Processing of the synaptic cell adhesion molecule neurexin-3β by Alzheimer disease α- and γ-secretases

Journal of Biological Chemistry

Volumn 286, Issue 4, 2011, Pages 2762-2773

  Bot, Nathalie ^a   Schweizer, Claude ^a   Halima, Saoussen Ben ^a,b   Fraering, Patrick C ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AUTISM SPECTRUM DISORDERS; CATALYTIC SUBUNITS; CELL ADHESION MOLECULES; ELECTROPHYSIOLOGICAL STUDIES; EXTRACELLULAR DOMAINS; FUNCTIONAL UNITS; GENOME-WIDE ASSOCIATION; IN-VIVO; N-TERMINALS; NEUREXINS; NEUROLIGINS; PRESYNAPTIC; SECRETASES; SIGNAL TRANSDUCTION PATHWAYS; SPECIFIC BINDING; SYNAPTIC CLEFT;

BIOMOLECULES; CELL ADHESION; ELECTROPHYSIOLOGY; ENZYME ACTIVITY; SIGNAL TRANSDUCTION;

ADHESION;

ALPHA SECRETASE; GAMMA SECRETASE; NEUREXIN; NEUREXIN 3BETA; NEUROLIGIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CATALYSIS; CELL STRAIN HEK293; CHO CELL; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENE MUTATION; HELA CELL; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ACTIVATED-LEUKOCYTE CELL ADHESION MOLECULE; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CATALYTIC DOMAIN; CHO CELLS; CRICETINAE; CRICETULUS; HEK293 CELLS; HUMANS; MICE; MUTATION; NERVE TISSUE PROTEINS; PROTEIN STRUCTURE, TERTIARY; SYNAPSES;

EID: 78951488794     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.142521     Document Type: Article

References (65)

