Role of brain dopamine in food reward and reinforcement

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 361, Issue 1471, 2006, Pages 1149-1158

  Wise, Roy A ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Dopamine; Food; Reinforcement; Reward

Indexed keywords

BRAIN; FEEDING; FOOD; NERVOUS SYSTEM;

ANIMALIA;

EID: 33845325494     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2006.1854     Document Type: Review

References (137)

1. Bailey, C. S., Hsiao, S. & King, J. E. 1986 Hedonic reactivity to sucrose in rats: modification by pimozide. Physiol. Behav. 38, 447-452. (doi:10.1016/0031-9384(86)90409-9)
2. Baldwin, A. E., Sadeghian, K., Holahan, M. R. & Kelley, A. E. 2002 Appetitive instrumental learning is impaired by inhibition of cAMP-dependent protein kinase within the nucleus accumbens. Neurobiol. Learn. Mem. 77, 44-62. (doi:10.1006/nlme.2000.4002)
3. Bassareo, V. & Di Chiara, G. 1999 Differential responsiveness of dopamine transmission to food-stimuli in nucleus accumbens shell/core compartments. Neuroscience 89, 637-641. (doi:10.1016/S0306-4522(98)00583-1)
4. Beninger, R. J. 1983 The role of dopamine in locomotor activity and learning. Brain Res. Rev. 6, 173-196. (doi:10.1016/0165-0173(83)90038-3)
5. Beninger, R. J. & Phillips, A. G. 1980 The effect of pimozide on the establishment of conditioned reinforcement. Psychopharmacology 68, 147-153. (doi:10.1007/BF00 432132)
6. Berridge, K. C. 2000 Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns. Neurosci. Biobehav. Rev. 24, 173-198. (doi:10.1016/S0149-7634(99)00072-X)
7. Berridge, K. C. & Grill, H. J. 1984 Isohedonic tastes support a two-dimensional hypothesis of palatability. Appetite 5, 221-231.
8. Berridge, K. C. & Robinson, T. E. 1998 What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res. Rev. 28, 309-369. (doi:10.1016/S0165-0173(98)00019-8)
9. Berridge, K. C. & Robinson, T. E. 2003 Parsing reward. Trends Neurosci. 26, 507-513. (doi:10.1016/S0166-2236(03)00233-9)
10. Berridge, K. C. & Winkielman, P. 2003 What is an unconscious emotion? (The case for unconscious 'liking'). Cognition Emotion 17, 181-211. (doi:10.1080/02699930 302289)
11. Berridge, K. C., Venier, I. L. & Robinson, T. E. 1989 Taste reactivity analysis of 6-hydroxydopamine-induced aphagia: implications for arousal and anhedonia hypotheses of dopamine function, Behav. Neurosci. 103, 36-45. (doi:10.1037/0735-7044.103.1.36)
12. Bindra, D. 1972 A unified account of classical conditioning and operant training. In Classical conditioning II: current theory and research (ed. A. H. Black & W. F. Prokasy WF), pp. 453-481. New York, NY: Appleton-Century- Crofts.
13. Blass, E. M. & Epstein, A. N. 1971 A lateral preoptic osmosensitive zone for thirst in the rat. J. Comp. Physiol. Psychol. 76, 378-394.
14. Bozarth, M. A. & Wise, R. A. 1981 Intracranial self-administration of morphine into the ventral tegmental area in rats. Life Sci. 28, 551-555. (doi:10.1016/0024-3205(81)90148-X)
15. Bozarth, M. A. & Wise, R. A. 1986 Involvement of the ventral tegmental dopamine system in opioid and psychomotor stimulant reinforcement. In Problems of drug dependence 1985 (ed. L. S. Harris), pp. 190-196. Washington, D.C.: U.S. Government Printing Office.
16. Cannon, C. M. & Palmiter, R. D. 2003 Reward without dopamine. J. Neurosci. 23, 10 827-10 831.
17. Carlezon Jr, W. A., Devine, D. P. & Wise, R. A. 1995 Habit-forming actions of nomifensine in nucleus accumbens. Psychopharmacology 122, 194-197. (doi:10.1007/BF022 46095)
18. Carlezon Jr, W. A. & Wise, R. A. 1996 Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortex. J. Neurosci. 16, 3112-3122.
