Dopamine receptor signaling

Journal of Receptors and Signal Transduction

Volumn 24, Issue 3, 2004, Pages 165-205

  Neve, Kim A ^a   Seamans, Jeremy K ^b   Trantham Davidson, Heather ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Adenylate cyclase; Calcium channel; Extracellular signal regulated kinase; G protein; Glutamate; Phospholipase; Potassium channel; Protein kinase; Sodium channel

Indexed keywords

ADENYLATE CYCLASE; CALCIUM; CALCIUM CHANNEL; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE 5 RECEPTOR; DOPAMINE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; ION CHANNEL; PERTUSSIS TOXIN; PHOSPHOLIPASE; PHOSPHOLIPASE C; PHOSPHOPROTEIN DARPP 32; PHOSPHOPROTEIN PHOSPHATASE 1; POTASSIUM CHANNEL; PROTEIN KINASE; PROTEIN TYROSINE KINASE; RECEPTOR SUBTYPE; SODIUM CHANNEL; TRANSCRIPTION FACTOR;

CALCIUM CELL LEVEL; CONFERENCE PAPER; ENZYME ACTIVITY; HUMAN; NONHUMAN; OLIGOMERIZATION; PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GTP-BINDING PROTEINS; HUMANS; ION CHANNELS; MODELS, BIOLOGICAL; PHOSPHOLIPASE C; RECEPTORS, DOPAMINE; RECEPTORS, GLUTAMATE; SIGNAL TRANSDUCTION;

EID: 4944232441     PISSN: 10799893     EISSN: 15324281     Source Type: Journal    
DOI: 10.1081/RRS-200029981     Document Type: Conference Paper

References (261)

1. Neve KA, Neve RL. Molecular biology of dopamine receptors. In: Neve KA, Neve RL, eds. The Dopamine Receptors. Totawa, NJ: Humana Press, 1997:27-76.
2. Huff RM. Signaling pathways modulated by dopamine receptors. In: Neve KA, Neve RL, eds. The Dopamine Receptors. Totowa, NJ: Humana Press, 1997:167-192.
3. 5 dopamine receptors to multiple G proteins-implications for understanding the diversity in receptor-G protein coupling. Mol Neurobiol 1998; 16:125-134.
4. 1 dopamine receptors couple to multiple Gα proteins in different brain regions. J Neurochem 2001; 78:981-990.
5. 1 receptor signaling. J Neurosci 2000; 20:NIL1-NIL5.
6. olf levels are regulated by receptor usage and control dopamine and adenosine action in the striatum. J Neurosci 2001; 21:4390-4399.
7. olf: an olfactory neuron specific-G protein involved in odorant signal transduction. Science 1989; 244:790-795.
8. olf is necessary for coupling D1 and A2a receptors to adenylyl cyclase in the striatum. J Neurochem 2001; 76:1585-1588.
9. 5 dopamine receptors on the G protein γ7 subunit for activation of adenylylcyclase. J Biol Chem 2001; 276:39386-39393.
10. Watson JB, Coulter PM II, Margulies JE, De Lecea L, Danielson PE, Erlander MG, Sutcliffe JG. G-protein γ7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum. J Neurosci Res 1994; 39:108-116.
11. o. J Biol Chem 1995; 270:14672-14678.
12. Brown JH, Makman MH. Stimulation by dopamine of adenylate cyclase in retinal homogenates and of adenosine-3′:5′-cyclic monophosphate formation in intact retina. Proc Natl Acad Sci USA 1972; 69:539-543.
13. Kebabian JW, Petzold GL, Greengard P. Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor." Proc Natl Acad Sci USA 1972; 69:2145-2149.
14. sα. GTPγS. Science 1997; 278:1907-1916.
15. Glatt CE, Snyder SH. Cloning and expression of an adenylyl cyclase localized to the corpus striatum. Nature 1993; 361:536-538.
16. Lee KW, Hong JH, Choi IY, Che YZ, Lee JK, Yang SD, Song CW, Kang HS, Lee JH, Noh JS, Shin HS, Han PL. Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase. J Neurosci 2002; 22:7931-7940.
17. Iwamoto T, Okumura S, Iwatsubo K, Kawabe JI, Ohtsu K, Sakai I, Hashimoto Y, Izumitani A, Sango K, Ajiki K, Toya Y, Umemura S, Goshima Y, Arai N, Vatner SF, Ishikawa Y. Motor dysfunction in type 5 adenylyl cyclase-null mice. J Biol Chem 2003; 278:16936-16940.
18. Demchyshyn LL, O'Dowd BF, George SR. Structure of mammalian D1 and D5 dopamine receptors and their function and regulation in cells. In: Sidhu A, Laruelle M, Vernier P, eds. In: Dopamine Receptors and Transporters: Function, Imaging, and Clinical Implication. New York: Marcel Dekker, Inc., 2003:45-76.
19. Hemmings HC Jr, Greengard P, Tung HY, Cohen P. DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1. Nature 1984; 310:503-505.
20. Greengard P, Allen PB, Nairn AC. Beyond the dopamine receptor: the DARPP-32/Protein phosphatase-1 cascade. Neuron 1999; 23:435-447.
21. Bibb JA, Snyder GL, Nishi A, Yan Z, Meijer L, Fienberg AA, Tsai LH, Kwon YT, Girault JA, Czernik AJ, Huganir RL, Hemmings HC Jr, Nairn AC, Greengard P. Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature 1999; 402:669-671.
22. Nishi A, Bibb JA, Snyder GL, Higashi H, Nairn AC, Greengard P. Amplification of dopaminergic signaling by a positive feedback loop. Proc Natl Acad Sci USA 2000; 97:12840-12845.
