메뉴 건너뛰기




Volumn 67, Issue 9, 2010, Pages 880-886

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

Author keywords

Food intake; food reward; ghrelin; orexin

Indexed keywords

GHRELIN; OREXIN;

EID: 77950371376     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2009.10.030     Document Type: Article
Times cited : (303)

References (42)
  • 1
    • 0037057802 scopus 로고    scopus 로고
    • The need to feed: Homeostatic and hedonic control of eating
    • Saper C.B., Chou T.C., and Elmquist J.K. The need to feed: Homeostatic and hedonic control of eating. Neuron 36 (2002) 199-211
    • (2002) Neuron , vol.36 , pp. 199-211
    • Saper, C.B.1    Chou, T.C.2    Elmquist, J.K.3
  • 2
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschop M., Smiley D.L., and Heiman M.L. Ghrelin induces adiposity in rodents. Nature 407 (2000) 908-913
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 3
    • 0035433977 scopus 로고    scopus 로고
    • A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    • Cummings D.E., Purnell J.Q., Frayo R.S., Schmidova K., Wisse B.E., and Weigle D.S. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50 (2001) 1714-1719
    • (2001) Diabetes , vol.50 , pp. 1714-1719
    • Cummings, D.E.1    Purnell, J.Q.2    Frayo, R.S.3    Schmidova, K.4    Wisse, B.E.5    Weigle, D.S.6
  • 4
    • 0035940390 scopus 로고    scopus 로고
    • Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: Relationships between ghrelin and anabolic/catabolic factors
    • Nagaya N., Uematsu M., Kojima M., Date Y., Nakazato M., Okumura H., et al. Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: Relationships between ghrelin and anabolic/catabolic factors. Circulation 104 (2001) 2034-2038
    • (2001) Circulation , vol.104 , pp. 2034-2038
    • Nagaya, N.1    Uematsu, M.2    Kojima, M.3    Date, Y.4    Nakazato, M.5    Okumura, H.6
  • 5
    • 13444265857 scopus 로고    scopus 로고
    • Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa
    • Otto B., Cuntz U., Fruehauf E., Wawarta R., Folwaczny C., Riepl R.L., et al. Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur J Endocrinol 145 (2001) 669-673
    • (2001) Eur J Endocrinol , vol.145 , pp. 669-673
    • Otto, B.1    Cuntz, U.2    Fruehauf, E.3    Wawarta, R.4    Folwaczny, C.5    Riepl, R.L.6
  • 6
    • 0043030280 scopus 로고    scopus 로고
    • Minireview: From anorexia to obesity-the yin and yang of body weight control
    • Zigman J.M., and Elmquist J.K. Minireview: From anorexia to obesity-the yin and yang of body weight control. Endocrinology 144 (2003) 3749-3756
    • (2003) Endocrinology , vol.144 , pp. 3749-3756
    • Zigman, J.M.1    Elmquist, J.K.2
  • 7
  • 8
    • 0035863948 scopus 로고    scopus 로고
    • Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (primate, lemurian) and rat forebrain and pituitary
    • Mitchell V., Bouret S., Beauvillain J.C., Schilling A., Perret M., Kordon C., et al. Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (primate, lemurian) and rat forebrain and pituitary. J Comp Neurol 429 (2001) 469-489
    • (2001) J Comp Neurol , vol.429 , pp. 469-489
    • Mitchell, V.1    Bouret, S.2    Beauvillain, J.C.3    Schilling, A.4    Perret, M.5    Kordon, C.6
  • 10
    • 33748560432 scopus 로고    scopus 로고
    • Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
    • Abizaid A., Liu Z.W., Andrews Z.B., Shanabrough M., Borok E., Elsworth J.D., et al. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest 116 (2006) 3229-3239
    • (2006) J Clin Invest , vol.116 , pp. 3229-3239
    • Abizaid, A.1    Liu, Z.W.2    Andrews, Z.B.3    Shanabrough, M.4    Borok, E.5    Elsworth, J.D.6
  • 11
    • 33947139281 scopus 로고    scopus 로고
    • Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens
    • Jerlhag E., Egecioglu E., Dickson S.L., Douhan A., Svensson L., and Engel J.A. Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens. Addict Biol 12 (2007) 6-16
    • (2007) Addict Biol , vol.12 , pp. 6-16
    • Jerlhag, E.1    Egecioglu, E.2    Dickson, S.L.3    Douhan, A.4    Svensson, L.5    Engel, J.A.6
  • 12
    • 33748362868 scopus 로고    scopus 로고
    • Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: Implications for its involvement in brain reward
    • Jerlhag E., Egecioglu E., Dickson S.L., Andersson M., Svensson L., and Engel J.A. Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: Implications for its involvement in brain reward. Addict Biol 11 (2006) 45-54
    • (2006) Addict Biol , vol.11 , pp. 45-54
    • Jerlhag, E.1    Egecioglu, E.2    Dickson, S.L.3    Andersson, M.4    Svensson, L.5    Engel, J.A.6
  • 13
    • 27744593324 scopus 로고    scopus 로고
    • Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens
    • Naleid A.M., Grace M.K., Cummings D.E., and Levine A.S. Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens. Peptides 26 (2005) 2274-2279
    • (2005) Peptides , vol.26 , pp. 2274-2279
    • Naleid, A.M.1    Grace, M.K.2    Cummings, D.E.3    Levine, A.S.4
  • 14
    • 0036144322 scopus 로고    scopus 로고
    • Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers
    • Lawrence C.B., Snape A.C., Baudoin F.M., and Luckman S.M. Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers. Endocrinology 143 (2002) 155-162
    • (2002) Endocrinology , vol.143 , pp. 155-162
    • Lawrence, C.B.1    Snape, A.C.2    Baudoin, F.M.3    Luckman, S.M.4
  • 15
    • 0037967762 scopus 로고    scopus 로고
    • Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus
    • Olszewski P.K., Li D., Grace M.K., Billington C.J., Kotz C.M., and Levine A.S. Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus. Peptides 24 (2003) 597-602
    • (2003) Peptides , vol.24 , pp. 597-602
    • Olszewski, P.K.1    Li, D.2    Grace, M.K.3    Billington, C.J.4    Kotz, C.M.5    Levine, A.S.6
  • 16
    • 0037382853 scopus 로고    scopus 로고
    • Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin
    • Kohno D., Gao H.Z., Muroya S., Kikuyama S., and Yada T. Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 52 (2003) 948-956
    • (2003) Diabetes , vol.52 , pp. 948-956
    • Kohno, D.1    Gao, H.Z.2    Muroya, S.3    Kikuyama, S.4    Yada, T.5
  • 17
    • 0038521277 scopus 로고    scopus 로고
    • Hypothalamic orexin neurons regulate arousal according to energy balance in mice
    • Yamanaka A., Beuckmann C.T., Willie J.T., Hara J., Tsujino N., Mieda M., et al. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 38 (2003) 701-713
    • (2003) Neuron , vol.38 , pp. 701-713
    • Yamanaka, A.1    Beuckmann, C.T.2    Willie, J.T.3    Hara, J.4    Tsujino, N.5    Mieda, M.6
  • 19
    • 49349099488 scopus 로고    scopus 로고
    • Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine
    • Jerlhag E. Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine. Addict Biol 13 (2008) 358-363
    • (2008) Addict Biol , vol.13 , pp. 358-363
    • Jerlhag, E.1
  • 20
    • 9944233963 scopus 로고    scopus 로고
    • Augmentation of cocaine hyperactivity in rats by systemic ghrelin
    • Wellman P.J., Davis K.W., and Nation J.R. Augmentation of cocaine hyperactivity in rats by systemic ghrelin. Regul Pept 125 (2005) 151-154
    • (2005) Regul Pept , vol.125 , pp. 151-154
    • Wellman, P.J.1    Davis, K.W.2    Nation, J.R.3
  • 21
    • 33947157380 scopus 로고    scopus 로고
    • Augmented cocaine conditioned place preference in rats pretreated with systemic ghrelin
    • Davis K.W., Wellman P.J., and Clifford P.S. Augmented cocaine conditioned place preference in rats pretreated with systemic ghrelin. Regul Pept 140 (2007) 148-152
    • (2007) Regul Pept , vol.140 , pp. 148-152