19. Changizi, M. A., McGehee, R. M. & Hall, W. G. 2002 Evidence that appetitive responses for dehydration and food-deprivation are learned. Physiol. Behav. 75, 295-304. (doi:10.1016/S0031-9384(01)00660-6)
20. Clark, D. & White, F. J. 1987 Review: D1 dopamine receptor-the search for a function: a critical evaluation of the D1/D2 dopamine receptor classification and its function implications. Synapse 1, 347-388. (doi:10.1002/syn.890010408)
21. de Wit, H. & Wise, R. A. 1977 Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine. Can. J. Psychol. 31, 195-203.
22. de Wit, H. & Stewart, J. 1981 Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology 75, 134-143. (doi:10.1007/BF00432175)
23. de Wit, H. & Stewart, J. 1983 Drug reinstatement of heroin-reinforced responding in the rat. Psychopharmacology 79, 29-31. (doi:10.1007/BF00433012)
24. Denenberg, V. H., Kim, D. S. & Palmiter, R. D. 2004 The role of dopamine in learning, memory, and performance of a water escape task. Behav. Brain Res. 148, 73-78. (doi:10.1016/S0166-4328(03)00183-9)
25. Denton, D. 1982 The hunger for salt. Berlin, Germany: Springer-Verlag.
26. Devine, D. P. & Wise, R. A. 1994 Self-administration of morphine, DAMGO, and DPDPE into the ventral tegmental area of rats. J. Neurosci. 14, 1978-1984.
27. Devine, D. P., Leone, P., Pocock, D. & Wise, R. A. 1993 Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies. J. Pharmacol. Exp. Ther. 266, 1236-1246.
28. Di Chiara, G. & Imperato, A. 1988 Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc. Natl Acad. Sci., USA 85, 5274-5278.
29. Dickinson, A., Smith, J. & Mirenowicz, J. 2003 Dissociation of Pavlovian and instrumental incentive learning under dopamine antagonists. Behav. Neurosci. 114, 468-483. (doi:10.1037/0735-7044.114.3.468)
30. Dommett, E., Coizet, V., Blaha, C. D., Martindale, J., Lefebvre, V., Walton, N., Mayhew, J. E., Overton, P. G. & Redgrave, P. 2005 How visual stimuli activate dopaminergic neurons at short latency. Science 307, 1476-1479. (doi:10.1126/science.1107026)
31. Ervin, G. N., Fink, J. S., Young, R. C. & Smith, G. P. 1977 Different behavioral responses to L-DOPA after anterolateral or posterolateral hypothalamic injections of 6-hydroxydopamine. Brain Res. 132, 507-520. (doi:10.1016/0006-8993(77)90198-6)
32. Ettenberg, A. & Camp, C. H. 1986 Haloperidol induces a partial reinforcement extinction effect in rats: implications for a dopamine involvement in food reward. Pharmacol. Biochem. Behav. 25, 813-821. (doi:10.1016/0091-3057 (86)90392-8)
33. Ettenberg, A., Pettit, H. O., Bloom, F. E. & Koob, G. F. 1982 Heroin and cocaine intravenous self-administration in rats: mediation by separate neural systems. Psychopharmacology 78, 204-209. (doi:10.1007/BF00428151)
34. Fiorillo, C. D., Tobler, P. N. & Schultz, W. 2003 Discrete coding of reward probability and uncertainty by dopamine neurons. Science 299, 1898-1902. (doi:10.1126/science. 1077349)
35. Fitzsimons, J. T. 1961 Drinking by rats depleted of body fluid without increase in osmotic pressure. J. Physiol. 159, 297-309.
36. Fouriezos, G. & Wise, R. A. 1976 Pimozide-induced extinction of intracranial self-stimulation: response patterns rule out motor or performance deficits. Brain Res. 103, 377-380. (doi:10.1016/0006-8993(76)90809-X)
37. Fouriezos, G., Hansson, P. & Wise, R. A. 1978 Neuroleptic-induced attenuation of brain stimulation reward in rats. J. Comp. Physiol. Psychol. 92, 661-671.
