메뉴 건너뛰기




Volumn 73, Issue 2, 2012, Pages 317-332

Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 Agonism

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 2 RECEPTOR; GHRELIN RECEPTOR; MESSENGER RNA;

EID: 84863010954     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2011.10.038     Document Type: Article
Times cited : (263)

References (53)
  • 3
    • 14644387575 scopus 로고    scopus 로고
    • Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation
    • Bulenger S., Marullo S., Bouvier M. Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation. Trends Pharmacol. Sci. 2005, 26:131-137.
    • (2005) Trends Pharmacol. Sci. , vol.26 , pp. 131-137
    • Bulenger, S.1    Marullo, S.2    Bouvier, M.3
  • 4
    • 0027521351 scopus 로고
    • Aequorin-expressing mammalian cell lines used to report Ca2+ mobilization
    • Button D., Brownstein M. Aequorin-expressing mammalian cell lines used to report Ca2+ mobilization. Cell Calcium 1993, 14:663-671.
    • (1993) Cell Calcium , vol.14 , pp. 663-671
    • Button, D.1    Brownstein, M.2
  • 5
    • 45549109545 scopus 로고    scopus 로고
    • Constitutive activity of the cannabinoid CB1 receptor regulates the function of co-expressed Mu opioid receptors
    • Canals M., Milligan G. Constitutive activity of the cannabinoid CB1 receptor regulates the function of co-expressed Mu opioid receptors. J.Biol. Chem. 2008, 283:11424-11434.
    • (2008) J.Biol. Chem. , vol.283 , pp. 11424-11434
    • Canals, M.1    Milligan, G.2
  • 6
    • 0030229897 scopus 로고    scopus 로고
    • Genetic variants of the human obesity (OB) gene: association with body mass index in young women, psychiatric symptoms, and interaction with the dopamine D2 receptor (DRD2) gene
    • Comings D.E., Gade R., MacMurray J.P., Muhleman D., Peters W.R. Genetic variants of the human obesity (OB) gene: association with body mass index in young women, psychiatric symptoms, and interaction with the dopamine D2 receptor (DRD2) gene. Mol. Psychiatry 1996, 1:325-335.
    • (1996) Mol. Psychiatry , vol.1 , pp. 325-335
    • Comings, D.E.1    Gade, R.2    MacMurray, J.P.3    Muhleman, D.4    Peters, W.R.5
  • 10
    • 35748973918 scopus 로고    scopus 로고
    • Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans
    • Epstein L.H., Temple J.L., Neaderhiser B.J., Salis R.J., Erbe R.W., Leddy J.J. Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans. Behav. Neurosci. 2007, 121:877-886.
    • (2007) Behav. Neurosci. , vol.121 , pp. 877-886
    • Epstein, L.H.1    Temple, J.L.2    Neaderhiser, B.J.3    Salis, R.J.4    Erbe, R.W.5    Leddy, J.J.6
  • 15
    • 51449084843 scopus 로고    scopus 로고
    • Pulsatile cerebrospinal fluid and plasma ghrelin in relation to growth hormone secretion and food intake in the sheep
    • Grouselle D., Chaillou E., Caraty A., Bluet-Pajot M.T., Zizzari P., Tillet Y., Epelbaum J. Pulsatile cerebrospinal fluid and plasma ghrelin in relation to growth hormone secretion and food intake in the sheep. J.Neuroendocrinol. 2008, 20:1138-1146.
    • (2008) J.Neuroendocrinol. , vol.20 , pp. 1138-1146
    • Grouselle, D.1    Chaillou, E.2    Caraty, A.3    Bluet-Pajot, M.T.4    Zizzari, P.5    Tillet, Y.6    Epelbaum, J.7
  • 17
    • 28444493656 scopus 로고    scopus 로고
    • Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation
    • Guo W., Shi L., Filizola M., Weinstein H., Javitch J.A. Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proc. Natl. Acad. Sci. USA 2005, 102:17495-17500.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 17495-17500
    • Guo, W.1    Shi, L.2    Filizola, M.3    Weinstein, H.4    Javitch, J.A.5
  • 18
    • 69249158290 scopus 로고    scopus 로고
    • Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation
    • Han Y., Moreira I.S., Urizar E., Weinstein H., Javitch J.A. Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. Nat. Chem. Biol. 2009, 5:688-695.
