-
1
-
-
79953137657
-
Copper promotes the trafficking of the amyloid precursor protein
-
K.M. Acevedo Y.H. Hung A.H. Dalziel Q.X. Li K. Laughton K. Wikhe A. Rembach B. Roberts C.L. Masters A.I. Bush J. Camakaris Copper promotes the trafficking of the amyloid precursor protein J. Biol. Chem. 286 2011 8252 8262
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 8252-8262
-
-
Acevedo, K.M.1
Hung, Y.H.2
Dalziel, A.H.3
Li, Q.X.4
Laughton, K.5
Wikhe, K.6
Rembach, A.7
Roberts, B.8
Masters, C.L.9
Bush, A.I.10
Camakaris, J.11
-
2
-
-
80053571400
-
N-cadherin enhances APP dimerization at the extracellular domain and modulates Abeta production
-
M. Asada-Utsugi K. Uemura Y. Noda A. Kuzuya M. Maesako K. Ando M. Kubota K. Watanabe M. Takahashi T. Kihara S. Shimohama R. Takahashi O. Berezovska A. Kinoshita N-cadherin enhances APP dimerization at the extracellular domain and modulates Abeta production J. Neurochem. 119 2011 354 363
-
(2011)
J. Neurochem.
, vol.119
, pp. 354-363
-
-
Asada-Utsugi, M.1
Uemura, K.2
Noda, Y.3
Kuzuya, A.4
Maesako, M.5
Ando, K.6
Kubota, M.7
Watanabe, K.8
Takahashi, M.9
Kihara, T.10
Shimohama, S.11
Takahashi, R.12
Berezovska, O.13
Kinoshita, A.14
-
3
-
-
0037931743
-
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis
-
K.J. Barnham W.J. McKinstry G. Multhaup D. Galatis C.J. Morton C.C. Curtain N.A. Williamson A.R. White M.G. Hinds R.S. Norton K. Beyreuther C.L. Masters M.W. Parker R. Cappai Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis J. Biol. Chem. 278 2003 17401 17407
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 17401-17407
-
-
Barnham, K.J.1
McKinstry, W.J.2
Multhaup, G.3
Galatis, D.4
Morton, C.J.5
Curtain, C.C.6
Williamson, N.A.7
White, A.R.8
Hinds, M.G.9
Norton, R.S.10
Beyreuther, K.11
Masters, C.L.12
Parker, M.W.13
Cappai, R.14
-
4
-
-
79955675293
-
Copper in Alzheimer's disease: a meta-analysis of serum, plasma, and cerebrospinal fluid studies
-
S. Bucossi M. Ventriglia V. Panetta C. Salustri P. Pasqualetti S. Mariani M. Siotto P.M. Rossini R. Squitti Copper in Alzheimer's disease: a meta-analysis of serum, plasma, and cerebrospinal fluid studies J. Alzheimers Dis. 24 2011 175 185
-
(2011)
J. Alzheimers Dis.
, vol.24
, pp. 175-185
-
-
Bucossi, S.1
Ventriglia, M.2
Panetta, V.3
Salustri, C.4
Pasqualetti, P.5
Mariani, S.6
Siotto, M.7
Rossini, P.M.8
Squitti, R.9
-
5
-
-
58849090893
-
Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation
-
P.J. Crouch L.W. Hung P.A. Adlard M. Cortes V. Lal G. Filiz K.A. Perez M. Nurjono A. Caragounis T. Du K. Laughton I. Volitakis A.I. Bush Q.X. Li C.L. Masters R. Cappai R.A. Cherny P.S. Donnelly A.R. White K.J. Barnham Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation Proc. Natl. Acad. Sci. U. S. A. 106 2009 381 386
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 381-386
-
-
Crouch, P.J.1
Hung, L.W.2
Adlard, P.A.3
Cortes, M.4
Lal, V.5
Filiz, G.6
Perez, K.A.7
Nurjono, M.8
Caragounis, A.9
Du, T.10
Laughton, K.11
Volitakis, I.12
Bush, A.I.13
Li, Q.X.14
Masters, C.L.15
Cappai, R.16
Cherny, R.A.17
Donnelly, P.S.18
White, A.R.19
Barnham, K.J.20
more..