23. Fienberg AA, Hiroi N, Mermelstein PG, Song WJ, Snyder GL, Nishi A, Cheramy A, O'Callaghan JP, Miller DB, Cole DG, Corbett R, Haile CN, Cooper DC, Onn SP, Grace AA, Ouimet CC, White FJ, Hyman SE, Surmeier DJ, Girault JA, Nestler EJ, Greengard P. DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission. Science 1998; 281:838-839.
24. A receptor currents in neostriatal neurons through a PKA/DARPP-32/PP1 signaling cascade. J Neurophysiol 2000; 83:2996-3004.
25. Nally RE, McNamara FN, Clifford JJ, Kinsella A, Tighe O, Croke DT, Fienberg AA, Greengard P, Waddington JL. Topographical assessment of ethological and dopamine receptor agonist-induced behavioral phenotype in mutants with congenic DARPP-32 'knockout.' Neuropsychopharmacology 2003; 28:2055-2063.
26. Cantrell AR, Smith RD, Goldin AL, Scheuer T, Catterall WA. Dopaminergic modulation of sodium current in hippocampal neurons via cAMP-dependent phosphorylation of specific sites in the sodium channel a subunit. J Neurosci 1997; 17:7330-7338.
27. Surmeier DJ, Eberwine J, Wilson CJ, Cao Y, Stefani A, Kitai ST. Dopamine receptor subtypes colocalize in rat striatonigral neurons. Proc Natl Acad Sci USA 1992; 89:10178-10182.
28. Li M, West JW, Lai Y, Scheuer T, Catterall WA. Functional modulation of brain sodium channels by cAMP-dependent phosphorylation. Neuron 1992; 8:1151-1159.
29. Smith RD, Goldin AL. Phosphorylation at a single site in the rat brain sodium channel is necessary and sufficient for current reduction by protein kinase A. J Neurosci 1997; 17:6086-6093.
30. + channel α subunit by cAMP-dependent protein kinase and phosphoprotein phosphatases. J Biol Chem 1993; 268:27355-27362.
31. Liu FC, Graybiel AM. Spatiotemporal dynamics of CREB phosphorylation: transient versus sustained phosphorylation in the developing striatum. Neuron 1996; 17:1133-1144.
32. Zhang DS, Zhang L, Lou DW, Nakabeppu Y, Zhang JH, Xu M. The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression. J Neurochem 2002; 82:1453-1464.
33. Konradi C, Cole RL, Heckers S, Hyman SE. Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J Neurosci 1994; 14:5623-5634.
34. Cole RL, Konradi C, Douglass J, Hyman SE. Neuronal adaptation to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron 1995; 14:813-823.
35. Brami-Cherrier K, Valjent E, Garcia M, Pagès C, Hipskind RA, Caboche J. Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: A new route to cAMP response element-binding protein phosphorylation. J Neurosci 2002; 22:8911-8921.
36. Berke JD, Hyman SE. Addiction, dopamine, and the molecular mechanisms of memory. Neuron 2000; 25:515-532.
37. 2+ mobilization in Xenopus oocytes. Proc Natl Acad Sci USA 1990; 87:2196-2200.
38. Lezcano N, Mrzljak L, Eubanks S, Levenson R, Goldman-Rakic P, Bergson C. Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein. Science 2000; 287:1660-1664.
39. Lezcano N, Bergson C. D1/D5 dopamine receptors stimulate intracellular calcium release in primary cultures of neocortical and hippocampal neurons. J Neurophysiol 2002; 87:2167-2175.
40. Undie AS, Friedman E. Stimulation of a dopamine D1 receptor enhances inositol phosphates formation in rat brain. J Pharmacol Exp Ther 1990; 253:987-992.
41. 3H]phosphatidylinositol 4,5-bisphosphate hydrolysis in postmortem human brain membranes and characterization of stimulation by dopamine D1 receptors. J Neurochem 1997; 69:639-644.
42. Undie AS, Weinstock J, Sarau HM, Friedman E. Evidence for a distinct D1-like dopamine receptor that couples to activation of phosphoinositide metabolism in brain. J Neurochem 1994; 62:2045-2048.
43. Jin LQ, Goswami S, Cai GP, Zhen XC, Friedman E. SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain. J Neurochem 2003; 85:378-386.
44. 1 receptors are not linked to stimulation of adenylate cyclase. Synapse 2003; 50:320-333.
45. 1 -like dopamine sites in rat striatum: possible role in dopamine-mediated inositol phosphate formation. Mol Pharmacol 1995; 48:988-994.
46. 1A knockout mice. Mol Pharmacol 1997; 51:6-11.
47. 1-like receptor not coupled to adenylyl cyclase. Neuroscience 1999; 93:1483-1489.
48. 1A dopamine receptor mutants: ethologically based resolution of behavioural topography indicates genetic background as a determinant of knockout phenotype. Neuropsychopharmacology 2003; 28:86-99.
49. 1A receptor-deficient mice. Synapse 2001; 39:319-322.
50. Foehring RC, Surmeier DJ. Voltage-gated potassium currents in acutely dissociated rat cortical neurons. J Neurophysiol 1993; 70:51-63.
51. 2 receptors increases spike firing of nucleus accumbens neurons via G-protein βγ subunits. J Neurosci 2003; 23:5079-5087.
52. Sunahara RK, Dessauer CW, Gilman AG. Complexity and diversity of mammalian adenylyl cyclases. Annu Rev Pharmacol Toxicol 1996; 36:461-480.
53. 3 dopamine receptors. Mol Pharmacol 1997; 52:181-186.
54. Marshall JF, Ruskin DN, Lahoste GJ. D1/D2 dopamine receptor interactions in basal ganglia. In: Neve KA, Neve RL, eds. The Dopamine Receptors. Totawa, NJ: Humana Press, 1997:193-219.
