Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila

FASEB Journal

Volumn 25, Issue 7, 2011, Pages 2287-2295

  Alattia, Jean René ^a   Kuraishi, Takayuki ^a   Dimitrov, Mitko ^a   Chang, Isabelle ^a   Lemaitre, Bruno ^a   Fraering, Patrick C ^a  

^a EPFL   (Switzerland)

Author keywords

Embryonic neurodevelopment; Enzyme assay; Metal toxicity; Notch signaling

Indexed keywords

AMYLOID BETA PROTEIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; MERCURY; NOTCH RECEPTOR;

ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME INHIBITION; INSECT DEVELOPMENT; MERCURIALISM; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BLOTTING, WESTERN; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MERCURY; METHYLMERCURY COMPOUNDS; NERVOUS SYSTEM DISEASES; RECEPTORS, NOTCH; WING;

DROSOPHILA MELANOGASTER;

EID: 79960170037     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-174078     Document Type: Article

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