Trending Cardiovascular Nutrition Controversies

Journal of the American College of Cardiology

Volumn 69, Issue 9, 2017, Pages 1172-1187

  Freeman, Andrew M ^a   Morris, Pamela B ^b   Barnard, Neal ^c   Esselstyn, Caldwell B ^d   Ros, Emilio ^e   Agatston, Arthur ^f   Devries, Stephen ^g,h   O'Keefe, James ⁱ   Miller, Michael ^j   Ornish, Dean ^k   Williams, Kim ^l   Kris Etherton, Penny ^m  

^a DEPARTMENT OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

^e HOSPITAL CLÍNIC   (Spain)

^f FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^g Gaples Institute for Integrative Cardiology   (United States)

^h NORTHWESTERN UNIVERSITY   (United States)

ⁱ SAINT LUKE S MID AMERICA HEART INSTITUTE   (United States)

^j UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^k UNIVERSITY OF CALIFORNIA   (United States)

^l RUSH UNIVERSITY MEDICAL CENTER   (United States)

^m PENNSYLVANIA STATE UNIVERSITY   (United States)

more..

Author keywords

cardiovascular risk; fats; green leafy vegetables; healthy dietary patterns; nutrition

Indexed keywords

ALPHA TOCOPHEROL; CANOLA OIL; COCONUT OIL; GLUTEN; OLIVE OIL; OMEGA 3 FATTY ACID; PALM OIL; SUNFLOWER OIL;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL DIET; CORONARY ARTERY ATHEROSCLEROSIS; DIETARY INTAKE; DIETARY SUPPLEMENT; EGG; FRUIT; HEART INFARCTION; HUMAN; ISCHEMIC HEART DISEASE; LEAFY VEGETABLE; MEDITERRANEAN DIET; NUT; NUTRITION; REVIEW; RISK REDUCTION; VEGETABLE; VEGETARIAN DIET; WEIGHT REDUCTION; CARDIOVASCULAR DISEASES; DIET;

CARDIOVASCULAR DISEASES; DIET; HUMANS;

EID: 85014084332     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2016.10.086     Document Type: Review

References (146)