55. Gorelova N, Seamans JK, Yang CR. Mechanisms of dopamine activation of fast-spiking interneurons that exert inhibition in rat prefrontal cortex. J Neurophysiol 2002; 88:3150-3166.
56. Yang CR, Seamans JK. Dopamine D1 receptor actions in layers V-VI rat prefrontal cortex neurons in vitro: modulation of dendritic-somatic signal integration. J Neurosci 1996; 16:1922-1935.
57. Dong Y, White FJ. Dopamine D1-class receptors selectively modulate a slowly inactivating potassium current in rat medial prefrontal cortex pyramidal neurons. J Neurosci 2003; 23:2686-2695.
58. Yang CR, Seamans JK, Gorelova N. Developing a neuronal model for the pathophysiology of schizophrenia based on the nature of electrophysiological actions of dopamine in the prefrontal cortex. Neuropsychopharmacology 1999; 21:161-194.
59. Dong Y, Cooper D, Nasif F, Hu XT, White FJ. Dopamine modulates inwardly rectifying potassium currents in medial prefrontal cortex pyramidal neurons. J Neurosci 2004; 24:3077-3085.
60. Paupardin-Tritsch D, Colombaioni L, Deterre P, Gerschenfeld HM. Two different mechanisms of calcium spike modulation by dopamine. J Neurosci 1985; 5:2522-2532.
61. Marchetti C, Carbone E, Lux HD. Effects of dopamine and noradrenaline on Ca channels of cultured sensory and sympathetic neurons of chick. Pflugers Arch 1986; 406:104-111.
62. 1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons. Neuron 1995; 14:385-397.
63. 2+ conductance. J Neurosci 1997; 17:3334-3342.
64. Schiller J, Schiller Y, Stuart G, Sakmann B. Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons. J Physiol 1997; 505:605-616.
65. 2+ channels in the proximal versus distal dendrites to synaptic integration in prefrontal cortical neurons. J Neurosci 1997; 17:5936-5948.
66. Gross RA, Uhler MD, Macdonald RL. The cyclic AMP-dependent protein kinase catalytic subunit selectively enhances calcium currents in rat nodose neurones. J Physiol 1990; 429:483-496.
67. Lai Y, Peterson BZ, Catterall WA. Selective dephosphorylation of the subunits of skeletal muscle calcium channels by purified phosphoprotein phosphatases. J Neurochem 1993; 61:1333-1339.
68. 2+ potentials via differential protein kinase A and C activation in rat prefrontal cortical neurons. J Neurosci 2004; 24:8-23.
69. + channel densities in the soma and axon initial segment of subicular pyramidal neurons. J Neurosci 1996; 16:6676-6686.
70. Stuart G, Sakmann B. Amplification of EPSPs by axosomatic sodium channels in neocortical pyramidal neurons. Neuron 1995; 15:1065-1076.
71. Hutcheon B, Miura RM, Puil E. Models of subthreshold membrane resonance in neocortical neurons. J Neurophysiol 1996; 76:698-714.
72. Calabresi P, Mercuri N, Stanzione P, Stefani A, Bernardi G. Intracellular studies on the dopamine-induced firing inhibition of neostriatal neurons in vitro: evidence for D1 receptor involvement. Neuroscience 1987; 20:757-771.
73. 1 receptor modulates the voltage-gated sodium current in rat striatal neurones through a protein kinase A. J Physiol (Lond) 1995; 483:95-107.
74. Schiffmann SN, Desdouits F, Menu R, Greengard P, Vincent JD, Vanderhaeghen JJ, Girault JA. Modulation of the voltage-gated sodium current in rat striatal neurons by DARPP-32, an inhibitor of protein phosphatase. Eur J Neurosci 1998; 10:1312-1320.
75. Moorman JR, Kirsch GE, VanDongen AM, Joho RH, Brown AM. Fast and slow gating of sodium channels encoded by a single mRNA. Neuron 1990; 4:243-252.
76. + current in pyramidal neurons from rat and cat sensorimotor cortex. J Neurosci 1993; 13:660-673.
77. + currents is compatible with modal-gating hypothesis for sodium channels. J Neurophysiol 1994; 71:2562-2565.
78. Connors BW, Gutnick MJ, Prince DA. Electrophysiological properties of neocortical neurons in vitro. J Neurophysiol 1982; 48:1302-1320.
79. Crill WE. Persistent sodium current in mammalian central neurons. Annu Rev Physiol 1996; 58:349-362.
80. 5 dopamine receptor activation differentially modulates rapidly inactivating and persistent sodium currents in prefrontal cortex pyramidal neurons. J Neurosci 2001; 21:2268-2277.
81. Gorelova NA, Yang CR. Dopamine D1/D5 receptor activation modulates a persistent sodium current in rat prefrontal cortical neurons in vitro. J Neurophysiol 2000; 84:75-87.
82. Geijo-Barrientos E, Pastore C. The effects of dopamine on the subthreshold electrophysiological responses of rat prefrontal cortex neurons in vitro. Eur J Neurosci 1995; 7:358-366.
83. Cepeda C, Radisavljevic Z, Peacock W, Levine MS, Buchwald NA. Differential modulation by dopamine of responses evoked by excitatory amino acids in human cortex. Synapse 1992; 11:330-341.
84. 1A-deficient mutant mice. J Neurosci 1996; 16:5870-5882.
85. Cepeda C, Levine MS. Dopamine and N-methyl-D-aspartate receptor interactions in the neostriatum. Dev Neurosci 1998; 20:1-18.