1. Missler, M., Fernandez-Chacon, R., and Südhof, T. C. (1998) J. Neurochem. 71, 1339-1347
2. Rowen, L., Young, J., Birditt, B., Kaur, A., Madan, A., Philipps, D. L., Qin, S., Minx, P., Wilson, R. K., Hood, L., and Graveley, B. R. (2002) Genomics 79, 587-597
3. Ushkaryov, Y. A., and Südhof, T. C. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 6410-6414
4. Missler, M., and Südhof, T. C. (1998) Trends Genet 14, 20-26
5. de Wit, J., Sylwestrak, E., O'Sullivan, M. L., Otto, S., Tiglio, K., Savas, J. N., Yates, J. R., 3rd, Comoletti, D., Taylor, P., and Ghosh, A. (2009) Neuron 64, 799-806
6. Ko, J., Fuccillo, M. V., Malenka, R. C., and Südhof, T. C. (2009) Neuron 64, 791-798
7. Uemura, T., Lee, S. J., Yasumura, M., Takeuchi, T., Yoshida, T., Ra, M., Taguchi, R., Sakimura, K., and Mishina, M. (2010) Cell 141, 1068-1079
8. Zhang, C., Atasoy, D., Araç, D., Yang, X., Fucillo, M. V., Robison, A. J., Ko, J., Brunger, A. T., and Südhof, T. C. (2010) Neuron 66, 403-416
9. Scheiffele, P., Fan, J., Choih, J., Fetter, R., and Serafini, T. (2000) Cell 101, 657-669
10. Graf, E. R., Zhang, X., Jin, S. X., Linhoff, M. W., and Craig, A. M. (2004) Cell 119, 1013-1026
11. Nam, C. I., and Chen, L. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 6137-6142
12. Levinson, J. N., and El-Husseini, A. (2005) Neuron 48, 171-174
13. Song, J. Y., Ichtchenko, K., Südhof, T. C., and Brose, N. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 1100-1105
14. Bourgeron, T. (2009) Curr. Opin Neurobiol. 19, 231-234
15. Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., Nelson, N., Boiani, N., Schooley, K. A., Gerhart, M., Davis, R., Fitzner, J. N., Johnson, R. S., Paxton, R. J., March, C. J., and Cerretti, D. P. (1997) Nature 385, 729-733
16. Moss, M. L., Jin, S. L., Becherer, J. D., Bickett, D. M., Burkhart, W., Chen, W. J., Hassler, D., Leesnitzer, M. T., McGeehan, G., Milla, M., Moyer, M., Rocque, W., Seaton, T., Schoenen, F., Warner, J., and Willard, D. (1997) J. Neuroimmunol. 72, 127-129
17. Blobel, C. P. (2000) Curr. Opin Cell Biol. 12, 606-612
18. Cho, R. W., Park, J. M., Wolff, S. B., Xu, D., Hopf, C., Kim, J. A., Reddy, R. C., Petralia, R. S., Perin, M. S., Linden, D. J., and Worley, P. F. (2008) Neuron 57, 858-871
19. Hinkle, C. L., Diestel, S., Lieberman, J., and Maness, P. F. (2006) J. Neurobiol. 66, 1378-1395
20. Kalus, I., Bormann, U., Mzoughi, M., Schachner, M., and Kleene, R. (2006) J. Neurochem. 98, 78-88
21. Maretzky, T., Schulte, M., Ludwig, A., Rose-John, S., Blobel, C., Hartmann, D., Altevogt, P., Saftig, P., and Reiss, K. (2005) Mol. Cell. Biol. 25, 9040-9053
22. Tanabe, Y., Kasahara, T., Momoi, T., and Fujita, E. (2008) Neurosci. Lett. 444, 16-21
23. Fraering, P. C. (2007) Curr. Genomics 8, 531-549
24. Kim, D. Y., Carey, B. W., Wang, H., Ingano, L. A., Binshtok, A. M., Wertz, M. H., Pettingell, W. H., He, P., Lee, V. M., Woolf, C. J., and Kovacs, D. M. (2007) Nat. Cell Biol. 9, 755-764
25. Savonenko, A. V., Melnikova, T., Laird, F. M., Stewart, K. A., Price, D. L., and Wong, P. C. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 5585-5590
26. Laird, F. M., Cai, H., Savonenko, A. V., Farah, M. H., He, K., Melnikova, T., Wen, H., Chiang, H. C., Xu, G., Koliatsos, V. E., Borchelt, D. R., Price, D. L., Lee, H. K., and Wong, P. C. (2005) J. Neurosci. 25, 11693-11709
27. Ohno, M., Sametsky, E. A., Younkin, L. H., Oakley, H., Younkin, S. G., Citron, M., Vassar, R., and Disterhoft, J. F. (2004) Neuron 41, 27-33
28. Wang, H., Song, L., Laird, F., Wong, P. C., and Lee, H. K. (2008) J. Neurosci. 28, 8677-8681
