-43. CrossRef Medline
    • (2011) Physiol Behav , vol.103 , pp. 39-43
    • Davis, J.F.1    Choi, D.L.2    Clegg, D.J.3    Benoit, S.C.4
  • 31
    • 27844463517 scopus 로고    scopus 로고
    • Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    • Després JP, Golay A, Sjöström L (2005) Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med 353:2121-2134. CrossRef Medline
    • (2005) N Engl J Med , vol.353 , pp. 2121-2134
    • Després, J.P.1    Golay, A.2    Sjöström, L.3
  • 33
    • 0033990419 scopus 로고    scopus 로고
    • Preferential modulation of mesolimbic vs. Nigrostriatal dopaminergic function by serotonin2C/2B receptor agonists: A combined in vivo electrophysiological and microdialysis study
    • Di Giovanni G, Di Matteo V, Di Mascio M, Esposito E (2000) Preferential modulation of mesolimbic vs. nigrostriatal dopaminergic function by serotonin2C/2B receptor agonists: a combined in vivo electrophysiological and microdialysis study. Synapse 35:53-61. CrossRef
    • (2000) Synapse , vol.35 , pp. 53-61
    • Di Giovanni, G.1    Di Matteo, V.2    Di Mascio, M.3    Esposito, E.4
  • 34
    • 0028925758 scopus 로고
    • Dopamine receptors in the substantia nigra are involved in the regulation of muscle tone
    • Double KL, Crocker AD (1995) Dopamine receptors in the substantia nigra are involved in the regulation of muscle tone. Proc Natl Acad SciUSA92:1669-1673. Medline
    • (1995) Proc Natl Acad Sciusa , vol.92 , pp. 1669-1673
    • Double, K.L.1    Crocker, A.D.2
  • 37
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD (1997) Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:165-168. CrossRef Medline
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 38
  • 39
    • 58149301316 scopus 로고    scopus 로고
    • Pharmacological targeting of the serotonergic system for the treatment of obesity
    • Garfield AS, Heisler LK (2009) Pharmacological targeting of the serotonergic system for the treatment of obesity. J Physiol 587: 49-60. CrossRef Medline
    • (2009) J Physiol , vol.587 , pp. 49-60
    • Garfield, A.S.1    Heisler, L.K.2
  • 41
    • 0242551383 scopus 로고    scopus 로고
    • The impact of stress on addiction
    • Goeders NE (2003) The impact of stress on addiction. Eur Neuropsychopharmacol 13:435-441. Medline
    • (2003) Eur Neuropsychopharmacol , vol.13 , pp. 435-441
    • Goeders, N.E.1
  • 42
    • 36849076744 scopus 로고    scopus 로고
    • D1 but not D5 dopamine receptors are critical for LTP, spatial learning, and LTP-induced arc and zif268 expression in the hippocampus
    • Granado N, Ortiz O, Suárez LM, Martín ED, Ceña V, Solís JM, Moratalla R (2008) D1 but not D5 dopamine receptors are critical for LTP, spatial learning, and LTP-induced arc and zif268 expression in the hippocampus. Cereb Cortex 18:1-12. CrossRef Medline
    • (2008) Cereb Cortex , vol.18 , pp. 1-12
    • Granado, N.1    Ortiz, O.2    Suárez, L.M.3    Martín, E.D.4    Ceña, V.5    Solís, J.M.6    Moratalla, R.7
  • 45
    • 0029666267 scopus 로고    scopus 로고
    • A peptide derived from a β2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation
    • Hebert TE, Moffett S, Morello J-P, Loisel TP, Bichet DG, Barret C, Bouvier M (1996) A peptide derived from a β2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation. J Biol Chem 271:16384-16392. Medline
    • (1996) J Biol Chem , vol.271 , pp. 16384-16392
    • Hebert, T.E.1    Moffett, S.2    Morello, J.-P.3    Loisel, T.P.4    Bichet, D.G.5    Barret, C.6    Bouvier, M.7
  • 46