86. Flores-Hernández J, Cepeda C, Hernández-Echeagaray E, Calvert CR, Jokel ES, Fienberg AA, Greengard P, Levine MS. Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: Role of D1 receptors and DARPP-32. J Neurophysiol 2002; 88:3010-3020.
87. Huang Y-Y, Kandel ER. D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus. Proc Natl Acad Sci USA 1995; 92:2446-2450.
88. Zheng P, Zhang XX, Bunney BS, Shi WX. Opposite modulation of cortical N-methyl-D-aspartate receptor-mediated responses by low and high concentrations of dopamine. Neuroscience 1999; 91:527-535.
89. Seamans JK, Durstewitz D, Christie BR, Stevens CF, Sejnowski TJ. Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons. Proc Natl Acad Sci USA 2001; 98:301-306.
90. 1 dopamine receptors potentiate NMDA-mediated excitability increase in layer V prefrontal cortical pyramidal neurons. Cereb Cortex 2001; 11:452-462.
91. Tseng KY, O'Donnell P. Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signaling mechanisms. J Neurosci 2004; 24:5131-5139.
92. r 32 kDa)/protein phosphatase-1 pathway regulates dephosphorylation of the NMDA receptor. J Neurosci 1998; 18:10297-10303.
93. Cepeda C, Colwell CS, Itri JN, Chandler SH, Levine MS. Dopaminergic modulation of NMDA-induced whole cell currents in neostriatal neurons in slices: contribution of calcium conductances. J Neurophysiol 1998; 79:82-94.
94. 1-like receptors of synaptic transmission and NMDA receptors in rat nucleus accumbens is attenuated by the protein kinase C inhibitor Ro 32-0432. Neuropharmacology 1999; 38:223-231.
95. Colwell CS, Levine MS. Excitatory synaptic transmission in neostriatal neurons: regulation by cyclic AMP-dependent mechanisms. J Neurosci 1995; 15:1704-1713.
96. Durstewitz D, Seamans JK, Sejnowski TJ. Dopamine-mediated stabilization of delay-period activity in a network model of prefrontal cortex. J Neurophysiol 2000; 83:1733-1750.
97. Lavin A, Grace AA. Stimulation of D1-type dopamine receptors enhances excitability in prefrontal cortical pyramidal neurons in a state-dependent manner. Neuroscience 2001; 104:335-346.
98. Cepeda C, Buchwald NA, Levine MS. Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activated. Proc Natl Acad Sci USA 1993; 90:9576-9580.
99. 2+ conductance. Neuroreport 1997; 8:2183-2186.
100. Yan Z, Hsieh-Wilson L, Feng J, Tomizawa K, Allen PB, Fienberg AA, Nairn AC, Greengard P. Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin. Nat Neurosci 1999; 2:13-17.
101. Snyder GL, Allen PB, Fienberg AA, Valle CG, Huganir RL, Nairn AC, Greengard P. Regulation of phosphorylation of the GluR1 AMPA receptor in the neostriatum by dopamine and psychostimulants in vivo. J Neurosci 2000; 20:4480-4488.
102. 1 dopamine receptor stimulation increases GluR1 phosphorylation in postnatal nucleus accumbens cultures. J Neurochem 2002; 81:984-992.
103. Li AJ, Suzuki M, Suzuki S, Ikemoto M, Imamura T. Differential phosphorylation at serine sites in glutamate receptor-1 within neonatal rat hippocampus. Neurosci Lett 2003; 341:41-44.
104. Gonzalez-Islas C, Hablitz JJ. Dopamine enhances EPSCs in layer II-III pyramidal neurons in rat prefrontal cortex. J Neurosci 2003; 23:867-875.
105. Dunah AW, Standaert DG. Dopamine D1 receptor-dependent trafficking of striatal NMDA glutamate receptors to the postsynaptic membrane. J Neurosci 2001; 21:5546-5558.
106. Chao SZ, Ariano MA, Peterson DA, Wolf ME. D1 dopamine receptor stimulation increases GluR1 surface expression in nucleus accumbens neurons. J Neurochem 2002; 83:704-712.
107. Dunah AW, Sirianni AC, Fienberg AA, Bastia E, Schwarzschild MA, Standaert DG. Dopamine D1-dependent trafficking of striatal N-methyl-D-aspartate glutamate receptors requires Fyn protein tyrosine kinase but not DARPP-32. Mol Pharmacol 2004; 65:121-129.
108. Lee FJ, Xue S, Pei L, Vukusic B, Chéry N, Wang Y, Wang YT, Niznik HB, Yu X, Liu F. Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor. Cell 2002; 111:219-230.
109. 1 receptor trafficking and desensitization by oligomerization with glutamate N-methyl-D-aspartate receptors. J Biol Chem 2003; 278:20196-20202.
110. Pei L, Lee FJS, Moszczynsak A, Vukusic B, Liu F. Regulation of dopamine D1 receptor function by physical interaction with the NMDA receptors. J Neurosci 2004; 24:1149-1158.
111. Nicola SM, Malenka RC. Modulation of synaptic transmission by dopamine and norepinephrine in ventral but not dorsal striatum. J Neurophysiol 1998; 79:1768-1776.
112. Pisani A, Bonsi P, Centonze D, Calabresi P, Bernardi G. Activation of D2-like dopamine receptors reduces synaptic inputs to striatal cholinergic interneurons. J Neurosci 2000; 20:RC69.
113. A currents in striatal cholinergic interneurons through a PKA/PP1 cascade. Neuron 1997; 19:1115-1126.
114. Liu F, Wan Q, Pristupa ZB, Yu XM, Wang YT, Niznik HB. Direct protein-protein coupling enables cross-talk between dopamine D5 and γ-aminobutyric acid A receptors. Nature 2000; 403:274-280.