29. Harrison, S. M., Harper, A. J., Hawkins, J., Duddy, G., Grau, E., Pugh, P. L., Winter, P. H., Shilliam, C. S., Hughes, Z. A., Dawson, L. A., Gonzalez, M. I., Upton, N., Pangalos, M. N., and Dingwall, C. (2003) Mol. Cell. Neurosci. 24, 646-655
30. Rockenstein, E., Mante, M., Alford, M., Adame, A., Crews, L., Hashimoto, M., Esposito, L., Mucke, L., and Masliah, E. (2005) J. Biol. Chem. 280, 32957-32967
31. Saura, C. A., Choi, S. Y., Beglopoulos, V., Malkani, S., Zhang, D., Shankaranarayana Rao, B. S., Chattarji, S., Kelleher, R. J., 3rd, Kandel, E. R., Duff, K., Kirkwood, A., and Shen, J. (2004) Neuron 42, 23-36
32. Zhang, C., Wu, B., Beglopoulos, V., Wines-Samuelson, M., Zhang, D., Dragatsis, I., Südhof, T. C., and Shen, J. (2009) Nature 460, 632-636
33. Ullrich, B., Ushkaryov, Y. A., and Südhof, T. C. (1995) Neuron 14, 497-507
34. Dull, T., Zufferey, R., Kelly, M., Mandel, R. J., Nguyen, M., Trono, D., and Naldini, L. (1998) J. Virol. 72, 8463-8471
35. Liao, Y. F., Wang, B. J., Cheng, H. T., Kuo, L. H., and Wolfe, M. S. (2004) J. Biol. Chem. 279, 49523-49532
36. Beel, A. J., Mobley, C. K., Kim, H. J., Tian, F., Hadziselimovic, A., Jap, B., Prestegard, J. H., and Sanders, C. R. (2008) Biochemistry 47, 9428-9446
37. Cacquevel, M., Aeschbach, L., Osenkowski, P., Li, D., Ye, W., Wolfe, M. S., Li, H., Selkoe, D. J., and Fraering, P. C. (2008) J. Neurochem. 104, 210-220
38. Marambaud, P., Wen, P. H., Dutt, A., Shioi, J., Takashima, A., Siman, R., and Robakis, N. K. (2003) Cell 114, 635-645
39. Fortini, M. E. (2002) Nat. Rev. Mol. Cell Biol. 3, 673-684
40. Selkoe, D. J., and Wolfe, M. S. (2007) Cell 131, 215-221
41. Herreman, A., Hartmann, D., Annaert, W., Saftig, P., Craessaerts, K., Serneels, L., Umans, L., Schrijvers, V., Checler, F., Vanderstichele, H., Baekelandt, V., Dressel, R., Cupers, P., Huylebroeck, D., Zwijsen, A., Van Leuven, F., and De Strooper, B. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 11872-11877
42. Herreman, A., Van Gassen, G., Bentahir, M., Nyabi, O., Craessaerts, K., Mueller, U., Annaert, W., and De Strooper, B. (2003) J. Cell Sci. 116, 1127-1136
43. Cupers, P., Orlans, I., Craessaerts, K., Annaert, W., and De Strooper, B. (2001) J. Neurochem. 78, 1168-1178
44. Fraering, P. C., Ye, W., Strub, J. M., Dolios, G., LaVoie, M. J., Ostaszewski, B. L., van Dorsselaer, A., Wang, R., Selkoe, D. J., and Wolfe, M. S. (2004) Biochemistry 43, 9774-9789
45. Kaimori, J. Y., Nagasawa, Y., Menezes, L. F., Garcia-Gonzalez, M. A., Deng, J., Imai, E., Onuchic, L. F., Guay-Woodford, L. M., and Germino, G. G. (2007) Hum. Mol. Genet. 16, 942-956
46. Dean, C., and Dresbach, T. (2006) Trends Neurosci. 29, 21-29
47. Dean, C., Scholl, F. G., Choih, J., DeMaria, S., Berger, J., Isacoff, E., and Scheiffele, P. (2003) Nat. Neurosci. 6, 708-716
48. Missler, M., Zhang, W., Rohlmann, A., Kattenstroth, G., Hammer, R. E., Gottmann, K., and Südhof, T. C. (2003) Nature 423, 939-948
49. Lisé, M. F., and El-Husseini, A. (2006) Cell. Mol. Life Sci. 63, 1833-1849
50. Hata, Y., Butz, S., and Südhof, T. C. (1996) J. Neurosci. 16, 2488-2494
51. Levinson, J. N., Chéry, N., Huang, K., Wong, T. P., Gerrow, K., Kang, R., Prange, O., Wang, Y. T., and El-Husseini, A. (2005) J. Biol. Chem. 280, 17312-17319
52. Hishimoto, A., Liu, Q. R., Drgon, T., Pletnikova, O., Walther, D., Zhu, X. G., Troncoso, J. C., and Uhl, G. R. (2007) Hum. Mol. Genet. 16, 2880-2891
53. Fortini, M. E. (2009) Dev. Cell 16, 633-647
54. Kenchappa, R. S., Zampieri, N., Chao, M. V., Barker, P. A., Teng, H. K., Hempstead, B. L., and Carter, B. D. (2006) Neuron 50, 219-232
55. Kim, D. Y., Ingano, L. A., Carey, B. W., Pettingell, W. H., and Kovacs, D. M. (2005) J. Biol. Chem. 280, 23251-23261
