Semiconductor Quantum Dots and FRET

FRET - Förster Resonance Energy Transfer: From Theory to Applications

Volumn , Issue , 2013, Pages 475-605

  Algar, W Russ ^a   Massey, Melissa ^b   Krull, Ulrich J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Bioconjugate; Biological applications; Energy transfer; FRET acceptor; FRET donor; Nanomaterials; Quantum dot

Indexed keywords

ENERGY TRANSFER; FORSTER RESONANCE ENERGY TRANSFER; NANOCRYSTALS; NANOSTRUCTURED MATERIALS;

BIOCONJUGATES; BIOLOGICAL APPLICATIONS;

SEMICONDUCTOR QUANTUM DOTS;

EID: 85015460468     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527656028.ch12     Document Type: Chapter

References (380)

1. Forster, T. (1993) Intermolecule energy migration and fluorescence, in Biological Physics (eds E.V. Mielczarek, E. Greenbaum, and R.S. Knox), American Institute of Physics, New York, pp. 148-160.
2. Valeur, B. (2001) Molecular Fluorescence: Principles and Applications, Wiley-VCH Verlag GmbH,Weinheim.
3. Reed, M.A., Randall, J.N., Aggarwal, R.J., Matyi, R.J., Moore, T.M., and Wetsel, A.E. (1988) Observation of discrete electronic states in a zero-dimensional semiconductor nanostructure. Physical Review Letters, 60, 535-537.
4. Reed, M.A., Bate, R.T., Bradshaw, K., Duncan, W.M., Frensley, W.R., Lee, J.W., and Shih, H.D. (1986) Spatial quantization in GaAs-AlGaAs multiple quantum dots. Journal of Vacuum Science & Technology B, 4, 358-360.
5. Zheng, J., Nicovich, P.R., and Dickson, R. M. (2007) Highly fluorescent noble-metal quantum dots. Annual Review of Physical Chemistry, 58, 409-431.
6. Rossetti, R., Nakahara, S., and Brus, L.E. (1983) Quantum size effects in the redox potentials, resonance Raman spectra, and electronic spectra of CdS crystallites in aqueous solution. Journal of Chemical Physics, 79, 1086-1088.
7. Steigerwald, M.L., Alivisatos, A.P., Gibson, J.M., Harris, T.D., Kortan, R., Muller, A.J., Thayer, A.M., Duncan, T.M.,Douglass, D.C., and Brus, L.E. (1988) Surface derivatization and isolation of semiconductor cluster molecules. Journal of the American Chemical Society, 110, 3046-3050.
8. Dabbousi, B.O., Viejo-Rodriguez, J., Mikulec, F.V., Heine, J.R., Mattoussi, H., Ober, R., Jensen, K.F., and Bawendi, M.G. (1997) (CdSe)ZnS core-shell quantum dots: synthesis and characterization of a size series of highly luminescent nanocrystallites. The Journal of Physical Chemistry. B, 101, 9463-9475.
9. Hines, M.A. and Guyot-Sionnest, P. (1996) Synthesis and characterization of strongly luminescing ZnS-capped CdSe nanocrystals. The Journal of Physical Chemistry, 100, 468-471.
10. Murray, C.B., Norris, D.J., and Bawendi, M.G. (1993) Synthesis and characterization of nearly monodisperse CdE (E1/4S, Se, Te) semiconductor nanocrystallites. Journal of the American Chemical Society, 115, 8706-8715.
11. Chan, W.C.W. and Nie, S. (1998) Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science, 281, 2016-2018.
12. Bruchez, M., Moronne, M., Gin, P., Weiss, S., and Alivisatos, A.P. (1998) Semiconductor nanocrystals as fluorescent biological labels. Science, 281, 2013-2016.
13. Thomson Reuters, ISI Web of Science.
14. Alivisatos, A.P. (2008) Birth of a nanoscience building block. ACS Nano, 2, 1514-1516.
15. Scholes, G.D. and Rumbles, G. (2006) Excitons in nanoscale systems. Nature Materials, 5, 683-696.
16. Alivisatos, A.P. (1996) Semiconductor clusters, nanocrystals, and quantum dots. Science, 271, 933-937.
17. Smith, A.M. and Nie, S. (2004) Quantum dot nanocrystals for in vivo molecular and cellular imaging. Photochemistry and Photobiology, 80, 377-385.
18. Peng, X., Schlamp, M.C., Kadavanich, A.V., and Alivisatos, A.P. (1997) Epitaxial growth of highly luminescent CdSe/CdS core/shell nanocrystals with photostability and electronic accessibility. Journal of the American Chemical Society, 119, 7019-7029.
19. Talapin, D.V., Haubold, S., Rogach, A.L., Kornowski, A., Haase, M., and Weller, H.J. (2001) A novel organometallic synthesis of highly luminescent CdTe nanocrystals. The Journal of Physical Chemistry. B, 105, 2260-2263.
20. Xu, S., Kumar, S., and Nann, T. (2006) Rapid synthesis of high-quality InP nanocrystals. Journal of the American Chemical Society, 128, 1054-1055.
21. Bharali, D.J., Lucey, D.W., Jayakumar, H., Pudavar, H.E., and Prasad, P.N. (2005) Folate-receptor-mediated delivery of InP quantum dots for bioimaging using confocal and two-photon microscopy. Journal of the American Chemical Society, 127, 11364-11371.
22. Qian, H., Dong, C., Peng, J., Qiu, X., Xu, Y., and Ren, J. (2007) High-quality and water-soluble near-infrared photolumineseent CdHgTe/CdS quantum dots prepared by adjusting size and composition. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces, 111, 16852-16857.
23. Swafford, L.A.,Weigand, L.A., Bowers, M.J., McBride, J.R., Rapaport, J.L.,Watt, T.L., Dixit, S.K., Feldman, L.C., and Rosenthal, S.J. (2006) Homogeneously alloyed CdSxSe1±x nanocrystals: synthesis, characterization, and composition/sizedependent band gap. Journal of the American Chemical Society, 128, 12299-12306.
24. Chan, W.C.W., Maxwell, D.J., Gao, X., Bailey, R.E., Han, M., and Nie, S. (2002) Luminescent quantum dots for multiplexed biological detection and imaging. Current Opinion in Biotechnology, 13, 40-46.
25. Alivisatos, A.P. (1996) Perspectives on the physical chemistry of semiconductor nanocrystals. The Journal of Physical Chemistry, 100, 13226-13239.
26. Peng, X., Manna, L., Yang, W., Wickham, J., Scher, E., Kadavanich, A., and Alivisatos, A.P. (2000) Shape control of CdSe nanocrystals. Nature, 404, 59-61.
27. Peng, Z.A. and Peng, X.J. (2001) Mechanisms of the shape evolution of CdSe nanocrystals. Journal of the American Chemical Society, 123, 1389-1395.
28. Fu, A., Gu, W., Boussert, B., Koski, K., Gerion, D., Manna, L., Gros, M.L., Larabell, C.A., and Alivisatos, A.P. (2007) Semiconductor quantum rods as single molecule fluorescent biological labels. Nano Letters, 7, 179-182.
29. Manna, L., Scher, E.C., and Alivisatos, A.P. (2000) Synthesis of soluble and processable rod-, arrow-, teardrop-, and tetrapod-shaped CdSe nanocrystals. Journal of the American Chemical Society, 122, 12700-12706.
30. Wang, Y. and Herron, N. (1991) Nanometer-sized semiconductor clusters: materials synthesis, quantum size effects, and photophysical properties. The Journal of Physical Chemistry, 95, 525-532.
31. Bawendi, M.G., Steigerwald, M.L., and Brus, L.E. (1990) The quantummechanics of larger semiconductor clusters (quantum dots). Annual Review of Physical Chemistry, 41, 477-496.
32. Michalet, X., Pinaud, F.F., Bentolila, L.A., Tsay, J.M., Li, J.J., Sundaresan, G., Wu, A. M., Gambhir, S.S., and Weiss, S. (2005) Quantum dots for live cells, in vivo imaging, and diagnostics. Science, 307, 538-544.
33. Nirmal, M. and Brus, L. (1999) Luminescence photophysics in semiconductor nanocrystals. Accounts of Chemical Research, 32, 407-414.
34. Steckel, J.S., Zimmer, J.P., Coe-Sullivan, S., Stott, N.E., Bulovic, V., and Bawendi, M.G. (2004) Blue luminescence from (CdS)ZnS core-shell nanocrystals. Angewandte Chemie, International Edition, 43, 2154-2158.
35. Behrendt, J.M. and Sutherland, A.J. (2009) Quantum dot-polymer bead composites for biological sensing applications, in Biosensing Using Nanomaterials (ed. A. MerkoSci), John Wiley & Sons, Inc., Hoboken, pp. 291-331.
36. Medintz, I.L., Uyeda, H.T., Goldman, E.R., and Mattoussi, H. (2005) Quantum dot bioconjugates for imaging, labelling and sensing. Nature Materials, 4, 435-445.
37. Reiss, P., Bleuse, J., and Pron, A. (2002) Highly luminescent CdSe/ZnSe core/ shell nanocrystals of low size dispersion. Nano Letters, 2, 781-784.
38. Gao, X., Yang, L., Petros, J.A., Marshall, F. F., Simons, J.W., and Nie, S. (2005) In vivo molecular and cellular imaging with quantum dots. Current Opinion in Biotechnology, 16, 63-72.
39. Alivisatos, A.P., Gu, W., and Larabell, C. (2005) Quantum dots as cellular probes. Annual Review of Biomedical Engineering, 7, 55-76.
40. Grabolle, M., Kapusta, P., Nann, T., Shu, X., Ziegler, J., and Resch-Genger, U. (2009) Fluorescence lifetime multiplexing with nanocrystals and organic labels. Analytical Chemistry, 81, 7807-7813.
41. Javier, A., Magana, D., Jennings, T., and Strouse, G.F. (2003) Nanosecond exciton recombination dynamics in colloidal CdSe quantum dots under ambient conditions. Applied Physics Letters, 83, 1423-1425.
42. Underwood, D.F., Kippeny, T., and Rosenthal, S.J. (2001) Ultrafast carrier dynamics in CdSe nanocrystals determined by femtosecond fluorescence upconversion spectroscopy. The Journal of Physical Chemistry. B, 105, 436-443.
43. Yu, W.W., Qu, L., Guo, W., and Peng, X. (2003) Experimental determination of the extinction coefficient of CdTe, CdSe, and CdS nanocrystals. Chemistry of Materials, 15, 2854-2860.
44. Leatherdale, C.A., Woo, W.K., Mikulec, F.V., and Bawendi, M.G. (2002) On the absorption cross section of CdSe nanocrystal quantum dots. The Journal of Physical Chemistry. B, 106, 7619-7622.
45. Pu, S.C., Yang, M.J., Hsu, C.C., Lai, C.W., Hsieh, C.C., Lin, S.H., Cheng, Y.M., and Chou, P.T. (2006) The empirical correlation between size and two-photon absorption cross section of CdSe and CdTe quantum dots. Small, 2, 1308-1313.
46. Clapp, A.R., Pons, T., Medintz, I.L., Delehanty, J.B., Melinger, J.S., Tiefenbrunn, T., Dawson, P.E., Fisher, B.R., O'Rourke, B., and Mattoussi, H. (2007) Two-photon excitation of quantumdot- based fluorescence resonance energy transfer and its applications. Advanced Materials, 19, 1921-1926.
47. Larson, D.R., Zipfel, W.R., Williams, R.M., Clark, S.W., Bruchez, M.P., Wise, F.W., and Webb, W.W. (2003)Watersoluble quantum dots for multiphoton fluorescence imaging in vivo. Science, 300, 1434-1436.
48. Bruchez, M.P. (2005) Turning all the lights on: quantum dots in cellular assays. Current Opinion in Chemical Biology, 9, 533-537.
49. Lee, J.A., Mardyani, S., Hung, A., Rhee, A., Klostranec, J., Mu, Y., Li, D., and Chan, W.C.W. (2007) Toward the accurate read-out of quantum dot barcodes: design of deconvolution algorithms and assessment of fluorescence signals in buffer. Advanced Materials, 19, 3113-3118.
