Zinc and copper differentially modulate amyloid precursor protein processing by γ-secretase and amyloid-β peptide production

Journal of Biological Chemistry

Volumn 292, Issue 9, 2017, Pages 3751-3767

  Gerber, Hermeto ^a,b,c   Wu, Fang ^b,d   Dimitrov, Mitko ^b   Osuna, Guillermo M Garcia ^b   Fraering, Patrick C ^a,b  

^a Eclosion   (Switzerland)

^b EPFL   (Switzerland)

^c UNIVERSITY OF FRIBOURG   (Switzerland)

^d Chinese National Human Genome Center at Shanghai   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; COPPER; DIMERIZATION; GLYCOPROTEINS; LIPID BILAYERS; NEURODEGENERATIVE DISEASES; PEPTIDES; POLYPEPTIDES; PROTEINS; ZINC;

ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEINS; AMYLOID-BETA PEPTIDES; HISTIDINE RESIDUES; MOLECULAR MECHANISM; PRECURSOR PROTEINS; THERAPEUTIC STRATEGY; TRANS-MEMBRANE DOMAINS;

SUBSTRATES;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID PRECURSOR PROTEIN; COPPER; DIMER; GAMMA SECRETASE; HISTIDINE; LYSINE; MEMBRANE PROTEIN; NICASTRIN; NOTCH RECEPTOR; PRESENILIN; ZINC ION; APP PROTEIN, HUMAN; LIPID BILAYER; NICASTRIN PROTEIN; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; SECRETASE; ZINC;

ALZHEIMER DISEASE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIMERIZATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IC50; LIPID BILAYER; NEUROTOXICITY; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS REGULATION; PROTEIN TARGETING; BRAIN; CELL FREE SYSTEM; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; MUTATION; PLASMID; PROTEIN MULTIMERIZATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; BRAIN; CELL-FREE SYSTEM; COPPER; HEK293 CELLS; HISTIDINE; HUMANS; INHIBITORY CONCENTRATION 50; LIPID BILAYERS; LYSINE; MEMBRANE GLYCOPROTEINS; MUTATION; PEPTIDE FRAGMENTS; PLASMIDS; PRESENILINS; PROTEIN DOMAINS; PROTEIN MULTIMERIZATION; RECOMBINANT PROTEINS; ZINC;

EID: 85014599039     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.754101     Document Type: Article

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