38. Franklin, K. B. J. 1978 Catecholamines and self-stimulation: reward and performance effects dissociated. Pharmacol. Biochem. Behav. 9, 813-820. (doi:10.1016/0091-3057 (78)90361-1)
39. Franklin, K. B. J. & McCoy, S. N. 1979 Pimozide-induced extinction in rats: stimulus control of responding rules out motor deficit. Pharmacol. Biochem. Behav. 11, 71-75. (doi:10.1016/0091-3057(79)90299-5)
40. Freed, W. J. & Mendelson, J. 1974 Airlicking: thirsty rats prefer a warm dry airstream to a warm humid airstream. Physiol. Behav. 12, 557-561. (doi:10.1016/0031-9384 (74)90203-0)
41. Gallistel, C. R. & Karras, D. 1984 Pimozide and amphetamine have opposing effects on the reward summation function. Pharmacol. Biochem. Behav. 2, 73-77. (doi:10.1016/0091-3057(84)90104-7)
42. Gallistel, C. R., Boytim, M., Gomita, Y. & Klebanoff, L. 1982 Does pimozide block the reinforcing effect of brain stimulation? Pharmacol. Biochem. Behav. 17, 769-781. (doi:10.1016/0091-3057(82)90360-4)
43. Geary, N. & Smith, G. 1985 Pimozide decreases the positive reinforcing effect of sham fed sucrose in the rat. Pharmacol. Biochem. Behav. 22, 787-790. (doi:10.1016/0091-3057 (85)90528-3)
44. Goeders, N. E. & Smith, J. E. 1983 Cortical dopaminergic involvement in cocaine reinforcement. Science 221, 773-775.
45. Goeders, N. E. & Smith, J. E. 1986 Reinforcing properties of cocaine in the medial prefrontal cortex: primary action on presynaptic dopaminergic terminals. Pharmacol. Biochem. Behav. 25, 191-199. (doi:10.1016/0091-3057 (86)90252-2)
46. Goeders, N. E., Lane, J. D. & Smith, J. E. 1984 Self-administration of methionine enkephalin into the nucleus accumbens. Pharmacol. Biochem. Behav. 20, 451-455. (doi:10.1016/0091-3057(84)90284-3)
47. Grill, H. J. & Norgren, R. 1978 The taste reactivity test. II. Mimetic responses to gustatory stimuli in chronic thalamic and chronic decerebrate rats. Brain Res. 143, 281-297. (doi:10.1016/0006-8993(78)90569-3)
48. Haertzen, C. A. 1966 Development of scales based on patterns of drug effects, using the Addiction Research Center Inventory. Psychol. Rep. 18, 163-194.
49. Hajnal, A., Smith, G. P. & Norgren, R. 2004 Oral sucrose stimulation increases accumbens dopamine in the rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286, R31-R37.
50. Hall, W. G. & Bryan, T. E. 1981 The ontogeny of feeding in rats: IV. Taste development as measured by intake and behavioral responses to oral infusions of sucrose and quinine. J. Comp. Physiol. Psychol. 95, 240-251.
51. Hernandez, L. & Hoebel, B. G. 1988 Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. Life Sci. 42, 1705-1712. (doi:10.1016/0024-3205(88)90036-7)
52. Hoebel, B. G., Monaco, A. P., Hernandez, L., Aulisi, E. F., Stanley, B. G. & Lenard, L. 1983 Self-injection of amphetamine directly into the brain. Psychopharmacology 81, 158-163. (doi:10.1007/BF00429012)
53. Hornykiewicz, O. 1979 Brain dopamine in Parkinson's disease and other neurological disturbances. In The neurobiology of dopamine (ed. A. S. Horn, J. Korf & B. H. C. Westerink), pp. 633-653. New York, NY: Academic Press.
54. Horvath, T. L. & Diano, S. 2004 The floating blueprint of hypothalamic feeding circuits. Nat. Rev. Neurosci. 5, 662-667. (doi:10.1038/nrn1479)
55. Hull, C. L. 1937 Mind, mechanism, and adaptive behavior. Psychol. Rev. 44, 1-32.
56. Hurd, J. L., Weiss, F., Koob, G. F., Anden, N.-E. & Ungerstedt, U. 1989 Cocaine reinforcement and extracellular dopamine overflow in rat nucleus accumbens: an in vivo microdialysis study. Brain Res. 498, 199-203. (doi:10.1016/0006-8993(89)90422-8)
57. Ikemoto, S. 2003 Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies. J. Neurosci. 23, 9305-9511.
58. 2 receptors in the nucleus accumbens in mediating reward. J. Neurosci. 17, 8580-8587.