50. Medintz, I.L., Farrell, D., Susumu, K., Trammell, S.A., Deschamps, J.R., Brunel, F.M., Dawson, P.E., and Mattoussi, H. (2009) Multiplex charge-transfer interactions between quantum dots and peptide-bridged ruthenium complexes. Analytical Chemistry, 81, 4831-4839.
51. Dubertret, B., Skourides, P., Norris, D.J., Noireaux, V., Brivanlou, A.H., and Libchaber, A. (2002) In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science, 298, 1759- 1762.
52. Sukhanova, A., Devy, J., Venteo, L., Kaplan, H., Artemyev, M., Oleinikov, V., Klinov, D., Pluot, M., Cohen, J.H.M., and Nabiev, I. (2004) Biocompatible fluorescent nanocrystals for immunolabeling of membrane proteins and cells. Analytical Biochemistry, 324, 60-67.
53. Wu, X., Liu, H., Liu, J., Haley, K.N., Treadway, J.A., Larson, J.P., Ge, N., Peale, F., and Bruchez, M.P. (2003) Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nature Biotechnology, 21, 41-46.
54. Lee, S.F. and Osborne, M.A. (2009) Brightening, blinking, bluing and bleaching in the life of a quantum dot: friend or foe? ChemPhysChem, 10, 2174-2191.
55. Murphy, C.J. (2002) Optical sensing with quantum dots. Analytical Chemistry, 74, 520A-526A.
56. Murphy, C.J. and Coffer, J.L. (2002) Quantum dots: a primer. Applied Spectroscopy, 56, 16A-27A.
57. Talapin, D.V., Mekis, I., Gotzinger, S., Kornowski, A., Benson, O., and Weller, H. (2004) CdSe/CdS/ZnS and CdSe/ZnSe/ ZnS core-shell-shell nanocrystals. The Journal of Physical Chemistry. B, 108, 18826-18831.
58. Allen, P.M., Liu, W., Chauhan, V.P., Lee, J., Ting, A.Y., Fukumura, D., Jain, R. K., and Bawendi, M.G. (2010) InAs (ZnCdS) quantum dots optimized for biological imaging in the near-infrared. Journal of the American Chemical Society, 132, 470-471.
59. Chen, Y., Vela, J., Htoon, H., Casson, J.L., Werder, D.J., Bussian, D.A., Klimov, V.I., and Hollingsworth, J.A. (2008) "Giant" multishell CdSe nanocrystal quantum dots with suppressed blinking. Journal of the American Chemical Society, 130, 5026-5027.
60. Su, Y., He, Y., Lu, H., Sai, L., Li, Q., Li, W., Wang, L., Shen, P., Huang, Q., and Fan, C. (2009) The cytotoxicity of cadmium based, aqueous phase - synthesized, quantum dots and its modulation by surface coating. Biomaterials, 30, 19-25.
61. Derfus, A.M., Chan,W.C.W., and Bhatia, S.N. (2004) Probing the cytotoxicity of semiconductor quantum dots. Nano Letters, 4, 11-18.
62. Kim, S., Fisher, B., Eisler, H.J., and Bawendi, M. (2003) Type-II quantum dots: CdTe/CdSe(core/shell) and CdSe/ ZnTe(core/shell) heterostructures. Journal of the American Chemical Society, 125, 11466-11467.
63. Smith, A.M., Mohs, A.M., and Nie, S. (2009) Tuning the optical and electronic properties of colloidal nanocrystals by lattice strain. Nature Nanotechnology, 4, 56-63.
64. Steigerwald, M.L. and Brus, L.E. (1989) Synthesis, stabilization, and electronicstructure of quantum semiconductor nanoclusters. Annual Review of Materials Science, 19, 471-495.
65. McGuire, J.A., Joo, J., Pietryga, J.M., Schaller, R.D., and Klimov, V.I. (2008) New aspects of carrier multiplication in semiconductor nanocrystals. Accounts of Chemical Research, 41, 1810-1819.
66. Brus, L.E. (1984) Electron-electron and electron-hole interactions in small semiconductor crystallites: the size dependence of the lowest excited electronic state. Journal of Chemical Physics, 80, 4403-4409.
67. Brus, L.E. (1984) On the development of bulk optical properties in small semiconductor crystallites. Journal of Luminescence, 31-32, 381-384.
68. Klimov, V.I. (2007) Spectral and dynamical properties of multiexcitons in semiconductor nanocrystals. Annual Review of Physical Chemistry, 58, 635-673.
69. Nozik, A.J. (2001) Spectroscopy and hot electron relaxation dynamics in semiconductor quantum wells and quantum dots. Annual Review of Physical Chemistry, 52, 193-231.
70. Klimov, V.I., McBranch, D.W., Leatherdale, C.A., and Bawendi, M.G. (1999) Electron and hole relaxation pathways in semiconductor quantum dots. Physical Review. B, Condensed Matter and Materials Physics, 60, 13740-13749.
71. Guyot-Sionnest, P., Shim, M., Matranga, C., and Hines, M. (1999) Intraband relaxation in CdSe quantum dots. Physical Review. B, Condensed Matter and Materials Physics, 60, R2181-R2184.
72. Burda, C., Link, S., Mohamed, M., and El-Sayed, M. (2001) The relaxation pathways of CdSe nanoparticles monitored with femtosecond timeresolution from the visible to the IR: assignment of the transient features by carrier quenching. The Journal of Physical Chemistry. B, 105, 12286-12292.
73. Guyot-Sionnest, P., Wehrenberg, B., and Yu, D. (2005) Intraband relaxation in CdSe nanocrystals and the strong influence of the surface ligands. Journal of Chemical Physics, 123, 074709.
74. Klimov, V.I. (2000) Optical nonlinearities and ultrafast carrier dynamics in semiconductor nanocrystals. The Journal of Physical Chemistry. B, 104, 6112-6123.
75. Klimov, V.I., Mikhailovsky, A.A., McBranch, D.W., Leatherdale, C.A., and Bawendi, M.G. (2000) Mechanisms for intraband energy relaxation in semiconductor quantum dots: the role of electron-hole interactions. Physical Review. B, Condensed Matter and Materials Physics, 61, R13349-R13352.
76. Efros, A.L., Kharchenko, V.A., and Rosen, M. (1995) Breaking the phonon bottleneck in nanometer quantum dots: role of auger-like processes. Solid State Communications, 93, 281-284.
77. Pandey, A. and Guyot-Sionnest, P. (2008) Slow electron cooling in colloidal quantum dots. Science, 322, 929-932.
78. Califano, M. (2009) Electron relaxation following UV excitation in CdSe nanocrystals: sub-picosecond-fast population of the 1P states across a gap wider than 10 phonon energies. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces, 113, 19859-19862.
79. Smith, A.M. and Nie, S. (2010) Semiconductor nanocrystals: structure, properties, and band gap engineering. Accounts of Chemical Research, 43, 190-200.
80. Empedocles, S.A., Neuhauser, R., Shimizu, K., and Bawendi, M.G. (1999) Photoluminescence from single semiconductor nanostructures. Advanced Materials, 11, 1243-1256.
81. Empedocles, S.A., Norris, D.J., and Bawendi, M.G. (1996) Photoluminescence spectroscopy of single CdSe nanocrystallite quantum dots. Physical Review. B, Condensed Matter and Materials Physics, 77, 3873-3876.
82. Kloepfer, J.A., Bradforth, S.E., and Nadeau, J.L. (2005) Photophysical properties of biologically compatible CdSe quantum dot structures. The Journal of Physical Chemistry. B, 109, 9996-10003.
83. Wu, F., Zhang, J.Z., Kho, R., and Mehra, R.K. (2000) Radiative and nonradiative lifetimes of band edge states and deep trap states of CdS nanoparticles determined by time-correlated single photon counting. Chemical Physics Letters, 330, 237-242.
84. Nirmal, M., Dabbousi, B.O., Bawendi, M.G.,Macklin, J.J., Trautman, J.K.,Harris, T.D., and Brus, L.E. (1996) Fluorescence intermittency in single cadmium selenide nanocrystals. Nature, 383, 802-804.
85. Efros, A.L. and Rosen, M. (1997) Random telegraph signal in the photoluminescence intensity of a single quantum dot. Physical Review Letters, 78, 1110-1113.
86. Kuno, M., Fromm, D.P., Hamann, H.F., Gallagher, A., and Nesbitt, D.J. (2001) "On"/"off" fluorescence intermittency of single semiconductor quantum dots. Journal of Chemical Physics, 115, 1028-1040.
87. Gomez, D.E., Embden, J.V., Jasieniak, J., Smith, T.A., and Mulvaney, P. (2006) Blinking and surface chemistry of single CdSe nanocrystals. Small, 2, 204-208.
88. Shimizu, K.T., Neuhauser, R.G., Leatherdale, C.A., Empedocles, S.A., and Bawendi, M.G. (2001) Blinking statistics in single semiconductor nanocrystal quantum dots. Physical Review. B, Condensed Matter and Materials Physics, 63, 205316.
89. Yao, J., Larson, D.R., Vishwasrao, H.D., Zipfel, W.R., and Webb, W.W. (2005) Blinking and nonradiant dark fraction of water-soluble quantum dots in aqueous solution. Proceedings of the National Academy of Sciences of the United States of America, 102, 14284-14289.
90. Pons, T., Medintz, I.L., Farrell, D., Wang, X., Grimes, A.F., English, D.S., Berti, L., and Mattoussi, H. (2011) Single-molecule colocalization studies shed light on the idea of fully emitting versus dark single quantum dots. Small, 7, 2101-2108.
91. Medintz, I.L., Clapp, A.R., Mattoussi, H., Goldman, E.R., Fisher, B., and Mauro, J.M. (2003) Self-assembled nanoscale biosensors based on quantum dot FRETdonors. Nature Materials, 2, 630-638.
92. Mattoussi, H., Mauro, J.M., Goldman, E.R., Anderson, G.P., Sundar, V.C., Mikulec, F.V., and Bawendi, M.G. (2000) Self-assembly of CdSe-ZnS quantum dot bioconjugates using an engineered recombinant protein. Journal of the American Chemical Society, 122, 12142-12150.
93. Kim, J.,Wong, C.Y., and Scholes, G.D. (2009) Exciton fine structure and spin relaxation in semiconductor colloidal quantum dots. Accounts of Chemical Research, 42, 1037-1046.
94. Norris, D.J. and Bawendi, M.G. (1995) Structure in the lowest absorption feature of CdSe quantum dots. Journal of Chemical Physics, 103, 5260-5268.
95. Ekimov, A.I., Hache, F., Schanne-Klein, M. C., Ricard, D., Flytzanis, C., Kudryavtsev, I. A., Yazeva, T.V., Rodina, A.V., and Efros, A. L. (1993) Absorption and intensitydependent photoluminescence measurements on CdSe quantum dots: assignment of the 1st electronic transitions. Journal of the Optical Society of America. B, Optical Physics, 10, 100-107.
96. Norris, D.J., Efros, A.L., Rosen, M., and Bawendi, M.G. (1996) Size dependence of exciton fine structure in CdSe quantum dots. Physical Review. B, Condensed Matter and Materials Physics, 53, 16347-16354.
97. Nirmal, M., Norris, D.J., Kuno, M., Bawendi, M.G., Efros, A.L., and Rosen, M. (1995) Observation of the dark exciton in CdSe quantum dots. Physical Review Letters, 75, 3728-3731.
98. Efros, A.L., Rosen, M., Kuno, M., Nirmal, M., Norris, D.J., and Bawendi, M. (1996) Band-edge exciton in quantum dots of semiconductors with a degenerate valence band: dark and bright exciton states. Physical Review. B, Condensed Matter and Materials Physics, 54, 4843-4856.
99. Bagga, A., Chattopadhyay, D.K., and Ghosh, S. (2006) Origin of Stokes shift in InAs and CdSe quantum dots: exchange splitting of excitonic states. Physical Review. B, Condensed Matter and Materials Physics, 74, 035341.