115. Jose PA, Eisner GM, Felder RA. Renal dopamine receptors in health and hypertension. Pharmacol Ther 1998; 80:149-182.
116. 2 dopamine receptor colocalization in neowstriatal neurons. Nat Neurosci 2000; 3:226-230.
117. +-ATPase activity in renal tubule cells. Proc Natl Acad Sci USA 1991; 88:2798-2801.
118. Shahedi M, Laborde K, Azimi S, Hamdani S, Sachs C. Mechanisms of dopamine effects on Na-K-ATPase activity in Madin-Darby canine kidney (MDCK) epithelial cells. Pflügers Arch 1995; 429:832-840.
119. +-ATPase activity. Am J Physiol Renal Physiol 2002; 282:F1084-F1096.
120. Gerfen CR, Miyachi S, Paletzki R, Brown P. D1 dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1/2/MAP kinase. J Neurosci 2002; 22:5042-5054.
121. 1 dopamine receptor agonists mediate activation of p38 mitogen-activated protein kinase and c-jun amino-terminal kinase by a protein kinase A dependent mechanism in SK-N-MC human neuroblastoma cells. Mol Pharmacol 1998; 54:453-458.
122. Weissman JT, Ma JN, Essex A, Gao Y, Burstein ES. G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Gαi regulated pathway. Oncogene 2004; 23:241-249.
123. de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 1998; 396:474-477.
124. Kurose H, Katada T, Amano T, Ui M. Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via α-adrenergic, cholinergic, and opiate receptors in neuroblastoma × glioma hybrid cells. J Biol Chem 1983; 258:4870-4875.
125. Bokoch GM, Katada T, Northup JK, Hewlett EL, Gilman AG. Identification of the predominant substrate for ADP-ribosylation by islet activating protein. J Biol Chem 1983; 258:2072-2075.
126. Robinson SW, Caron MG. Interactions of dopamine receptors with G proteins. In: Neve KA, Neve RL, eds. The Dopamine Receptors. Totawa, NJ: Humana Press, 1997:137-165.
127. Neve KA, DuRand CJ, Teeter MM. Structural analysis of the mammalian D2, D3, and D4 dopamine receptors. In: Sidhu A, Laruelle M, Vernier P, eds. Dopamine Receptors and Transporters: Function, Imaging, and Clinical Implication. New York: Marcel Dekker Inc., 2003:77-144.
128. 2+ currents in rat anterior pituitary cells. Neuron 1992; 8:455-463.
129. i2 in GH4C1 pituitary cells. J Biol Chem 1994; 269:13880-13886.
130. z-Mediated hormonal inhibition of cyclic AMP accumulation. Science 1992; 255:339-342.
131. Obadiah J, Avidor-Reiss T, Fishburn CS, Carmon S, Bayewitch M, Vogel Z, Fuchs S, Levavi-Sivan B. Adenylyl cyclase interaction with the D2 dopamine receptor family: differential coupling to Gi, Gz, and Gs. Cell Mol Neurobiol 1999; 19:653-664.
132. Ganz MB, Pachter JA, Barber DL. Multiple receptors coupled to adenylate cyclase regulate Na-H exchange independent of cAMP. J Biol Chem 1990; 265:8989-8992.
133. + exchange assessed by quantification of extracellular acidification. J Biol Chem 1992; 267:25748-25753.
134. 7 cells: involvement of protein kinase-Cε. Endocrinology 1994; 134:783-789.
135. 2L dopamine receptors in NS20Y neuroblastoma cells. J Neurosci 1998; 18:8692-8699.
136. 2 dopamine receptor/G protein interaction-evidence for agonist selection of G protein subtype. J Biol Chem 2001; 276:28667-28675.
137. 2 receptor with Gαi1, Gαi2, Gαi3 and Gαo G proteins: evidence for agonist regulation of G protein selectivity. Br J Pharmacol 2003; 138:775-786.
138. Leaney JL, Tinker A. The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel. Proc Natl Acad Sci USA 2000; 97:5651-5656.
139. o-Coupled dopamine D2 receptors inhibits ERK1/ERK2 in pituitary cells-a key step in the transcriptional suppression of the prolactin gene. J Biol Chem 2002; 277:35819-35825.
140. 2short dopamine receptor with G proteins: analysis of receptor G protein selectivity. Biochem Pharmacol 2003; 65:1139-1150.
141. Jiang MS, Spicher K, Boulay G, Wang Y, Birnbaumer L. Most central nervous system D2 dopamine receptors are coupled to their effecters by Go. Proc Natl Acad Sci USA 2001; 98:3577-3582.
142. 4 dopamine receptors couple to a voltage-dependent potassium current in N18TG2 × mesencephalon hybrid cell (MES-23.5) via distinct G proteins. Synapse 1999; 31:108-118.
143. iα subtypes. Biochemistry 2000; 39:3734-3744.
144. t2) to inhibit forskolin-stimulated cAMP accumulation. J Biol Chem 1997; 272:16599-16602.
145. 35S]thio)-triphosphate binding and antibody study. Mol Pharmacol 1999; 55:564-574.
146. o subtype of G proteins in SH-SY5Y cells. Br J Pharmacol 1999; 128:1181-1188.
147. Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hébert TE, Van Tol HHM. G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. J Biol Chem 2002; 277:46010-46019.
148. 3 receptor structure. J Pharmacol Exp Ther 2000; 295:274-283.
149. De Camilli P, Macconi D, Spada A. Dopamine inhibits adenylate cyclase in human prolactin-secreting pituitary adenomas. Nature 1979; 278:252-254.