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 688-695
    • Han, Y.1    Moreira, I.S.2    Urizar, E.3    Weinstein, H.4    Javitch, J.A.5
  • 19
    • 11144225093 scopus 로고    scopus 로고
    • Common structural basis for constitutive activity of the ghrelin receptor family
    • Holst B., Holliday N.D., Bach A., Elling C.E., Cox H.M., Schwartz T.W. Common structural basis for constitutive activity of the ghrelin receptor family. J.Biol. Chem. 2004, 279:53806-53817.
    • (2004) J.Biol. Chem. , vol.279 , pp. 53806-53817
    • Holst, B.1    Holliday, N.D.2    Bach, A.3    Elling, C.E.4    Cox, H.M.5    Schwartz, T.W.6
  • 20
    • 34447530948 scopus 로고    scopus 로고
    • Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism
    • Holst B., Mokrosinski J., Lang M., Brandt E., Nygaard R., Frimurer T.M., Beck-Sickinger A.G., Schwartz T.W. Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J.Biol. Chem. 2007, 282:15799-15811.
    • (2007) J.Biol. Chem. , vol.282 , pp. 15799-15811
    • Holst, B.1    Mokrosinski, J.2    Lang, M.3    Brandt, E.4    Nygaard, R.5    Frimurer, T.M.6    Beck-Sickinger, A.G.7    Schwartz, T.W.8
  • 22
    • 0028260220 scopus 로고
    • Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase
    • Inglese J., Luttrell L.M., Iñiguez-Lluhi J.A., Touhara K., Koch W.J., Lefkowitz R.J. Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. Proc. Natl. Acad. Sci. USA 1994, 91:3637-3641.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3637-3641
    • Inglese, J.1    Luttrell, L.M.2    Iñiguez-Lluhi, J.A.3    Touhara, K.4    Koch, W.J.5    Lefkowitz, R.J.6
  • 23
    • 33746583963 scopus 로고    scopus 로고
    • Ghrelin amplifies dopamine signaling by crosstalk involving formation of GHS-R/D1R heterodimers
    • Jiang H., Betancourt L., Smith R.G. Ghrelin amplifies dopamine signaling by crosstalk involving formation of GHS-R/D1R heterodimers. Mol. Endocrinol. 2006, 20:1772-1785.
    • (2006) Mol. Endocrinol. , vol.20 , pp. 1772-1785
    • Jiang, H.1    Betancourt, L.2    Smith, R.G.3
  • 24
    • 77951666149 scopus 로고    scopus 로고
    • Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
    • Johnson P.M., Kenny P.J. Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat. Neurosci. 2010, 13:635-641.
    • (2010) Nat. Neurosci. , vol.13 , pp. 635-641
    • Johnson, P.M.1    Kenny, P.J.2
  • 26
    • 33847071711 scopus 로고    scopus 로고
    • The low-density lipoprotein class A module of the relaxin receptor (leucine-rich repeat containing G-protein coupled receptor 7): its role in signaling and trafficking to the cell membrane
    • Kern A., Agoulnik A.I., Bryant-Greenwood G.D. The low-density lipoprotein class A module of the relaxin receptor (leucine-rich repeat containing G-protein coupled receptor 7): its role in signaling and trafficking to the cell membrane. Endocrinology 2007, 148:1181-1194.
    • (2007) Endocrinology , vol.148 , pp. 1181-1194
    • Kern, A.1    Agoulnik, A.I.2    Bryant-Greenwood, G.D.3
  • 27
    • 0028085776 scopus 로고
    • Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling
    • Koch W.J., Hawes B.E., Inglese J., Luttrell L.M., Lefkowitz R.J. Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. J.Biol. Chem. 1994, 269:6193-6197.
    • (1994) J.Biol. Chem. , vol.269 , pp. 6193-6197
    • Koch, W.J.1    Hawes, B.E.2    Inglese, J.3    Luttrell, L.M.4    Lefkowitz, R.J.5
  • 28
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402:656-660.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 29
    • 0041728947 scopus 로고    scopus 로고
    • Treatment with cabergoline is associated with weight loss in patients with hyperprolactinemia
    • Korner J., Lo J., Freda P.U., Wardlaw S.L. Treatment with cabergoline is associated with weight loss in patients with hyperprolactinemia. Obes. Res. 2003, 11:311-312.
    • (2003) Obes. Res. , vol.11 , pp. 311-312
    • Korner, J.1    Lo, J.2    Freda, P.U.3    Wardlaw, S.L.4
  • 30
    • 33748522433 scopus 로고    scopus 로고
    • A review of the receptor-binding and pharmacokinetic properties of dopamine agonists
    • Kvernmo T., Härtter S., Burger E. A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin. Ther. 2006, 28:1065-1078.
    • (2006) Clin. Ther. , vol.28 , pp. 1065-1078
    • Kvernmo, T.1    Härtter, S.2    Burger, E.3
  • 31
    • 48749126827 scopus 로고    scopus 로고
    • Ligand sensitivity in dimeric associations of the serotonin 5HT2c receptor
    • Mancia F., Assur Z., Herman A.G., Siegel R., Hendrickson W.A. Ligand sensitivity in dimeric associations of the serotonin 5HT2c receptor. EMBO Rep. 2008, 9:363-369.
    • (2008) EMBO Rep. , vol.9 , pp. 363-369
    • Mancia, F.1    Assur, Z.2    Herman, A.G.3    Siegel, R.4    Hendrickson, W.A.5
  • 32
  • 34
    • 69249206623 scopus 로고    scopus 로고
    • G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function
    • Milligan G. G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function. Br. J. Pharmacol. 2009, 158:5-14.
    • (2009) Br. J. Pharmacol. , vol.158 , pp. 5-14
    • Milligan, G.1
  • 36
    • 36148975300 scopus 로고    scopus 로고
    • Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological invitro and invivo evaluations
    • Moulin A., Demange L., Bergé G., Gagne D., Ryan J., Mousseaux D., Heitz A., Perrissoud D., Locatelli V., Torsello A., et al. Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological invitro and invivo evaluations. J.Med. Chem. 2007, 50:5790-5806.
    • (2007) J.Med. Chem. , vol.50 , pp. 5790-5806
    • Moulin, A.1    Demange, L.2    Bergé, G.3    Gagne, D.4    Ryan, J.5    Mousseaux, D.6    Heitz, A.7    Perrissoud, D.8    Locatelli, V.9    Torsello, A.10
  • 37
    • 10344262615 scopus 로고    scopus 로고
    • Protein kinase C mediates phosphorylation, desensitization, and trafficking of the D2 dopamine receptor
    • Namkung Y., Sibley D.R. Protein kinase C mediates phosphorylation, desensitization, and trafficking of the D2 dopamine receptor. J.Biol. Chem. 2004, 279:49533-49541.
    • (2004) J.Biol. Chem. , vol.279 , pp. 49533-49541
    • Namkung, Y.1    Sibley, D.R.2
  • 38
    • 34447650048 scopus 로고    scopus 로고
    • Is dopamine a physiologically relevant mediator of feeding behavior?
    • Palmiter R.D. Is dopamine a physiologically relevant mediator of feeding behavior?. Trends Neurosci. 2007, 30:375-381.