100. Yu, Z., Li, J., O'Connor, D.B.,Wang, L.W., and Barbara, P.F. (2003) Large resonant Stokes shift in CdS nanocrystals. The Journal of Physical Chemistry. B, 107, 5670-5674.
101. Crooker, S.A., Barrick, T., Hollingsworth, J.A., and Klimov, V.I. (2003) Multiple temperature regimes of radiative decay in CdSe nanocrystal quantum dots: intrinsic limits to the dark-exciton lifetime. Applied Physics Letters, 82, 2793-2795.
102. Empedocles, S.A., Neuhauser, R., and Bawendi, M.G. (1999) Three-dimensional orientation measurements of symmetric single chromophores using polarization microscopy. Nature, 399, 126-130.
103. Hu, J., Li, L.S., Yang,W., Manna, L., Wang, L.W., and Alivisatos, A.P. (2001) Linearly polarized emission from colloidal semiconductor quantum rods. Science, 292, 2060-2063.
104. Krauss, T.D. and Brus, L.E. (1999) Charge, polarizability, and photoionization of single semiconductor nanocrystals. Physical Review Letters, 83, 4840-4843.
105. Ye, M. and Searson, P.C. (2011) Blinking in quantum dots: the origin of the grey state and power law statistics. Physical Review. B, Condensed Matter and Materials Physics, 84, 125317.
106. Hohng, S. and Ha, T. (2004) Nearcomplete suppression of quantum dot blinking in ambient conditions. Journal of the American Chemical Society, 126, 1324-1325.
107. Wang, X., Ren, X., Kahen, K., Hahn, M.A., Rajeswaran, M., Maccagnano- Zacher, S., Silcox, J., Gragg, G.E., Efros, A.L., and Krauss, T.D. (2009) Nonblinking semiconductor nanocrystals. Nature, 459, 686-689.
108. Medintz, I.L., Pons, T., Trammell, S.A., Grimes, A.F., English, D.S., Blanco- Canosa, J.B., Dawson, P.E., and Mattoussi, H. (2008) Interactions between redox complexes and semiconductor quantum dots coupled via a peptide bridge. Journal of the American Chemical Society, 130, 16745-16756.
109. Shim, M.,Wang, C., and Guyot- Sionnest, P. (2001) Charge-tunable optical properties in colloidal semiconductor nanocrystals. The Journal of Physical Chemistry. B, 105, 2369-2373.
110. Warburton, R.J. (2002) Self-assembled semiconductor quantum dots. Contemporary Physics, 43, 351-364.
111. Peng, Z.A. and Peng, X.G. (2001) Formation of high-quality CdTe, CdSe, and CdS nanocrystals using CdO as precursor. Journal of the American Chemical Society, 123, 183-184.
112. Yu, K., Singh, S., Patrito, N., and Chu, V. (2004) Effect of reaction media on the growth and photoluminescence of colloidal CdSe nanocrystals. Langmuir, 20, 11161-11168.
113. Yu, K., Zaman, B., Singh, S., Wang, D., and Ripmeester, J.A. (2005) The effect of dispersion media on photoluminescence of colloidal CdSe nanocrystals synthesized from TOP. Chemistry of Materials, 17, 2552-2561.
114. Qu, L., Peng, Z.A., and Peng, X. (2001) Alternative routes toward high quality CdSe nanocrystals. Nano Letters, 1, 333-337.
115. Qu, L. and Peng, X. (2002) Control of photoluminescence properties of CdSe nanocrystals in growth. Journal of the American Chemical Society, 124, 2049-2055.
116. Li, J.J.,Wang, Y.A., Gu,W., Keay, J.C., Mishima, T.D., Johnson, M.B., and Peng, X. (2003) Large-scale synthesis of nearly monodisperse CdSe/CdS core/shell nanocrystals using air-stable reagents via successive ion layer adsorption and reaction. Journal of the American Chemical Society, 125, 12567-12575.
117. Yin, Y. and Alivisatos, A.P. (2005) Colloidal nanocrystal synthesis and the organic-inorganic interface. Nature, 437, 664-670.
118. Peng, Z.A. and Peng, X.G. (2002) Nearly monodisperse and shape-controlled CdSe nanocrystals via alternative routes: nucleation and growth. Journal of the American Chemical Society, 124, 3343-3353.
119. Rogach, A.L., Franzi, T., Klar, T.A., Feldmann, J., Gaponik, N., Lesnyak, V.,Shavel, A., Eychmuller, A., Rakovich, Y.P., and Donegan, J.F. (2007) Aqueous synthesis of thiol-capped CdTe nanocrystals: state-of-the-art. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces, 111, 14628-14637.
120. Zhang, Y. and Clapp, A. (2011) Overview of stabilizing ligands for biocompatible quantum dot nanocrystals. Sensors, 11, 11036-11055.
121. Algar,W.R., Susmu, K., Delehanty, J.B., and Medintz, I.L. (2011) Semiconductor quantum dots in bioanalysis: crossing the valley of death. Analytical Chemistry, 83, 8826-8837.
122. Resch-Genger, U., Grabolle, M., Cavaliere- Jaricot, S., Nitschke, R., and Nann, T. (2008) Quantum dots versus organic dyes as fluorescent labels. Nature Methods, 5, 763-775.
123. Aldana, J., Lavelle, N., Wang, Y., and Peng, X. (2005) Size-dependent dissociation pH of thiolate ligands from cadmium chalcogenide nanocrystals. Journal of the American Chemical Society, 127, 2496-2504.
124. Algar,W.R. and Krull, U.J. (2007) Luminescence and stability of aqueous thioalkyl acid capped CdSe/ZnS quantum dots correlated to ligand ionization. ChemPhysChem, 8, 561-568.
125. Breus, V.V., Heyes, C.D., Tron, K., and Nienhaus, G.U. (2009) Zwitterionic biocompatible quantum dots for wide pH stability and weak nonspecific binding to cells. ACS Nano, 3, 2573-2580.
126. Liu, W.H., Choi, H.S., Zimmer, J.P., Tanaka, E., Frangioni, J.V., and Bawendi, M. (2007) Compact cysteinecoated CdSe(ZnCdS) quantum dots for in vivo applications. Journal of the American Chemical Society, 129, 14530-14531.
127. Susumu, K., Oh, E., Delehanty, J.B., Blanco-Canosa, J.B., Johnson, B.J., Jain, V., Hervey, W.J., Algar, W.R., Boeneman, K., Dawson, P.E., and Medintz, I.L. (2011) Multifunctional compact zwitterionic ligands for preparing robust biocompatible semiconductor quantum dots and gold nanoparticles. Journal of the American Chemical Society, 133, 9480-9496.
128. Dif, A., Boulmedais, F., Pinot, M., Roullier, V., Baudy-Floc'h, M., Coquelle, F.M., Clarke, S., Neveu, P., Vignaux, F., Borgne, R.L., Dahan, M., Gueroui, Z., and Marchi-Artzner, V. (2009) Small and stable peptidic PEGylated quantum dots to target polyhistidine-tagged proteins with controlled stoichiometry. Journal of the American Chemical Society, 131, 14738-14746.
129. Uyeda, H.T., Medintz, I.L., Jaiswal, J.K., Simon, S.M., and Mattoussi, H. (2005) Synthesis of compact multidentate ligands to prepare stable hydrophilic quantum dot fluorophores. Journal of the American Chemical Society, 127, 3870-3878.
130. Susumu, K., Uyeda, H.T.,Medintz, I.L., Pons, T., Delehanty, J.B., andMattoussi, H. (2007) Enhancing the stability and biological functionalities of quantum dots via compact multifunctional ligands. Journal of the American Chemical Society, 129, 13987-13996.
131. Mei, B.C., Susumu, K., Medintz, I.L., Delehanty, J.B., Mountziaris, T.J., and Mattoussi, H. (2008) Modular poly (ethylene glycol) ligands for biocompatible semiconductor and gold nanocrystals with extended pH and ionic stability. Journal of Materials Chemistry, 18, 4949-4958.
132. Liu, W., Howarth, M., Greytak, A.B., Zheng, Y., Nocera, D.G., Ting, A.Y., and Bawendi, M.G. (2008) Compact biocompatible quantum dots functionalized for cellular imaging. Journal of the American Chemical Society, 130, 1274-1284.
133. Dubois, F., Mahler, B., Dubertret, B., Doris, E., and Mioskowski, C. (2007) A versatile strategy for quantum dot ligand exchange. Journal of the American Chemical Society, 129, 482-483.
134. Wang, J., Xu, J., Goodman, M.D., Chen, Y., Cai, M., Shinar, J., and Lin, Z.Q. (2008) A simple biphasic route to water soluble dithiocarbamate functionalized quantum dots. Journal of Materials Chemistry, 18, 3270-3274.
135. Zhang, Y., Schnoes, A.M., and Clapp, A.R. (2010) Dithiocarbamates as capping ligands for water-soluble quantum dots.ACS Applied Materials & Interfaces, 2, 3384-3395.
136. Jiang, W., Mardyani, S., Fischer, H., and Chan, W.C.W. (2006) Design and characterization of lysine cross-linked mercapto-acid biocompatible quantum dots. Chemistry of Materials, 18, 872-878.
137. Pong, B.K., Trout, B.L., and Lee, J.Y. (2008) Modified ligand-exchange for efficient solubilization of CdSe/ZnS quantum dots in water: a procedure guided by computational studies. Langmuir, 24, 5270-5276.
138. Aldana, J.,Wang, Y.A., and Peng, X. (2001) Photochemical instability of CdSe nanocrystals coated by hydrophilic thiols. Journal of the American Chemical Society, 123, 8844-8850.
139. Dreaden, E.C., Alkilany, A.M., Huang, X., Murphy, C.J., and El-Sayed, M.A. (2012) The golden age: gold nanoparticles for biomedicine. Chemical Society Reviews, 41, 2740-2779.
140. Kim, S. and Bawendi, M.G. (2003) Oligomeric ligands for luminescent and stable nanocrystal quantum dots. Journal of the American Chemical Society, 125, 14652-14653.
141. Wang, Q., Xu, Y., Zhao, X., Chang, Y., Liu, Y., Jiang, L., Sharma, J., Seo, D.K., and Yan, H. (2007) A facile one-step in situ functionalization of quantum dots with preserved photoluminescence for bioconjugation. Journal of the American Chemical Society, 129, 6380-6381.
142. Gao, X., Cui, Y., Levenson, R.M., Chung, L.W.K., and Nie, S. (2004) In vivo cancer targeting and imaging with semiconductor quantum dots. Nature Biotechnology, 22, 969-976.
143. Pellegrino, T., Manna, L., Kudera, S., Liedl, T., Koktysh, D., Rogach, A.L., Keller, S., Radler, J., Natile, G. and Parak, W.J. (2004) Hydrophobic nanocrystals coated with an amphiphilic polymer shell: a general route to water soluble nanocrystals. Nano Letters, 4, 703-707.
144. Smith, A.M., Duan, H., Rhyner, M.N., Ruan, G., and Nie, S. (2006) A systematic examination of surface coatings on the optical and chemical properties of semiconductor quantum dots. Physical Chemistry Chemical Physics, 8, 3895-3903.
145. Pons, T., Uyeda, H.T., Medintz, I.L., and Mattoussi, H. (2006) Hydrodynamic dimensions, electrophoretic mobility, and stability of hydrophilic quantum dots. The Journal of Physical Chemistry. B, 110, 20308-20316.
146. Yildiz, I., Deniz, E., McCaughan, B., Cruickshank, S.F., Callan, J.F., and Raymo, F.M. (2010) Hydrophilic CdSe- ZnS core-shell quantum dots with reactive functional groups on their surface. Langmuir, 26, 11503-11511.
147. Liu, W., Greytak, A.B., Lee, J.,Wong, C.R., Park, J., Marshall, L.F., Jiang,W., Curtin, P.N., Ting, A.Y., Nocera, D.G., Fukumura, D., Jain, R.K., and Bawendi, M.G. (2010) Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazolebased random copolymer ligand. Journal of the American Chemical Society, 132, 472-483.