150. Stoof JC, Kebabian JW. Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum. Nature 1981; 294:366-368.
151. Kelly MA, Rubinstein M, Phillips TJ, Lessov CN, Burkhart-Kasch S, Zhang G, Bunzow JR, Fang Y, Gerhardt GA, Grandy DK, Low MJ. Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. J Neurosci 1998; 18:3470-3479.
152. 4 receptor: one decade of research. Eur J Pharmacol 2000; 405:303-327.
153. 3 receptor. Mol Pharmacol 1997; 52:508-514.
154. 3 dopamine receptor heterodimers exhibit unique functional properties. J Biol Chem 2001; 276:30308-30314.
155. 2 heterodimers by the antiparkinsonian agents, S32504, pramipexole and ropinirole. J Neurochem 2003; 87:631-641.
156. Taussig R, Tang W-J, Hepler JR, Gilman AG. Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. J Biol Chem 1994; 269:6093-6100.
157. i- mediated inhibition of type V adenylyl cyclase. J Biol Chem 2002; 277:28823-28829.
158. Nishi A, Snyder GL, Greengard P. Bidirectional regulation of DARPP-32 phosphorylation by dopamine. J Neurosci 1997; 17:8147-8155.
159. Nishi A, Snyder GL, Fienberg AA, Fisone G, Aperia A, Naim AC, Greengard P. Requirement for DARPP-32 in mediating effect of dopamine D2 receptor activation. Eur. J Neurosci 1999; 11:2589-2592.
160. Lew JY, Garcia-Espana A, Lee KY, Carr KD, Goldstein M, Haycock JW, Meller E. Increased site-specific phosphorylation of tyrosine hydroxylase accompanies stimulation of enzymatic activity induced by cessation of dopamine neuronal activity. Mol Pharmacol 1999; 55:202-209.
161. Shin R-M, Masuda M, Miura M, Sano H, Shirasawa T, Song W-J, Kobayashi K, Aosaki T. Dopamine D4 receptor-Induced postsynaptic inhibition of GABAergic currents in mouse globus pallidus neurons. J Neurosci 2003; 23:11662-11672.
162. 4 signaling in prefrontal cortex. J Neurosci 2003; 23:9852-9861.
163. Kotecha SA, Oak JN, Jackson MF, Perez Y, Orser BA, Van Tol HHM, MacDonald JF. A D2 class dopamine receptor transactivates a receptor tyrosine kinase to inhibit NMDA receptor transmission. Neuron 2002; 35:1111-1122.
164. Chen J, Devivo M, Dingus J, Harry A, Li J, Sui J, Carty DJ, Blank JL, Exton JH, Stoffel RH, Inglese J, Lefkowitz RJ, Logothetis DE, Hildebrandt JD, Iyengar R. A region of adenylyl cyclase 2 critical for regulation by G protein βγ subunits. Science 1995; 268:1166-1169.
165. Weitmann S, Schultz G, Kleuss C. Adenylyl cyclase type II domains involved in Gβγ stimulation. Biochemistry 2001; 40:10853-10858.
166. Lacey MG, Mercuri NB, North RA. Dopamine acts on D2 receptors to increase potassium conductance in neurones of rat substantia nigra zona compacta. J Physiol (Lond) 1987; 392:397-416.
167. K. Synapse 1994; 17:230-240.
168. Greif GJ, Lin Y-J, Liu J-C, Freedman JE. Dopamine-modulated potassium channels on rat striatal neurons: Specific activation and cellular expression. J Neurosci 1995; 15:4533-4544.
169. Wickman KD, Iñiguez-Lluhi JA, Davenport PA, Taussig R, Krapivinsky GB, Linder ME, Gilman AG, Clapham DE. Recombinant G-protein βγ- subunits activate the muscarinic-gated atrial potassium channel. Nature 1994; 368:255-257.
170. 1 receptors. Br J Pharmacol 1995; 116:2346-2348.
171. + channels. Cell Signal 1997; 9:551-573.
172. Kuzhikandathil EV, Yu WF, Oxford GS. Human dopamine D3 and D2L receptors couple to inward rectifier potassium channels in mammalian cell lines. Mol Cell Neurosci 1998; 12:390-402.
173. + channel mRNAs are differentially expressed in the adult rat brain. J Neurosci 1996; 16:3559.
174. + channels composed of Kir3.2 subunits in dopaminergic neurons of the substantia nigra. J Neurosci 1999; 19:1006-1017.
175. Kuzhikandathil EV, Oxford GS. Dominant-negative mutants identify a role for GIRK channels in D3 dopamine receptor-mediated regulation of spontaneous secretory activity. J Gen Physiol 2000; 115:697-706.
176. Rebois RV, Hebert TE. Protein complexes involved in heptahelical receptor-mediated signal transduction. Receptors Channels 2003; 9:169-194.
177. 2 dopamine, but not A1 adenosine, receptor-mediated inhibition of striatal dopamine release. J Neurochem 1991; 57:147-152.
178. 2 dopamine receptors associated with inhibition of dopamine release from rat neostriatum are independent of cyclic AMP. Neurosci Lett 1986; 71:192-196.
179. 3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neurons. J Neurosci 2003; 23:5693-5697.
180. 1 receptor activation in mice lacking girk2 channels. Psychopharmacology 2002; 159:370-378.
181. 2 dopamine receptor modulation of sodium and potassium currents in rat neostriatal neurons. Prog Brain Res 1993, 99(309-24):309-324.
182. 3 dopamine receptors in differentiated neuroblastoma X glioma NG108-15 cells. Br J Pharmacol 1994; 111:391-393.
183. 4 dopamine receptors. Br J Pharmacol 1994; 112:728-734.
184. Kuzhikandathil EV, Oxford GS. Activation of human D3 dopamine receptor inhibits P/Q-type calcium channels and secretory activity in AtT-20 cells. J Neurosci 1999; 19:1698-1707.