1. 1 Eckel, R.H., Jakicic, J.M., Ard, J.D., et al. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology American/Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 63 (2014), 2960–2984.
2. 2 U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 2010. 7th edition, December 2010, U.S. Government Printing Office, Washington, DC.
3. 3 U.S. Department of Agriculture and U.S. Department of Health and Human Services. Scientific Report of the 2015 Dietary Guidelines Advisory Committee. Part A. Executive Summary. Available at: http://www.health.gov/dietaryguidelines/2015-scientific-report/02-executive-summary.asp. Accessed January 5, 2017.
4. 4 Gidding, S.S., Lichtenstein, A.H., Faith, M.S., et al. Implementing American Heart Association pediatric and adult nutrition guidelines: a scientific statement from the American Heart Association Nutrition Committee of the Council on Nutrition, Physical Activity and Metabolism, Council on Cardiovascular Disease in the Young, Council on Arteriosclerosis, Thrombosis and Vascular Biology, Council on Cardiovascular Nursing, Council on Epidemiology and Prevention, and Council for High Blood Pressure Research. Circulation 119 (2009), 1161–1175.
5. 5 Expert Panel on Integrated Guidelines for CV Health and Risk Reduction in Children and Adolescents; National Heart, Lung, and Blood Institute. Expert panel on integrated guidelines for CV health and risk reduction in children and adolescents: summary report. Pediatrics 128 Suppl 5 (2011), S213–S256.
6. 6 Maki, K.C., Slavin, J.L., Rains, T.M., et al. Limitations of observational evidence: implications for evidence-based dietary recommendations. Adv Nutr 5 (2014), 7–15.
7. 7 Willett, W.C., Nutrition and chronic disease. Public Health Rev 26 (1998), 9–10.
8. 8 Byers, T., The role of epidemiology in developing nutritional recommendations: past, present, and future. Am J Clin Nutr 69 (1999), 1304S–1308S.
9. 9 Davies, H.T., Crombie, I.K., Bias in case-control studies. Hosp Med 61 (2000), 279–281.
10. 10 Kearns, C.E., Schmidt, L.A., Glantz, S.A., Sugar industry and coronary heart disease research: a historical analysis of internal industry documents. JAMA Intern Med 176 (2016), 1680–1685.
11. 11 U.S. Department of Health and Human Services and U.S. Department of Agriculture. 2015-2020 Dietary Guidelines for Americans. 8th edition. December 2015. Available at: http://health.gov/dietaryguidelines/2015/guidelines. Accessed January 5, 2017.
12. 12 Shikany, J.M., Safford, M.M., Newby, P.K., et al. Southern dietary pattern is associated with hazard of acute coronary heart disease in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. Circulation 132 (2015), 804–814.
13. 13 Wang, D.D., Li, Y., Chiuve, S.E., Stampfer, M.J., et al. Association of specific dietary fats with total and cause-specific mortality. JAMA Intern Med 176 (2016), 1134–1145.
14. 14 Dehghan, M., Mente, A., Teo, K.K., et al., Ongoing Telmisartan Alone and in Combination With Ramipril Global End Point Trial (ONTARGET)/Telmisartan Randomized Assessment Study in ACEI Intolerant Subjects With Cardiovascular Disease (TRANSCEND) Trial Investigators. Relationship between healthy diet and risk of cardiovascular disease among patients on drug therapies for secondary prevention: a prospective cohort study of 31 546 high-risk individuals from 40 countries. Circulation 126 (2012), 2705–2712.
15. 15 Li, S., Chiuve, S.E., Flint, A., et al. Better diet quality and decreased mortality among myocardial infarction survivors. JAMA Intern Med 173 (2013), 1808–1819.
16. 16 Stewart, R.A., Wallentin, L., Benatar, J., et al., STABILITY Investigators. Dietary patterns and the risk of major adverse cardiovascular events in a global study of high-risk patients with stable coronary heart disease. Eur Heart J 37 (2016), 1993–2001.