-
6
-
-
0035421638
-
Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability
-
C. De Jonghe C. Esselens S. Kumar-Singh K. Craessaerts S. Serneels F. Checler W. Annaert C. Van Broeckhoven B. De Strooper Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability Hum. Mol. Genet. 10 2001 1665 1671
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 1665-1671
-
-
De Jonghe, C.1
Esselens, C.2
Kumar-Singh, S.3
Craessaerts, K.4
Serneels, S.5
Checler, F.6
Annaert, W.7
Van Broeckhoven, C.8
De Strooper, B.9
-
7
-
-
57449084208
-
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain
-
R. Deane A. Sagare K. Hamm M. Parisi S. Lane M.B. Finn D.M. Holtzman B.V. Zlokovic apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain J. Clin. Invest. 118 2008 4002 4013
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 4002-4013
-
-
Deane, R.1
Sagare, A.2
Hamm, K.3
Parisi, M.4
Lane, S.5
Finn, M.B.6
Holtzman, D.M.7
Zlokovic, B.V.8
-
10
-
-
84865127699
-
Copper and oxidative stress in the pathogenesis of Alzheimer's disease
-
G. Eskici P.H. Axelsen Copper and oxidative stress in the pathogenesis of Alzheimer's disease Biochemistry 51 2012 6289 6311
-
(2012)
Biochemistry
, vol.51
, pp. 6289-6311
-
-
Eskici, G.1
Axelsen, P.H.2
-
11
-
-
77954344206
-
PBT2 rapidly improves cognition in Alzheimer's disease: additional phase II analyses
-
N.G. Faux C.W. Ritchie A. Gunn A. Rembach A. Tsatsanis J. Bedo J. Harrison L. Lannfelt K. Blennow H. Zetterberg M. Ingelsson C.L. Masters R.E. Tanzi J.L. Cummings C.M. Herd A.I. Bush PBT2 rapidly improves cognition in Alzheimer's disease: additional phase II analyses J. Alzheimers Dis. 20 2010 509 516
-
(2010)
J. Alzheimers Dis.
, vol.20
, pp. 509-516
-
-
Faux, N.G.1
Ritchie, C.W.2
Gunn, A.3
Rembach, A.4
Tsatsanis, A.5
Bedo, J.6
Harrison, J.7
Lannfelt, L.8
Blennow, K.9
Zetterberg, H.10
Ingelsson, M.11
Masters, C.L.12
Tanzi, R.E.13
Cummings, J.L.14
Herd, C.M.15
Bush, A.I.16
-
12
-
-
84869232590
-
Copper signaling in the mammalian nervous system: synaptic effects
-
E.D. Gaier B.A. Eipper R.E. Mains Copper signaling in the mammalian nervous system: synaptic effects J. Neurosci. Res. 91 2013 2 19
-
(2013)
J. Neurosci. Res.
, vol.91
, pp. 2-19
-
-
Gaier, E.D.1
Eipper, B.A.2
Mains, R.E.3
-
13
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
-
J. Hardy D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
14
-
-
0028177269
-
The beta A4 amyloid precursor protein binding to copper
-
L. Hesse D. Beher C.L. Masters G. Multhaup The beta A4 amyloid precursor protein binding to copper FEBS Lett. 349 1994 109 116
-
(1994)
FEBS Lett.
, vol.349
, pp. 109-116
-
-
Hesse, L.1
Beher, D.2
Masters, C.L.3
Multhaup, G.4
-
15
-
-
43749112022
-
Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP
-
D. Kaden L.M. Munter M. Joshi C. Treiber C. Weise T. Bethge P. Voigt M. Schaefer M. Beyermann B. Reif G. Multhaup Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP J. Biol. Chem. 283 2008 7271 7279
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 7271-7279
-
-
Kaden, D.1
Munter, L.M.2
Joshi, M.3
Treiber, C.4
Weise, C.5
Bethge, T.6
Voigt, P.7
Schaefer, M.8
Beyermann, M.9
Reif, B.10
Multhaup, G.11
-
16
-
-
0024362166
-
Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability
-
J. Kardos I. Kovacs F. Hajos M. Kalman M. Simonyi Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability Neurosci. Lett. 103 1989 139 144
-
(1989)
Neurosci. Lett.