185. Okada Y, Miyamoto T, Toda K. Dopamine modulates a voltage-gated calcium channel in rat olfactory receptor neurons. Brain Res 2003; 968:248-255.
186. 2+ currents in rat neostriatal cholinergic interneurons through a membrane-delimited, protein-kinase-C-insensitive pathway. J Neurophysiol 1997; 77:1003-1015.
187. βγ subunit. Proc Natl Acad Sci USA 1998; 95:4035-4039.
188. Page KM, Stephens GJ, Berrow NS, Dolphin AC. The intracellular loop between domains I and II of the B-type calcium channel confers aspects of G-protein sensitivity to the E-type calcium channel. J Neurosci 1997; 17:1330-1338.
189. 1A subunit. Proc Natl Acad Sci USA 1997; 94:1512-1516.
190. 1 subunit is responsible for channel inhibition by G protein-coupled receptors. Proc Natl Acad Sci USA 1997; 94:8866-8871.
191. 3-calcineurin-signaling cascade. J Neurosci 2000; 20:8987-8995.
192. 2+ channels in mammalian central neurons. Trends Neurosci 1995; 18:89-98.
193. 2-like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones. J Physiol 2000; 523:163-173.
194. 2+ channels. Eur J Neurosci 2003; 17:447-454.
195. Gutkind JS. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem 1998; 273:1839-1842.
196. 2-adrenergic receptors expressed in fibroblasts. J Biol Chem 1993; 268:22235-22238.
197. Faure M, Voyno-Yasenetskaya TA, Bourne HR. cAMP and βγ subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J Biol Chem 1994; 269:7851-7854.
198. Huff RM. Signal transduction pathways modulated by the D2 subfamily of dopamine receptors. Cell Signal 1996; 8:453-459.
199. Luo YQ, Kokkonen GC, Wang XT, Neve KA, Roth GS. D2 dopamine receptors stimulate mitogenesis through pertussis toxin-sensitive G proteins and ras-involved ERK and SAP/JNK pathways in rat C6-D2L glioma cells. J Neurochem 1998; 71:980-990.
200. 2 dopamine receptors. J Neurochem 1998; 70:2139-2146.
201. Choi EY, Jeong DW, Park KW, Baik JH. G protein-mediated mitogen-activated protein kinase activation by two dopamine D2 receptors. Biochem Biophys Res Commun 1999; 256:33-40.
202. i3 in cellular transformation by dopamine D2S receptor activation in BALB/c 3T3 cells. Mol Cell Biol 2000; 20:1497-1506.
203. 2L receptor stimulation of the mitogen-activated protein kinase pathway is dependent on transactivation of the platelet-derived growth factor receptor. Mol Pharmacol 2001; 60:92-103.
204. Kim SJ, Kim MY, Lee EJ, Ahn YS, Baik JH. Distinct regulation of internalization and mitogen-activated protein kinase activation by two isoforms of the dopamine D2 receptor. Mol Endocrinol 2004; 18:640-652.
205. 3 receptors mediate mitogen-activated protein kinase activation via a phosphatidylinositol 3-kinase and an atypical protein kinase C-dependent mechanism. Mol Pharmacol 1999; 56:1025-1030.
206. 4MN9D cells. Mol Pharmacol 2001; 60:857-864.
207. 2 dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons. Proc Natl Acad Sci USA 1999; 96:11607-11612.
208. 2 dopamine receptor stimulation in unilateral 6-hydroxydopamine-lesioned rats. J Neurosci 2000; 20:1849-1857.
209. Wang C, Buck DC, Yang R, Macey TA, Neve KA. Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases. J Biol Chem, 2004. Submitted for publication.
210. Daub H, Weiss FU, Wallasch C, Ullrich A. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 1996; 379:557-560.
211. 2-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. J Biol Chem 2000; 275:9572-9580.
212. Wetzker R, Böhmer F-D. Transactivation joins multiple tracks to the ERK/MAPK cascade. Nat Rev Mol Cell Biol 2003; 4:651-657.
213. 2 receptor. J Biol Chem 2003; 278:47053-47061.
214. Lajiness ME, Chio CL, Huff RM. D2 dopamine receptor stimulation of mitogenesis in transfected Chinese hamster ovary cells: relationship to dopamine stimulation of tyrosine phosphorylations. J Pharmacol Exp Ther 1993; 267:1573-1581.
215. Hill CS, Treisman R. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 1995; 80:199-211.
216. Fukunaga K, Miyamoto E. Role of MAP kinase in neurons. Mol Neurobiol 1998; 16:79-95.
217. Otani S, Auclair N, Desce JM, Roisin MP, Crépel F. Dopamine receptors and groups I and II mGluRs cooperate for long-term depression induction in rat prefrontal cortex through converging postsynaptic activation of MAP kinases. J Neurosci 1999; 19:9788-9802.
218. Impey S, Obrietan K, Storm DR. Making new connections: role of ERK/MAP kinase signaling in neuronal plasticity. Neuron 1999; 23:11-14.
219. Iaccarino C, Samad TA, Mathis C, Kercret H, Picetti R, Borrelli E. Control of lactotrop proliferation by dopamine: Essential role of signaling through D2 receptors and ERKs. Proc Natl Acad Sci USA 2002; 99:14530-14535.
220. 2 dopamine receptors mediate the potentiation of arachidonic acid release in Chinese hamster ovary cells. Mol Pharmacol 1991; 39:364-369.
221. Piomelli D, Pilon C, Giros B, Sokoloff P, Martres M-P, Schwartz J-C. Dopamine activation of the arachidonic acid cascade as a basis for D1/D2 receptor synergism. Nature 1991; 353:164-167.