17. 17 National Cholesterol Education Program, National Heart, Lung, and Blood Institute, National Institutes of Health. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. Circulation 106 (2002), 3143–3421.
18. 18 Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: National Academies Press, 2002/2005.
19. 19 U.S. Department of Agriculture, U.S. Department of Health and Human Services. Scientific Report of the 2015 Dietary Guidelines Advisory Committee. 2015, U.S. Department of Health and Human Services, Washington, DC.
20. 20 Hopkins, P.N., Effects of dietary cholesterol on serum cholesterol: a meta-analysis and review. Am J Clin Nutr 55 (1992), 1060–1070.
21. 21 Weggemans, R.M., Zock, P.L., Katan, M., Dietary cholesterol from eggs increase the ratio of total cholesterol to high-density lipoprotein cholesterol in humans: a meta-analysis. Am J Clin Nutr 73 (2001), 885–891.
22. 22 Ros, E., Intestinal absorption of triglyceride and cholesterol. Dietary and pharmacological inhibition to reduce cardiovascular risk. Atherosclerosis 151 (2000), 357–379.
23. 23 Berger, S., Raman, G., Vishwanathan, R., et al. Dietary cholesterol and cardiovascular disease: A systematic review and meta-analysis. Am J Clin Nutr 102 (2015), 276–294.
24. 24 United States Department of Agriculture Agricultural Research Service. National Nutrient Database for Standard Reference Release 28. Basic Report: 15271, Crustaceans, shrimp, cooked (not previously frozen). Available at: https://ndb.nal.usda.gov/ndb/foods/show/4740?fgcd=&man=&lfacet=&count=&max=35&sort=&qlookup=shrimp&offset=&format=Abridged&new=&measureby. Accessed January 5, 2017.
25. 25 DeLany, J.P., Windhauser, M.M., Champagne, C.M., et al. Differential oxidation of individual dietary fatty acids in humans. Am J Clin Nutr 72 (2000), 905–911.
26. 26 Feranil, A.B., Duazo, P.L., Kuzawa, C.W., et al. Coconut oil is associated with a beneficial lipid profile in pre-menopausal women in the Philippines. Asia Pac J Clin Nutr 20 (2011), 190–195.
27. 27 Assunção, M.L., Ferreira, H.S., dos Santos, A.F., et al. Effects of dietary coconut oil on the biochemical and anthropometric profiles of women presenting abdominal obesity. Lipids 44 (2009), 593–601.
28. 28 Marina, A.M., CheMan, Y.B., Amin, I., Virgin coconut oil: emerging functional food oil. Trends Sci Food Technol 20 (2009), 481–487.
29. 29 Babu, A.S., Veluswamy, S.K., Arena, R., et al. Virgin coconut oil and its potential cardioprotective effects. Postgrad Med 126 (2014), 76–83.
30. 30 Prior, I., Davidson, F., Salmond, C., et al. Cholesterol, coconuts and diet on Polynesian atolls: a natural experiment: the Pukapula and Tokelau island studies. Am J Clin Nutr 34 (1981), 1552–1561.
31. 31 Jacobson, T.A., Maki, K.C., Orringer, C.E., et al., NLA Expert Panel. National Lipid Association recommendations for patient-centered management of dyslipidemia: part 2. J Clin Lipidol 9 (2015), S1–S122.e1.
32. 32 Eyres, L., Eyres, M.F., Chisholm, A., et al. Coconut oil consumption and cardiovascular risk factors in humans. Nutr Rev 74 (2016), 267–280.
33. 33 Sun, Y., Neelakantan, N., Wu, Y., et al. Palm oil consumption increases LDL cholesterol compared with vegetable oils low in saturated fat in a meta-analysis of clinical trials. J Nutr 145 (2015), 1549–1558.
34. 34 Chen, B.K., Seligman, B., Farquhar, J.W., et al. Multi-Country analysis of palm oil consumption and cardiovascular disease mortality for countries at different stages of economic development: 1980–1997. Global Health, 7, 2011, 45.