    • Davis, K.W.1    Wellman, P.J.2    Clifford, P.S.3
  • 24
    • 42649116436 scopus 로고    scopus 로고
    • Ghrelin modulates brain activity in areas that control appetitive behavior
    • Malik S., McGlone F., Bedrossian D., and Dagher A. Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metab 7 (2008) 400-409
    • (2008) Cell Metab , vol.7 , pp. 400-409
    • Malik, S.1    McGlone, F.2    Bedrossian, D.3    Dagher, A.4
  • 25
    • 0033588184 scopus 로고    scopus 로고
    • Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
    • Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., et al. Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation. Cell 98 (1999) 437-451
    • (1999) Cell , vol.98 , pp. 437-451
    • Chemelli, R.M.1    Willie, J.T.2    Sinton, C.M.3    Elmquist, J.K.4    Scammell, T.5    Lee, C.6
  • 26
    • 31044451759 scopus 로고    scopus 로고
    • Mice lacking ghrelin receptors resist the development of diet-induced obesity
    • Zigman J.M., Nakano Y., Coppari R., Balthasar N., Marcus J.N., Lee C.E., et al. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest 115 (2005) 3564-3572
    • (2005) J Clin Invest , vol.115 , pp. 3564-3572
    • Zigman, J.M.1    Nakano, Y.2    Coppari, R.3    Balthasar, N.4    Marcus, J.N.5    Lee, C.E.6
  • 27
    • 41149167542 scopus 로고    scopus 로고
    • Orexin signaling mediates the antidepressant-like effect of calorie restriction
    • Lutter M., Krishnan V., Russo S.J., Jung S., McClung C.A., and Nestler E.J. Orexin signaling mediates the antidepressant-like effect of calorie restriction. J Neurosci 28 (2008) 3071-3075
    • (2008) J Neurosci , vol.28 , pp. 3071-3075
    • Lutter, M.1    Krishnan, V.2    Russo, S.J.3    Jung, S.4    McClung, C.A.5    Nestler, E.J.6
  • 28
    • 0034993663 scopus 로고    scopus 로고
    • Leptin reverses sucrose-conditioned place preference in food-restricted rats
    • Figlewicz D.P., Higgins M.S., Ng-Evans S.B., and Havel P.J. Leptin reverses sucrose-conditioned place preference in food-restricted rats. Physiol Behav 73 (2001) 229-234
    • (2001) Physiol Behav , vol.73 , pp. 229-234
    • Figlewicz, D.P.1    Higgins, M.S.2    Ng-Evans, S.B.3    Havel, P.J.4
  • 30
    • 35348825010 scopus 로고    scopus 로고
    • Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity
    • Rudolph J., Esler W.P., O'Connor S., Coish P.D., Wickens P.L., Brands M., et al. Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity. J Med Chem 50 (2007) 5202-5216
    • (2007) J Med Chem , vol.50 , pp. 5202-5216
    • Rudolph, J.1    Esler, W.P.2    O'Connor, S.3    Coish, P.D.4    Wickens, P.L.5    Brands, M.6
  • 31
    • 35548949948 scopus 로고    scopus 로고
    • Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss
    • Esler W.P., Rudolph J., Claus T.H., Tang W., Barucci N., Brown S.E., et al. Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss. Endocrinology 148 (2007) 5175-5185
    • (2007) Endocrinology , vol.148 , pp. 5175-5185
    • Esler, W.P.1    Rudolph, J.2    Claus, T.H.3    Tang, W.4    Barucci, N.5    Brown, S.E.6
  • 32
    • 25644432796 scopus 로고    scopus 로고
    • A role for lateral hypothalamic orexin neurons in reward seeking
    • Harris G.C., Wimmer M., and Aston-Jones G. A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437 (2005) 556-559
    • (2005) Nature , vol.437 , pp. 556-559
    • Harris, G.C.1    Wimmer, M.2    Aston-Jones, G.3
  • 33
    • 0037444572 scopus 로고    scopus 로고
    • Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine
    • Colby C.R., Whisler K., Steffen C., Nestler E.J., and Self D.W. Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine. J Neurosci 23 (2003) 2488-2493
    • (2003) J Neurosci , vol.23 , pp. 2488-2493
    • Colby, C.R.1    Whisler, K.2    Steffen, C.3    Nestler, E.J.4    Self, D.W.5