59. Johanson, I. B. & Hall, W. G. 1979 Appetitive learning in 1-day-old rat pups. Science 205, 419-421.
60. Kelleher, R. T. & Morse, W. H. 1968 Schedules using noxious stimuli. 3. Responding maintained with response produced electric shocks. J. Exp. Anal. Behav. 11, 819-838. (doi:10.1901/jeab.1968.11-819)
61. Koob, G. F. 1982 The dopamine anhedonia hypothesis: a pharmacological phrenology. Behav. Brain Sci. 5, 63-64.
62. Kraly, F. S., Gibbs, J. & Smith, G. P. 1975 Disordered drinking after abdominal vagotomy in rats. Nat. Neurosci. 258, 226-228.
63. Le Magnen, J. 1959 Effects des administrations post-prandiales de glucose sur l'établissement des appétits. C.R. Soc. Biol. 153, 212-215.
64. Liebman, J. M. & Butcher, L. L. 1974 Comparative involvement of dopamine and noradrenaline in rate-free self-stimulation in substantia nigra, lateral hypothalamus, and mesencephalic central gray. N-S. Arch. Pharmacol. 284, 167-194. (doi:10.1007/BF00501121)
65. Ljungberg, T., Apicella, P. & Schultz, W. 1991 Responses of monkey midbrain dopamine neurons during delayed alternation performance. Brain Res. 567, 337-341. (doi:10.1016/0006-8993(91)90816-E)
66. Ljungberg, T., Apicella, P. & Schultz, W. 1992 Responses of monkey dopamine neurons during learning of behavioral reactions. J. Neurophysiol. 67, 145-163.
67. Mason, S. T., Beninger, R. J., Fibiger, H. C. & Phillips, A. G. 1980 Pimozide-induced suppression of responding: evidence against a block of food reward. Pharmacol. Biochem. Behav. 12, 917-923. (doi:10.1016/0091-3057(80)90453- 0)
68. McFarland, K. & Ettenberg, A. 1998 Haloperidol does not affect motivational processes in an operant runway model of food-seeking behavior. Behav. Nenrosci. 112, 630-635. (doi:10.1037/0735-7044.112.3.630)
69. Mendelson, J. & Chillag, D. 1970 Tongue cooling: a new reward for thirsty rodents. Science 170, 1418-1419.
70. Messier, C. & White, N. M. 1984 Contingent and non-contingent actions of sucrose and saccharin reinforcers: effects on taste preference and memory. Physiol. Behav. 32, 195-203. (doi:10.1016/0031-9384(84)90129-X)
71. Olds, M. E. 1982 Reinforcing effects of morphine in the nucleus accumbens. Brain Res. 237, 429-440. (doi:10.1016/0006-8993(82)90454-1)
72. Olds, J. & Milner, P. M. 1954 Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. J. Comp. Physiol. Psychol. 47, 419-127.
73. Pavlov, I. P. 1928 Lectures on conditioned reflexes. New York, NY: International Publishers.
74. Pecina, S., Berridge, K. C. & Parker, L. A. 1997 Pimozide does not shift palatability: separation of anhedonia from sensorimotor suppression by taste reactivity. Pharmacol. Biochem. Behav. 58, 801-811.
75. Peck, J. W. & Novin, D. 1971 Evidence that osmoreceptors mediating drinking in rabbits are in the lateral preoptic area. J. Comp. Physiol. Psychol. 74, 134-147.
76. Pettit, H. O. & Justice, J. B. 1989 Dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis. Pharmacol. Biochem. Behav. 34, 899-904. (doi:10.1016/0091-3057(89)90291-8)
77. Pettit, H. O., Ettenberg, A., Bloom, F. E. & Koob, G. F. 1984 Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacology 84, 167-173. (doi:10.1007/BF00427441)
78. Pfaffmann, C. 1960 The pleasures of sensation. Psychol. Rev. 67, 253-268.
79. Pickens, R. & Harris, W. C. 1968 Self-administration of d-amphetamine by rats. Psychopharmacologia 12, 158-163. (doi:10.1007/BF00401545)
80. Quartermain, D., Miller, N. E. & Wolf, G. 1967 Role of experience in relationship between sodium deficiency and rate of bar pressing for salt. J. Comp. Physiol. Psychol. 63, 417-420.
