The lipidome associated with the ? -secretase complex is required for its integrity and activity

Biochemical Journal

Volumn 473, Issue 3, 2016, Pages 321-334

  Ayciriex, Sophie ^a   Gerber, Hermeto ^b   Osuna, Guillermo M Garcia ^b   Chami, Mohamed ^c   Stahlberg, Henning ^c   Shevchenko, Andrej ^a   Fraering, Patrick C ^b  

^a MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^b EPFL   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Intramembrane cleaving protease; Lipid microenvironment; Lipid species; Mass spectrometry; Proteoliposomes; Quantitative shotgun lipidomics; secretase

Indexed keywords

CHOLESTEROL; GAMMA SECRETASE; LIPIDOME; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; PROTEASOME; PROTEOLIPOSOME; AMYLOID PRECURSOR PROTEIN; PROTEOLIPID; PROTEOLIPOSOMES; SECRETASE;

ANIMAL CELL; ARTICLE; CHO CELL LINE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME STRUCTURE; FEMALE; IMMUNOPRECIPITATION; LIPID COMPOSITION; LIPIDOMICS; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING; ALZHEIMER DISEASE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; HUMAN; LIPID METABOLISM; METABOLISM;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; HUMANS; LIPID METABOLISM; PROTEOLIPIDS; SUBSTRATE SPECIFICITY;

EID: 84957922422     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20150448     Document Type: Article

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