Central infusion of melanocortin agonist MTII in rats: Assessment of c- Fos expression and taste aversion

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 274, Issue 1 43-1, 1998, Pages

  Thiele, Todd E ^a   Van Dijk, Gertjan ^a   Yagaloff, Keith A ^b   Fisher, Stewart L ^b   Schwartz, Michael ^a   Burn, Paul ^b   Seeley, Randy J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Hoffman La Roche Department of Metabolic Diseases   (United States)

Author keywords

Hypothalamus; Leptin; Lithium chloride; Obesity; Satiety

Indexed keywords

HORMONE DERIVATIVE; LEPTIN; LITHIUM CHLORIDE; MELANOCORTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FOOD INTAKE; GENE EXPRESSION; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; OBESITY; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; SATIETY; TASTE AVERSION;

EID: 0031914232     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.274.1.r248     Document Type: Article

References (23)

1. Brady, L. S., M. A. Smith, P. W. Gold, and M. Herkenham. Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology 52: 441-447, 1990.
2. Campfield, L. A., F. J. Smith, and P. Burn. The OB protein (leptin) pathway: a link between adipose tissue mass and central neural networks. Horm. Metab. Res. 28: 619-632, 1996.
3. Campfield, L. A., F. J. Smith, Y. Guisez, R. Devos, and P. Burn. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549, 1995.
4. Fan, W., B. A. Boston, R. A. Kesterson, V. J. Hruby, and R. D. Cone. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385: 165-168, 1997.
5. Huszar, D., C. A. Lynch, V. Fairchild-Huntress, J. H. Dunmore, Q. Fang, L. R. Berkemeier, W. Gu, B. A. Boston, R. D. Cone, F. J. Smith, L. A. Campfield, P. Burn, and F. Lee. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88: 131-141, 1997.
6. Kiss, J. Z., M. D. Cassell, and M. Palkovits. Analysis of the ACTH/beta-End/alpha-MSH-immunoreactive afferent input to the hypothalamic paraventricular nucleus of rat. Brain Res. 324: 91-99, 1984.
7. McMahon, L. R., and P. J. Wellman. PVN infusion of GLP-1-(7-36) amide suppresses feeding and drinking but does not induce conditioned taste aversions or alter locomotion in rats. Am. J. Physiol. 274 (Regulatory Integrative Comp. Physiol. 43): R23-R29, 1998.
8. 4-R) in neuroendocrine and autonomic control circuits in the brain. Mol. Endocrinol. 8: 1298-1308, 1994.
9. Ogawa, Y., H. Masuzaki, N. Isse, K. Mori, M. Shigemoto, N. Satoh, N. Tamura, K. Hosoda, Y. Yoshimasa, H. Jingami, T. Kawada, and K. Nakao. Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese zucker fatty (fa/fa) rats. J. Clin. Invest. 96: 1647-1652, 1995.
10. Poggioli, R., A. V. Vergoni, and A. Bertolini. ACTH-(1-24) and alpha-MSH antagonize feeding behavior stimulated by kappa opiate agonists. Peptides 7: 843-848, 1986.
11. Schioth, H. B., R. Muceniece, and J. E. Wikberg. Characterisation of the melanocortin 4 receptor by radioligand binding. Pharmacol. Toxicol. 79: 161-165, 1996.
12. Scrocchi, L. A., T. J. Brown, N. MacLusky, P. L. Brubaker, A. B. Auerbach, A. L. Joyner, and D. J. Drucker. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat. Med. 2: 1254-1258, 1996.
13. Seeley, R. J., K. A. Yagaloff, S. L. Fischer, P. Burn, T. E. Thiele, G. van Dijk, D. G. Baskin, and M. W. Schwartz. A role for melanocortin receptors in leptin action. Nature. In press.
14. Seeley, R. J., G. van Dijk, L. A. Campfield, F. J. Smith, P. Burn, J. A. Nelligan, S. M. Bell, D. G. Baskin, S. C. Woods, and M. W. Schwartz. Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats. Horm. Metab. Res. 28: 664-668, 1996.
15. Smith, M. S. Lactation alters neuropeptide-Y and proopiomelanocortin gene expression in the arcuate nucleus of the rat. Endocrinology 133: 1258-1265, 1993.
16. Tang-Christensen, M., P. J. Larsen, R. Goke, A. Fink-Jensen, D. S. Jessop, M. Moller, and S. P. Sheikh. Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol. 40): R848-R856, 1996.
17. Thiele, T. E., G. van Dijk, L. A. Campfield, F. J. Smith, P. Burn, S. C. Woods, I. L. Bernstein, and R. J. Seeley. Central administration of GLP-1, but not leptin, produces conditioned taste aversions in the rat. Am. J. Physiol. 272 (Regulatory Integrative Comp. Physiol. 41): R726-R730, 1997.
18. Turton, M. D., D. O'Shea, I. Gunn, S. A. Beak, C. M. B. Edwards, K. Meeran, S. J. Choi, G. M. Taylor, M. M. Heath, P. D. Lambert, J. P. H. Wilding, D. M. Smith, M. A. Ghatei, J. Herbert, and S. R. Bloom. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379: 69-72, 1996.
19. Van Dijk, G., T. E. Thiele, J. C. K. Donahey, L. A. Campfield, F. J. Smith, P. Burn, I. L. Bernstein, S. C. Woods, and R. J. Seeley. Central infusion of leptin and GLP-1-(7-36) amide differentially stimulate c-Fos-like immunoreactivity in the rat brain. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol. 40): R1096-R1100, 1996.
20. West, D. B., D. Fey, and S. C. Woods. Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. Am. J. Physiol. 246 (Regulatory Integrative Comp. Physiol. 15): R776-R787, 1984.
21. Woods, S. C., D. B. West, L. J. Stein, L. D. McKay, E. C. Lotter, S. G. Porte, N. J. Kenney, and D. Porte, Jr. Peptides and the control of meal size. Diabetologia 20: 305-313, 1981.
22. Yalow, R. S., J. Eng, and E. Straus. The role of CCK-line peptides in appetite regulation. Adv. Metab. Disord. 10: 435-456, 1983.
23. Zhang, Y., R. Proenca, M. Maffie, M. Barone, L. Leopold, and J. M. Friedman. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994.