High constitutive activity is an intrinsic feature of ghrelin receptor protein: A study with a functional monomeric GHS-R1a receptor reconstituted in lipid discs

Journal of Biological Chemistry

Volumn 287, Issue 6, 2012, Pages 3630-3641

  Damian, Marjorie ^a   Marie, Jacky ^a   Leyris, Jean Philippe ^a,b   Fehrentz, Jean Alain ^a   Verdié, Pascal ^a   Martinez, Jean ^a   Banères, Jean Louis ^a   Mary, Sophie ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b HÔPITAL SAINT ELOI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AGONIST-DEPENDENT MANNER; ARRESTINS; CELLULAR ENVIRONMENT; G-PROTEIN COUPLED RECEPTORS; GHRELIN RECEPTOR; GUANOSINES; HETEROLOGOUS SYSTEMS; IN-VIVO; INTRINSIC FEATURES; INTRINSIC FLUORESCENCE; INTRINSIC PROPERTY; MOLECULAR MECHANISM; THERAPEUTIC APPLICATION;

PURIFICATION;

LIGANDS;

BETA ARRESTIN 2; GHRELIN; GHRELIN RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MONOMER; TRANSCRIPTION FACTOR AP 2;

ARTICLE; CELL INCLUSION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; INTERNALIZATION; LIGAND BINDING; LIPID DISC; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; PROTEIN CONFORMATION;

ANIMALS; ARRESTINS; ENZYME ACTIVATION; FISH PROTEINS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; LIPIDS; MEMBRANE PROTEINS; MEMBRANES, ARTIFICIAL; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GHRELIN; SEPIA;

EID: 84856715703     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.288324     Document Type: Article

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