81. Ranaldi, R., Pocock, D., Zereik, R. & Wise, R. A. 1999 Dopamine fluctuations in the nucleus accumbens during maintenance, extinction, and reinstatement of intravenous D-amphetamine self- administration. J. Neurosci. 19, 4102-4109.
82. Rescorla, R. A. & Solomon, R. L. 1967 Two-process learning theory: relationships between Pavlovian conditioning and instrumental learning. Psychol. Rev. 74, 151-182.
83. Robbins, T. W. 1978 The acquisition of responding with conditioned reinforcement: effects of pipradrol, methylphenidate, D-amphetamine and nomifensine. Psychopharmacology 58, 78-87. (doi:10.1007/BF00426794)
84. Roberts, D. C. S., Corcoran, M. E. & Fibiger, H. C. 1977 On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine. Pharmacol. Biochem. Behav. 6, 615-620. (doi:10.1016/0091-3057 (77)90084-3)
85. Roberts, D. C. S., Koob, G. F., Klonoff, P. & Fibiger, H. C. 1980 Extinction and recovery of cocaine self-administration following 6-OHDA lesions of the nucleus accumbens. Pharmacol. Biochem. Behav. 12, 781-787. (doi:10.1016/0091-3057(80)90166-5)
86. Robinson, T. E. & Berridge, K. C. 2003 Addiction. Ann. Rev. Psychol. 54, 25-53. (doi:10.1146/annurev.psych.54.101601. 145237)
87. Robinson, S., Sandstrom, S. M., Denenberg, V. H. & Palmiter, R. D. 2005 Distinguishing whether dopamine regulates liking, wanting, and/or learning about rewards. Behav. Neurosci. 119, 5-15. (doi:10.1037/0735-7044.119.1.5)
88. Rodgers, W. & Rozin, P. 1966 Novel food preferences in thiamine-deficient rats. J. Comp. Physiol. Psychol. 61, 1-4.
89. Romo, R. & Schultz, W. 1990 Dopamine neurons of the monkey midbrain: contingencies of responses to active touch during self-initiated arm movements. J. Neurophysiol. 63, 592-606.
90. Rozin, P. 1969 Adaptive food sampling patterns in vitamin deficient rats. J. Comp. Physiol. Psychol. 69, 126-132.
91. Rozin, P. & Kalat, J. W. 1971 Specific hungers and poison avoidance as adaptive specializations of learning. Psychol. Rev. 78, 459-486.
92. Rozin, P. & Rodgers, W. 1967 Novel-diet preferences in vitamin-deficient rats and rats recovered from vitamin deficiency. J. Comp. Physiol. Psychol. 63, 421-428.
93. Salamone, J. D. 1986 Different effects of haloperidol and extinction on instrumental behaviours. Psychopharmacology 88, 18-23. (doi:10.1007/BF00310507)
94. Salamone, J. D. & Correa, M. 2002 Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine. Behav. Brain Res. 137, 3-25. (doi:10.1016/S0166- 4328(02)00 282-6)
95. Salamone, J. D., Wisniecki, A., Carlson, B. B. & Correa, M. 2001 Nucleus accumbens dopamine depletions make animals highly sensitive to high fixed ratio requirements but do not impair primary food reinforcement. Neuroscience 105, 863-870. (doi:10.1016/S0306-4522(01)00249-4)
96. Salamone, J. D., Correa, M., Mingote, S. M. & Weber, S. M. 2005 Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine. Curr. Opin. Pharmacol. 5, 34-41. (doi:10.1016/j.coph.2004.09.004)
97. Saper, C. B., Chou, T. C. & Elmquist, J. K. 2002 The need to feed: homeostatic and hedonic control of eating. Neuron 36, 199-211. (doi:10.1016/S0896-6273(02)00969-8)
98. Schneider, L. H., Gibbs, J. & Smith, G. P. 1986 Selective D-1 or D-2 receptor antagonists inhibit sucrose sham feeding in rats. Appetite 7, 294-295.
