Differential role of D1 and D2 receptors in the perifornical lateral hypothalamus in controlling ethanol drinking and food intake: Possible interaction with local orexin neurons

Alcoholism: Clinical and Experimental Research

Volumn 38, Issue 3, 2014, Pages 777-786

  Chen, Yu Wei ^a,b   Morganstern, Irene ^b   Barson, Jessica R ^b   Hoebel, Bartley G ^a   Leibowitz, Sarah F ^b  

^a PRINCETON UNIVERSITY   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Dopamine; Ethanol; Lateral hypothalamus; Melanin concentrating hormone; Orexin

Indexed keywords

ALCOHOL; DIGOXIGENIN; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; MELANIN CONCENTRATING HORMONE; MESSENGER RNA; OREXIN; QUINELORANE; SULPIRIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRINKING BEHAVIOR; FLUID INTAKE; FOOD INTAKE; GENE EXPRESSION; IN SITU HYBRIDIZATION; LATERAL HYPOTHALAMUS; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

DOPAMINE; ETHANOL; LATERAL HYPOTHALAMUS; MELANIN-CONCENTRATING HORMONE; OREXIN;

ALCOHOL DRINKING; ANIMALS; EATING; HYPOTHALAMIC HORMONES; HYPOTHALAMUS; IN SITU HYBRIDIZATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MELANINS; NEUROPEPTIDES; OREXIN RECEPTORS; PITUITARY HORMONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2;

EID: 84896319848     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12313     Document Type: Article

References (58)

1. Agabio R, Cortis G, Fadda F, Gessa GL, Lobina C, Reali R, Colombo G (1996) Circadian drinking pattern of Sardinian alcohol-preferring rats. Alcohol Alcohol 31:385-388.
2. Bahi A, Dreyer JL (2012) Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice. Psychopharmacology 222:141-153.
3. Barson JR, Carr AJ, Soun JE, Sobhani NC, Rada P, Leibowitz SF, Hoebel BG (2010) Opioids in the hypothalamic paraventricular nucleus stimulate ethanol intake. Alcohol Clin Exp Res 34:214-222.
4. Beaulieu JM, Gainetdinov RR (2011) The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev 63:182-217.
5. Bice PJ, Liang T, Zhang L, Strother WN, Carr LG (2008) Drd2 expression in the high alcohol-preferring and low alcohol-preferring mice. Mamm Genome 19:69-76.
6. Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P, Nogami H, Briggs AH, Cohn JB (1990) Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 263:2055-2060.
7. Bossert JM, Poles GC, Wihbey KA, Koya E, Shaham Y (2007) Differential effects of blockade of dopamine D1-family receptors in nucleus accumbens core or shell on reinstatement of heroin seeking induced by contextual and discrete cues. J Neurosci 27:12655-12663.
8. Caulliez R, Meile MJ, Nicolaidis S (1996) A lateral hypothalamic D1 dopaminergic mechanism in conditioned taste aversion. Brain Res 729:234-245.
9. Chang GQ, Gaysinskaya V, Karatayev O, Leibowitz SF (2008) Maternal high-fat diet and fetal programming: increased proliferation of hypothalamic peptide-producing neurons that increase risk for overeating and obesity. J Neurosci 28:12107-12119.
10. Chen YW, Barson JR, Chen A, Hoebel BG, Leibowitz SF (2013) Opioids in the perifornical lateral hypothalamus suppress ethanol drinking. Alcohol 47:31-38.
11. Conductier G, Nahon JL, Guyon A (2011) Dopamine depresses melanin concentrating hormone neuronal activity through multiple effects on alpha2-noradrenergic, D1 and D2-like dopaminergic receptors. Neuroscience 178:89-100.
12. Crombag HS, Grimm JW, Shaham Y (2002) Effect of dopamine receptor antagonists on renewal of cocaine seeking by reexposure to drug-associated contextual cues. Neuropsychopharmacology 27:1006-1015.
13. Dayas CV, McGranahan TM, Martin-Fardon R, Weiss F (2008) Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse. Biol Psychiatry 63:152-157.
14. Delis F, Thanos PK, Rombola C, Rosko L, Grandy D, Wang GJ, Volkow ND (2013) Chronic mild stress increases alcohol intake in mice with low dopamine D2 receptor levels. Behav Neurosci 127:95-105.
15. Duncan EA, Proulx K, Woods SC (2005) Central administration of melanin-concentrating hormone increases alcohol and sucrose/quinine intake in rats. Alcohol Clin Exp Res 29:958-964.
16. Duncan EA, Sorrell JE, Adamantidis A, Rider T, Jandacek RJ, Seeley RJ, Lakaye B, Woods SC (2007) Alcohol drinking in MCH receptor-1-deficient mice. Alcohol Clin Exp Res 31:1325-1337.
17. Fetissov SO, Meguid MM, Sato T, Zhang LH (2002) Expression of dopaminergic receptors in the hypothalamus of lean and obese Zucker rats and food intake. Am J Physiol Regul Integr Comp Physiol 283:R905-R910.
18. Gothelf D, Falk B, Singer P, Kairi M, Phillip M, Zigel L, Poraz I, Frishman S, Constantini N, Zalsman G, Weizman A, Apter A (2002) Weight gain associated with increased food intake and low habitual activity levels in male adolescent schizophrenic inpatients treated with olanzapine. Am J Psychiatry 159:1055-1057.
19. Graham DL, Hoppenot R, Hendryx A, Self DW (2007) Differential ability of D1 and D2 dopamine receptor agonists to induce and modulate expression and reinstatement of cocaine place preference in rats. Psychopharmacology 191:719-730.
20. Hamlin AS, Newby J, McNally GP (2007) The neural correlates and role of D1 dopamine receptors in renewal of extinguished alcohol-seeking. Neuroscience 146:525-536.
21. Harris GC, Aston-Jones G (2006) Arousal and reward: a dichotomy in orexin function. Trends Neurosci 29:571-577.
22. Ida T, Nakahara K, Murakami T, Hanada R, Nakazato M, Murakami N (2000) Possible involvement of orexin in the stress reaction in rats. Biochem Biophys Res Commun 270:318-323.
23. Jiao X, Pare WP, Tejani-Butt SM (2006) Alcohol consumption alters dopamine transporter sites in Wistar-Kyoto rat brain. Brain Res 1073-1074:175-182.
24. Lawrence AJ, Cowen MS, Yang HJ, Chen F, Oldfield B (2006) The orexin system regulates alcohol-seeking in rats. Br J Pharmacol 148:752-759.
25. de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS II, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95:322-327.
26. Leibowitz KL, Chang GQ, Pamy PS, Hill JO, Gayles EC, Leibowitz SF (2007) Weight gain model in prepubertal rats: prediction and phenotyping of obesity-prone animals at normal body weight. Int J Obes (Lond) 31:1210-1221.
27. Leibowitz SF, Rossakis C (1979) Pharmacological characterization of perifornical hypothalamic dopamine receptors mediating feeding inhibition in the rat. Brain Res 172:115-130.
28. Liu X, Weiss F (2002) Reversal of ethanol-seeking behavior by D1 and D2 antagonists in an animal model of relapse: differences in antagonist potency in previously ethanol-dependent versus nondependent rats. J Pharmacol Exp Ther 300:882-889.
29. Martinetti MP, Andrzejewski ME, Hineline PN, Lewis MJ (2000) Ethanol consumption and the matching law: a choice analysis using a limited-access paradigm. Exp Clin Psychopharmacol 8:395-403.
30. Meador-Woodruff JH, Mansour A, Healy DJ, Kuehn R, Zhou QY, Bunzow JR, Akil H, Civelli O, Watson SJ Jr (1991) Comparison of the distributions of D1 and D2 dopamine receptor mRNAs in rat brain. Neuropsychopharmacology 5:231-242.
31. Meguid MM, Yang ZJ, Koseki M (1995) Eating induced rise in LHA-dopamine correlates with meal size in normal and bulbectomized rats. Brain Res Bull 36:487-490.
32. Morganstern I, Barson JR, Leibowitz SF (2011) Regulation of drug and palatable food overconsumption by similar peptide systems. Curr Drug Abuse Rev 4:163-173.
33. Morganstern I, Chang GQ, Barson JR, Ye Z, Karatayev O, Leibowitz SF (2010a) Differential effects of acute and chronic ethanol exposure on orexin expression in the perifornical lateral hypothalamus. Alcohol Clin Exp Res 34:886-896.
34. Morganstern I, Chang GQ, Chen YW, Barson JR, Zhiyu Y, Hoebel BG, Leibowitz SF (2010b) Role of melanin-concentrating hormone in the control of ethanol consumption: region-specific effects revealed by expression and injection studies. Physiol Behav 101:428-437.
35. Morutto SL, Phillips GD (1998) Interactions between sulpiride infusions within the perifornical region of the lateral hypothalamus and the nucleus accumbens on measures of locomotor activity and conditioned place preference. Behav Pharmacol 9:345-355.
36. Morutto SL, Phillips GD (1999) Post-session intra-perifornical region quinpirole infusions retard the consolidation of an appetitive differential conditioning task. Behav Pharmacol 10:113-118.
37. Nowend KL, Arizzi M, Carlson BB, Salamone JD (2001) D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption. Pharmacol Biochem Behav 69:373-382.
38. Parada MA, Hernandez L, Hoebel BG (1988) Sulpiride injections in the lateral hypothalamus induce feeding and drinking in rats. Pharmacol Biochem Behav 30:917-923.
39. Parada MA, Hernandez L, Puig de Parada M, Paez X, Hoebel BG (1990) Dopamine in the lateral hypothalamus may be involved in the inhibition of locomotion related to food and water seeking. Brain Res Bull 25:961-968.
40. Ray LA, Chin PF, Heydari A, Miotto K (2011) A human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving. Psychopharmacology 217:341-351.
41. Rusk IN, Cooper SJ (1994) Parametric studies of selective D1 or D2 antagonists: effects on appetitive and feeding behaviour. Behav Pharmacol 5:615-622.
42. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573-585.
43. Schneider ER, Rada P, Darby RD, Leibowitz SF, Hoebel BG (2007) Orexigenic peptides and alcohol intake: differential effects of orexin, galanin, and ghrelin. Alcohol Clin Exp Res 31:1858-1865.
44. Smith DG, Tzavara ET, Shaw J, Luecke S, Wade M, Davis R, Salhoff C, Nomikos GG, Gehlert DR (2005) Mesolimbic dopamine super-sensitivity in melanin-concentrating hormone-1 receptor-deficient mice. J Neurosci 25:914-922.
45. Spanagel R, Weiss F (1999) The dopamine hypothesis of reward: past and current status. Trends Neurosci 22:521-527.
46. Thanos PK, Katana JM, Ashby CR Jr, Michaelides M, Gardner EL, Heidbreder CA, Volkow ND (2005) The selective dopamine D3 receptor antagonist SB-277011-A attenuates ethanol consumption in ethanol preferring (P) and non-preferring (NP) rats. Pharmacol Biochem Behav 81:190-197.
47. Thanos PK, Taintor NB, Rivera SN, Umegaki H, Ikari H, Roth G, Ingram DK, Hitzemann R, Fowler JS, Gatley SJ, Wang GJ, Volkow ND (2004) DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking. Alcohol Clin Exp Res 28:720-728.
48. Touzani K, Bodnar RJ, Sclafani A (2009) Lateral hypothalamus dopamine D1-like receptors and glucose-conditioned flavor preferences in rats. Neurobiol Learn Mem 92:464-467.
49. Tupala E, Hall H, Bergstrom K, Mantere T, Rasanen P, Sarkioja T, Tiihonen J (2003) Dopamine D2 receptors and transporters in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography. Hum Brain Mapp 20:91-102.
50. Volkow ND, Wang GJ, Fowler JS, Logan J, Hitzemann R, Ding YS, Pappas N, Shea C, Piscani K (1996) Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcohol Clin Exp Res 20:1594-1598.
51. Wamsley JK, Gehlert DR, Filloux FM, Dawson TM (1989) Comparison of the distribution of D-1 and D-2 dopamine receptors in the rat brain. J Chem Neuroanat 2:119-137.
52. Wellman PJ (2005) Modulation of eating by central catecholamine systems. Curr Drug Targets 6:191-199.
53. Wise RA (2004) Dopamine, learning and motivation. Nat Rev Neurosci 5:483-494.
54. Wortley KE, Chang GQ, Davydova Z, Leibowitz SF (2003) Peptides that regulate food intake: orexin gene expression is increased during states of hypertriglyceridemia. Am J Physiol Regul Integr Comp Physiol 284:R1454-R1465.
55. Yamanaka A, Muraki Y, Tsujino N, Goto K, Sakurai T (2003) Regulation of orexin neurons by the monoaminergic and cholinergic systems. Biochem Biophys Res Commun 303:120-129.
56. Yan QS, Zheng SZ, Feng MJ, Yan SE (2005) Involvement of 5-HT1B receptors within the ventral tegmental area in ethanol-induced increases in mesolimbic dopaminergic transmission. Brain Res 1060:126-137.
57. Zarrindast MR, Owji AA, Hosseini-Nia T (1991) Evaluation of dopamine receptor involvement in rat feeding behaviour. Gen Pharmacol 22:1011-1016.
58. Zippel U, Plagemann A, Davidowa H (2003) Altered action of dopamine and cholecystokinin on lateral hypothalamic neurons in rats raised under different feeding conditions. Behav Brain Res 147:89-94.