, vol.103
, pp. 139-144
-
-
Kardos, J.1
Kovacs, I.2
Hajos, F.3
Kalman, M.4
Simonyi, M.5
-
17
-
-
0042887148
-
Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes
-
A. Kinoshita H. Fukumoto T. Shah C.M. Whelan M.C. Irizarry B.T. Hyman Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes J. Cell Sci. 116 2003 3339 3346
-
(2003)
J. Cell Sci.
, vol.116
, pp. 3339-3346
-
-
Kinoshita, A.1
Fukumoto, H.2
Shah, T.3
Whelan, C.M.4
Irizarry, M.C.5
Hyman, B.T.6
-
18
-
-
39749193587
-
Copper binding to the Alzheimer's disease amyloid precursor protein
-
G.K. Kong L.A. Miles G.A. Crespi C.J. Morton H.L. Ng K.J. Barnham W.J. McKinstry R. Cappai M.W. Parker Copper binding to the Alzheimer's disease amyloid precursor protein Eur. Biophys. J. 37 2008 269 279
-
(2008)
Eur. Biophys. J.
, vol.37
, pp. 269-279
-
-
Kong, G.K.1
Miles, L.A.2
Crespi, G.A.3
Morton, C.J.4
Ng, H.L.5
Barnham, K.J.6
McKinstry, W.J.7
Cappai, R.8
Parker, M.W.9
-
19
-
-
77956276601
-
Insulin regulates presenilin 1 localization via PI3K/Akt signaling
-
M. Maesako K. Uemura M. Kubota K. Ando A. Kuzuya M. Asada T. Kihara A. Kinoshita Insulin regulates presenilin 1 localization via PI3K/Akt signaling Neurosci. Lett. 483 2010 157 161
-
(2010)
Neurosci. Lett.
, vol.483
, pp. 157-161
-
-
Maesako, M.1
Uemura, K.2
Kubota, M.3
Ando, K.4
Kuzuya, A.5
Asada, M.6
Kihara, T.7
Kinoshita, A.8
-
20
-
-
0037160028
-
Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron
-
C.J. Maynard R. Cappai I. Volitakis R.A. Cherny A.R. White K. Beyreuther C.L. Masters A.I. Bush Q.X. Li Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron J. Biol. Chem. 277 2002 44670 44676
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 44670-44676
-
-
Maynard, C.J.1
Cappai, R.2
Volitakis, I.3
Cherny, R.A.4
White, A.R.5
Beyreuther, K.6
Masters, C.L.7
Bush, A.I.8
Li, Q.X.9
-
21
-
-
67650831663
-
Chronic exposure to high levels of zinc or copper has little effect on brain metal homeostasis or Abeta accumulation in transgenic APP-C100 mice
-
C.J. Maynard R. Cappai I. Volitakis K.M. Laughton C.L. Masters A.I. Bush Q.X. Li Chronic exposure to high levels of zinc or copper has little effect on brain metal homeostasis or Abeta accumulation in transgenic APP-C100 mice Cell. Mol. Neurobiol. 29 2009 757 767
-
(2009)
Cell. Mol. Neurobiol.
, vol.29
, pp. 757-767
-
-
Maynard, C.J.1
Cappai, R.2
Volitakis, I.3
Laughton, K.M.4
Masters, C.L.5
Bush, A.I.6
Li, Q.X.7
-
22
-
-
77954132249
-
Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
-
J.J. Palop L. Mucke Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks Nat. Neurosci. 13 2010 812 818
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 812-818
-
-
Palop, J.J.1
Mucke, L.2
-
23
-
-
28644437291
-
The amyloid-beta precursor protein: integrating structure with biological function
-
C. Reinhard S.S. Hebert B. De Strooper The amyloid-beta precursor protein: integrating structure with biological function EMBO J. 24 2005 3996 4006
-
(2005)
EMBO J.
, vol.24
, pp. 3996-4006
-
-
Reinhard, C.1
Hebert, S.S.2
De Strooper, B.3
-
24
-
-
84655164280
-
The role of metallobiology and amyloid-beta peptides in Alzheimer's disease
-
B.R. Roberts T.M. Ryan A.I. Bush C.L. Masters J.A. Duce The role of metallobiology and amyloid-beta peptides in Alzheimer's disease J. Neurochem. 120 Suppl. 1 2012 149 166
-
(2012)
J. Neurochem.
, vol.120
, Issue.Suppl. 1
, pp. 149-166
-
-
Roberts, B.R.1
Ryan, T.M.2
Bush, A.I.3
Masters, C.L.4
Duce, J.A.5
-
25
-
-
0035066332
-
Alzheimer's disease: genes, proteins, and therapy
-
D.J. Selkoe Alzheimer's disease: genes, proteins, and therapy Physiol. Rev. 81 2001 741 766
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
27
-
-
84864572336
-
The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism
-
L. Spoerri L.J. Vella C.L. Pham K.J. Barnham R. Cappai The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism J. Biol. Chem. 287 2012 26840 26853
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 26840-26853
-
-
Spoerri, L.1
Vella, L.J.2
Pham, C.L.3
Barnham, K.J.4
Cappai, R.5
-
28
-
-
84862508553
-
Copper dysfunction in Alzheimer's disease: from meta-analysis of biochemical studies to new insight into genetics
-
R. Squitti Copper dysfunction in Alzheimer's disease: from meta-analysis of biochemical studies to new insight into genetics J. Trace Elem. Med. Biol. 26 2012 93 96
-
(2012)