99. Schneider, L. H., Davis, J. D., Watson, C. A. & Smith, G. P. 1990 Similar effect of raclopride and reduced sucrose concentration on the microstructure of sucrose sham feeding. Eur. J. Pharmacol. 186, 61-70. (doi:10.1016/0014-2999(90)94060-B)
100. Schneirla, T. C. 1959 An evolutionary and developmental theory of biphasic processes underlying approach and withdrawal. In Nebraska Symposium on Motivation (ed. M. R. Jones), pp. 1-42. Lincoln, NE: University of Nebraska Press.
101. Schultz, W. 1986 Responses of midbrain dopamine neurons to behavioral trigger stimuli in the monkey. J. Neurophysiol. 56, 1439-1461.
102. Schultz, W. 2002 Getting formal with dopamine and reward. Neuron 36, 241-263. (doi:10.1016/S0896-6273(02)00967-4)
103. Schultz, W., Apicella, P. & Ljungberg, T. 1993 Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task. J. Neurosci. 13, 900-913.
104. Sclafani, A. 2004 Oral and postoral determinants of food reward. Physiol. Behav. 81, 773-779. (doi:10.1016/j.physbeh.2004.04.031)
105. Skinner, B. F. 1933 On the rate of extinction of a conditioned reflex. J. Gen. Psychol. 8, 114-129.
106. Skinner, B. F. 1935 Two types of conditioned reflex and a pseudotype. J. Gen. Psychol. 12, 66-77.
107. Skinner, B. F. 1938 The behavior of organisms. New York, NY: Appleton-Century-Crofts.
108. Smith, G. P. 1995 Dopamine and food reward. In Progress in psychobiology and physiological psychology (ed. A. Morrison & S. Fluharty), pp. 83-144. New York, NY: Academic Press.
109. Steiner, J. E. 1973 The gustofacial response: observation on normal and anencephalic newborn infants. Symp. Oral Sens. Percept. 4, 254-278.
110. Steiner, J. E. 1974 Innate, discriminative human facial expressions to taste and smell stimulation. Ann. NY Acad. Sci. 237, 229-233.
111. Steiner, J. E., Glaser, D., Hawilo, M. E. & Berridge, K. C. 2001 Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates. Neurosci. Biobehav. Rev. 25, 53-74. (doi:10.1016/S0149-7634(00)00051-8)
112. Stricker, E. M. & Zigmond, M. J. 1985 Brain catecholamine and motivated behavior: specific or nonspecific contributions. In Catecholamines: neuropharmacology and central nervous system theoretical aspects (ed. E. Usdin, A. Carlsson, A. Dahlstrom & J. Engel), pp. 259-269. New York, NY: Liss.
113. Szczypka, M. S., Rainey, M. A., Kim, D. S., Alaynick, W. A., Marck, B. T., Matsumoto, A. M. & Palmiter, R. D. 1999 Feeding behavior in dopamine-deficient mice. Proc. Natl Acad. Sci. USA 96, 12 138-12 143. (doi:10.1073/pnas.96.21.12138)
114. Szczypka, M. S., Kwok, K., Brot, M. D., Marck, B. T., Matsumoto, A. M., Donahue, B. A. & Palmiter, R. D. 2001 Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice. Neuron 30, 819-828. (doi:10.1016/S0896-6273(01)00319-1)
115. Taylor, J. R. & Robbins, T. W. 1986 6-hydroxydopamine lesions of the nucleus accumbens, but not of the caudate nucleus, attenuate enhanced responding with conditioned reinforcement produced by intra-accumbens amphetamine. Psychopharmacology 90, 310-317. (doi:10.1007/BF00179197)
116. Thorndike, E. L. 1933 A theory of the action of the after-effects of a connection upon it. Psychol. Rev. 40, 434-439.