    • 0242583841 scopus 로고    scopus 로고
    • Serotonin and drug reward: Focus on 5-HT2C receptors
    • Higgins GA, Fletcher PJ (2003) Serotonin and drug reward: focus on 5-HT2C receptors. Eur J Pharmacol 480:151-162. Medline
    • (2003) Eur J Pharmacol , vol.480 , pp. 151-162
    • Higgins, G.A.1    Fletcher, P.J.2
  • 47
    • 0242330291 scopus 로고    scopus 로고
    • High constitutive signaling of the ghrelin receptor—identi-fication of a potent inverse agonist
    • Holst B, Cygankiewicz A, Jensen TH, Ankersen M, Schwartz TW (2003) High constitutive signaling of the ghrelin receptor—identi-fication of a potent inverse agonist. Mol Endocrinol 17:2201-2210. CrossRef Medline
    • (2003) Mol Endocrinol , vol.17 , pp. 2201-2210
    • Holst, B.1    Cygankiewicz, A.2    Jensen, T.H.3    Ankersen, M.4    Schwartz, T.W.5
  • 48
    • 11144225093 scopus 로고    scopus 로고
    • Common structural basis for constitutive activity of the ghrelin receptor family
    • Holst B, Holliday ND, Bach A, Elling CE, Cox HM, Schwartz TW (2004) Common structural basis for constitutive activity of the ghrelin receptor family. J Biol Chem 279:53806-53817. CrossRef Medline
    • (2004) J Biol Chem , vol.279 , pp. 53806-53817
    • Holst, B.1    Holliday, N.D.2    Bach, A.3    Elling, C.E.4    Cox, H.M.5    Schwartz, T.W.6
  • 49
    • 0034731310 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin: Two major forms of rat ghrelin peptide in gastrointestinal tissue
    • Hosoda H, Kojima M, Matsuo H, Kangawa K (2000) Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 279:909-913. CrossRef Medline
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 909-913
    • Hosoda, H.1    Kojima, M.2    Matsuo, H.3    Kangawa, K.4
  • 51
    • 0142219825 scopus 로고    scopus 로고
    • Involvement of the olfactory tubercle in cocaine reward: Intracranial self-administration studies
    • Ikemoto S (2003) Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies. J Neurosci 23: 9305-9311. Medline
    • (2003) J Neurosci , vol.23 , pp. 9305-9311
    • Ikemoto, S.1
  • 52
    • 0030612015 scopus 로고    scopus 로고
    • Role of Dopamine D1 and D2 receptors in the nucleus accumbens in mediating reward
    • Ikemoto S, Glazier BS, Murphy JM, McBride WJ (1997) Role of Dopamine D1 and D2 receptors in the nucleus accumbens in mediating reward. J Neurosci 17:8580-8587. Medline
    • (1997) J Neurosci , vol.17 , pp. 8580-8587
    • Ikemoto, S.1    Glazier, B.S.2    Murphy, J.M.3    McBride, W.J.4
  • 53
    • 0035430665 scopus 로고    scopus 로고
    • Ghrelin: An orexigenic and somatotrophic signal from the stomach
    • Inui A (2001) Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat Rev Neurosci 2:551-560. CrossRef Medline
    • (2001) Nat Rev Neurosci , vol.2 , pp. 551-560
    • Inui, A.1
  • 54
    • 0342804352 scopus 로고    scopus 로고
    • Melanocortin-3 receptor mRNA expression in pro-opiomelanocortin neurones of the rat arcuate nucleus
    • Medline
    • Jégou S, Boutelet I, Vaudry H (2000) Melanocortin-3 receptor mRNA expression in pro-opiomelanocortin neurones of the rat arcuate nucleus. J Neuroendocrinol 12:501-505. Medline
    • (2000) J Neuroendocrinol , vol.12 , pp. 501-505
    • Jégou, S.1    Boutelet, I.2    Vaudry, H.3
  • 55
    • 77955512728 scopus 로고    scopus 로고
    • Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference
    • Jerlhag E, Egecioglu E, Dickson S, Engel J (2010) Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference. Psychopharmacology (Berl) 211:415-422. CrossRef Medline
