Metal-associated amyloid-β species in Alzheimer's disease

Current Opinion in Chemical Biology

Volumn 16, Issue 1-2, 2012, Pages 67-73

  Pithadia, Amit S ^a   Lim, Mi Hee ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ASCORBIC ACID; CATALASE; CLIOQUINOL; COPPER; HISTIDINE; IRON; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; ZINC;

ALZHEIMER DISEASE; APOPTOSIS; BLOOD BRAIN BARRIER; CARBOXY TERMINAL SEQUENCE; CELL DEATH; COGNITIVE DEFECT; HUMAN; METAL BINDING; NERVE CELL; NEUROBLASTOMA CELL; NEUROPATHOLOGY; NEUROTOXICITY; NEUROTRANSMISSION; OXIDATIVE STRESS; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW;

ALZHEIMER DISEASE; AMYLOID; HUMANS; METALS; REACTIVE OXYGEN SPECIES;

EID: 84859651929     PISSN: 13675931     EISSN: 18790402     Source Type: Journal    
DOI: 10.1016/j.cbpa.2012.01.016     Document Type: Review

References (47)

1. Alzheimer's Association Alzheimer's disease facts and figures. Alzheimers Dement 2011, 7:208-244.
2. Jakob-Roetne R., Jacobsen H. Alzheimer's disease: from pathology to therapeutic approaches. Angew Chem Int Ed 2009, 48:3030-3059.
3. Rauk A. The chemistry of Alzheimer's disease. Chem Soc Rev 2009, 38:2698-2715.
4. Hardy J.A., Higgins G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science 1992, 256:184-185.
5. Wang Y.-J., Zhou H.-D., Zhou X.-F. Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives. Drug Discov Today 2006, 11:931-938.
6. Kurz A., Perneczky R. Amyloid clearance as a treatment target against Alzheimer's disease. J Alzheimers Dis 2011, 24:61-73.
7. Scott L.E., Orvig C. Medicinal inorganic chemistry approaches to passivation and removal of aberrant metal ions in disease. Chem Rev 2009, 109:4885-4910.
8. Maynard C.J., Bush A.I., Masters C.L., Cappai R., Li Q.-X. Metals and amyloid-β in Alzheimer's disease. Int J Exp Pathol 2005, 86:147-159.
9. Smith D.G., Cappai R., Barnham K.J. The redox chemistry of the Alzheimer's disease amyloid β peptide. Biochim Biophys Acta 2007, 1768:1976-1990.
10. Zatta P., Drago D., Bolognin S., Sensi S.L. Alzheimer's disease, metal ions and metal homeostatic therapy. Trends Pharmacol Sci 2009, 30:346-355.
11. Hureau C., Faller P. Aβ-mediated ROS production by Cu ions: structural insights, mechanisms and relevance to Alzheimer's disease. Biochimie 2009, 91:1212-1217.
12. Bonda D.J., Lee H.-g., Blair J.A., Zhu X., Perry G., Smith M.A. Role of metal dyshomeostasis in Alzheimer's disease. Metallomics 2011, 3:267-270.
13. Jomova K., Valko M. Advances in metal-induced oxidative stress and human diseases. Toxicology 2011, 283:65-87.
14. DeToma A.S., Salamekh S., Ramamoorthy A., Lim M.H. Misfolded proteins in Alzheimer's disease and type II diabetes. Chem Soc Rev 2012, 41:608-621.
15. Zhu X., Su B., Wang X., Smith M.A., Perry G. Causes of oxidative stress in Alzheimer's disease. Cell Mol Life Sci 2007, 64:2202-2210.
16. Haass C., Selkoe D.J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide. Nat Rev Mol Cell Biol 2007, 8:101-112.
17. Lippard S.J., Berg J.M. Principles of Bioinorganic Chemistry 1994, University Science Books.
18. Bertini I., Gray H.B., Stiefel E.I., Valentine J.S. Biological Inorganic Chemistry: Structure and Reactivity 2007, University Science Books.
19. Burdette S.C., Lippard S.J. Meeting of the minds: metalloneurochemistry. Proc Natl Acad Sci USA 2003, 100:3605-3610.
20. Que E.L., Domaille D.W., Chang C.J. Metals in neurobiology: probing their chemistry and biology with molecular imaging. Chem Rev 2008, 108:1517-1549.
21. Bush A.I., Tanzi R.E. Therapeutics for Alzheimer's disease based on the metal hypothesis. Neurotherapeutics 2008, 5:421-432.
22. Frederickson C.J., Koh J.-Y., Bush A.I. The neurobiology of zinc in health and disease. Nat Rev Neurosci 2005, 6:449-462.
23. Faller P. Copper and zinc binding to amyloid-β: coordination, dynamics, aggregation, reactivity and metal-ion transfer. ChemBioChem 2009, 10:2837-2845.
24. Faller P., Hureau C. Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide. Dalton Trans 2009, 1080-1094.