117. Tombaugh, T. N., Szostak, C., Voorneveld, P. & Tombaugh, J. W. 1982 Failure to obtain functional equivalence between dopamine receptor blockade and extinction: evidence supporting a sensory-motor conditioning hypothesis. Pharmacol. Biochem. Behav. 16, 67-72. (doi:10.1016/0091-3057(82)90015-6)
118. Ungerstedt, U. 1971 Adipsia and aphagia after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. Acta Physiol. Scand. Suppl. 367, 95-122.
119. White, N. M. & McDonald, R. J. 2002 Multiple parallel memory systems in the brain of the rat. Neurobiol. Learn. Mem. 774, 125-184. (doi:10.1006/nlme.2001.4008)
120. Wise, R. A. 1982 Neuroleptics and operant behavior: the anhedonia hypothesis. Behav. Brain Sci. 5, 39-87.
121. Wise, R. A. 1989 The brain and reward. In The neuropharmacological basis of reward (ed. J. M. Liebman & S. J. Cooper), pp. 377-424. Oxford, UK: Oxford University Press.
122. Wise, R. A. 2004a Dopamine, learning and motivation. Nat. Rev. Neurosci. 5, 483-494. (doi:10.1038/nrn1406)
123. Wise, R. A. 2004b Drive, incentive, and reinforcement: the antecedents and consequences of motivation. Nebr. Symp. Motiv. 50, 159-195.
124. Wise, R. A. & Raptis, L. 1986 Effects of naloxone and pimozide on initiation and maintenance measures of free feeding. Brain Res. 368, 62-68. (doi:10.1016/0006-8993(86)91042-5)
125. Wise, R. A. & Rompré, P.-P. 1989 Brain dopamine and reward. Ann. Rev. Psychol. 40, 191-225. (doi:10.1146/annurev.ps.40.020189.001203)
126. Wise, R. A. & Schwartz, H. V. 1981 Pimozide attenuates acquisition of lever pressing for food in rats. Pharmacol. Biochem. Behav. 15, 655-656. (doi:10.1016/0091-3057 (81)90225-2)
127. Wise, R. A., Spindler, J. & Legault, L. 1978a Major attenuation of food reward with performance sparing doses of pimozide in the rat. Can. J. Psychol. 32, 77-85.
128. Wise, R. A., Spindler, J., deWit, H. & Gerber, G. J. 1978b Neuroleptic-induced 'anhedonia' in rats: pimozide blocks reward quality of food. Science 201, 262-264.
129. Wise, R. A., Murray, A. & Bozarth, M. A. 1990 Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever pressing in rats. Psychopharmacology 100, 355-360. (doi:10.1007/BF02244606)
130. Wise, R. A., Leone, P., Rivest, R. & Leeb, K. 1995a Elevations of nucleus accumbens dopamine and DOPAC levels during intravenous heroin self-administration. Synapse 21, 140-148. (doi:10.1002/syn.890210207)
131. Wise, R. A., Newton, P., Leeb, K., Burnette, B., Pocock, P. & Justice, J. B. 1995b Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats. Psychopharmacology 120, 10-20. (doi:10.1007/BF02246140)
132. Xenakis, S. & Sclafani, A. 1981 The effects of pimozide on the consumption of a palatable saccharin-glucose solution in the rat. Pharmacol. Biochem. Behav. 15, 435-442. (doi:10.1016/0091-3057(81)90274-4)
133. Xenakis, S. & Sclafani, A. 1982 The dopaminergic mediation of a sweet reward in normal and VMH hyperphagic rats. Pharmacol. Biochem. Behav. 16, 293-302. (doi:10.1016/0091-3057(82)90163-0)
134. Yokel, R. A. & Wise, R. A. 1975 Increased lever pressing for amphetamine after pimozide in rats: implications for a dopamine theory of reward. Science 187, 547-549.
135. Yokel, R. A. & Wise, R. A. 1976 Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats. Psychopharmacology 48, 311-318. (doi:10.1007/BF00496868)
136. Zangen, A., Ikemo, S., Zadina, J. E. & Wise, R. A. 2002 Rewarding and psychomotor stimulant effects of endomorphin-1: anterior-posterior differences within the ventral tegmental area and lack of effect in nucleus accumbens. J. Neurosci. 22, 7225-7233.
137. Zhou, Q.-Y. & Palmiter, R. D. 1995 Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell 83, 1197-1209. (doi:10.1016/0092-8674(95)90145-0)