    • (2010) Psychopharmacology (Berl) , vol.211 , pp. 415-422
    • Jerlhag, E.1    Egecioglu, E.2    Dickson, S.3    Engel, J.4
  • 56
    • 33746583963 scopus 로고    scopus 로고
    • Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 het-erodimers
    • Jiang H, Betancourt L, Smith RG (2006) Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 het-erodimers. Mol Endocrinol 20:1772-1785. CrossRef Medline
    • (2006) Mol Endocrinol , vol.20 , pp. 1772-1785
    • Jiang, H.1    Betancourt, L.2    Smith, R.G.3
  • 58
    • 0032589511 scopus 로고    scopus 로고
    • Heterodimerization of a functional GABAB receptor is mediated by parallel coiled-coil α-helices
    • Kammerer RA, Frank S, Schulthess T, Landwehr R, Lustig A, Engel J (1999) Heterodimerization of a functional GABAB receptor is mediated by parallel coiled-coil α-helices. Biochemistry 38:13263-13269. Medline
    • (1999) Biochemistry , vol.38 , pp. 13263-13269
    • Kammerer, R.A.1    Frank, S.2    Schulthess, T.3    Landwehr, R.4    Lustig, A.5    Engel, J.6
  • 60
    • 84863010954 scopus 로고    scopus 로고
    • Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism
    • Kern A, Albarran-Zeckler R, Walsh HE, Smith RG (2012) Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism. Neuron 73:317-332. CrossRef Medline
    • (2012) Neuron , vol.73 , pp. 317-332
    • Kern, A.1    Albarran-Zeckler, R.2    Walsh, H.E.3    Smith, R.G.4
  • 61
    • 0031884124 scopus 로고    scopus 로고
    • Different developmental patterns of melanocortin MC3 and MC4 receptor mRNA: Predominance of Mc4 in fetal rat nervous system
    • Kistler H, Lauber, Lichtensteiger (1998) Different developmental patterns of melanocortin MC3 and MC4 receptor mRNA: predominance of Mc4 in fetal rat nervous system. J Neuroendocrinol 10:133-146. Medline
    • (1998) J Neuroendocrinol , vol.10 , pp. 133-146
    • Kistler, H.1    Lauber, L.2
  • 62
    • 0019875964 scopus 로고
    • Membrane protein oligomeric structure and transport function
    • Klingenberg M (1981) Membrane protein oligomeric structure and transport function. Nature 290:449-454. Medline
    • (1981) Nature , vol.290 , pp. 449-454
    • Klingenberg, M.1
  • 63
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660. CrossRef Medline
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 64
    • 70349239336 scopus 로고    scopus 로고
    • Shedding light on the intricate puzzle of ghrelin’s effects on appetite regulation
    • Kola B, Korbonits M (2009) Shedding light on the intricate puzzle of ghrelin’s effects on appetite regulation. J Endocrinol 202:191-198. CrossRef Medline
    • (2009) J Endocrinol , vol.202 , pp. 191-198
    • Kola, B.1    Korbonits, M.2
  • 69
    • 0023820013 scopus 로고
    • Dopamine D1 receptors in the nucleus accumbens: Involvement in the reinforcing effect of tegmental stimulation
    • Medline
    • Kurumiya S, Nakajima S (1988) Dopamine D1 receptors in the nucleus accumbens: involvement in the reinforcing effect of tegmental stimulation. Brain Res 448:1-6. Medline
    • (1988) Brain Res , vol.448 , pp. 1-6
    • Kurumiya, S.1    Nakajima, S.2
  • 70
    • 84922661146 scopus 로고    scopus 로고
    • Intravenous ghrelin administration increases alcohol craving in alcohol-dependent heavy drinkers: A preliminary investigation
    • Leggio L, Zywiak WH, Fricchione SR, Edwards SM, de la Monte SM, Swift RM, Kenna GA (2014) Intravenous ghrelin administration increases alcohol craving in alcohol-dependent heavy drinkers: a preliminary investigation. Biol Psychiatry 76:734-741. CrossRef Medline
