Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice

Peptides

Volumn 30, Issue 10, 2009, Pages 1892-1900

  Kumar, K Ganesh ^a   Sutton, Gregory M ^a   Dong, Jesse Z ^b   Roubert, Pierre ^c   Plas, Pascale ^c   Halem, Heather A ^b   Culler, Michael D ^b   Yang, Hyunwon ^a   Dixit, Vishwa D ^a   Butler, Andrew A ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b Biomeasure Inc   (United States)

^c IPSEN   (France)

Author keywords

Diabetes; Insulin; Melanocortins; Melanocyte stimulating hormones; Obesity; Proopiomelanocortin

Indexed keywords

BIM 22493; BIM 22511; CYCLIC AMP; GLUCOSE; INSULIN; LIPID; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN 5 RECEPTOR; MELANOCORTIN RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BODY WEIGHT; CONTROLLED STUDY; DIET RESTRICTION; DISEASE SEVERITY; DRUG MECHANISM; FATTY LIVER; FOOD INTAKE; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE TEST; HUMAN; HYPERINSULINEMIA; KNOCKOUT MOUSE; LIPOGENESIS; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; OBESITY; OSMOTIC MINIPUMP; PRIORITY JOURNAL; WEIGHT REDUCTION;

ANIMALS; DIET; EATING; ENERGY METABOLISM; FEMALE; GLUCOSE; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4; WEIGHT LOSS;

MUS;

EID: 70349314321     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2009.07.012     Document Type: Article

References (38)