35. 35 Kabagambe, E.K., Baylin, A., Ascherio, A., et al. The type of oil used for cooking is associated with the risk of nonfatal acute myocardial infarction in Costa Rica. J Nutr 135 (2005), 2674–2679.
36. 36 Lin, L., Allemekinders, H., Dansby, A., et al. Evidence of health benefits of canola oil. Nutr Rev 71 (2013), 370–385.
37. 37 Maki, K.C., Lawless, A.L., Kelley, K.M., et al. Corn oil improves the plasma lipoprotein lipid profile compared with extra-virgin olive oil consumption in men and women with elevated cholesterol: results from a randomized controlled feeding trial. J Clin Lipidol 9 (2015), 49–57.
38. 38 Mensink, R.P., Zock, P.L., Kester, A.D.M., et al. Effects of dietary fatty acids and carbohydrates on the ratio of total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 77 (2003), 1146–1155.
39. 39 Estruch, R., Martínez-González, M.A., Corella, D., et al., PREDIMED Study Investigators. Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Intern Med 145 (2006), 1–11.
40. 40 Covas, M.I., Nyyssönen, K., Poulsen, H.E., et al., EUROLIVE Study Group. The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med 145 (2006), 333–341.
41. 41 Hernáez, Á., Fernández-Castillejo, S., Farràs, M., et al. Olive oil polyphenols enhance high-density lipoprotein function in humans: a randomized controlled trial. Arterioscler Thromb Vasc Biol 34 (2014), 2115–2119.
42. 42 Schwingshackl, L., Christoph, M., Hoffmann, G., Effects of olive oil on markers of inflammation and endothelial function: a systematic review and meta-analysis. Nutrients 7 (2015), 7651–7675.
43. 43 Schwingshackl, L., Hoffmann, G., Monounsaturated fatty acids, olive oil and health status: a systematic review and meta-analysis of cohort studies. Lipids Health Dis, 13, 2014, 154.
44. 44 Guasch-Ferré, M., Hruby, A., Salas-Salvadó, J., et al. Olive oil consumption and risk of type 2 diabetes in US women. Am J Clin Nutr 102 (2015), 479–486.
45. 45 Estruch, R., Ros, E., Salas-Salvadó, J., et al., PREDIMED Study Investigators. Primary prevention of cardiovascular disease with a Mediterranean diet. [Published correction appears in N Engl J Med. 2014;370:886] N Engl J Med 368 (2013), 1279–1290.
46. 46 Bester, D., Esterhuyse, A.J., Truter, E.J., et al. Cardiovascular effects of edible oils: a comparison between four popular edible oils. Nutr Res Rev 23 (2010), 334–348.
47. 47 Miller, M., Stone, N.J., Ballantyne, C., et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation 123 (2011), 2292–2333.
48. 48 Produce for Better Health Foundation. State of the Plate, 2015 Study on America's Consumption of Fruit and Vegetables, Produce for Better Health Foundation, 2015. Available at: http://www.pbhfoundation.org/pdfs/about/res/pbh_res/State_of_the_Plate_2015_WEB_Bookmarked.pdf. Accessed January 5, 2017.
49. 49 Wu, X., Beecher, G.R., Holden, J.M., et al. Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. J Agric Food Chem 54 (2006), 4069–4075.
50. 50 Wedick, N.M., Pan, A., Cassidy, A., et al. Dietary flavonoid intakes and risk of type 2 diabetes in US men and women. Am J Clin Nutr 95 (2012), 925–933.
51. 51 Cassidy, A., Mukamal, K.J., Liu, L., et al. High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women. Circulation 127 (2013), 188–196.
52. 52 Johnson, S.A., Figueroa, A., Navaei, N., et al. Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trial. J Acad Nutr Diet 115 (2015), 369–377.
53. 53 Muraki, I., Imamura, F., Manson, J.E., et al. Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies. BMJ, 347, 2013, f5001.
54. 54 Boeing, H., Bechthold, A., Bub, A., et al. Critical review: vegetables and fruit in the prevention of chronic diseases. Eur J Nutr 51 (2012), 637–663.
55. 55 Slavin, J., Lloyd, B., Health benefits of fruits and vegetables. Adv Nutr 3 (2012), 506–516.