    • (2014) Biol Psychiatry , vol.76 , pp. 734-741
    • Leggio, L.1    Zywiak, W.H.2    Fricchione, S.R.3    Edwards, S.M.4    de La Monte, S.M.5    Swift, R.M.6    Kenna, G.A.7
  • 74
    • 0033667466 scopus 로고    scopus 로고
    • A trafficking checkpoint controls GABA(B) receptor heterodimerization
    • Margeta-Mitrovic M, Jan YN, Jan LY (2000) A trafficking checkpoint controls GABA(B) receptor heterodimerization. Neuron 27:97-106. Medline
    • (2000) Neuron , vol.27 , pp. 97-106
    • Margeta-Mitrovic, M.1    Jan, Y.N.2    Jan, L.Y.3
  • 76
    • 0030608679 scopus 로고    scopus 로고
    • Dopamine D1-deficient mutant mice do not express the late phase of hippocampal long-term potentiation
    • Matthies H, Becker A, Krug M (1997) Dopamine D1-deficient mutant mice do not express the late phase of hippocampal long-term potentiation. Neuroreport 8:3533. Medline
    • (1997) Neuroreport , vol.8 , pp. 3533
    • Matthies, H.1    Becker, A.2    Krug, M.3
  • 78
    • 20544476874 scopus 로고    scopus 로고
    • The magic of l-dopa: Why is it the gold standard Parkinson’s disease therapy?
    • Mercuri NB, Bernardi G (2005) The magic of l-dopa: why is it the gold standard Parkinson’s disease therapy? Trends Pharmacol Sci 26: 341-344. CrossRef Medline
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 341-344
    • Mercuri, N.B.1    Bernardi, G.2
  • 80
    • 0035863948 scopus 로고    scopus 로고
    • Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microce-bus murinus (Primate, Lemurian) and rat forebrain and pituitary
    • Mitchell V, Bouret S, Beauvillain J-C, Schilling A, Perret M, Kordon C, Epelbaum J (2001) Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microce-bus murinus (Primate, Lemurian) and rat forebrain and pituitary. J Comp Neurol 429:469-489. Medline
    • (2001) J Comp Neurol , vol.429 , pp. 469-489
    • Mitchell, V.1    Bouret, S.2    Beauvillain, J.-C.3    Schilling, A.4    Perret, M.5    Kordon, C.6    Epelbaum, J.7
  • 81
    • 70449527787 scopus 로고    scopus 로고
    • Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease by blocking microglial activation
    • Moon M, Kim H, Hwang L, Seo J-H, Kim S, Hwang S, Kim S, Lee D, Chung H, Oh M, Lee KT, Park S (2009) Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease by blocking microglial activation. Neurotox Res 15:332-347. CrossRef Medline
    • (2009) Neurotox Res , vol.15 , pp. 332-347
    • Moon, M.1    Kim, H.2    Hwang, L.3    Seo, J.-H.4    Kim, S.5    Hwang, S.6    Kim, S.7    Lee, D.8    Chung, H.9    Oh, M.10    Lee, K.T.11    Park, S.12
  • 82
    • 0024465007 scopus 로고
    • Subtypes of dopamine receptors involved in the mechanism of reinforcement
    • Nakajima S (1989) Subtypes of dopamine receptors involved in the mechanism of reinforcement. Neurosci Biobehav Rev 13:123-128. Medline
    • (1989) Neurosci Biobehav Rev , vol.13 , pp. 123-128
    • Nakajima, S.1
  • 83
    • 0022538265 scopus 로고
    • Reduction of the rewarding effect of brain stimulation by a blockade of dopamine D1 receptor with SCH 23390
    • Nakajima S, McKenzie GM (1986) Reduction of the rewarding effect of brain stimulation by a blockade of dopamine D1 receptor with SCH 23390. Pharmacol Biochem Behav 24:919-923. Medline
    • (1986) Pharmacol Biochem Behav , vol.24 , pp. 919-923
    • Nakajima, S.1    McKenzie, G.M.2
  • 85
    • 0031721271 scopus 로고    scopus 로고
    • Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene
    • Nonogaki K, Strack AM, Dallman MF, Tecott LH (1998) Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat Med 4:1152-1156. CrossRef Medline
    • (1998) Nat Med , vol.4 , pp. 1152-1156
    • Nonogaki, K.1    Strack, A.M.2    Dallman, M.F.3    Tecott, L.H.4
  • 86
    • 31744434071 scopus 로고    scopus 로고
    • A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice
    • Nonogaki K, Ohashi-Nozue K, Oka Y (2006) A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice. Biochem Biophys Res Commun 341:703-707. CrossRef Medline
    • (2006) Biochem Biophys Res Commun , vol.341 , pp. 703-707
    • Nonogaki, K.1    Ohashi-Nozue, K.2    Oka, Y.3
  • 87
    • 0029997176 scopus 로고    scopus 로고
    • D1/D5 dopamine receptor activation increases the magnitude of early long-term potentiation at CA1 hippocampal synapses
    • Otmakhova NA, Lisman JE (1996) D1/D5 dopamine receptor activation increases the magnitude of early long-term potentiation at CA1 hippocampal synapses. J Neurosci 16:7478-7486. Medline
    • (1996) J Neurosci , vol.16 , pp. 7478-7486
    • Otmakhova, N.A.1    Lisman, J.E.2
  • 89
    • 10844255797 scopus 로고    scopus 로고
    • Oligomerization of G protein-coupled receptors: Past, present, and future
    • Park PS, Filipek S, Wells JW, Palczewski K (2004) Oligomerization of G protein-coupled receptors: past, present, and future. Biochemistry 43:15643-15656. CrossRef Medline
    • (2004) Biochemistry , vol.43 , pp. 15643-15656
    • Park, P.S.1    Filipek, S.2    Wells, J.W.3    Palczewski, K.4
  • 90
    • 77955747334 scopus 로고    scopus 로고
    • Altered metabolic and neurochemical responses to chronic unpredictable stressors in ghrelin receptor-deficient mice
    • Patterson ZR, Ducharme R, Anisman H, Abizaid A (2010) Altered metabolic and neurochemical responses to chronic unpredictable stressors in ghrelin receptor-deficient mice. Eur J Neurosci 32: 632-639. CrossRef Medline
    • (2010) Eur J Neurosci , vol.32 , pp. 632-639
    • Patterson, Z.R.1    Ducharme, R.2    Anisman, H.3    Abizaid, A.4
  • 93
    • 0038548401 scopus 로고    scopus 로고
    • Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice
    • Poncelet M, Maruani J, Calassi R, Soubrié P (2003) Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice. Neurosci Lett 343:216-218. Medline
    • (2003) Neurosci Lett , vol.343 , pp. 216-218
    • Poncelet, M.1    Maruani, J.2    Calassi, R.3    Soubrié, P.4
  • 98
    • 0029903640 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 is a disulfide-linked dimer
    • Romano C, Yang W-L, O’Malley KL (1996) Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J Biol Chem 271:28612-28616. Medline
    • (1996) J Biol Chem , vol.271 , pp. 28612-28616
    • Romano, C.1    Yang, W.-L.2    O’Malley, K.L.3
  • 102
    • 0028085278 scopus 로고
    • The role of D1-dopamine receptor in working memory: Local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task
    • Sawaguchi T, Goldman-Rakic PS (1994) The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task. J Neurophysiol 71:515-28.
    • (1994) J Neurophysiol , vol.71 , pp. 515-528
    • Sawaguchi, T.1    Goldman-Rakic, P.S.2
  • 103
    • 0025330556 scopus 로고
    • Effects of dopamine antagonists on neuronal activity related to a delayed response task in monkey prefrontal cortex
    • Sawaguchi T, Matsumura M, Kubota K (1990) Effects of dopamine antagonists on neuronal activity related to a delayed response task in monkey prefrontal cortex. J Neurophysiol 63:1401-1412.