222. Chio CL, Drong RF, Riley DT, Gill GS, Slightom JL, Huff RM. D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells. J Biol Chem 1994; 269:11813-11819.
223. 2. J Neurochem 1995; 64:2765-2772.
224. 3 receptor. Life Sci 1999; 64:939-951.
225. 2 activity in bovine rod outer segments by the βγ subunits of transducin and its inhibition by the α subunit. Proc Natl Acad Sci USA 1987; 84:3623-3627.
226. 2. J Neurosci 1999; 19:3739-3751.
227. 2+-mobilizing agent. Br J Pharmacol 1998; 124:1651-1658.
228. Piomelli D, Greengard P. Lipoxygenase metabolites of arachidonic acid in neuronal transmembrane signalling. Trends Pharmacol Sci 1990; 11:367-373.
229. 2 receptor-dependent potentiation of arachidonic acid release. J Neurochem 1992; 59:379-382.
230. L'hirondel M, Chéramy A, Godeheu G, Glowinski J. Effects of arachidonic acid on dopamine synthesis, spontaneous release, and uptake in striatal synaptosomes from the rat. J Neurochem 1995; 64:1406-1409.
231. Zhang L, Reith MEA Regulation of the functional activity of the human dopamine transporter by the arachidonic acid pathway. Eur J Pharmacol 1996; 315:345-354.
232. Mitchell R, McCulloch D, Lutz E, Johnson M, MacKenzie C, Fennell M, Fink G, Zhou W, Sealfon SC. Rhodopsin-family receptors associate with small G proteins to activate phospholipase D. Nature 1998; 392:411-414.
233. Senogles SE. The D2s dopamine receptor stimulates phospholipase D activity: a novel signaling pathway for dopamine. Mol Pharmacol 2000; 58:455-462.
234. Senogles SE. D2s dopamine receptor mediates phospholipase D and antiproliferation. Mol Cell Endocrinol 2003; 209:61-69.
235. 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly. J Biol Chem 1995; 270:24631-24634.
236. 13. Science 1998; 280:2112-2114.
237. Mao J, Yuan H, Xie W, Wu D. Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein α subunit Gα 13. Proc Natl Acad Sci USA 1998; 95:12973-12976.
238. Gulledge AT, Jaffe DB. Multiple effects of dopamine on layer V pyramidal cell excitability in rat prefrontal cortex. J Neurophysiol 2001; 86:586-595.
239. + channels by a G-protein-coupled pathway. Proc Natl Acad Sci USA 1994; 91:12351-12355.
240. + exchanger gene family: structure and function studies. Am J Physiol Gastrointest. Liver Physiol 1995; 269:G1-G11.
241. Cox BA, Rosser MP, Kozlowski MR, Duwe KM, Neve RL, Neve KA. Regulation and functional characterization of a rat recombinant dopamine D3 receptor. Synapse 1995; 21:1-9.
242. Chio CL, Lajiness ME, Huff RM. Activation of heterologously expressed D3 dopamine receptors: comparison with D2 dopamine receptors. Mol Pharmacol 1994; 45:51-60.
243. + exchange through distinct Cdc42-dependent and RhoA-dependent pathways. J Biol Chem 1996; 271:6152-6158.
244. 2B-adrenergic receptors for inhibiting the Na-H exchanger, NHE1. J Biol Chem 2003; 278:15128-15135.
245. 1 dopamine agonists. Am J Physiol 1993; 264:F1032-F1037.
246. 2 dopamine receptor-deficient mice. J Neurophysiol 2001; 85:659-670.
247. Seamans JK, Gorelova N, Durstewitz D, Yang CR. Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons. J Neurosci 2001; 21:3628-3638.
248. A currents in prefrontal neurons via different dopamine receptor subtypes. Soc Neurosci Abstr 2003; 573:16.
249. Valenzuela CF, Kazlauskas A, Brozowski SJ, Weiner JL, Demali KA, McDonald BJ, Moss SJ, Dunwiddie TV, Harris RA. Platelet-derived growth factor receptor is a novel modulator of type A γ-aminobutyric acid-gated ion channels. Mol Pharmacol 1995; 48:1099-1107.
250. Rocheville M, Lange DC, Kumar U, Patel SC, Patel RC, Patel YC. Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science 2000; 288:154-157.
251. 2 receptors. J Biol Chem 2002; 277:18091-18097.
252. 2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. J Biol Chem 2003; 278:46741-46749.
253. 2 receptors. Neuroreport 1999; 10:2051-2054.
254. Agnati LF, Ferré S, Lluis C, Franco R, Fuxe K. Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons. Pharmacol Rev 2003; 55:509-550.
255. 2 receptor signaling by actin-binding protein (ABP-280). Mol Pharmacol 2000; 57:446-452.
256. 3 receptors with actin-binding protein 280 (ABP-280). Biochem Pharmacol 2002; 63:859-863.
257. Smith FD, Oxford GS, Milgram SL. Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein. J Biol Chem 1999; 274:19894-19900.
258. 2-dopamine receptor reduces receptor signaling by arresting the G protein activation switch. J Biol Chem 2000; 275:32672-32680.
259. Oldenhof J, Vickery R, Anafi M, Oak J, Ray A, Schools O, Pawson T, von Zastrow M, Van Tol HHM. SH3 binding domains in the dopamine D4 receptor. Biochemistry 1998; 37:15726-15736.
260. Oldenhof J, Ray A, Vickery R, Van Tol HHM. SH3 ligands in the dopamine D3 receptor. Cell Signal 2001; 13:411-416.
261. 3-adrenergic receptor is required for MAP kinase activation. J Biol Chem 2000; 275:38131-38134.