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D. Geho, N. Lahar, P. Gurnani, M. Huebschman, P. Herrmann, V. Espina, A. Shi, J. Wulfkuhle, H. Garner, and E. Petricoin III Pegylated, streptavidin-conjugated quantum dots are effective detection elements for reverse-phase protein microarrays Bioconjug Chem 16 2005 559 566
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D.R. Larson, W.R. Zipfel, R.M. Williams, S.W. Clark, M.P. Bruchez, F.W. Wise, and W.W. Webb Water-soluble quantum dots for multiphoton fluorescence imaging in vivo Science 300 2003 1434 1436
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S. Kim, Y.T. Lim, E.G. Soltesz, A.M. De Grand, J. Lee, A. Nakayama, J.A. Parker, T. Mihaljevic, R.G. Laurence, D.M. Dor, and L.H. Cohn Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping Nat Biotechnol 22 2004 93 97
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E.B. Voura, J.K. Jaiswal, H. Mattoussi, and S.M. Simon Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy Nat Med 10 2004 993 998
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X. Gao, Y. Cui, R.M. Levenson, L.W. Chung, and S. Nie In vivo cancer targeting and imaging with semiconductor quantum dots Nat Biotechnol 22 2004 969 976 Specifically describes materials modified with PEG, conjugated to antibodies, and demonstrates targeting to prostate-specific membrane antigen in live animals with non-invasive imaging using spectral imaging to remove animal autofluorescence background. This is the first demonstration of non-invasive imaging of molecularly targeted materials in live animals.
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Nat Biotechnol
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M. Stroh, J.P. Zimmer, D.G. Duda, T.S. Levchenko, K.S. Cohen, E.B. Brown, D.T. Scadden, V.P. Torchilin, M.G. Bawendi, D. Fukumura, and R.K. Jain Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo Nat Med 11 2005 678 682 A great demonstration of 'made-for-purpose' quantum dot materials. The authors designed quantum dots (both spectrally and as novel materials) to work with second harmonic generation, two photon, and GFP materials, to characterize cell mobility, vascular permeability, and several additional properties of tumors in mice.
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Nat Med
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Cell motility and metastatic potential studies based on quantum dot imaging of phagokinetic tracks
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W.J. Parak, R. Boudreau, M. Le Gros, D. Gerion, D. Zanchet, C.M. Micheel, S.C. Williams, A.P. Alivisatos, and C. Larabell Cell motility and metastatic potential studies based on quantum dot imaging of phagokinetic tracks Adv Mater 14 2002 882 885
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S. Murasawa, A. Kawamoto, M. Horii, S. Nakamori, and T. Asahara Niche-dependent translineage commitment of endothelial progenitor cells, not cell fusion in general, into myocardial lineage cells Arterioscler Thromb Vasc Biol 25 2005 1388 1394 Using commercially available reagents, these authors demonstrated the use of quantum dot labeled cells to determine the frequency of cell-fusion events, an important problem in stem cell biology.
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Optical coding of mammalian cells using semiconductor quantum dots
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L.C. Mattheakis, J.M. Dias, Y.J. Choi, J. Gong, M.P. Bruchez, J. Liu, and E. Wang Optical coding of mammalian cells using semiconductor quantum dots Anal Biochem 327 2004 200 208
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Multicolor coding of cells with cationic peptide coated quantum dots
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B.C. Lagerholm, M. Wang, L.A. Ernst, D.H. Ly, H. Liu, M.P. Bruchez, and A.S. Waggoner Multicolor coding of cells with cationic peptide coated quantum dots Nano Lett 4 2004 2019 2022
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Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules
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M. Han, X. Gao, J.Z. Su, and S. Nie Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules Nat Biotechnol 19 2001 631 635 The first publication really describing the use of multiple quantum dots to discretely 'encode' objects for use in multiplexed assays.
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Nat Biotechnol
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Multiplexed SNP genotyping using the Qbead system: A quantum dot-encoded microsphere-based assay
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H. Xu, M.Y. Sha, E.Y. Wong, J. Uphoff, Y. Xu, J.A. Treadway, A. Truong, E. O'Brien, S. Asquith, M. Stubbins, N.K. Spurr, E.H. Lai, and W. Mahoney Multiplexed SNP genotyping using the Qbead system: a quantum dot-encoded microsphere-based assay Nucleic Acids Research 15 2003 e43
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