    • (1990) J Neurophysiol , vol.63 , pp. 1401-1412
    • Sawaguchi, T.1    Matsumura, M.2    Kubota, K.3
  • 104
    • 84872064517 scopus 로고    scopus 로고
    • Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling
    • Schellekens H, van Oeffelen WE, Dinan TG, Cryan JF (2013) Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling. J Biol Chem 288:181-191. CrossRef Medline
    • (2013) J Biol Chem , vol.288 , pp. 181-191
    • Schellekens, H.1    van Oeffelen, W.E.2    Dinan, T.G.3    Cryan, J.F.4
  • 106
    • 0032519004 scopus 로고    scopus 로고
    • D1 receptor modulation of hippocampal-prefrontal cortical circuits integrating spatial memory with executive functions in the rat
    • Seamans JK, Floresco SB, Phillips AG (1998) D1 receptor modulation of hippocampal-prefrontal cortical circuits integrating spatial memory with executive functions in the rat. J Neurosci 18:1613-1621. Medline
    • (1998) J Neurosci , vol.18 , pp. 1613-1621
    • Seamans, J.K.1    Floresco, S.B.2    Phillips, A.G.3
  • 107
    • 0035866247 scopus 로고    scopus 로고
    • Leptin attenuates acute food deprivation-induced relapse to heroin seeking
    • Shalev U, Yap J, Shaham Y (2001) Leptin attenuates acute food deprivation-induced relapse to heroin seeking. J Neurosci 21: RC129. Medline
    • (2001) J Neurosci , vol.21
    • Shalev, U.1    Yap, J.2    Shaham, Y.3
  • 108
    • 0033919137 scopus 로고    scopus 로고
    • Stress and relapse to drug seeking in rats: Studies on the generality of the effect
    • Shalev U, Highfield D, Yap J, Shaham Y (2000) Stress and relapse to drug seeking in rats: studies on the generality of the effect. Psychopharmacology (Berl) 150:337-346. Medline
    • (2000) Psychopharmacology (Berl) , vol.150 , pp. 337-346
    • Shalev, U.1    Highfield, D.2    Yap, J.3    Shaham, Y.4
  • 109
    • 25144473425 scopus 로고    scopus 로고
    • Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice
    • Shaw AM, Irani BG, Moore MC, Haskell-Luevano C, Millard WJ (2005) Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice. Peptides 26:1720-1727. CrossRef Medline
    • (2005) Peptides , vol.26 , pp. 1720-1727
    • Shaw, A.M.1    Irani, B.G.2    Moore, M.C.3    Haskell-Luevano, C.4    Millard, W.J.5
  • 110
    • 33644753922 scopus 로고    scopus 로고
    • Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes
    • Sinha R, Garcia M, Paliwal P, Kreek M, Rounsaville BJ (2006) Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes. Arch Gen Psychiatry 63:324-331. CrossRef Medline
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 324-331
    • Sinha, R.1    Garcia, M.2    Paliwal, P.3    Kreek, M.4    Rounsaville, B.J.5
  • 111
    • 34249984987 scopus 로고    scopus 로고
    • 5-HT(2C) receptor activation inhibits appetitive and consummatory components of feeding and increases brain c-fos immunoreactivity in mice
    • Somerville EM, Horwood JM, Lee MD, Kennett GA, Clifton PG (2007) 5-HT(2C) receptor activation inhibits appetitive and consummatory components of feeding and increases brain c-fos immunoreactivity in mice. Eur J Neurosci 25:3115-3124. CrossRef Medline
    • (2007) Eur J Neurosci , vol.25 , pp. 3115-3124
    • Somerville, E.M.1    Horwood, J.M.2    Lee, M.D.3    Kennett, G.A.4    Clifton, P.G.5
  • 112
    • 84882687705 scopus 로고    scopus 로고
    • Ghrelin receptor (GHS-R1A) antagonism suppresses both alcohol consumption and the alcohol deprivation effect in rats following long-term voluntary alcohol consumption
    • Suchankova P, Steensland P, Fredriksson I, Engel JA, Jerlhag E (2013) Ghrelin receptor (GHS-R1A) antagonism suppresses both alcohol consumption and the alcohol deprivation effect in rats following long-term voluntary alcohol consumption. PLoS One 8:e71284. CrossRef Medline
    • (2013) Plos One , vol.8
    • Suchankova, P.1    Steensland, P.2    Fredriksson, I.3    Engel, J.A.4    Jerlhag, E.5
  • 113
    • 33645839593 scopus 로고    scopus 로고
    • Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors
    • Sutton GM, Trevaskis JL, Hulver MW, McMillan RP, Markward NJ, Babin MJ, Meyer EA, Butler AA (2006) Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. Endocrinology 147:2183-2196. CrossRef Medline
    • (2006) Endocrinology , vol.147 , pp. 2183-2196
    • Sutton, G.M.1    Trevaskis, J.L.2    Hulver, M.W.3    McMillan, R.P.4    Markward, N.J.5    Babin, M.J.6    Meyer, E.A.7    Butler, A.A.8
  • 114
    • 41149127699 scopus 로고    scopus 로고
    • Dimerization and oligomerization of G-protein-coupled receptors: Debated structures with established and emerging functions
    • Szidonya L, Cserzö M, Hunyady L (2008) Dimerization and oligomerization of G-protein-coupled receptors: debated structures with established and emerging functions. J Endocrinol 196:435-453. CrossRef Medline
    • (2008) J Endocrinol , vol.196 , pp. 435-453
    • Szidonya, L.1    Cserzö, M.2    Hunyady, L.3
  • 115
    • 0031765095 scopus 로고    scopus 로고
    • Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurons in the mediobasal hypothalamus
    • Tannenbaum GS, Lapointe M, Beaudet A, Howard AD (1998) Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurons in the mediobasal hypothalamus. Endocrinology 139:4420-4423. CrossRef Medline
    • (1998) Endocrinology , vol.139 , pp. 4420-4423
    • Tannenbaum, G.S.1    Lapointe, M.2    Beaudet, A.3    Howard, A.D.4
  • 117
  • 118
    • 79251598360 scopus 로고    scopus 로고
    • Central dopaminergic circuitry controlling food intake and reward: Implications for the regulation of obesity
    • Vucetic Z, Reyes TM (2010) Central dopaminergic circuitry controlling food intake and reward: implications for the regulation of obesity. Wiley Interdiscip Rev Syst Biol Med 2:577-593. CrossRef Medline
    • (2010) Wiley Interdiscip Rev Syst Biol Med , vol.2 , pp. 577-593
    • Vucetic, Z.1    Reyes, T.M.2
  • 119
    • 84904745018 scopus 로고    scopus 로고
    • Ghrelin and ghrelin receptor modulation of psychostimulant action
    • CrossRef
    • Wellman PJ, Clifford PS, Rodriguez JA (2013) Ghrelin and ghrelin receptor modulation of psychostimulant action. Front Neurosci 7:171. CrossRef
    • (2013) Front Neurosci , vol.7 , pp. 171
    • Wellman, P.J.1    Clifford, P.S.2    Rodriguez, J.A.3
  • 121
    • 0023690397 scopus 로고
    • Effect of nigrostriatal dopamine depletion on the post-training, memory-improving action of amphetamine
    • White NM (1988) Effect of nigrostriatal dopamine depletion on the post-training, memory-improving action of amphetamine. Life Sci 43:7-12. Medline
    • (1988) Life Sci , vol.43 , pp. 7-12
    • White, N.M.1
  • 122
    • 0024433316 scopus 로고
    • Reward or reinforcement: What’s the difference?
