Hypothalamic paraventricular 5-hydroxytryptamine inhibits the effects of ghrelin on eating and energy substrate utilization

Pharmacology Biochemistry and Behavior

Volumn 97, Issue 1, 2010, Pages 152-155

  Currie, Paul J ^a   John, Catherine S ^a   Nicholson, Marjorie L ^a   Chapman, Colin D ^a   Loera, Katherine E ^a  

^a REED COLLEGE   (United States)

Author keywords

5 HT agonist; DOI; Energy metabolism; Food intake; Ghrelin; Paraventricular nucleus; Respiratory quotient; Serotonin

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; APPETITE STIMULANT; CARBOHYDRATE; GHRELIN; SEROTONIN;

ANTERIOR HYPOTHALAMUS; ARTICLE; CALORIMETER; CONTROLLED STUDY; DRUG MECHANISM; ENERGY METABOLISM; FEEDING BEHAVIOR; FOOD INTAKE; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; RESPIRATORY QUOTIENT; SIGNAL TRANSDUCTION;

ANIMALS; EATING; ENERGY METABOLISM; GHRELIN; MALE; MICROINJECTIONS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SUBSTRATE SPECIFICITY;

RATTUS;

EID: 77957749960     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2010.05.027     Document Type: Article

References (34)

1. Cowley M.A., Smith R.G., Diano S., Tschöp M., Pronchuk N., Grove K., et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003, 37:649-661.
2. Currie P.J. Integration of hypothalamic feeding and metabolic signals: focus on neuropeptide Y. Appetite 2003, 41:335-337.
3. Currie P.J., Coscina D.V. Regional differences in neuropeptide Y-induced feeding and energy substrate utilization. Brain Res 1996, 737:238-242.
4. 2A/2C receptors within specific hypothalamic nuclei differentially antagonizes NPY-induced feeding. NeuroReport 1997, 8:3759-3762.
5. Currie P.J., Coscina D.V. V. 5-Hydroxytryptaminergic receptor agonists: effects on neuropeptide Y potentiation of feeding and respiratory quotient. Brain Res 1998, 803:212-217.
6. 2A/2C antagonists in the paraventricular nucleus attenuate the action of DOI on NPY-stimulated eating. NeuroReport 1999, 10:3033-3036.
7. Currie P.J., Coiro C.D., Niyomchai T., Lira A., Farahmand F. Hypothalamic paraventricular 5-hydroxytryptamine: receptor specific inhibition of NPY-stimulated eating and energy metabolism. Pharm Biochem Behav 2002, 71:709-716.
8. Currie P.J., Mirza A., Fuld R., Park D. Vasselli JR ghrelin is an orexigenic and metabolic signaling peptide in the arcuate and paraventricular nuclei. Am J Physiol 2005, 289:R353-R358.
9. Currie P.J., Nicholson M.L., Conrad V.K., Gottschlich A., Leora K.E., John C.S., Chapman C.D. Hypothalamic serotonin microinjections inhibit the effects of ghrelin on eating and energy substrate utilization. Program No. 470.4. Abstract Viewer/Itinerary Planner 2009, Society for Neuroscience, Washington, DC, [CD-ROM].
10. Date Y., Kojima M., Hosoda H., Sawaguchi A., Mondal M.S., Suganama T., et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000, 141:4255-4261.
11. Dehlin E., Liu J., Yun S., Fox E., Snyder S., Gineste C., et al. Regulation of ghrelin structure and membrane binding by phosphorylation. Peptides 2008, 54:904-911.
12. El-Salhy M. Ghrelin in gastrointestinal diseases and disorders: a possible role in the pathophysiology and clinical implications. Int J Mol Med 2009, 24:727-732.
13. 1 agonists TFMPP and RU 24969 on feeding following peripheral or medial hypothalamic injection. Brain Res 1992, 580:265-272.
14. Gil-Campos M., Aguilera C.M., Canete R., Gil A. Ghrelin: a hormone regulating food intake and energy homeostasis. Br J Nutr 2006, 96:201-226.
15. Heisler L.K., Jobst E.E., Sutton G.M., Zhou L.G., Borok E., Thornton-Jones Z. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 2006, 51:239-249.
16. Hori Y., Kageyama H., Guan Jian-L., Kohno D., Yada T., Takenoya F., et al. Synaptic interaction between ghrelin and ghrelin-containing neurons in the rat hypothalamus. Reg Peptides 2008, 145:122-127.
17. Hosoda H., Kojima M., Matsuo H., Kanagawa K. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Bichem Biophys Res Commun 2000, 279:909-913.
18. Kangawa K. Discovery of ghrelin: it's structure and physiological significance. Acta Pharmacol Sin 2006, 27:14.
19. Kojima M., Kangawa K. Ghrelin: structure and function. Physiol Rev 2005, 85:495-522.
20. Lawrence C.B., Snape A.C., Baudoin F.M.H., Luckman S.M. Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centres. Endocrinology 2002, 143:155-162.
21. Lee M.D., Somerville E.M., Kennett G.A., Dourish C.T., Clifton P.G. Reduced hypophagic effects of d-fenfluramine and 5-HT2C receptor agonists in 5-HT1B receptor knockout mice. Psychopharmacology 2004, 176:39-49.
22. 1B receptors in the mouse: converging evidence from behavioural and c-Fos immunoreactivity studies. Eur J Neurosci 2004, 19:3017-3025.
23. Melis M.R., Mascia M.S., Succu S., Torsello A., Muller E.E., Deghenghi R., et al. Ghrelin injected into the paraventricular nucleus of the hypothalamus of male rats induces feeding but not penile erection. Neurosci Lett 2002, 329:339-343.
24. Mondal M.S., Date Y., Yamaguchi H., Toshinai K., Tsuruta T., Kangawa K., et al. Identification of ghrelin and its receptors in neurons of the rat arcuate nucleus. Regul Pept 2005, 126:55-59.
25. Nonogaki K., Ohashi-Nozue K., Yoshitomo O. A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice. Biomed Biophys Res Comm 2006, 341:703-707.
26. Olszewski P.K., Grace M.K., Billington C.J., Levine A.S. Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity. Peptides 2003, 24:919-923.
27. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 2007, Academic Press, New York.
28. Shuto Y., Shibasaki T., Otagiri A., Kuriyama H., Ohata H., Tamara H., et al. Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion feeding and adiposity. J Clin Invest 2002, 109:1429-1436.
29. Singewald N., Salchner P., Sharp T. Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs. Biol Psychiatry 2003, 53:275-283.
30. Smith R.G., Leonard R., Bailey A.R., Palyha O., Feighner S., Tan C., et al. Growth hormone secretagogue receptor family members and ligands. Endocrine 2001, 14:9-14.
31. Szentirmai E., Kapas L., Krueger J.M. Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats. Am J Physiol 2007, 292:R575-R585.
32. Vickers S.P., Benwell K.R., Porter R.H., Bickerdike M.J., Kennett G.A., Dourish C.T. Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats. Br J Pharmacol 2000, 130:1305-1314.
33. 2C receptors. Neuropsychopharmacology 2001, 41:200-209.
34. Willesen M.G., Kristensen P., Romer J. Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 1999, 70:306-316.