Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 2, 2002, Pages 822-827

  Banks, William A ^a,b,c   Tschöp, Matthias ^a,b   Robinson, Sandra M ^a,b   Heiman, Mark L ^a,b  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APPETITE STIMULANT; DESOCTANOYLGHRELIN; GHRELIN; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DIFFUSION; DRUG POTENCY; DRUG TRANSPORT; HUMAN; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; HUMANS; KINETICS; MICE; PEPTIDE HORMONES; PEPTIDES; TISSUE DISTRIBUTION;

EID: 0036073405     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.034827     Document Type: Article

References (29)

1. Endocrine activities of ghrelin a natural growth hormone secretagogue (GHS) in humans: Comparison and interactions with hexarelin a nonnatural peptidyl GHS and GH-releasing hormone
2. Blood to brain and brain to blood passage of native horseradish peroxidase, wheat germ agglutinin and albumin: Pharmacokinetic and morphological assessments
3. Partial saturation and regional variation in the blood to brain transport of leptin in normal weight mice
4. Impaired transport of leptin across the blood-brain barrier in obesity
5. Quantifying carrier-mediated transport of peptides from the brain to the blood
6. Exchange of peptides between the circulation and the nervous system: Role of the blood-brain barrier
7. Differential permeability of the blood-brain barrier to two pancreatic peptides: Insulin and amylin
8. Leptin enters the brain by a saturable system independent of insulin
9. Saturable transport of insulin from plasma into the central nervous system of dogs in vivo: A mechanism for regulated insulin delivery to the brain
10. Transport of α-aminoisobutyric acid across brain capillary and cellular membranes
11. Unnatural growth hormone-releasing peptide begets natural ghrelin
12. Supravital analysis of disorders in the cerebrovascular permeability
13. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
14. Sequestration of centrally administered insulin by the brain: Effects of starvation, aluminum and TNF-α
15. Serum immunoreactive-leptin concentrations in normal-weight and obese humans
16. Seasonal changes in CSF insulin levels in marmots: Insulin may not be a satiety signal for fasting in winter
17. Leptin and the regulation of body weight in mammals
18. Intracranial haemorrhage and blood-brain barrier problems in the new-born
19. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues
20. Murine tumor necrosis factor-α is transported from blood to brain in the mouse
21. Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
22. Minireview: Ghrelin and the regulation of energy balance - A hypothalamic perspective
23. Ghrelin is a growth-hormone-releasing acylated peptide from stomach
24. Long survival time of an isolated perfused rat brain
25. Selective transport of blood-borne interleukin-1α into the posterior division of the septum of the mouse brain
26. Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa
27. Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins
28. Ghrelin induces adiposity in rodents
29. GH-releasing peptide-2 increases fat mass in mice lacking NPY: Indication for a crucial mediating role of hypothalamic agouti-related protein