1. Albarado D.C., McClaine J., Stephens J.M., Mynatt R.L., Ye J., Bannon A.W., et al. Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice. Endocrinology 145 (2004) 243-252
2. An J.J., Rhee Y., Kim S.H., Kim D.M., Han D.H., Hwang J.H., et al. Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle. J Biol Chem 282 (2007) 2862-2870
3. Balthasar N., Dalgaard L.T., Lee C.E., Yu J., Funahashi H., Williams T., et al. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123 (2005) 493-505
4. Browning J.D., and Horton J.D. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 114 (2004) 147-152
5. Brzoska T., Luger T.A., Maaser C., Abels C., and Bohm M. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev 29 (2008) 581-602
6. Butler A.A. The melanocortin system and energy balance. Peptides 27 (2006) 281-290
7. Butler A.A., Kesterson R.A., Khong K., Cullen M.J., Pelleymounter M.A., Dekoning J., et al. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141 (2000) 3518-3521
8. Cettour-Rose P., and Rohner-Jeanrenaud F. The leptin-like effects of 3-d peripheral administration of a melanocortin agonist are more marked in genetically obese Zucker (fa/fa) than in lean rats. Endocrinology 143 (2002) 2277-2283
9. Chen A.S., Marsh D.J., Trumbauer M.E., Frazier E.G., Guan X.M., Yu H., et al. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 26 (2000) 97-102
10. Chen A.S., Metzger J.M., Trumbauer M.E., Guan X.M., Yu H., Frazier E.G., et al. Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Res 9 (2000) 145-154
11. Cone R.D. Anatomy and regulation of the central melanocortin system. Nat Neurosci 8 (2005) 571-578
12. Cone R.D. Studies on the physiological functions of the melanocortin system. Endocr Rev 27 (2006) 736-749
13. Ellacott K.L., Murphy J.G., Marks D.L., and Cone R.D. Obesity-induced inflammation in white adipose tissue is attenuated by loss of melanocortin-3 receptor signaling. Endocrinology 148 (2007) 6186-6194
14. Farooqi I.S., and O'Rahilly S. Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity. Nat Clin Pract Endocrinol Metab 4 (2008) 569-577
15. Hill J.O. Understanding and addressing the epidemic of obesity: an energy balance perspective. Endocr Rev 27 (2006) 750-761
16. Hotamisligil G.S. Inflammation and metabolic disorders. Nature 444 (2006) 860-867
17. Lam D.D., and Heisler L.K. Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes. Expert Rev Mol Med 9 (2007) 1-24
18. Lee M., Kim A., Conwell I.M., Hruby V., Mayorov A., Cai M., et al. Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression. Peptides 29 (2008) 440-447
19. Lin J., Choi Y.H., Hartzell D.L., Li C., Della-Fera M.A., and Baile C.A. CNS melanocortin and leptin effects on stearoyl-CoA desaturase-1 and resistin expression. Biochem Biophys Res Commun 311 (2003) 324-328
20. MacNeil D.J., Howard A.D., Guan X., Fong T.M., Nargund R.P., Bednarek M.A., et al. The role of melanocortins in body weight regulation: opportunities for the treatment of obesity. Eur J Pharmacol 440 (2002) 141-157
21. Marks D.L., Hruby V., Brookhart G., and Cone R.D. The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R). Peptides 27 (2006) 259-264
22. Marsh D.J., Hollopeter G., Huszar D., Laufer R., Yagaloff K.A., Fisher S.L., et al. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 21 (1999) 119-122
23. Miller K.A., Gunn T.M., Carrasquillo M.M., Lamoreux M.L., Galbraith D.B., and Barsh G.S. Genetic studies of the mouse mutations mahogany and mahoganoid. Genetics 146 (1997) 1407-1415
24. Nijenhuis W.A., Oosterom J., and Adan R.A. AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor. Mol Endocrinol 15 (2001) 164-171
25. Obici S., Feng Z., Tan J., Liu L., Karkanias G., and Rossetti L. Central melanocortin receptors regulate insulin action. J Clin Invest 108 (2001) 1079-1085
26. Perlemuter G., Bigorgne A., Cassard-Doulcier A.M., and Naveau S. Nonalcoholic fatty liver disease: from pathogenesis to patient care. Nat Clin Pract Endocrinol Metab 3 (2007) 458-469
27. Phan L.K., Chung W.K., and Leibel R.L. The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity. Am J Physiol Endocrinol Metab 291 (2006) E611-E620
28. Phan L.K., Lin F., LeDuc C.A., Chung W.K., and Leibel R.L. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. J Clin Invest 110 (2002) 1449-1459
29. Pissios P., and Maratos-Flier E. More than satiety: central serotonin signaling and glucose homeostasis. Cell Metab 6 (2007) 345-347
30. Qi Y., Nie Z., Lee Y.S., Singhal N.S., Scherer P.E., Lazar M.A., et al. Loss of resistin improves glucose homeostasis in leptin deficiency. Diabetes 55 (2006) 3083-3090
31. Rangwala S.M., Rich A.S., Rhoades B., Shapiro J.S., Obici S., Rossetti L., et al. Abnormal glucose homeostasis due to chronic hyperresistinemia. Diabetes 53 (2004) 1937-1941
32. Rossi M., Kim M.S., Morgan D.G., Small C.J., Edwards C.M., Sunter D., et al. A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology 139 (1998) 4428-4431
33. Singhal N.S., Patel R.T., Qi Y., Lee Y.S., and Ahima R.S. Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice. Am J Physiol Endocrinol Metab 295 (2008) E331-E338
34. Sutton G.M., Trevaskis J.L., Hulver M.W., McMillan R.P., Markward N.J., Babin M.J., et al. Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. Endocrinology 147 (2006) 2183-2196
35. Tolle V., and Low M.J. In vivo evidence for inverse agonism of Agouti-related peptide in the central nervous system of proopiomelanocortin-deficient mice. Diabetes 57 (2008) 86-94
36. Trevaskis J.L., Meyer E.A., Galgani J.E., and Butler A.A. Counterintuitive effects of double-heterozygous null melanocortin-4 receptor and leptin genes on diet-induced obesity and insulin resistance in C57BL/6J mice. Endocrinology 149 (2008) 174-184
37. Uyeda K., and Repa J.J. Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Cell Metab 4 (2006) 107-110
38. Zhou L., Sutton G.M., Rochford J.J., Semple R.K., Lam D.D., Oksanen L.J., et al. Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways. Cell Metab 6 (2007) 398-405