56. 56 Wang, S., Melnyk, J.P., Tsao, R., et al. How natural dietary antioxidants in fruits, vegetables and legumes promote vascular health. Food Res Int 44 (2011), 14–22.
57. 57 Papas, A.M., Diet and antioxidant status. Food Chem Toxicol 37 (1999), 999–1007.
58. 58 Harman, D., Aging: A theory based on free radical and radiation chemistry. J Gerontol 11 (1956), 298–300.
59. 59 Sies, H., Oxidative stress: oxidants and antioxidants. Exp Physiol 82 (1997), 291–295.
60. 60 Heitzer, T., Schlinzig, T., Krohn, K., et al. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. [Published correction appears in Circulation 2003;108:500] Circulation 104 (2001), 2673–2678.
61. 61 Reuter, S., Gupta, S.C., Chaturvedi, M.M., et al. Oxidative stress, inflammation, and cancer: how are they linked?. Free Radic Biol Med 49 (2010), 1603–1616.
62. 62 Wruck, C.J., Fragoulis, A., Gurzynski, A., et al. Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice. Ann Rheum Dis 70 (2011), 844–850.
63. 63 Moylan, J.S., Reid, M.B., Oxidative stress, chronic disease, and muscle wasting. Muscle Nerve 35 (2007), 411–429.
64. 64 Perry, G., Cash, A.D., Smith, M., Alzheimer disease and oxidative stress. J Biomed Biotechnol 2 (2002), 120–123.
65. 65 Jenner, P., Oxidative stress in Parkinson's disease. Ann Neurol 53 Suppl 3 (2003), S26–S36 discussion S36–8.
66. 66 Stampfer, M.J., Hennekens, C.H., Manson, J.E., Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 328 (1994), 1444–1449.
67. 67 Losonczy, K.G., Harris, T.B., Havlik, R.J., Vitamin E and vitamin C supplement use and risk of all- cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly. Am J Clin Nutr 64 (1996), 190–196.
68. 68 Enstrom, J.E., Kanim, L.E., Klein, M.A., Vitamin C intake and mortality among a sample of the United States population. Epidemiology 3 (1992), 194–202.
69. 69 Chun, O.K., Floegel, A., Chung, S.J., et al. Estimation of antioxidant intakes from diet and supplements in U.S. adults. [Published correction appears in J Nutr 2010;140:1062] J Nutr 140 (2010), 317–324.
70. 70 Bailey, R.L., Gahche, J.J., Lentino, C.V., et al. Dietary supplement use in the United States, 2003–2006. J Nutr 141 (2011), 261–266.
71. 71 GISSI-Prevenzione Investigators (Gruppo Italiano per lo Studio della Sopravvivivenza nell'Infaro miocardico). Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 354 (1999), 447–455.
72. 72 Vivekananthan, D.P., Penn, M.S., Sapp, S.K., et al. Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 361 (2003), 2017–2023.
73. 73 Hennekens, C.H., Buring, J.E., Manson, J.E., et al. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 334 (1996), 1145–1149.
74. 74 Bjelakovic, G., Nikolova, D., Simonetti, R.G., et al. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet 364 (2004), 1219–1228.
75. 75 Lawson, K.A., Wright, M.E., Subar, A., et al. Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study. J Natl Cancer Inst 99 (2007), 754–764.
76. 76 Mattson, M.P., Hormesis defined. Ageing Res Rev 7 (2008), 1–7.
77. 77 Yang, W., Hekimi, S., A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol, 8, 2010, e1000556.
78. 78 Bjelakovic, G., Gluud, C., Surviving antioxidant supplements. J Natl Cancer Inst 99 (2007), 742–743.
79. 79 Moyer, M.W., The myth of antioxidants. Sci Am 308 (2013), 62–67.
80. 80 Pérez, V., Bokov, A., Remmen, H., et al. Is the oxidative stress theory of aging dead?. Biochim Biophys Acta 1790 (2009), 1005–1014.
81. 81 Mattson, M.P., What doesn't kill you…. Sci Am 313 (2015), 40–45.
82. 82 Hasnain, B.I., Mooradian, A.D., Recent trials of antioxidant therapy: what should we be telling our patients?. Cleve Clin J Med 71 (2004), 327–334.
83. 83 Ros, E., Health benefits of nut consumption. Nutrients 2 (2010), 652–682.
84. 84 Afshin, A., Micha, R., Khatibzadeh, S., et al. Consumption of nuts and legumes and risk of incident ischemic heart disease, stroke, and diabetes: a systematic review and meta-analysis. Am J Clin Nutr 100 (2014), 278–288.
85. 85 Viguiliouk, E., Kendall, C.W., Blanco Mejia, S., et al. Effect of tree nuts on glycemic control in diabetes: a systematic review and meta-analysis of randomized controlled dietary trials. PLoS One, 9, 2014, e103376.
86. 86 Zhou, D., Yu, H., He, F., et al. Nut consumption in relation to cardiovascular disease risk and type 2 diabetes: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr 100 (2014), 270–277.
87. 87 Sabaté, J., Oda, K., Ros, E., Nut consumption and blood lipids: a pooled analysis of 25 intervention trials. Arch Intern Med 170 (2010), 821–827.
88. 88 Salas-Salvadó, J., Fernández-Ballart, J., Ros, E., et al., PREDIMED Study Investigators. Effect of the Mediterranean diet supplemented with nuts on metabolic syndrome status: one-year results of the PREDIMED randomized trial. Arch Intern Med 168 (2008), 2449–2458.
89. 89 Babio, N., Toledo, E., Estruch, R., et al., PREDIMED Study Investigators. Mediterranean diets and metabolic syndrome status in the PREDIMED randomized trial. CMAJ 186 (2014), E649–E657.
90. 90 Eckel, R.H., Jakicic, J.M., Ard, J.D., et al. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. [Published correction appears in J Am Coll Cardiol 2014;63:3027–8] J Am Coll Cardiol 63 (2014), 2960–2984.
91. 91 Luo, C., Zhang, Y., Ding, Y., et al. Nut consumption and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis. Am J Clin Nutr 100 (2014), 256–269.
92. 92 Grosso, G., Yang, J., Marventano, S., et al. Nut consumption on all-cause, cardiovascular, and cancer mortality risk: a systematic review and meta-analysis of epidemiologic studies. Am J Clin Nutr 101 (2015), 783–793.
93. 93 Meschia, J.F., Bushnell, C., Boden-Albala, B., et al., American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, Council on Functional Genomics and Translational Biology, and Council on Hypertension. Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 45 (2014), 3754–3832.
94. 94 Bes-Rastrollo, M., Wedick, N.M., Martínez-González, M.A., et al. Prospective study of nut consumption, long-term weight change, and obesity risk in women. Am J Clin Nutr 89 (2009), 1913–1919.
95. 95 Ibarrola-Jurado, N., Bulló, M., Guasch-Ferré, M., et al., PREDIMED Study Investigators. Cross-sectional assessment of nut consumption and obesity, metabolic syndrome and other cardiometabolic risk factors: the PREDIMED study. PLoS One, 8, 2013, e57367.
96. 96 Flores-Mateo, G., Rojas-Rueda, D., Basora, J., et al. Nut intake and adiposity: meta-analysis of clinical trials. Am J Clin Nutr 97 (2013), 1346–1355.
97. 97 Jackson, C.L., Hu, F.B., Long-term associations of nut consumption with body weight and obesity. Am J Clin Nutr 100 Suppl 1 (2014), 408S–411S.
98. 98 Estruch, R., Martínez-González, M.A., Corella, D., et al., PREDIMED Study Investigators. Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial. Lancet Diabetes Endocrinol 4 (2016), 666–676.
99. 99 Rajaram, S., Sabaté, J., Nuts, body weight and insulin resistance. Br J Nutr 96 Suppl 2 (2006), S79–S86.
100. 100 Bondonno, C.P., Liu, A.H., Croft, K.D., et al. Short-term effects of a high nitrate diet on nitrate metabolism in healthy individuals. Nutrients 7 (2015), 1906–1915.
101. 101 Liu, A.H., Bondonno, C.P., Croft, K.D., et al. Effects of a nitrate-rich meal on arterial stiffness and blood pressure in healthy volunteers. Nitric Oxide 35 (2013), 123–130.
102. 102 Woodside, J.V., McGrath, A.J., Lyner, N., et al. Carotenoids and health in older people. Maturitas 80 (2015), 63–68.
103. 103 Hozawa, A., Jacobs, D.R. Jr., Steffes, M.W., et al. Circulating carotenoid concentrations and incident hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study. J Hypertens 27 (2009), 237–242.
104. 104 Gammone, M.A., Riccioni, G., D'Orazio, N., Carotenoids: potential allies of cardiovascular health?. Food Nutr Res, 59, 2015, 26762.
105. 105 Li, M., Fan, Y., Zhang, X., et al. Fruit and vegetable intake and risk of type 2 diabetes mellitus: meta-analysis of prospective cohort studies. BMJ Open, 4, 2014, e005497.
106. 106 Larsson, S.C., Wolk, A., Magnesium intake and risk of type 2 diabetes: a meta-analysis. J Intern Med 262 (2007), 208–214.
107. 107 Houston, M.C., Nutraceuticals, vitamins, antioxidants, and minerals in the prevention and treatment of hypertension. Prog Cardiovasc Dis 47 (2005), 396–449.
108. 108 Jasuja, R., Passam, F.H., Kennedy, D.R., et al. Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents. J Clin Invest 122 (2012), 2104–2113.
109. 109 Pagliaro, B., Santolamazza, C., Simonelli, F., et al. Phytochemical compounds and protection from cardiovascular diseases: a state of the art. Biomed Res Int, 2015, 2015, 918069.
110. 110 Joshipura, K.J., Hung, H.C., Li, T.Y., et al. Intakes of fruits, vegetables and carbohydrate and the risk of CVD. Public Health Nutr 12 (2009), 115–121.
111. 111 Böhm, V., Bitsch, R., Intestinal absorption of lycopene from different matrices and interactions to other carotenoids, the lipid status, and the antioxidant capacity of human plasma. Eur J Nutr 38 (1999), 118–125.
112. 112 Paterson, E., Gordon, M.H., Niwat, C., et al. Supplementation with fruit and vegetable soups and beverages increases plasma carotenoid concentrations but does not alter markers of oxidative stress or cardiovascular risk factors. J Nutr 136 (2006), 2849–2855.
113. 113 George, T.W., Waroonphan, S., Niwat, C., et al. Effects of acute consumption of a fruit and vegetable purée-based drink on vasodilation and oxidative status. Br J Nutr 109 (2013), 1442–1452.
114. 114 United States Department of Agriculture, Agriculture Research Service. USDA Nutrient Database for Standard Reference, Release 14. 2001. Available at: http://www.ars.usda.gov/Services/docs.htm?docid=21215. Accessed January 5, 2017.
115. 115 Position of the American Dietetic Association: vegetarian diets. J Am Diet Assoc 109 (2009), 1266–1282.
116. 116 Crowe, F.L., Appleby, P.N., Travis, R.C., et al. Risk of hospitalization or death from ischemic heart disease among British vegetarians and non-vegetarians: results from the EPIC-Oxford Cohort Study. Am J Clin Nutr 97 (2013), 597–603.
117. 117 Tonstad, S., Butler, T., Yan, R., Fraser, G.E., Type of vegetarian diet, body weight, and prevalence of type 2 diabetes. Diabetes Care 32 (2009), 791–796.
118. 118 Rizzo, N.S., Sabaté, J., Jaceldo-Siegl, K., et al. Vegetarian dietary patterns are associated with a lower risk of metabolic syndrome: the Adventist Health Study 2. Diabetes Care 34 (2011), 11225–11227.
119. 119 Yokoyama, Y., Nishimura, K., Barnard, N.D., et al. Vegetarian diets and blood pressure: a meta-analysis. JAMA Intern Med 174 (2014), 577–587.
120. 120 Barnard, N.D., Levin, S.M., Yokoyama, Y., A systematic review and meta-analysis of changes in body weight in clinical trials of vegetarian diets. J Acad Nutr Diet 115 (2015), 954–969.
121. 121 Kwok, C.S., Umar, S., Myint, P.K., et al. Vegetarian diet, Seventh Day Adventist and risk of cardiovascular mortality: a systematic review and meta-analysis. Int J Cardiol 176 (2014), 680–686.
122. 122 Willcox, B., Willcox, D., Todoriki, H., et al. Caloric restriction, the traditional Okinawan diet, and healthy aging. Ann NY Acad Sci 1114 (2001), 434–455.
123. 123 Sinnett, P.F., Whyte, H.M., Epidemiological studies in a total highland population, Tukisenta, New Guinea. Cardiovascular disease and relevant clinical, electrocardiographic, radiological and biochemical findings. J Chron Dis 26 (1973), 265–290.
124. 124 Campbell, T.C., Parpia, B., Chen, J., Diet, lifestyle, and the etiology of coronary artery disease: the Cornell China study. Am J Cardiol 82 (1998), 18T–21T.
125. 125 Miller, K., Rubenstein, A., Astrand, P.O., Lipid values in Kalahari bushmen. Arch Intern Med 121 (1968), 414–417.
126. 126 Connor, W.E., Cerqueira, M.T., Connor, R.W., et al. The plasma lipids, lipoproteins, and diet of the Tarahumara Indians of Mexico. Am J Clin Nutr 31 (1978), 1131–1142.
127. 127 Ornish, D.M., Scherwitz, L.W., Doody, R.S., et al. Effects of stress management training and dietary changes in treating ischemic heart disease. JAMA 249 (1983), 54–59.
128. 128 Gould, K.L., Ornish, D., Scherwitz, L., et al. Changes in myocardial perfusion abnormalities by positron emission tomography after long-term, intense risk factor modification. JAMA 274 (1995), 894–901.
129. 129 Ornish, D., Brown, S.E., Scherwitz, L.W., et al. Can lifestyle changes reverse coronary artery disease? The Lifestyle Heart Trial. Lancet 336 (1990), 129–133.
130. 130 Ornish, D., Scherwitz, L.W., Billings, J.H., et al. Intensive lifestyle changes for reversal of coronary artery disease. [Published correction appears in JAMA 1999;281:1380] JAMA 280 (1998), 2001–2007.
131. 131 Ornish, D., Avoiding revascularization with lifestyle changes: The Multi Center Lifestyle Demonstration Project. Am J Cardiol 82 (1999), 72T–76T.
132. 132 Silberman, A., Banthia, R., Estay, I.S., et al. The effectiveness and efficacy of an intensive cardiac rehabilitation program in 24 sites. Am J Health Promot 24 (2010), 260–266.
133. 133 Esselstyn, C.B. Jr., Ellis, S.G., Medendorp, S.V., et al. A strategy to arrest and reverse coronary artery disease; a 5-year longitudinal study of a single physician's practice. J Fam Prac 41 (1995), 560–568.
134. 134 Esselstyn, C.B. Jr, Updating a 12-year experience with arrest and reversal therapy for coronary heart disease (an overdue requiem for palliative cardiology). Am J Cardiol 84 (1999), 339–341.
135. 135 Esselstyn, C.B. Jr., Gendy, G., Doyle, J., et al. A way to reverse CAD?. J Fam Prac 63 (2014), 356–364b.
136. 136 Song, M., Fung, T.T., Hu, F.B., et al. Association of animal and plant protein intake with all-cause and cause-specific mortality. JAMA Intern Med 176 (2016), 1453–1463.
137. 137 Lundin, K.E., Wijmenga, C., Coeliac disease and autoimmune disease-genetic overlap and screening. Nat Rev Gastroenterol Hepatol 12 (2015), 507–515.
138. 138 Ludvigsson, J.F., Leffler, D.A., Bai, J.C., et al. The Oslo definitions for coeliac disease and related terms. Gut 62 (2013), 43–52.
139. 139 Lebwohl, B., Ludvigsson, J.F., Green, P.H., Celiac disease and non-celiac gluten sensitivity. BMJ, 351, 2015, h4347.
140. 140 Dickey, W., Kearney, N., Overweight in celiac disease: prevalence, clinical characteristics, and effect of a gluten-free diet. Am J Gastroenterol 101 (2006), 2356–2359.
141. 141 El-Chammas, K., Danner, E., Gluten-free diet in nonceliac disease. Nutr Clin Pract 26 (2011), 294–299.
142. 142 Marcason, W., Is there evidence to support the claim that a gluten-free diet should be used for weight loss?. J Am Diet Assoc, 111, 2011, 1786.
143. 143 Theethira, T.G., Dennis, M., Celiac disease and the gluten-free diet: consequences and recommendations for improvement. Dig Dis 33 (2015), 175–182.
144. 144 Valletta, E., Fornaro, M., Cipolli, M., et al. Celiac disease and obesity: need for nutritional follow-up after diagnosis. