Heterodimerization of a functional GABA(B) receptor is mediated by parallel coiled-coil α-helices

Biochemistry

Volumn 38, Issue 40, 1999, Pages 13263-13269

  Kammerer, Richard A ^a   Frank, Sabine ^a   Schulthess, Therese ^a   Landwehr, Ruth ^a   Lustig, Ariel ^a   Engel, Jürgen ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; RECEPTOR SUBUNIT; GABA TYPE B RECEPTOR, SUBUNIT 1; GABBR2 PROTEIN, HUMAN; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN;

ALPHA HELIX; AMINO ACID COMPOSITION; ARTICLE; CARBOXY TERMINAL SEQUENCE; DIMERIZATION; GABAERGIC SYSTEM; GENE EXPRESSION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; STOICHIOMETRY; ADULT; AMINO ACID SEQUENCE; CHEMISTRY; CIRCULAR DICHROISM; ELECTRICITY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT; SYNTHESIS;

ESCHERICHIA COLI;

ADULT; AMINO ACID SEQUENCE; CIRCULAR DICHROISM; DIMERIZATION; ELECTROSTATICS; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, GABA-B; RECOMBINANT PROTEINS; REPETITIVE SEQUENCES, AMINO ACID; SEQUENCE ALIGNMENT;

EID: 0032589511     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991018t     Document Type: Article

References (55)

1. Bowery, N. G. (1993) Annu. Rev. Pharmacol. Toxicol. 33, 109-147.
2. Mott, D. D., and Lewis, D. V. (1994) Int. Rev. Neurobiol. 36, 97-223.
3. Rabow, L. E., Russek, S. J., and Farb, D. H. (1995) Synapse 21, 189-274.
4. Bettler, B., Kaupmann, K., and Bowery, N. G. (1998) Curr. Opin. Neurobiol. 8, 345-350.
5. Kaupmann, K., Huggel, K., Heid, J., Flor, P. J., Bischoff, S., Mickel, S. J., McMaster, G., Angst, C., Bittiger, H., Froestl, W., and Bettler, B. (1997) Nature 386, 239-246.
6. Jones, K. A., Borowsky, B., Tamm, J. A., Craig, D. A., Durkin, M. M., Dai, M., Yao, W.-J., Johnson, M., Gunwaldsen, C., Huang, L.-Y., Tang, C., Shen, Q., Salon, J. A., Morse, K., Laz, T., Smith, K. E., Nagarathnam, D., Noble, S. A., Branchek, T. A., and Gerald, C. (1998) Nature 396, 674-679.
7. White, J. H., Wise, A., Main, M. J., Green, A., Fraser, N. J., Disney, G. H., Barnes, A. A., Emson, P., Foord, S. M., and Marshall, F. H. (1998) Nature 396, 679-682.
8. Kaupmann, K., Malitschek, B., Schuler, V., Heid, J., Froestl, W., Beck, P., Mosbacher, J., Bischoff, S., Kulik, A., Shigemoto, R., Karschin, A., and Bettler, B. (1998) Nature 396, 683-687.
9. Kuner, R., Köhr, G., Grünewald, S., Eisenhardt, G., Bach, A., and Kornau, H.-C. (1999) Science 283, 74-77.
10. Ng, G. Y. K., McDonald, T., Bonnert, T., Rigby, M., Heavens, R., Whiting, P., Chateauneuf, A., Coulombe, N., Kargman, S., Caskey, T., Evans, J. F., O'Neill, G. P., and Liu, Q. (1999) Genomics 56, 288-295.
11. Ng, G. Y. K., Clark, J., Coulombe, N., Ethier, N., Herbert, T. E., Sullivan, R., Kargman, S., Chateauneuf, A., Tsukamoto, N., McDonald, T., Whiting, P., Mezey, E., Johnson, M. P., Liu, Q., Kolakowski, Jr., L. F., Evans, J. F., Bonner, T. I., and O'Neill, G. P. (1999) J. Biol. Chem. 274, 7607-7610.
12. Pin, J.-P., and Duvoisin, R. (1995) Neuropharmacology 34, 1-26.
13. Brown, E. M., Gamba, G., Riccardi, D., Lombardi, M., Butters, R., Kifor, O., Sun, A., Hediger, M. A., Lytton, J., and Herbert, S. C. (1993) Nature 366, 575-580.
14. Herrada, G., and Dulac, C. (1997) Cell 90, 763-773.
15. Matsunami, H., and Buck, L. B. (1997) Cell 90, 775-784.
16. Couve, A., Filippov, A. K., Connolly, C. N., Bettler, B., Brown, D. A., and Moss, S. J. (1998) J. Biol. Chem. 273, 26361-26367.
17. Cohen, C., and Parry, D. A. D. (1990) Proteins 7, 1-15.
18. Lupas, A. (1996) Trends Biochem. Sci. 21, 375-382.
19. Kammerer, R. A. (1997) Matrix Biol. 15, 555-565.
20. Kohn, W. D., Mant, C. T., and Hodges, R. S. (1997) J. Biol. Chem. 272, 2583-2586.
21. Crick, F. H. C. (1953) Acta Crystallogr. 6, 685-689.
22. O'Shea, E. K., Klemm, J. D., Kim, P. S., and Alber, T. (1991) Science 254, 539-544.
23. Harbury, P. B., Zhang, T., Kim, P. S., and Alber, T. (1993) Science 262, 1401-1407.
24. Harbury, P. B., Kim, P. S., and Alber, T. (1994) Nature 371, 80-83.
25. Malaskevich, V. N., Kammerer, R. A., Efimov, V. P., Schulthess, T., and Engel, J. (1996) Science 274, 761-765.
26. Sodek, J., Hodges, R. S., Smillie, L. B., and Jurasek, L. (1972) Proc. Natl. Acad. Sci. U.S.A. 69, 3800-3804.
27. McLachlan, A. D., and Stewart, M. (1975) J. Mol. Biol. 98, 293-304.
28. Snead, O. C., III (1995) Ann. Neurol. 37, 146-157.
29. Caddick, S. J., and Hosford, D. A. (1996) Mol. Neurobiol. 13, 23-32.
30. Dichter, M. A. (1997) Epilepsia 38, S2-6.
31. Brandenberger, R., Kammerer, R. A., Engel, J., and Chiquet, M. (1996) J. Cell Biol. 135, 1583-1592.
32. Kammerer, R. A., Schulthess, T., Landwehr, R., Lustig, A., Fischer, D., and Engel, J. (1998) J. Biol. Chem. 273, 10602-10608.
33. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd ed.; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
34. Edelhoch, H. (1967) Biochemistry 6, 1948-1954.
35. Schägger, H., and von Jagow, G. (1987) Anal. Biochem. 166, 368-379.
36. Chen, Y. H., Yang, J. T., and Chau, K. H. (1974) Biochemistry 13, 3350-3359.
37. van Holde, K. E. (1985) Physical Biochemistry, 2nd ed.; chapts 4 and 5, pp 93-136, Prentice Hall, Englewood Cliff, NJ.
38. Lupas, A. (1996) Methods Enzymol. 266, 513-525.
39. Woolfson, D. N., and Alber, T. (1995) Protein Sci. 4, 1596-1607.
40. Hu, J. C., O'Shea, E. K., Kim, P. S., and Sauer, R. T. (1990) Science 250, 1400-1403.
41. O'Shea, E. K., Rutkowski, R., Stafford, W. F., III, and Kim, P. S. (1989) Science 245, 646-648.
42. Muhle-Goll, C., Gibson, T., Schuck, P., Schubert, D., Nalis, D., Nilges, M., and Pastore, A. (1994) Biochemistry 33, 11296-11306.
43. Lavigne, P., Kondejewski, L. H., Houston, M. E., Jr., Sönnichsen, F. D., Lix, B., Sykes, B. D., Hodges, R. S., and Kay, C. M. (1995) J. Mol. Biol. 254, 505-520.
44. Spek, E. J., Bui, A. H., Lu, M., and Kallenbach, N. R. (1998) Protein Sci. 7, 2431-2437.
45. O'Shea, E. K., Rutkowski, R., and Kim, P. S. (1992) Cell 68, 699-708.
46. Muhle-Goll, C., Nilges, M., and Pastore, A. (1995) Biochemistry 34, 13554-13564.
47. Lavigne, P., Crump, M. P., Gagné, S. M., Hodges, R. S., Kay, C. M., and Sykes, B. D. (1998) J. Mol. Biol. 281, 165-181.
48. Gonzalez, L., Jr., Brown, R. A., Richardson, D., and Alber, T. (1996) Nature Struct. Biol. 3, 1002-1009.
49. Gonzalez, L., Jr., Woolfson, D. N., and Alber, T. (1996) Nature Struct. Biol. 3, 1011-1018.
50. Lumb, K. J., and Kim, P. S. (1995) Biochemistry 34, 8642-8648.
51. Cusack, S., Berthet-Colominas, C., Hartlein, M., Nassar, N., and Leberman, R. (1990) Nature 347, 249-255.
52. Lavigne, P., Sönnichsen, F. D., Kay, C. M., and Hodges, R. S. (1996) Science 271, 1136-1137.
53. Lumb, K. J., and Kim, P. S. (1996) Science 271, 1137-1138.
54. Krylov, D., Barchi, J., and Vinson, C. (1998) J. Mol. Biol. 279, 959-972.
55. Dames, S. A., Kammerer, R. A., Moskau, D., Engel, J., and Alexandrescu, A. T. (1999) FEBS Lett. 446, 75-80.