J. Trace Elem. Med. Biol.
, vol.26
, pp. 93-96
-
-
Squitti, R.1
-
29
-
-
84863595757
-
Alzheimer's amyloid beta (Abeta) prions
-
J. Stohr J.C. Watts Z.L. Mensinger A. Oehler S.K. Grillo S.J. DeArmond S.B. Prusiner K. Giles Purified synthetic Alzheimer's amyloid beta (Abeta) prions Proc. Natl. Acad. Sci. U. S. A. 109 2012 11025 11030
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 11025-11030
-
-
Stohr, J.1
Watts, J.C.2
Mensinger, Z.L.3
Oehler, A.4
Grillo, S.K.5
DeArmond, S.J.6
Prusiner, S.B.7
Giles, K.8
Purified9
synthetic10
-
30
-
-
78149282621
-
Impairment of recognition memory and hippocampal long-term potentiation after acute exposure to clioquinol
-
A. Takeda S. Takada M. Ando K. Itagaki H. Tamano M. Suzuki H. Iwaki N. Oku Impairment of recognition memory and hippocampal long-term potentiation after acute exposure to clioquinol Neuroscience 171 2010 443 450
-
(2010)
Neuroscience
, vol.171
, pp. 443-450
-
-
Takeda, A.1
Takada, S.2
Ando, M.3
Itagaki, K.4
Tamano, H.5
Suzuki, M.6
Iwaki, H.7
Oku, N.8
-
31
-
-
78650047391
-
Substrate docking to gamma-secretase allows access of gamma-secretase modulators to an allosteric site
-
K. Uemura K.C. Farner T. Hashimoto N. Nasser-Ghodsi M.S. Wolfe E.H. Koo B.T. Hyman O. Berezovska Substrate docking to gamma-secretase allows access of gamma-secretase modulators to an allosteric site Nat. Commun. 1 2010 130
-
(2010)
Nat. Commun.
, vol.1
, pp. 130
-
-
Uemura, K.1
Farner, K.C.2
Hashimoto, T.3
Nasser-Ghodsi, N.4
Wolfe, M.S.5
Koo, E.H.6
Hyman, B.T.7
Berezovska, O.8
-
32
-
-
0029964789
-
Copper modulation of NMDA responses in mouse and rat cultured hippocampal neurons
-
V. Vlachova H. Zemkova L. Vyklicky Jr. Copper modulation of NMDA responses in mouse and rat cultured hippocampal neurons Eur. J. Neurosci. 8 1996 2257 2264
-
(1996)
Eur. J. Neurosci.
, vol.8
, pp. 2257-2264
-
-
Vlachova, V.1
Zemkova, H.2
Vyklicky, L.3
-
33
-
-
0032830357
-
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice
-
A.R. White R. Reyes J.F. Mercer J. Camakaris H. Zheng A.I. Bush G. Multhaup K. Beyreuther C.L. Masters R. Cappai Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice Brain Res. 842 1999 439 444
-
(1999)
Brain Res.
, vol.842
, pp. 439-444
-
-
White, A.R.1
Reyes, R.2
Mercer, J.F.3
Camakaris, J.4
Zheng, H.5
Bush, A.I.6
Multhaup, G.7
Beyreuther, K.8
Masters, C.L.9
Cappai, R.10
-
34
-
-
84863116075
-
Abeta neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-d-aspartate receptors
-
H. You S. Tsutsui S. Hameed T.J. Kannanayakal L. Chen P. Xia J.D. Engbers S.A. Lipton P.K. Stys G.W. Zamponi Abeta neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl- d -aspartate receptors Proc. Natl. Acad. Sci. U. S. A. 109 2012 1737 1742
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 1737-1742
-
-
You, H.1
Tsutsui, S.2
Hameed, S.3
Kannanayakal, T.J.4
Chen, L.5
Xia, P.6
Engbers, J.D.7
Lipton, S.A.8
Stys, P.K.9
Zamponi, G.W.10
|