25. Gaggelli E., Kozlowski H., Valensin D., Valensin G. Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyothrophic lateral sclerosis). Chem Rev 2006, 106:1995-2044.
26. 2+ interactions with Alzheimer's amyloid-β peptide. Acc Chem Res 2011, 44:1146-1155.
27. Karr J.W., Szalai V.A. Cu(II) binding to monomeric, oligomeric, and fibrillar forms of the Alzheimer's disease amyloid-β peptide. Biochemistry 2008, 47:5006-5016.
28. Dorlet P., Gambarelli S., Faller P., Hureau C. Pulse EPR spectroscopy reveals the coordination sphere of copper(II) ions in the 1-16 amyloid-β peptide: a key role of the first two N-terminus residues. Angew Chem Int Ed 2009, 48:9273-9276.
29. I in a linear bis-His coordination environment: insight into a possible neuroprotective mechanism for the amyloid-β peptide. J Am Chem Soc 2008, 130:17826-17835.
30. Himes R.A., Park G.Y., Siluvai G.S., Blackburn N.J., Karlin K.D. Structural studies of copper(I) complexes of amyloid-β peptide fragments: formation of two-coordinate bis(histidine) complexes. Angew Chem Int Ed 2008, 47:9084-9087.
31. Shearer J., Callan P.E., Tran T., Szalai V.A. Cu K-edge X-ray absorption spectroscopy reveals differential copper coordination within amyloid-β oligomers compared to amyloid-β monomers. Chem Commun 2010, 46:9137-9139.
32. + for the copper-binding domain of amyloid-β peptide of Alzheimer's disease. Inorg Chem 2011, 50:1614-1618.
33. Bousejra-ElGarah F., Bijani C., Coppel Y., Faller P., Hureau C. Iron(II) binding to amyloid-β, the Alzheimer's peptide. Inorg Chem 2011, 50:9024-9030.
34. Noy D., Solomonov I., Sinkevich O., Arad T., Kjaer K., Sagi I. Zinc-amyloid β interactions on a millisecond time-scale stabilize non-fibrillar Alzheimer-related species. J Am Chem Soc 2008, 130:1376-1383.
35. 3+ on amyloid-β stability, oligomerization, and aggregation. J Biol Chem 2011, 286:9646-9656.
36. Pramanik D., Dey S.G. Active site environment of heme-bound amyloid β peptide associated with Alzheimer's disease. J Am Chem Soc 2011, 133:81-87.
37. Atamna H., Boyle K. Amyloid-β peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease. Proc Natl Acad Sci USA 2006, 103:3381-3386.
38. Atamna H. Heme binding to amyloid β peptide: mechanistic role in Alzheimer's disease. J Alzheimers Dis 2006, 10:255-266.
39. Hureau C., Sasaki I., Gras E., Faller P. Two functions, one molecule: a metal-binding and a targeting moiety to combat Alzheimer's disease. ChemBioChem 2010, 11:950-953.
40. Braymer J.J., DeToma A.S., Choi J.-S., Ko K.S., Lim M.H. Recent development of bifunctional small molecules to study metal-amyloid-β species in Alzheimer's disease. Int J Alzheimers Dis 2011, 623051.
41. Perez L.R., Franz K.J. Minding metals: tailoring chelating agents for neurodegenerative disease. Dalton Trans 2010, 39:2177-2187.
42. Cherny R.A., Atwood C.S., Xilinas M.E., Gray D.N., Jones W.D., McLean C.A., Barnham K.J., Volitakis I., Fraser F.W., Kim Y.-S., et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 2001, 30:665-676.
43. Adlard P.A., Cherny R.A., Finkelstein D.I., Gautier E., Robb E., Cortes M., Volitakis I., Liu X., Smith J.P., Perez K., et al. Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Aβ. Neuron 2008, 59:43-55.
44. Kung H.F., Lee C.-W., Zhuang Z.-P., Kung M.-P., Hou C., Plössl K. Novel stilbenes as probes for amyloid plaques. J Am Chem Soc 2001, 123:12740-12741.
45. Ono K., Hasegawa K., Naiki H., Yamada M. Curcumin has potent anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro. J Neurosci Res 2004, 75:742-750.
46. Wu W.-h., Lei P., Liu Q., Hu J., Gunn A.P., Chen M.-s., Rui Y.-f., Su X.-y., Xie Z.-p., Zhao Y.-F., et al. Sequestration of copper from β-amyloid promotes selective lysis by cyclen-hybrid cleave agents. J Biol Chem 2008, 283:31657-31664.
47. Choi J.-S., Braymer J.J., Nanga R.P.R., Ramamoorthy A., Lim M.H. Design of small molecules that target metal-Aβ species and regulate metal-induced Aβ aggregation and neurotoxicity. Proc Natl Acad Sci USA 2010, 107:21990-21995.