Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction

Nature Biotechnology

Volumn 22, Issue 2, 2004, Pages 198-203

  Lidke, Diane S ^a   Nagy, Peter ^a   Heintzmann, Rainer ^a   Arndt Jovin, Donna J ^a   Post, Janine N ^a   Grecco, Hernan E ^b   Jares Erijman, Elizabeth A ^b   Jovin, Thomas M ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; SEMICONDUCTOR QUANTUM DOTS;

EPIDERMAL GROWTH FACTORS (EGF);

BIOTECHNOLOGY;

CITRINE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; FLUORESCENT DYE; HYBRID PROTEIN; LIGAND; MONOMER; OLIGOMER; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

ANIMAL CELL; ARTICLE; BIOTECHNOLOGY; CELL LINE; CELL STRAIN A431; CHO CELL; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DIMERIZATION; ENDOCYTOSIS; ENDOSOME; FILOPODIUM; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; INTERNALIZATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; QUANTUM MECHANICS; SIGNAL TRANSDUCTION;

ANIMALS; CELL MEMBRANE; CRICETINAE; ENDOSOMES; EPIDERMAL GROWTH FACTOR; HUMANS; MOTION; ONCOGENE PROTEINS V-ERBB; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN TRANSPORT; QUANTUM DOTS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SPECTROMETRY, FLUORESCENCE;

ANIMALIA;

EID: 0742270981     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt929     Document Type: Article

References (31)

1. Yarden, Y. & Sliwkowski, M.X. Untangling the ErbB signalling network. Nat. Rev. Mol. Cell Biol. 2, 127-137 (2001).
2. Jorissen, R.N. et al. Epidermal growth factor receptor: mechanisms of activation and signalling. Exp. Cell Res. 284, 31-53 (2003).
3. Schlessinger, J. Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110, 669-672 (2002).
4. Gadella, T.W.J. Jr. & Jovin, T.M. Oligomerization of epidermal growth factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy. A stereochemical model for tyrosine kinase receptor activation. J. Cell Biol. 129, 1543-1558 (1995).
5. Moriki, T., Maruyama, H. & Maruyama, I.N. Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain. J. Mol. Biol. 311, 1011-1026 (2001).
6. Sako, Y., Minoghchi, S. & Yanagida, T. Single-molecule imaging of EGFR signalling on the surface of living cells. Nat. Cell Biol. 2, 168-172 (2000).
7. Hynes, N.E., Horsch, K., Olayioye, M.A. & Badache, A. The ErbB receptor tyrosine family as signal integrators. Endocr. Relat. Cancer 8, 151-159 (2001).
8. Jaiswal, J.K., Mattoussi, H., Mauro, J.M. & Simon, S.M. Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat. Biotechnol. 21, 47-51 (2003).
9. Gulliford, T.J., Huang, G.C., Ouyang, X. & Epstein, R.J. Reduced ability of transforming growth factor-alpha to induce EGF receptor heterodimerization and downregulation suggests a mechanism of oncogenic synergy with ErbB2. Oncogene 15, 2219-2223 (1997).
10. Olayioye, M.A., Beuvink, I., Horsch, K., Daly, J.M. & Hynes, N.E. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. J. Biol. Chem. 274, 17209-17218 (1999).
11. Cho, H.S. & Leahy, D.J. Structure of the extracellular region of HER3 reveals an interdomain tether. Science 297, 1330-1333: (2002).
12. Cho, H.S. et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 421, 756-760 (2003).
13. Ferguson, K.M. et al. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Mol. Cell 11, 507-517 (2003).
14. Garrett, T.P.J. et al. The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors. Mol. Cell 11, 495-505 (2003).
15. Ogiso, H. et al. Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell 110, 775-787 (2002).
16. Nagy, P. et al. Lipid rafts and the local density of ErbB proteins influence the biological role of homo- and heteroassociations of ErbB2. J. Cell Sci. 115, 4251-4262 (2002).
17. Martin-Fernandez, M., Clarke, D.T., Tobin M.J., Jones, S.V. & Jones, G.R. Preformed oligomeric epidermal growth factor receptors undergo an ectodomain structure change during signaling. Biophys. J. 82, 2415-2427. (2002).
18. Lidke, D.S. et al. Imaging molecular interactions in cells by dynamic and static fluorescence anisotropy (rFLIM and emFRET). Biochem. Soc. Trans. 31, 1020-1027 (2003).
19. Deb, T.B. et al. Epidermal growth factor (EGF) receptor kinase-independent signaling by EGF. J. Biol. Chem. 276, 15554-15560 (2001).
20. Mendrola, J.M., Berger, M.B., King, M.C. & Lemmon, M.A. The single transmembrane domains of erbB receptors self-associate in cell membranes. J. Biol. Chem. 277, 4704-4712 (2002).
21. Graus-Porta, D., Beerli, R.R., Daly, J.M. & Hynes, N.E. ErbB-2, the preferred heterodimerization partner of all erbB receptors, is a mediator of lateral signaling. EMBO J. 16, 1647-1655 (1997).
22. Wang, Z., Zhang, L., Yeung, T.K. & Chen, X. Endocytosis deficiency of epidermal growth factor (EGF) receptor-ErbB2 heterodimers in response to EGF stimulation. Mol. Biol. Cell 10, 1621-1636 (1999).
23. Wilkinson, J.C. & Staros, J.V. Effect of ErbB2 coexpression on the kinetic interactions of epidermal growth factor with its receptor in intact cells. Biochemistry 41, 8-14 (2002).
24. Nagy, P., Arndt-Jovin, D. & Jovin, T.M. Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor (erbB1) and induce apoptosis in erbB1-overexpressing cells. Exp. Cell Res. 285, 39-49 (2003).
25. Bridges, A.J. et al. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J. Med. Chem. 39, 267-276 (1996).
26. Hasson, T. Myosin VI: two distinct roles endocytosis. J. Cell Sci. 116, 3453-3461 (2003).
27. Small, J.V., Stradal, T., Vignal, E. & Rottner, K. The lamellipodium: where motility begins. Trends Cell Biol. 12, 112-120 (2002).
28. Sliwkowski, M.X. et al. Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin. J. Biol. Chem. 269, 14661-14665 (1994).
29. Dahan, M. et al. Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking. Science 302, 442-445 (2003).
30. Brock, R., Hamelers, I.H. & Jovin, T.M. Comparison of fixation protocols for adherent cultured cells applied to a GFP fusion protein of the epidermal growth factor receptor. Cytometry 35, 353-362 (1999).
31. Zacharias, D.A., Violin, J.D., Newton, A.C. & Tsien, R.Y. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 296, 913-916 (2002).