148. Wu, P., He, Y., Wang, H.F., and Yan, X.P. (2010) Conjugation of glucose oxidase onto Mn-doped ZnS quantum dots for phosphorescent sensing of glucose in biological fluids. Analytical Chemistry, 82, 1427-1433.
149. Ji, X., Zheng, J., Xu, J., Rastogi, V.K., Chen, T.C., DeFrank, J.J., and Leblanc, R.M. (2005) (CdSe)ZnS quantum dots and organophosphorus hydrolase bioconjugate as biosensors for detection of paraoxon. The Journal of Physical Chemistry. B, 109, 3793-3799.
150. Goldman, E.R., Medintz, I.L., Whitley, J.L., Hayhurst, A., Clapp, A.R., Uyeda, H.T., Deschamps, J.R., Lassman, M.E., and Mattoussi, H. (2005) A hybrid quantum dot-antibody fragment fluorescence resonance energy transferbased TNTsensor. Journal of the American Chemical Society, 127, 6744-6751.
151. Wei, Q., Lee, M., Yu, X., Lee, E.K., Seong, G.H., Choo, J., and Cho, Y.W. (2006) Development of an open sandwich fluoroimmunoassay based on fluorescence resonance energy transfer. Analytical Biochemistry, 358, 31-37.
152. Pathak, S., Davidson, M.C., and Silva, G.A. (2007) Characterization of the functional binding properties of antibody conjugated quantum dots. Nano Letters, 7, 1839-1845.
153. Tang, B., Lao, L., Xu, K., Zhuo, L., Ge, J., Li, Q., and Yu, L. (2008) A new nanobiosensor for glucose with high sensitivity and selectivity in serum based on fluorescence resonance energy transfer (FRET) between CdTe quantum dots and Au nanoparticles. Chemistry, 14, 3637-3644.
154. Medintz, I.L., Clapp, A.R., Brunel, F.M., Tiefenbrunn, T., Uyeda, H.T., Chang, E.L., Deschamps, J.R., Dawson, P.E., and Mattoussi, H. (2006) Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot- peptide conjugates. Nature Materials, 5, 581-589.
155. Chang, E., Miller, J.S., Sun, J., Yu, W.W., Colvin, V.L., Drezek, R., and West, J.L. (2005) Protease-activated quantum dot probes. Biochemical and Biophysical Research Communications, 334, 1317-1321.
156. Shi, L., Paoli, V.D., Rosenzweig, N., and Rosenzweig, Z. (2006) Synthesis and application of quantum dots FRET-based protease sensors. Journal of the American Chemical Society, 128, 10378-10379.
157. Delehanty, J.B., Medintz, I.L., Pons, T., Brunel, F.M., Dawson, P.E., and Mattoussi, H. (2006) Self-assembled quantum dot-peptide bioconjugates for selective intracellular delivery. Bioconjugate Chemistry, 17, 920-927.
158. Kim, J.H., Morikis, D., and Ozkan, M. (2004) Adaptation of inorganic quantum dots for stable molecular beacons. Sensors and Actuators B, 102, 315-319.
159. Zhang, C.Y., Yeh, H.C., Kuroki, M.T., and Wang, T.H. (2005) Single-quantum-dotbased DNA nanosensor. Nature Materials, 4, 826-831.
160. Levy, M., Cater, S.F., and Ellington, A.D. (2005) Quantum-dot aptamer beacons for the detection of proteins. Chembiochem, 6, 2163-2166.
161. Zhou, D., Piper, J.D., Abell, C., Klenerman, D., Kang, D.J., and Ying, L. (2005) Fluorescence resonance energy transfer between a quantum dot donor and a dye acceptor attached to DNA. Chemical Communications, 4807-4809.
162. Higuchi, Y., Oka, M., Kawakami, S., and Hashida, M. (2008) Mannosylated semiconductor quantum dots for the labeling of macrophages. Journal of Controlled Release, 125, 131-136.
163. Babu, P., Sinha, S., and Surolia, A. (2007) Sugar-quantum dot conjugates for a selective and sensitive detection of lectins. Bioconjugate Chemistry, 18, 146-151.
164. Kikkeri, R., Lepenies, B., Adibekian, A., Laurino, P., and Seeberger, P.H. (2009) In vitro imaging and in vivo liver targeting with carbohydrate capped quantum dots. Journal of the American Chemical Society, 131, 2110-2112.
165. Algar,W.R., Prasuhn, D.E., Stewart, M.H., Jennings, T.L., Blanco-Canosa, J.B., Dawson, P.E., and Medintz, I.L. (2011) The controlled display of biomolecules on nanoparticles: a challenge suited to bioorthogonal chemistry. Bioconjugate Chemistry, 22, 825-858.
166. Fernandez-Arguelles, M.T., Costa- Fernandez, J.M., Pereiro, R., and Sanz- Medel, A. (2008) Simple bio-conjugation of polymer-coated quantum dots with antibodies for fluorescence-based immunoassays. The Analyst, 133, 444-447.
167. Nikiforov, T.T. and Beechem, J.M. (2006) Development of homogeneous binding assays based on fluorescence resonance energy transfer between quantum dots and Alexa Fluor fluorophores. Analytical Biochemistry, 357, 68-76.
168. Barat, B., Sirk, S.J., McCabe, K.E., Li, J., Lepin, E.J., Remenyi, R., Koh, A.L., Olafsen, T., Gambhir, S.S.,Weiss, S., and Wu, A.M. (2009) Cys-diabody quantum dot conjugates (ImmunoQdots) for cancer marker detection. Bioconjugate Chemistry, 20, 1474-1481.
169. Bernardin, A., Cazet, A., Guyon, L., Delannoy, P., Vinet, F., Bonnaffe, D., and Texier, I. (2010) Copper-free click chemistry for highly luminescent quantum dot conjugates: application to in vivo metabolic imaging. Bioconjugate Chemistry, 21, 583-588.
170. Han, H.S., Devaraj, N.K., Lee, J., Hilderbrand, S.A.,Weissleder, R., and Bawendi, M.G. (2010) Development of a bioorthogonal and highly efficient conjugation method for quantum dots using tetrazine-norbornene cycloaddition.Journal of the American Chemical Society, 132, 7838-7839.
171. Prasuhn, D.E., Blanco-Canosa, J.B., Vora, G.J., Delehanty, J.B., Susumu, K., Mei, B.C., Dawson, P.E., and Medintz, I.L. (2010) Combining chemoselective ligation with polyhistidine-driven self-assembly for the modular display of biomolecules on quantum dots. ACS Nano, 4, 267-278.
172. Blanco-Canosa, J.B., Medintz, I.L., Farrell, D., Mattoussi, H., and Dawson, P.E. (2010) Rapid covalent ligation of fluorescent peptides to water solubilized quantum dots. Journal of the American Chemical Society, 132, 10027-10033.
173. Xia, Z., Xiang, Y., So, M.K., Koh, A.L., Sinclair, R., and Rao, J. (2008) Multiplex detection of protease activity with quantum dot nanosensors prepared by intein-mediated specific bioconjugation. Analytical Chemistry, 80, 8649-8655.
174. Chen, I., Choi, Y.A., and Ting, A.Y. (2007) Phage display evolution of a peptide substrate for yeast biotin ligase and application to two-color quantum dot labeling of cell surface proteins. Journal of the American Chemical Society, 129, 6619-6625.
175. Zhang, Y., So, M.K., Loening, A.M., Yao, H., Gambhir, S.S., and Rao, J.H. (2006) HaloTag protein-mediated site-specific conjugation of bioluminescent proteins to quantum dots. Angewandte Chemie, International Edition, 45, 4936-4940.
176. Irrgang, J., Ksienczyk, J., Lapiene, V., and Niemeyer, C.M. (2009) Analysis of noncovalent bioconjugation of colloidal nanoparticles by means of atomic force microscopy and data clustering. Chemphyschem, 10, 1483-1491.
177. Medintz, I.L., Berti, L., Pons, T., Grimes, A.F., English, D.S., Alessandrini, A., Facci, P., and Mattoussi, H. (2007) A reactive peptidic linker for selfassembling hybrid quantum dot-DNA bioconjugates. Nano Letters, 7, 1741-1748.
178. Berti, L., D'Agostino, P.S., Boeneman, K., and Medintz, I.L. (2009) Improved peptidyl linkers for self-assembly of semiconductor quantum dot bioconjugates. Nano Research, 2, 121-129.
179. Sapsford, K.E., Pons, T., Medintz, I.L., Higashiya, S., Brunel, F.M., Dawson, P.E.,and Mattoussi, H. (2007) Kinetics of metal-affinity driven self-assembly between proteins or peptides and CdSe- ZnS quantum dots. The Journal of Physical Chemistry C, 111, 11528-11538.
180. Prasuhn, D.E., Deschamps, J.R., Susmu, K., Stewart, M.H., Boeneman, K., Blanco-Canosa, J.B., Dawson, P.E., and Medintz, I.L. (2010) Polyvalent display and packing of peptides and proteins on semiconductor quantum dots: predicted versus experimental results. Small, 6, 555-564.
181. Pons, T., Medintz, I.L., Wang, X., English, D.S., and Mattoussi, H. (2006) Solutionphase single quantum dot fluorescence resonance energy transfer. Journal of the American Chemical Society, 128, 15324-15331.
182. Sandros, M.G., Gao, D., Gokdemir, C., and Benson, D.E. (2005) General, highaffinity approach for the synthesis of fluorophore appended protein nanoparticle assemblies. Chemical Communications, 2832-2834.
183. Patolsky, F., Gill, R., Weizmann, Y., Mokari, T., Banin, U., and Willner, I. (2003) Lighting-up the dynamics of telomerization and DNA replication by CdSe-ZnS quantum dots. Journal of the American Chemical Society, 125, 13918-13919.
184. Gill, R., Willner, I., Shweky, I., and Banin, U. (2005) Fluorescence resonance energy transfer in CdSe/ZnS-DNA conjugates: probing hybridization and DNA cleavage. The Journal of Physical Chemistry B, 109, 23715-23719.
185. Kim, M.J., Park, H.Y., Kim, J., Ryu, J., Hong, S., Han, S.J., and Song, R. (2008) Western blot analysis using metalnitrilotriacetate conjugated CdSe/ZnS quantum dots. Analytical Biochemistry, 379, 124-126.
186. Gupta, M., Caniard, A., Touceda-Varela, A., Campopiano, D.J., andMareque-Rivas, J.C. (2008) Nitrilotriacetic acid-derivatized quantum dots for simple purification and site-selective fluorescent labeling of active proteins in a single step. Bioconjugate Chemistry, 19, 1964-1967.
187. Bae, P.K., Kim, K.N., Lee, S.J., Chang, H.J., Lee, C.K., and Park, J.K. (2009) The modification of quantum dot probes used for the targeted imaging of his-tagged fusion proteins. Biomaterials, 30, 836-842.
188. Susumu, K., Medintz, I.L., Delehanty, J.B., Boeneman, K., and Mattoussi, H. (2010) Modification of poly(ethylene glycol)-capped quantum dots with nickel nitrilotriacetic acid and self-assembly with histidine-tagged proteins. The Journal of Physical Chemistry C, 114, 13526-13531.
189. Yao, H., Zhang, Y., Xiao, F., Xia, Z., and Rao, J. (2007) Quantum dot/ bioluminescence resonance energy transfer based highly sensitive detection of proteases. Angewandte Chemie, International Edition, 46, 4346-4349.
190. Boeneman, K., Delehanty, J.B., Susumu, K., Stewart, M.H., and Medintz, I.L. (2010) Intracellular bioconjugation of targeted proteins with semiconductor quantum dots. Journal of the American Chemical Society, 132, 5975-5977.
191. Ho, Y.P., Chen, H.H., Leong, K.W., and Wang, T.H. (2006) Evaluating the intracellular stability and unpacking of DNA nanocomplexes by quantum dots- FRET. Journal of Controlled Release, 116, 83-89.