    • White NM (1989) Reward or reinforcement: what’s the difference? Neurosci Biobehav Rev 13:181-186. Medline
    • (1989) Neurosci Biobehav Rev , vol.13 , pp. 181-186
    • White, N.M.1
  • 123
    • 0032744366 scopus 로고    scopus 로고
    • Co-localization of growth hormone secretagogue receptor and npy mrna in the arcuate nucleus of the rat
    • Willesen MG, Kristensen P, Rømer J (1999) Co-localization of growth hormone secretagogue receptor and npy mrna in the arcuate nucleus of the rat. Neuroendocrinology 70:306-316. Medline
    • (1999) Neuroendocrinology , vol.70 , pp. 306-316
    • Willesen, M.G.1    Kristensen, P.2    Rømer, J.3
  • 124
    • 0031736282 scopus 로고    scopus 로고
    • Hyperphagia in pre-fed rats following oral δ9-THC
    • Williams CM, Rogers PJ, Kirkham TC (1998) Hyperphagia in pre-fed rats following oral δ9-THC. Physiol Behav 65:343-346. Medline
    • (1998) Physiol Behav , vol.65 , pp. 343-346
    • Williams, C.M.1    Rogers, P.J.2    Kirkham, T.C.3
  • 125
    • 0029116316 scopus 로고
    • Modulation of memory fields by dopamine D1 receptors in prefrontal cortex
    • Williams GV, Goldman-Rakic PS (1995) Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature 376:572-575. CrossRef Medline
    • (1995) Nature , vol.376 , pp. 572-575
    • Williams, G.V.1    Goldman-Rakic, P.S.2
  • 126
    • 63249095013 scopus 로고    scopus 로고
    • Dopamine and reward: The anhedonia hypothesis 30 years on
    • Wise R (2008) Dopamine and reward: the anhedonia hypothesis 30 years on. Neurotox Res 14:169-183. CrossRef Medline
    • (2008) Neurotox Res , vol.14 , pp. 169-183
    • Wise, R.1
  • 127
    • 33845325494 scopus 로고    scopus 로고
    • Role of brain dopamine in food reward and reinforcement
    • Wise RA (2006) Role of brain dopamine in food reward and reinforcement. Philos Trans R Soc B Biol Sci 361:1149-1158. CrossRef Medline
    • (2006) Philos Trans R Soc B Biol Sci , vol.361 , pp. 1149-1158
    • Wise, R.A.1
  • 128
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    • Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL (2008) Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132:387-396. Cross-Ref Medline
    • (2008) Cell , vol.132 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 129
    • 84924965507 scopus 로고    scopus 로고
    • “First do no harm.” A systematic review of the prevalence and management of antipsychotic adverse effects
    • Young SL, Taylor M, Lawrie SM (2015) “First do no harm.” A systematic review of the prevalence and management of antipsychotic adverse effects. J Psychopharmacol (Oxf) 29:353-362. CrossRef Medline
    • (2015) J Psychopharmacol (Oxf) , vol.29 , pp. 353-362
    • Young, S.L.1    Taylor, M.2    Lawrie, S.M.3
  • 130
    • 66149108361 scopus 로고    scopus 로고
    • Effects of repeated restraint stress on gastric motility in rats
    • CrossRef Medline
    • Zheng J, Dobner A, Babygirija R, Ludwig K, Takahashi T (2009) Effects of repeated restraint stress on gastric motility in rats. Am J Physiol 296:R1358-R1365. CrossRef Medline
    • (2009) Am J Physiol , vol.296 , pp. R1358-R1365
    • Zheng, J.1    Dobner, A.2    Babygirija, R.3    Ludwig, K.4    Takahashi, T.5
  • 132
    • 29044434688 scopus 로고    scopus 로고
    • Expression of ghrelin receptor mRNA in the rat and the mouse brain
    • Zigman JM, Jones JE, Lee CE, Saper CB, Elmquist JK (2006) Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol 494:528-548. CrossRef Medline
    • (2006) J Comp Neurol , vol.494 , pp. 528-548
    • Zigman, J.M.1    Jones, J.E.2    Lee, C.E.3    Saper, C.B.4    Elmquist, J.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.