56. Liu, Q., Zerbinatti, C. V., Zhang, J., Hoe, H. S., Wang, B., Cole, S. L., Herz, J., Muglia, L., and Bu, G. (2007) Neuron 56, 66-78
57. Biederer, T., and Südhof, T. C. (2000) J. Biol. Chem. 275, 39803-39806
58. Cheng, S. B., Amici, S. A., Ren, X. Q., McKay, S. B., Treuil, M. W., Lindstrom, J. M., Rao, J., and Anand, R. (2009) J. Biol. Chem. 284, 23251-23259
59. Moehlmann, T., Winkler, E., Xia, X., Edbauer, D., Murrell, J., Capell, A., Kaether, C., Zheng, H., Ghetti, B., Haass, C., and Steiner, H. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 8025-8030
60. Bentahir, M., Nyabi, O., Verhamme, J., Tolia, A., Horré, K., Wiltfang, J., Esselmann, H., and De Strooper, B. (2006) J. Neurochem. 96, 732-742
61. Jamain, S., Quach, H., Betancur, C., Råstam, M., Colineaux, C., Gillberg, I. C., Soderstrom, H., Giros, B., Leboyer, M., Gillberg, C., and Bourgeron, T. (2003) Nat. Genet. 34, 27-29
62. Kim, H. G., Kishikawa, S., Higgins, A. W., Seong, I. S., Donovan, D. J., Shen, Y., Lally, E., Weiss, L. A., Najm, J., Kutsche, K., Descartes, M., Holt, L., Braddock, S., Troxell, R., Kaplan, L., Volkmar, F., Klin, A., Tsatsanis, K., Harris, D. J., Noens, I., Pauls, D. L., Daly, M. J., MacDonald, M. E., Morton, C. C., Quade, B. J., and Gusella, J. F. (2008) Am. J. Hum. Genet. 82, 199-207
63. Szatmari, P., Paterson, A. D., Zwaigenbaum, L., Roberts, W., Brian, J., Liu, X. Q., Vincent, J. B., Skaug, J. L., Thompson, A. P., Senman, L., Feuk, L., Qian, C., Bryson, S. E., Jones, M. B., Marshall, C. R., Scherer, S. W., Vieland, V. J., Bartlett, C., Mangin, L. V., Goedken, R., Segre, A., Pericak- Vance, M. A., Cuccaro, M. L., Gilbert, J. R., Wright, H. H., Abramson, R. K., Betancur, C., Bourgeron, T., Gillberg, C., Leboyer, M., Buxbaum, J. D., Davis, K. L., Hollander, E., Silverman, J. M., Hallmayer, J., Lotspeich, L., Sutcliffe, J. S., Haines, J. L., Folstein, S. E., Piven, J., Wassink, T. H., Sheffield, V., Geschwind, D. H., Bucan, M., Brown, W. T., Cantor, R. M., Constantino, J. N., Gilliam, T. C., Herbert, M., Lajonchere, C., Ledbetter, D. H., Lese-Martin, C., Miller, J., Nelson, S., Samango- Sprouse, C. A., Spence, S., State, M., Tanzi, R. E., Coon, H., Dawson, G., Devlin, B., Estes, A., Flodman, P., Klei, L., McMahon, W. M., Minshew, N., Munson, J., Korvatska, E., Rodier, P. M., Schellenberg, G. D., Smith, M., Spence, M. A., Stodgell, C., Tepper, P. G., Wijsman, E. M., Yu, C. E., Rogé, B., Mantoulan, C., Wittemeyer, K., Poustka, A., Felder, B., Klauck, S. M., Schuster, C., Poustka, F., Bölte, S., Feineis-Matthews, S., Herbrecht, E., Schmötzer, G., Tsiantis, J., Papanikolaou, K., Maestrini, E., Bacchelli, E., Blasi, F., Carone, S., Toma, C., Van Engeland, H., de Jonge, M., Kemner, C., Koop, F., Langemeijer, M., Hijmans, C., Staal, W. G., Baird, G., Bolton, P. F., Rutter, M. L., Weisblatt, E., Green, J., Aldred, C., Wilkinson, J. A., Pickles, A., Le Couteur, A., Berney, T., McConachie, H., Bailey, A. J., Francis, K., Honeyman, G., Hutchinson, A., Parr, J. R., Wallace, S., Monaco, A. P., Barnby, G., Kobayashi, K., Lamb, J. A., Sousa, I., Sykes, N., Cook, E. H., Guter, S. J., Leventhal, B. L., Salt, J., Lord, C., Corsello, C., Hus, V., Weeks, D. E., Volkmar, F., Tauber, M., Fombonne, E., Shih, A., and Meyer, K. J. (2007) Nat. Genet. 39, 319-328
64. Ushkaryov, Y. A., Hata, Y., Ichtchenko, K., Moomaw, C., Afendis, S., Slaughter, C. A., and Südhof, T. C. (1994) J. Biol. Chem. 269, 11987-11992
65. Miller, R. K., Qadota, H., Stark, T. J., Mercer, K. B., Wortham, T. S., Anyanful, A., and Benian, G. M. (2009) Mol. Biol. Cell 20, 3608-3616