    • (2007) Trends Neurosci. , vol.30 , pp. 375-381
    • Palmiter, R.D.1
  • 41
    • 0242499401 scopus 로고    scopus 로고
    • Reduced dopaminergic tone in hypothalamic neural circuits: expression of a " thrifty" genotype underlying the metabolic syndrome?
    • Pijl H. Reduced dopaminergic tone in hypothalamic neural circuits: expression of a " thrifty" genotype underlying the metabolic syndrome?. Eur. J. Pharmacol. 2003, 480:125-131.
    • (2003) Eur. J. Pharmacol. , vol.480 , pp. 125-131
    • Pijl, H.1
  • 43
    • 78650147139 scopus 로고    scopus 로고
    • Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes
    • Smith N.J., Milligan G. Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes. Pharmacol. Rev. 2010, 62:701-725.
    • (2010) Pharmacol. Rev. , vol.62 , pp. 701-725
    • Smith, N.J.1    Milligan, G.2
  • 46
    • 54249101806 scopus 로고    scopus 로고
    • Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele
    • Stice E., Spoor S., Bohon C., Small D.M. Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele. Science 2008, 322:449-452.
    • (2008) Science , vol.322 , pp. 449-452
    • Stice, E.1    Spoor, S.2    Bohon, C.3    Small, D.M.4
  • 47
    • 1842480284 scopus 로고    scopus 로고
    • Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    • Sun Y., Wang P., Zheng H., Smith R.G. Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc. Natl. Acad. Sci. USA 2004, 101:4679-4684.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4679-4684
    • Sun, Y.1    Wang, P.2    Zheng, H.3    Smith, R.G.4
  • 48
    • 33646141847 scopus 로고    scopus 로고
    • Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    • Sun Y., Asnicar M., Saha P.K., Chan L., Smith R.G. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab. 2006, 3:379-386.
    • (2006) Cell Metab. , vol.3 , pp. 379-386
    • Sun, Y.1    Asnicar, M.2    Saha, P.K.3    Chan, L.4    Smith, R.G.5
  • 49
    • 1242276192 scopus 로고    scopus 로고
    • Roles of G-protein-coupled receptor dimerization
    • Terrillon S., Bouvier M. Roles of G-protein-coupled receptor dimerization. EMBO Rep. 2004, 5:30-34.
    • (2004) EMBO Rep. , vol.5 , pp. 30-34
    • Terrillon, S.1    Bouvier, M.2
  • 50
    • 38349054282 scopus 로고    scopus 로고
    • Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling
    • Vilardaga J.-P., Nikolaev V.O., Lorenz K., Ferrandon S., Zhuang Z., Lohse M.J. Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling. Nat. Chem. Biol. 2008, 4:126-131.
    • (2008) Nat. Chem. Biol. , vol.4 , pp. 126-131
    • Vilardaga, J.-P.1    Nikolaev, V.O.2    Lorenz, K.3    Ferrandon, S.4    Zhuang, Z.5    Lohse, M.J.6
  • 51
    • 78650752631 scopus 로고    scopus 로고
    • Reward, dopamine and the control of food intake: implications for obesity
    • Volkow N.D., Wang G.-J., Baler R.D. Reward, dopamine and the control of food intake: implications for obesity. Trends Cogn. Sci. (Regul. Ed.) 2011, 15:37-46.
    • (2011) Trends Cogn. Sci. (Regul. Ed.) , vol.15 , pp. 37-46
    • Volkow, N.D.1    Wang, G.-J.2    Baler, R.D.3
  • 52
    • 79251598360 scopus 로고    scopus 로고
    • Central dopaminergic circuitry controlling food intake and reward: implications for the regulation of obesity
    • Vucetic Z., Reyes T.M. Central dopaminergic circuitry controlling food intake and reward: implications for the regulation of obesity. Wiley Interdiscip Rev Syst Biol Med 2010, 2:577-593.
    • (2010) Wiley Interdiscip Rev Syst Biol Med , vol.2 , pp. 577-593
    • Vucetic, Z.1    Reyes, T.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.