  • 34
    • 2542460250 scopus 로고    scopus 로고
    • Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats
    • Figlewicz D.P., Bennett J., Evans S.B., Kaiyala K., Sipols A.J., and Benoit S.C. Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats. Behav Neurosci 118 (2004) 479-487
    • (2004) Behav Neurosci , vol.118 , pp. 479-487
    • Figlewicz, D.P.1    Bennett, J.2    Evans, S.B.3    Kaiyala, K.4    Sipols, A.J.5    Benoit, S.C.6
  • 35
    • 32344453801 scopus 로고    scopus 로고
    • Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine
    • Narita M., Nagumo Y., Hashimoto S., Khotib J., Miyatake M., Sakurai T., et al. Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J Neurosci 26 (2006) 398-405
    • (2006) J Neurosci , vol.26 , pp. 398-405
    • Narita, M.1    Nagumo, Y.2    Hashimoto, S.3    Khotib, J.4    Miyatake, M.5    Sakurai, T.6
  • 36
    • 33748664379 scopus 로고    scopus 로고
    • Drug insight: The functions of ghrelin and its potential as a multitherapeutic hormone
    • Kojima M., and Kangawa K. Drug insight: The functions of ghrelin and its potential as a multitherapeutic hormone. Nat Clin Pract Endocrinol Metab 2 (2006) 80-88
    • (2006) Nat Clin Pract Endocrinol Metab , vol.2 , pp. 80-88
    • Kojima, M.1    Kangawa, K.2
  • 37
    • 0032576592 scopus 로고    scopus 로고
    • Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area
    • Elias C.F., Saper C.B., Maratos-Flier E., Tritos N.A., Lee C., Kelly J., et al. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol 402 (1998) 442-459
    • (1998) J Comp Neurol , vol.402 , pp. 442-459
    • Elias, C.F.1    Saper, C.B.2    Maratos-Flier, E.3    Tritos, N.A.4    Lee, C.5    Kelly, J.6
  • 38
    • 0027443735 scopus 로고
    • Neuropeptide Y: Intraaccumbens injections produce a place preference that is blocked by cis-flupenthixol
    • Josselyn S.A., and Beninger R.J. Neuropeptide Y: Intraaccumbens injections produce a place preference that is blocked by cis-flupenthixol. Pharmacol Biochem Behav 46 (1993) 543-552
    • (1993) Pharmacol Biochem Behav , vol.46 , pp. 543-552
    • Josselyn, S.A.1    Beninger, R.J.2
  • 39
    • 35348824334 scopus 로고    scopus 로고
    • Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens
    • Zheng H., Patterson L.M., and Berthoud H.R. Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens. J Neurosci 27 (2007) 11075-11082
    • (2007) J Neurosci , vol.27 , pp. 11075-11082
    • Zheng, H.1    Patterson, L.M.2    Berthoud, H.R.3
  • 40
    • 0018099290 scopus 로고
    • Catecholamine innervation of the basal forebrain. IV. Topography of the dopamine projection to the basal forebrain and neostriatum
    • Fallon J.H., and Moore R.Y. Catecholamine innervation of the basal forebrain. IV. Topography of the dopamine projection to the basal forebrain and neostriatum. J Comp Neurol 180 (1978) 545-580
    • (1978) J Comp Neurol , vol.180 , pp. 545-580
    • Fallon, J.H.1    Moore, R.Y.2
  • 41
    • 0021498845 scopus 로고
    • A study of the contribution of hippocampal-accumbens-subpallidal projections to locomotor activity
    • Mogenson G.J., and Nielsen M. A study of the contribution of hippocampal-accumbens-subpallidal projections to locomotor activity. Behav Neural Biol 42 (1984) 38-51
    • (1984) Behav Neural Biol , vol.42 , pp. 38-51
    • Mogenson, G.J.1    Nielsen, M.2
  • 42
    • 33748371601 scopus 로고    scopus 로고
    • Neural mechanisms of addiction: The role of reward-related learning and memory
    • Hyman S.E., Malenka R.C., and Nestler E.J. Neural mechanisms of addiction: The role of reward-related learning and memory. Annu Rev Neurosci 29 (2006) 565-598
    • (2006) Annu Rev Neurosci , vol.29 , pp. 565-598
    • Hyman, S.E.1    Malenka, R.C.2    Nestler, E.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.