192. Lee, H., Kim, I.K., and Park, T.G. (2010) Intracellular trafficking and unpacking of siRNA/quantum dot-PEI complexes modified with and without cell penetrating peptide: confocal and flow cytometric FRETanalysis. Bioconjugate Chemistry, 21, 289-295.
193. Chen, H.H., Ho, Y.P., Jiang, X., Mao, H.Q., Wang, T.H., and Leong, K.W. (2008) Quantitative comparison of intracellular unpacking kinetics of polyplexes by a model constructed from quantum dot- FRET. Molecular Therapy: The Journal of the American Society of Gene Therapy, 16, 324-332.
194. Goldman, E.R., Balighian, E.D., Mattoussi, H., Kuno, M.K., Mauro, J.M., Tran, P.T., and Anderson, G.P. (2002) Avidin: a natural bridge for quantum dot-antibody conjugates. Journal of the American Chemical Society, 124, 6378-6382.
195. Vu, T.Q., Maddipati, R., Blute, T.A., Nehilla, B.J., Nusblat, L., and Desai, T.A. (2005) Peptide-conjugated quantum dots activate neuronal receptors and initiate downstream signaling of neurite growth. Nano Letters, 5, 603-607.
196. Lidke, D.S., Nagy, P., Heintzmann, R., Arndt-Jovin, D.J., Post, J.N., Grecco, H.E., Jares-Erijman, E.A., and Jovin, T.M. (2004) Quantum dot ligands provide new insights into erbB/HER receptormediated signal transduction. Nature Biotechnology, 22, 198-203.
197. Boeneman, K., Deschamps, J.R., Buckhout-White, S., Prasuhn, D.E., Blanco-Canosa, J.B., Dawson, P.E., Stewart, M.H., Susumu, K., Goldman, E.R., Ancona, M., and Medintz, I.L. (2010) Quantum dot DNA bioconjugates: attachment chemistry strongly influences the resulting composite architecture. ACS Nano, 4, 7253-7266.
198. Susumu, K., Uyeda, H.T., Medintz, I.L., and Mattoussi, H. (2007) Design of biotinfunctionalized luminescent quantum dots. Journal of Biomedicine & Biotechnology, 2007, 90651.
199. Lingerfelt, B.M., Mattoussi, H., Goldman, E.R., Mauro, J.M., and Anderson, G.P. (2003) Preparation of quantum dot-biotin conjugates and their use in immunochromatography assays. Analytical Chemistry, 75, 4043-4049.
200. Clapp, A.R., Medintz, I.L., Uyeda, H.T., Fisher, B.R., Goldman, E.R., Bawendi, M.G., and Mattoussi, H. (2005) Quantum dot-based multiplexed fluorescence resonance energy transfer. Journal of the American Chemical Society, 127, 18212-18221.
201. Allan, G. and Delerue, C. (2007) Energy transfer between semiconductor nanocrystals: validity of Forster's theory. Physical Review. B, Condensed Matter, 75, 195311.
202. Curutchet, C., Franceschetti, A., Zunger, A., and Scholes, G.D. (2008) Examining Forster energy transfer for semiconductor nanocrystalline quantum dot donors and acceptors. The Journal of Physical Chemistry C, 112, 13336-13341.
203. Clapp, A.R., Medintz, I.L., Mauro, J.M., Fisher, B.R., Bawendi, M.G., and Mattoussi, H. (2004) Fluorescence resonance energy transfer between quantum dot donors and dye-labeled protein acceptors. Journal of the American Chemical Society, 126, 301-310.
204. Pons, T., Medintz, I.L., Sapsford, K.E., Higashiya, S., Grimes, A.F., English, D.S., and Mattoussi, H. (2007) On the quenching of semiconductor quantum dot photoluminescence by proximal gold nanoparticles. Nano Letters, 7, 3157-3164.
205. Medintz, I.L., Sapsford, K.E., Clapp, A.R., Pons, T., Higashiya, S., Welch, J.T., and Mattoussi, H. (2006) Designer variable repeat length polypeptides as scaffolds for surface immobilization of quantum dots. The Journal of Physical Chemistry B, 110, 10683-10690.
206. Dayal, S. and Burda, C. (2007) Surface effects on quantum dot-based energy transfer. Journal of the American Chemical Society, 129, 7977-7981.
207. Chung, I., Shimizu, K.T., and Bawendi, M.G. (2003) Room temperature measurements of the 3D orientation of single CdSe quantum dots using polarization microscopy. Proceedings of the National Academy of Sciences of the United States of America, 100, 405-408.
208. Becker, K., Rogach, A.L., Feldmann, J., Talapin, D.V., and Lupton, J.M. (2009) Energetic disorder limits energy transfer in semiconductor nanocrystal-DNA-dye conjugates. Applied Physics Letters, 95, 143101.
209. Pons, T., Medintz, I.L., Sykora, M., and Mattoussi, H. (2006) Spectrally resolved energy transfer using quantum dot donors: ensemble and single-molecule photoluminescence studies. Physical Review. B, Condensed Matter, 73, 245302.
210. Clapp, A.R., Medintz, I.L., Fisher, B.R., Anderson, G.P., and Mattoussi, H. (2005) Can luminescent quantum dots be efficient energy acceptors with organic dye donors? Journal of the American Chemical Society, 127, 1242-1250.
211. Rogach, A.L., Klar, T.A., Lupton, J.M., Meijerink, A., and Feldmann, J. (2009) Energy transfer with semiconductor nanocrystals. Journal of Materials Chemistry, 19, 1208-1221.
212. Charbonniere, L.J. and Hildebrandt, N. (2008) Lanthanide complexes and quantum dots: a bright wedding for resonance energy transfer. European Journal of Inorganic Chemistry, 2008, 3241-3251.
213. Charbonniere, L.J., Hildebrandt, N., Ziessel, R.F., and Lohmannsroben, H.G. (2006) Lanthanides to quantum dots resonance energy transfer in timeresolved fluoro-immunoassays and luminescence microscopy. Journal of the American Chemical Society, 128, 12800-12809.
214. Geißler, D., Charbonniere, L.J., Ziessel, R.F., Butlin, N.G., Lohmannsroben, H.G., and Hildebrandt, N. (2010) Quantum dot biosensors for ultrasensitive multiplexed diagnostics. Angewandte Chemie, International Edition, 49, 1396-1401.
215. Hildebrandt, N., Charbonniere, L.J., Beck, M., Ziessel, R.F., and Lohmannsroben, H.G. (2005) Quantum dots as efficient energy acceptors in a time-resolved fluoroimmunoassay. Angewandte Chemie, International Edition, 44, 7612-7615.
216. Hildebrandt, N., Charbonniere, L.J., and Lohmannsroben, H.G. (2007) Timeresolved analysis of a highly sensitive Forster resonance energy transfer immunoassay using terbium complexes as donors and quantum dots as acceptors. Journal of Biomedicine & Biotechnology, 2007, 79169.
217. Harma, H., Soukka, T., Shavel, A., Gaonik, N., and Weller, H. (2007) Luminescent energy transfer between cadmium telluride nanoparticle and lanthanide(III) chelate in competitive bioaffinity assays of biotin and estradiol. Analytica Chimica Acta, 604, 177-183.
218. Bednarkiewicz, A., Nyk, M., Samoc, M., and Strek,W. (2010) Up-conversion FRET from Er3+/Yb3+: NaYF4 nanophosphor to CdSe quantum dots. The Journal of Physical Chemistry C, 114, 17535-17541.
219. Cissell, K.A., Campbell, S.A., and Deo, S.K. (2008) Rapid, single-step nucleic acid detection. Analytical and Bioanalytical Chemistry, 391, 2577-2581.
220. So, M.K., Xu, C., Loening, A.M., Gambhir, S.S., and Rao, J. (2006) Selfilluminating quantum dot conjugates for in vivo imaging. Nature Biotechnology, 24, 339-343.
221. Freeman, R., Liu, X., and Willner, I. (2011) Chemiluminescent and chemiluminescence resonance energy transfer (CRET) detection of DNA, metal ions, and aptamer-substrate complexes using hemin/G-quadruplexes and CdSe/ZnS quantum dots. Journal of the American Chemical Society, 133, 11597-11604.
222. Liu, X., Freeman, R., Golub, E., and Willner, I. (2011) Chemiluminescence and chemiluminescence resonance energy transfer (CRET) aptamer sensors using catalytical hemin/G-quadruplexes. ACS Nano, 5, 7648-7655.
223. Zhao, S., Huang, Y., Liu, R., Shi, M., and Liu, Y.M. (2010) A nonenzymatic chemiluminescent reaction enabling chemiluminescence resonance energy transfer to quantum dots. Chemistry, 16, 6142-6145.
224. Zhao, S., Huang, Y., Shi, M., Liu, R., and Liu, Y.M. (2010) Chemiluminescence resonance energy transfer-based detection for microchip electrophoresis. Analytical Chemistry, 82, 2036-2041.
225. Sapsford, K.E., Tyner, K.M., Dair, B.J., Deschamps, J.R., and Medintz, I.L. (2011) Analyzing nanomaterial bioconjugates: a review of current and emerging purification and characterization techniques. Analytical Chemistry, 83, 4453-4488.
226. Freeman, R., Bahshi, L., Finder, T., Gill, R., and Willner, I. (2009) Competitive analysis of saccharides or dopamine by boronic acid-functionalized CdSe-ZnS quantum dots. Chemical Communications, 764-766.
227. Lowe, S.B., Dick, J.A.G., Cohen, B.E., and Stevens, M.M. (2012) Multiplex sensing of protease and kinase enzyme activity via orthogonal coupling of quantum dot peptide conjugates. ACS Nano, 6, 851-857.
228. Freeman, R., Finder, T., Gill, R., and Willner, I. (2010) Probing protein kinase (CK2) and alkaline phosphatase with CdSe/ZnS quantum dots. Nano Letters, 10, 2192-2196.
229. Bakalova, R., Zhelev, Z., Ohba, H., and Baba, Y. (2005) Quantum dot-conjugated hybridization probes for preliminary screening of siRNA sequences. Journal of the American Chemical Society, 127, 11328-11335.
230. Algar,W.R. and Krull, U.J. (2007) Towards multi-colour strategies for the detection of oligonucleotide hybridization using quantum dots as energy donors in fluorescence resonance energy transfer (FRET). Analytica Chimica Acta, 581, 193-201.
231. Algar,W.R. and Krull, U.J. (2006) Adsorption and hybridization of oligonucleotides on mercaptoacetic acidcapped CdSe/ZnS quantum dots and quantum dot-oligonucleotide conjugates. Langmuir, 22, 11346-11352.
232. Zhou, D., Ying, L., Hong, X., Hall, E.A., Abell, C., and Klenerman, D. (2008) A compact functional quantum dot-DNA conjugate: preparation, hybridization, and specific label-free DNA detection. Langmuir, 24, 1659-1664.
233. Wu, C.S., Cupps, J.M., and Fan, X. (2009) Compact quantum dot probes for rapid and sensitive DNA detection using highly efficient fluorescence resonant energy transfer. Nanotechnology, 20, 305502.
234. Jiang, G., Susha, A.S., Lutich, A.A., Stefani, F.D., Feldmann, J., and Rogach, A.L. (2009) Cascaded FRET in conjugated polymer/quantum dot/dye-labeled DNA complexes for DNA hybridization detection. ACS Nano, 3, 4127-4131.
235. Xu, L., Zhu, Y., Ma, W., Kuang, H., Liu, L., Wang, L., and Xu, C. (2011) Sensitive and specific DNA detection based on nicking endonuclease-assisted fluorescence resonance energy transfer amplification. The Journal of Physical Chemistry C, 115, 16315-16321.
236. Nutiu, R. and Li, Y. (2003) Structureswitching signaling aptamers. Journal of the American Chemical Society, 125, 4771-4778.
237. Kim, G.I., Kim, K.W., Oh, M.K., and Sung, Y.M. (2009) The detection of platelet derived growth factor using decoupling of quencher-oligonucleotide from aptamer/ quantum dot bioconjugates. Nanotechnology, 20, 175503.
238. Chen, Z., Li, G., Zhang, L., Jiang, J., Li, Z., Peng, Z., and Deng, L. (2008) A new method for the detection of ATP using a quantum-dot-tagged aptamer. Analytical and Bioanalytical Chemistry, 392, 1185-1188.
239. Bagalkot, V., Zhang, L., Levy- Nissenbaum, E., Jon, S., Kantoff, P.W., Langer, R., and Farokhzad, O.C. (2007) Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bifluorescence resonance energy transfer. Nano Letters, 7, 3065-3070.
240. Chi, C.W., Lao, Y.H., Li, Y.S., and Chen, L.C. (2011) A quantum dot-aptamer beacon using a DNA intercalating dye as the FRETreporter: application to label-free thrombin detection. Biosensors & Bioelectronics, 26, 3346-3352.
241. Wu, C.S., Oo, M.K.K., and Fan, X. (2010) Highly sensitive multiplexed heavy metal detection using quantum-dot-labeled DNAzymes. ACS Nano, 4, 5897-5904.
242. Lopez-Otín, C. and Bond, J.S. (2008) Proteases: multifunctional enzymes in life and disease. The Journal of Biological Chemistry, 283, 30433-30437.
243. Boeneman, K., Mei, B.C., Dennis, A.M., Bao, G., Deschamps, J.R., Mattoussi, H., and Medintz, I.L. (2009) Sensing caspase activity with quantum dot-fluorescent protein assemblies. Journal of the American Chemical Society, 131, 3828- 3829.
244. Suzuki, M., Husimi, Y., Komatsu, Y., Suzuki, K., and Douglas, K.T. (2008) Quantum dot FRET biosensors that respond to pH, to proteolytic or nucleolytic cleavage, to DNA synthesis, or to a multiplexing combination. Journal of the American Chemical Society, 130, 5720-5725.
245. Sapsford, K.E., Farrell, D., Sun, S., Rasooly, A., Mattoussi, H., and Medintz, I.L. (2009) Monitoring of enzymatic proteolysis on a electroluminescent-CCD microchip platform using quantum dot- peptide substrates. Sensors and Actuators B, 139, 13-21.
246. Sapsford, K.E., Granek, J., Deschamps, J.R., Boeneman, K., Blanco-Canosa, J.B., Dawson, P.E., Susumu, K., Stewart, M.H., and Medintz, I.L. (2011) Monitoring botulinum neurotoxin a activity with peptide-functionalized quantum dot resonance energy transfer sensors. ACS Nano, 5, 2687-2699.
247. Algar,W.R., Wegner, D., Huston, A.L., Blanco-Canosa, J.B., Stewart, M.H., Armstrong, A., Dawson, P.E., Hildebrandt, N., and Medintz, I.L. (2012) Quantum dots as simultaneous acceptors and donors in time-gated Forster resonance energy transfer relays: characterization and biosensing. Journal of the American Chemical Society, 134, 1876-1891.
248. Ho, Y.P., Chen, H.H., Leong, K.W., and Wang, T.H. (2009) The convergence of quantum-dot-mediated fluorescence resonance energy transfer and microfluidics for monitoring DNA polyplex self-assembly in real time. Nanotechnology, 20, 095103.
249. Chen, H.H., Ho, Y.P., Jiang, X., Mao, H.Q., Wang, T.H., and Leong, K.W. (2009) Simultaneous non-invasive analysis of DNA condensation and stability by twostep QD-FRET. Nano Today, 4, 125-134.
250. Kim, J.H., Chaudhary, S., and Ozkan, M. (2007) Multicolour hybrid nanoprobes of molecular beacon conjugated quantum dots: FRETand gel electrophoresis assisted target DNA detection. Nanotechnology, 18, 195105.
251. Cady, N.C., Strickland, A.D., and Batt, C.A. (2007) Optimized linkage and quenching strategies for quantum dot molecular beacons. Molecular and Cellular Probes, 21, 116-124.
252. Chen, A.K., Behlke, M.A., and Tsourkas, A. (2007) Avoiding falsepositive signals with nuclease-vulnerable molecular beacons in single living cells. Nucleic Acids Research, 35, e105.
253. Peng, H., Zhang, L., Kjallman, T.H.M., Soeller, C., and Travas-Sejdic, J. (2007) DNA hybridization detection with blue luminescent quantum dots and dyelabeled single-stranded DNA. Journal of the American Chemical Society, 129, 3048-3049.
254. Lee, J., Choi, Y., Kim, J., Park, E., and Song, R. (2009) Positively charged compact quantum Dot-DNA complexes for detection of nucleic acids. Chemphyschem, 10, 806-811
255. Stringer, R.C., Hoehn, D., and Grant, S.A. (2008) Quantum dot-based biosensor for detection of human cardiac Troponin I using a liquid-core waveguide. IEEE Sensors Journal, 8, 295-300.
256. Medintz, I.L., Clapp, A.R., Melinger, J.S., Deschamps, J.R., and Mattoussi, H. (2005) A reagentless biosensing assembly based on quantum dot-donor Forster resonance energy transfer. Advanced Materials, 17, 2450-2455.
257. Weiss, S. (1999) Fluorescence spectroscopy of single biomolecules. Science, 283, 1676-1683.
258. Medintz, I.L., Konnert, J.H., Clapp, A.R., Stanish, I., Twigg, M.E., Mattoussi, H., Mauro, J.M., and Deschamps, J.R. (2004) A fluorescence resonance energy transferderived structure of a quantum dot- protein bioconjugate nanoassembly. Proceedings of the National Academy of Sciences of the United States of America, 101, 9612-9617.
259. Algar,W.R. and Krull, U.J. (2011) Characterization of the adsorption of oligonucleotides on mercaptopropionic acid-coated CdSe/ZnS quantum dots using fluorescence resonance energy transfer. Journal of Colloid and Interface Science, 359, 148-154.
260. Han, H., Zylstra, J., and Maye, M.M. (2011) Direct attachment of oligonucleotides to quantum dot interfaces. Chemistry of Materials, 23, 4975-4981.
261. Snee, P.T., Somers, R.C., Nair, G., Zimmer, J.P., Bawendi, M.G., and Nocera, D.G. (2006) A ratiometric CdSe/ZnS nanocrystal pH sensor. Journal of the American Chemical Society, 128, 13320-13321.
262. Chen, Y., Thakar, R., and Snee, P.T. (2008) Imparting nanoparticle function with size-controlled amphiphilic polymers. Journal of the American Chemical Society, 130, 3744-3745.
263. Krooswyk, J.D., Tyrakowski, C.M., and Snee, P.T. (2010) Multivariable response of semiconductor nanocrystal-dye sensors: the case of pH. The Journal of Physical Chemistry C, 114, 21348-21352.
264. Dennis, A.M., Rhee, W.J., Sotto, D., Dublin, S.N., and Bao, G. (2012)Quantum dot-fluorescent protein FRET probes for sensing intracellular pH. ACS Nano, 6, 2917-2924.
265. Freeman, R., Gill, R., Shweky, I., Kotler, M., Banin, U., and Willner, I. (2009) Biosensing and probing of intracellular metabolic pathways by NADH-sensitive quantum dots. Angewandte Chemie, International Edition, 48, 309-313.
266. Medintz, I.L., Trammell, S.A., Mattoussi, H., and Mauro, J.M. (2004) Reversible modulation of quantum dot photoluminescence using a proteinbound photochromic fluorescence resonance energy transfer acceptor. Journal of the American Chemical Society, 126, 30-31.
267. McLaurin, E.J., Greytak, A.B., Bawendi, M.G., and Nocera, D.G. (2009) Twophoton absorbing nanocrystal sensors for ratiometric detection of oxygen. Journal of the American Chemical Society, 131, 12994-13001.
268. Deniz, A.A., Laurence, T.A., Dahan, M., Chemla, D.S., Schultz, P.G., and Weiss, S. (2001) Ratiometric single-molecule studies of freely diffusing biomolecules. Annual Review of Physical Chemistry, 52, 233-253.
269. Roy, R., Hohng, S., and Ha, T. (2008) A practical guide to single-molecule FRET. Nature Methods, 5, 507-516.
270. Hohng, S. and Ha, T. (2005) Singlemolecule quantum-dot fluorescence resonance energy transfer. Chemphyschem, 6, 956-960.
271. Bailey, V.J., Easwaran, H., Zhang, Y., Griffiths, E., Belinsky, S.A., Herman, J.G., Baylin, S.B., Carraway, H.E., and Wang, T.H. (2009) MS-qFRET: a quantum dotbased method for analysis of DNA methylation. Genome Research, 19, 1455-1461.
272. Zhang, C.Y. and Johnson, L.W. (2006) Quantum dot-based fluorescence resonance energy transfer with improved FRETefficiency in capillary flows. Analytical Chemistry, 78, 5532-5537.
273. Zhang, C.Y. and Johnson, L.W. (2009) Single quantum-dot-based aptameric nanosensor for cocaine. Analytical Chemistry, 81, 3051-3055.
274. Zhang, C.Y. and Johnson, L.W. (2006) Quantum-dot-based nanosensor for RRE IIB RNA-Rev peptide interaction assay. Journal of the American Chemical Society, 128, 5324-5325.
275. Zhang, C.Y. and Johnson, L.W. (2007) Quantifying RNA-peptide interaction by single-quantum dot-based nanosensor: an approach for drug screening. Analytical Chemistry, 79, 7775-7781.
276. Zhang, C.Y. and Hu, J. (2010) Single quantum dot-based nanosensor for multiple DNA detection. Analytical Chemistry, 82, 1921-1927.
277. Zhang, Y. and Zhang, C.Y. (2012) Sensitive detection of microRNA with isothermal amplification and a singlequantum- dot-based nanosensor. Analytical Chemistry, 84, 224-231.
278. Sugawa, M., Nishikawa, S., Iwane, A.H., Biju, V., and Yanagida, T. (2010) Singlemolecule FRET imaging for enzymatic reactions at high ligand concentrations. Small, 6, 346-350.
279. Sapsford, K.E., Medintz, I.L., Golden, J.P., Deschamps, J.R., Uyeda, H.T., and Mattoussi, H. (2004) Surface-immobilized self-assembled protein-based quantum dot nanoassemblies. Langmuir, 20, 7720-7728.
280. Chen, L., Algar, W.R., Tavares, A.J., and Krull, U.J. (2011) Toward a solid-phase nucleic acid hybridization assay within microfluidic channels using immobilized quantum dots as donors in fluorescence resonance energy transfer. Analytical and Bioanalytical Chemistry, 399, 133-141.
281. Tavares, A.J., Noor, M.O., Vannoy, C.H., Algar,W.R., and Krull, U.J. (2012) Onchip transduction of nucleic acid hybridization using spatial profiles of immobilized quantum dots and fluorescence resonance energy transfer. Analytical Chemistry, 84, 312-319.
282. Qi, H.,Wang, L., Wong, K.W., and Du, Z. (2009) DNA-quantum dot sensing platform with combined Forster resonance energy transfer and photovoltaic effect. Applied Physics Letters, 94, 143902.
283. Kim, Y.P., Oh, Y.H., Oh, E., Ko, S., Han, M.K., and Kim, H.S. (2008) Energy transfer-based multiplexed assay of proteases by using gold nanoparticle and quantum dot conjugates on a surface. Analytical Chemistry, 80, 4634-4641.
284. Kim, Y.P., Oh, Y.H., Oh, E., and Kim, H.S. (2007) Chip-based protease assay using fluorescence resonance energy transfer between quantum dots and fluorophores. Biochip Journal, 1, 228-233.
285. Algar,W.R. and Krull, U.J. (2008) Multidentate surface ligand exchange for the immobilization of CdSe/ZnS quantum dots and surface quantum dot- oligonucleotide conjugates. Langmuir, 24, 5514-5520.
286. Algar,W.R. and Krull, U.J. (2011) Interfacial chemistry and the design of solid-phase nucleic acid hybridization assays using immobilized quantum dots as donors in fluorescence resonance energy transfer. Sensors, 11, 6214-6236.
287. Algar,W.R. and Krull, U.J. (2009) Interfacial transduction of nucleic acid hybridization using immobilized quantum dots as donors in fluorescence resonance energy transfer. Langmuir, 25, 633-638.
288. Algar,W.R. and Krull, U.J. (2009) Toward a multiplexed solid-phase nucleic acid hybridization assay using quantum dots as donors in fluorescence resonance energy transfer. Analytical Chemistry, 81, 4113-4210.
289. Algar,W.R. and Krull, U.J. (2010) Multiplexed interfacial transduction of nucleic acid hybridization using a single color of immobilized quantum dot donor and two acceptors in fluorescence resonance energy transfer. Analytical Chemistry, 82, 400-405.
290. Algar,W.R. and Krull, U.J. (2010) Developing mixed films of immobilized oligonucleotides and quantum dots for the multiplexed detection of nucleic acid hybridization using a combination of fluorescence resonance energy transfer and direct excitation of fluorescence. Langmuir, 26, 6041-6047.
291. Algar,W.R. and Krull, U.J. (2010) New opportunities in multiplexed optical bioanalyses using quantum dots and donor-acceptor interactions. Analytical and Bioanalytical Chemistry, 398, 2439- 2449.
292. Tran, P.T., Goldman, E.R., Anderson, G.P., Mauro, J.M., and Mattoussi, H. (2002) Use of luminescent CdSe-ZnS nanocrystal bioconjugates in quantum dot-based nanosensors. Physica Status Solidi B-Basic Research, 229, 427-432.
293. Feng, C.L., Zhong, X., Steinhart, M., Caminade, A.M., Majoral, J.P., and Knoll, W. (2007) Graded-bandgap quantum-dot-modified nanotubes: a sensitive biosensor for enhanced detection of DNA hybridization. Advanced Materials, 19, 1933-1936.
294. Feng, C.L., Zhong, X.H., Steinhart, M., Caminade, A.M., Majoral, J.P., and Knoll, W. (2008) Functional quantum-dot/ dendrimer nanotubes for sensitive detection of DNA hybridization. Small, 4, 566-571.
295. Beier, H.T., Cote, G.L., and Meissner, K.E. (2009) Whispering gallery mode biosensors consisting of quantum dotembedded microspheres. Annual Review of Biomedical Engineering, 37, 1974-1983.
296. Robelek, R., Niu, L., Schmid, E.L., and Knoll, W. (2004) Multiplexed hybridization detection of quantum dotconjugated DNA sequences using surface plasmon enhanced fluorescence microscopy and spectrometry. Analytical Chemistry, 76, 6160-6165.
297. Kinkhabwala, A., Yu, Z., Fan, S., Avlasevich, Y., Mullen, K., and Moerner, W.E. (2009) Large single-molecule fluorescence enhancements produced by a bowtie nanoantenna. Nature Photonics, 3, 654-657.
298. Ganesh, N., Zhang,W., Mathias, P.C., Chow, E., Soares, J.A.N.T., Malyarchuk, V., Smith, A.D., and Cunningham, B.T. (2007) Enhanced fluorescence emission from quantum dots on a photonic crystal surface. Nature Nanotechnology, 2, 515-520.
299. Samia, A.C.S., Dayal, S., and Burda, C. (2006) Quantum dot-based energy transfer: perspectives and potential for applications in photodynamic therapy. Photochemistry and Photobiology, 82, 617-625.
300. Tsay, J.M., Trzoss, M., Shi, L., Kong, X., Selke, M., Jung, M.E., and Weiss, S. (2007) Singlet oxygen production by peptide-coated quantum dotphotosensitizer conjugates. Journal of the American Chemical Society, 129, 6865-6871.
301. Biju, V., Mundayoor, S., Omkumar, R.V., Anas, A., and Ishikawa, M. (2010) Bioconjugated quantum dots for cancer research: present status, prospects and remaining issues. Biotechnology Advances, 28, 199-213.
302. Juzenas, P., Chen, W., Sun, Y.P., Coelho, M.A.N., Generalov, R., Generalova, N., and Christensen, I.L. (2008) Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer. Advanced Drug Delivery Reviews, 60, 1600-1614.
303. Bakalova, R., Ohba, H., Zhelev, Z., Nagase, T., Jose, R., Ishikawa, M., and Baba, Y. (2004) Quantum anti-CD conjugates: are they potential photosensitizers or potentiators of classical photosensitizing agents in photodynamic therapy of cancer? Nano Letters, 4, 1567-1573.
304. Samia, A.C.S., Chen, X., and Burda, C. (2003) Semiconductor quantum dots for photodynamic therapy. Journal of the American Chemical Society, 125, 15736-15737.
305. Qi, Z.D., Li, D.W., Jiang, P., Jiang, F.L., Li, Y. S., Liu, Y.,Wong, W.K., and Cheah, K.W. (2011) Biocompatible CdSe quantum dot-based photosensitizer under two-photon excitation for photodynamic therapy. Journal ofMaterials Chemistry, 21, 2455-2458.
306. Dodeigne, C., Thunus, L., and Lejeune, R. (2000) Chemiluminescence as a diagnostic tool. A review. Talanta, 51, 415-439.
307. Huang, X., Li, L., Qian, H., Ding, C., and Ren, J. (2006) A resonance energy transfer between chemiluminescent donors and luminescent quantum dots as acceptors. Angewandte Chemie, International Edition, 45, 5140-5143.
308. Wang, H.Q., Li, Y.Q., Wang, J.H., Xu, Q., Li, X.Q., and Zhao, Y.D. (2008) Influence of quantum dot's quantum yield to chemiluminescent resonance energy transfer. Analytica Chimica Acta, 610, 68-73.
309. Li, Z., Wang, Y., Zhang, G., Xu, W., and Han, Y. (2010) Chemiluminescence resonance energy transfer in the luminol- CdTe quantum dots conjugates. Journal of Luminescence, 130, 995-999.
310. Du, J., Yu, C., Pan, D., Li, J., Chen, W., Yan, M., Segura, T., and Lu, Y. (2010) Quantum-dot-decorated robust transductable bioluminescent nanocapsules. Journal of the American Chemical Society, 132, 12780-12781.
311. Haddock, S.H.D., Moline, M.A., and Case, J.F. (2010) Bioluminescence in the sea. Annual Review of Marine Science, 2, 443-493.
312. Rowe, L., Dikici, E., and Daunert, S. (2009) Engineering bioluminescent proteins: expanding their analytical potential. Analytical Chemistry, 81, 8662-8668.
313. Ma, N., Marshall, A.F., and Rao, J. (2010) Near-infrared light emitting luciferase via biomineralization. Journal of the American Chemical Society, 132, 6884-6885.
314. Xing, Y., So, M.K., Koh, A.L., Sinclair, R., and Rao, J. (2008) Improved QD-BRET conjugates for detection and imaging. Biochemical and Biophysical Research Communications, 372, 388-394.
315. Kosaka, N., Mitsunaga, M., Bhattacharyya, S., Miller, S.C., Choyke, P.L., and Kobayashi, H. (2011) Self-illuminating in vivo lymphatic imaging using a bioluminescence resonance energy transfer quantum dot nano-particle. Contrast Media & Molecular Imaging, 6, 55-59.
316. Diamandis, E.P. (1988) Immunoassays with time-resolved fluorescence spectroscopy: principles and applications. Clinical Biochemistry, 21, 139-150.
317. Charbonniere, L., Ziessel, R., Guardigli, M., Roda, A., Sabbatini, N., and Cesario, M. (2001) Lanthanide tags for timeresolved luminescence microscopy displaying improved stability and optical properties. Journal of the American Chemical Society, 123, 2436-2437.
318. Morgner, F., Geißler, D., Stufler, S., Butlin, N.G., Lohmannsroben, H.G., and Hildebrandt, N. (2010) A quantum-dot based molecular ruler for multiplexed optical analysis. Angewandte Chemie, International Edition, 49, 7570-7574.
319. Johansson, M.K., Cook, R.M., Xu, J.D., and Raymond, K.N. (2004) Time gating improves sensitivity in energy transfer assays with terbium chelate/dark quencher oligonucleotide probes. Journal of the American Chemical Society, 126, 16451-16455.
320. Petoud, S., Cohen, S.M., Bunzli, J.C.G., and Raymond, K.N. (2003) Stable lanthanide luminescence agents highly emissive in aqueous solution: multidentate 2-hydroxyisophthalamide complexes of Sm3+, Eu3+, Tb3+, Dy3+. Journal of the American Chemical Society, 125, 13324-13325.
321. Xu, J., Corneillie, T.M., Moore, E.G., Law, G.L., Butlin, N.G., and Raymond, K.N. (2011) Octadentate cages of Tb(III) 2- hydroxyisophthalamides: a new standard for luminescent lanthanide labels. Journal of the American Chemical Society, 133, 19900-19910.
322. Li, Y.Q.,Wang, J.H., Zhang, H.L., Yang, J., Guan, L.Y., Chen, H., Luo, Q.M., and Zhao, Y.D. (2010) High-sensitivity quantum dot-based fluorescence resonance energy transfer bioanalysis by capillary electrophoresis. Biosensors & Bioelectronics, 25, 1283-1289.
323. Hu, B., Zhang, L.P., Chen, M.L., Chen, M.L., and Wang, J.H. (2012) The inhibition of fluorescence resonance energy transfer between quantum dots for glucose assay. Biosensors & Bioelectronics, 32, 82-88.
324. Liu, T.C., Zhang, H.L.,Wang, J.H.,Wang, H.Q., Zhang, Z.H., Hua, X.F., Cao, Y.C., Luo, Q.M., and Zhao, Y.D. (2008) Study on molecular interactions between proteins on live cell membranes using quantum dot-based fluorescence resonance energy transfer. Analytical and Bioanalytical Chemistry, 391, 2819-2824.
325. Seker, U.O.S., Ozel, T., and Demir, H.V. (2011) Peptide-mediated constructs of quantum dot nanocomposites for enzymatic control of nonradiative energy transfer. Nano Letters, 11, 1530-1539.
326. Kagan, C.R., Murray, C.B., and Bawendi, M.G. (1996) Long-range resonance transfer of electronic excitations in close packed CdSe quantum-dot solids. Physical Review. B, Condensed Matter and Materials Physics, 54, 8633-8643.
327. Govorov, A.O., Lee, J., and Kotov, N.A. (2007) Theory of plasmon-enhanced Forster energy transfer in optically excited semiconductor and metal nanoparticles. Physical Review. B, Condensed Matter and Materials Physics, 76, 125308.
328. Lunz, M., Bradley, A.L., Chen, W.Y., and Gun'ko, Y.K. (2009) Two-dimensional Forster resonant energy transfer in a mixed quantum dot monolayer: experiment and theory. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces, 113, 3084-3088.
329. Lunz, M., Bradley, A.L., Chen, W.Y., Gerard, V.A., Byrne, S.J., Gun'ko, Y.K., Lesnyak, V., and Gaponik, N. (2010) Influence of quantum dot concentration on Forster resonant energy transfer in monodispersed nanocrystal quantum dot monolayers. Physical Review. B, Condensed Matter and Materials Physics, 81, 205316.
330. Lunz, M., Bradley, A.L., Gerard, V.A., Byrne, S.J., Gun'ko, Y.K., Lesnyak, V., and Gaponik, N. (2011) Concentration dependence of Forster resonant energy transfer between donor and acceptor nanocrystal quantum dot layers: effect of donor-donor interactions. Physical Review. B, Condensed Matter and Materials Physics, 83, 115423.
331. Link, S. and El-Sayed, M.A. (2000) Shape and size dependence of radiative, nonradiative and photothermal properties of gold nanocrystals. International Reviews in Physical Chemistry, 19, 409-453.
332. El-Sayed, M.A. (2001) Some interesting properties of metals confined in time and nanometer space of different shapes. Accounts of Chemical Research, 34, 257-264.
333. Kamat, P.V. (2002) Photophysical, photochemical and photocatalytic aspects of metal nanoparticles. The Journal of Physical Chemistry. B, 106, 7729-7744.
334. Eustis, S. and El-Sayed, M.A. (2006) Why gold nanoparticles are more precious than pretty gold: noble metal surface plasmon resonance and its enhancement of the radiative and nonradiative properties of nanocrystals of different shapes. Chemical Society Reviews, 35, 209-217.
335. Murphy, C.J., Gole, A.M., Stone, J.W., Sisco, P.N., Alkilany, A.M., Goldsmith, E.C., and Baxter, S.C. (2008) Gold nanoparticles in biology: beyond toxicity to cellular imaging. Accounts of Chemical Research, 41, 1721-1730.
336. Kelly, K.L., Coronado, E., Zhao, L.L., and Schatz, G.C. (2003) The optical properties of metal nanoparticles: the influence of size, shape, and dielectric environment. The Journal of Physical Chemistry. B, 107, 668-677.
337. Lakowicz, J.R. (2005) Radiative decay engineering 5: metal-enhanced fluorescence and plasmon emission. Analytical Biochemistry, 337, 171-194.
338. Singh, M.P. and Strouse, G.F. (2010) Involvement of the LSPR spectral overlap for energy transfer between a dye and Au nanoparticle. Journal of the American Chemical Society, 132, 9383-9391.
339. Jennings, T.L., Schlatterer, J.C., Singh, M.P., Greenbaum, N.L., and Strouse, G.F. (2006) NSETmolecular beacon analysis of hammerhead RNA substrate binding and catalysis. Nano Letters, 6, 1318-1324.
340. Jennings, T.L., Singh, M.P., and Strouse, G.F. (2006) Fluorescent lifetime quenching near d 1/4 1.5nm gold nanoparticles: probing NSET validity. Journal of the American Chemical Society, 128, 5462-5467.
341. Yun, C.S., Javier, A., Jennings, T., Fisher, M., Hira, S., Peterson, S., Hopkins, B., Reich, N.O., and Strouse, G. F. (2005) Nanometal surface energy transfer in optical rulers, breaking the FRET barrier. Journal of the American Chemical Society, 127, 3115-3119.
342. Oh, E., Hong, M.Y., Lee, D., Nam, S.H., Yoon, H.C., and Kim, H.S. (2005) Inhibition assay of biomolecules based on fluorescence resonance energy transfer (FRET) between quantum dots and gold nanoparticles. Journal of the American Chemical Society, 127, 3270-3271.
343. Oh, E., Lee, D., Kim, Y.P., Cha, S.Y., Oh, D.B., Kang, H.A., Kim, J., and Kim, H.S. (2006) Nanoparticle-based energy transfer for rapid and simple detection of protein glycosylation. Angewandte Chemie, International Edition, 45, 7959-7963.
344. Kim, Y.P., Park, S., Oh, E., Oh, Y.H., and Kim, H.S. (2009) On-chip detection of protein glycosylation based on energy transfer between nanoparticles. Biosensors & Bioelectronics, 24, 1189-1194.
345. Liang, G.X., Pan, H.C., Li, Y., Jiang, L.P., Zhang, J.R., and Zhu, J.J. (2009) Near infrared sensing based on fluorescence resonance energy transfer between Mn: CdTe quantum dots and Au nanorods. Biosensors & Bioelectronics, 24, 3693-3697.
346. Liu, J., Lee, J.H., and Lu, Y. (2007) Quantum dot encoding of aptamer-linked nanostructures for one-pot simultaneous detection of multiple analytes. Analytical Chemistry, 79, 4120-4125.
347. Li, X., Qian, J., Jiang, L., and He, S. (2009) Fluorescence quenching of quantum dots by gold nanorods and its application to DNA detection. Applied Physics Letters, 94, 063111.
348. Yang, R.H., Jin, J.Y., Chen, Y., Shao, N., Kang, H.Z., Xiao, Z., Tang, Z.W., Wu, Y. R., Zhu, Z., and Tan, W.H. (2008) Carbon nanotube-quenched fluorescent oligonucleotides: probes that fluoresce upon hybridization. Journal of the American Chemical Society, 130, 8351- 8358.
349. Loh, K.P., Bao, Q., Eda, G., and Chhowalla, M. (2010) Graphene oxide as a chemically tunable platform for optical applications. Nature Chemistry, 2, 1015-1024.
350. Liu, Y., Dong, X., and Chen, P. (2012) Biological and chemical sensors based on graphene materials. Chemical Society Reviews, 41, 2283-2307.
351. Liu, M., Zhao, H., Quan, X., Chen, S., and Fan, X. (2010) Distance-independent quenching of quantum dots by nanoscalegraphene in self-assembled sandwich immunoassay. Chemical Communications, 46, 7909-7911.
352. Lu, C.H., Zhu, C.L., Li, J., Liu, J.J., Chen, X., and Yang, H.H. (2010) Using graphene to protect DNA from cleavage during cellular delivery. Chemical Communications, 46, 3116-3118.
353. Morales-Narvaez, E., Perez-Lopez, B., Pires, L.B., and MerkoSci, A. (2012) Simple Forster resonance energy transfer evidence for the ultrahigh quantum dot quenching efficiency by graphene oxide compared to other carbon structures. Carbon, 50, 2987-2993.
354. Chen, L., Zhang, X., Zhou, G., Xiang, X., Ji, X., Zheng, Z., He, Z., and Wang, H. (2012) Simultaneous determination of human enterovirus 71 and coxsackievirus B3 by dual-color quantum dots and homogeneous immunoassay. Analytical Chemistry, 84, 3200-3207.
355. Dong, H., Gao,W., Yan, F., Ji, H., and Ju, H. (2010) Fluorescence resonance energy transfer between quantum dots and graphene oxide for sensing biomolecules. Analytical Chemistry, 82, 5511-5517.
356. Iijima, S. (1991) Helical microtubules of graphitic carbon. Nature, 354, 56-58.
357. Lahiff, E., Lynam, C., Gilmartin, N., O'Kennedy, R., and Diamond, R. (2010) The increasing importance of carbon nanotubes and nanostructured conducting polymers in biosensors. Analytical and Bioanalytical Chemistry, 398, 1575-1589.
358. O'Connell, M.J., Bachilo, S.M., Huffman, C.B., Moore, V.C., Strano, M.S., Haroz, E. H., Rialon, K.L., Boul, P.J., Noon,W.H., Kittrell, C., Ma, J., Hauge, R.H., Weisman, R.B., and Smalley, R.E. (2002) Band gap fluorescence from individual single-walled carbon nanotubes. Science, 297, 593-596.
359. Pan, B.F., Cui, D.X., Ozkan, C.S., Ozkan, M., Xu, P., Huang, T., Liu, F.T., Chen, H., Li, Q., He, R., and Gao, F. (2008) Effects of carbon nanotubes on photoluminescence properties of quantum dots. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces, 112, 939-944.
360. Biju, V., Itoh, T., Baba, Y., and Ishikawa, M. (2006) Quenching of photoluminescence in conjugates of quantum dots and single-walled carbon nanotube. The Journal of Physical Chemistry. B, 110, 26068-26074.
361. Shafran, E., Mangum, B.D., and Gerton, J.M. (2010) Energy transfer from an individual quantum dot to a carbon nanotube. Nano Letters, 10, 4049-4054.
362. Cui, D., Pan, B., Zhang, H., Gao, F., Wu, R., Wang, J., He, R., and Asahi, T. (2008) Self-assembly of quantum dots and carbon nanotubes for ultrasensitive DNA and antigen detection. Analytical Chemistry, 80, 7996-8001.
363. Tian, J., Zhao, H., Liu, M., Chen, Y., and Quan, X. (2012) Detection of influenza A virus based on fluorescence resonance energy transfer from quantum dots to carbon nanotubes. Analytica Chimica Acta, 723, 83-87.
364. Fleming, G.R. and Scholes, G.D. (2004) Physical chemistry: quantum mechanics for plants. Nature, 431, 256-257.
365. Andrews, D.L., Curutchet, C., and Scholes, G.D. (2011) Resonance energy transfer: beyond the limits. Laser & Photonics Reviews, 5, 114-123.
366. Yu, G., Gao, J., Hummelen, J.C.,Wudl, F., and Heeger, A.J. (1995) Polymer photovoltaic cells: enhanced efficiencies via a network of internal donor-acceptor heterojunctions. Science, 270, 1789-1791.
367. Sukhovatkin, V., Hinds, S., Brzozowski, L., and Sargent, E.H. (2009) Colloidal quantum-dot photodetectors exploiting multiexciton generation. Science, 324, 1542-1544.
368. Buhbut, S., Itzhakov, S., Tauber, E., Shalom, M., Hod, I., Geiger, T., Garini, Y., Oron, D., and Zaban, A. (2010) Built-in quantum dot antennas in dye-sensitized solar cells. ACS Nano, 4, 1293-1298.
369. Buhbut, S., Itzhakov, S., Oron, D., and Zaban, A. (2011) Quantum dot antennas for photoelectrochemical solar cells. The Journal of Physical Chemistry Letters, 2, 1917-1924.
370. Ruland, A., Schulz-Drost, C., Sgobba, V., and Guldi, D.M. (2011) Enhancing photocurrent efficiencies by resonance energy transfer in CdTe quantum dot multilayers: towards rainbow solar cells. Advanced Materials, 23, 4573-4577.
371. Demir, H.V., Nizamoglu, S., Erdem, T., Mutlugun, E., Gaponik, N., and Eychmuller, A. (2011) Quantum dot integrated LEDs using photonic and excitonic color conversion. Nano Today, 6, 632-647.
372. Achermann, M., Petruska, M.A., Kos, S., Smith, D.L., Koleske, D.D., and Klimov, V.I. (2004) Energy-transfer pumping of semiconductor nanocrystals using an epitaxial quantum well. Nature, 429, 642-646.
373. Rohrmoser, S., Baldauf, J., Harely, R.T., Lagoudakis, P.G., Sapra, S., Eychmuller, A., and Watson, I.M. (2007) Temperature dependence of exciton transfer in hybrid quantum well/ nanocrystal heterostructures. Applied Physics Letters, 91, 092126.
374. Nizamoglu, S., Mutlugun, E., Ozel, T., Demir, H.V., Sapra, S., Gaponik, N., and Eychmuller, A. (2008) Dual-color emitting quantum-dot-quantum-well CdSe-ZnS heteronanocrystals hybridized on InGaN/ GaN light emitting diodes for high-quality white light generation. Applied Physics Letters, 92, 113110.
375. Nizamoglu, S., Sari, E., Baek, J.H., Lee, I.H., and Demir, V.H. (2008) White emitting CdS quantum dot nanoluminophores hybridized on nearultraviolet LEDs for high-quality white light generation and tuning. New Journal of Physics, 10, 023026.
376. Achermann, M., Petruska, M.A., Koleske, D.D., Crawford, M.H., and Klimov, V.I.(2006) Nanocrystal-based light-emitting diodes utilizing high-efficiency nonradiative energy transfer for color conversion. Nano Letters, 6, 1396-1400.
377. Chanyawadee, S., Lagoudakis, P.G., Harley, R.T., Charlton, M.D.B., Talapin, D.V., Huang, H.W., and Lin, C.H. (2010) Increased color-conversion efficiency in hybrid light-emitting diodes utilizing nonradiative energy transfer. Advanced Materials, 22, 602-606.
378. Franzl, T., Klar, T.A., Schietinger, S., Rogach, A.L., and Feldmann, J. (2004) Exciton recycling in graded gap nanocrystal structures. Nano Letters, 4, 1599-1603.
379. Nizamoglu, S., Akin, O., and Demir, H.V. (2009) Quantum efficiency enhancement in nanocrystals using nonradiative energy transfer with optimized donor-acceptor ratio for hybrid LEDs. Applied Physics Letters, 94, 243107.
380. Nizamoglu, S. and Demir, H.V. (2008) Resonant nonradiative energy transfer in CdSe/ZnS core/shell nanocrystal solids enhances hybrid white light emitting diodes. Optics Express, 16, 13961-13968.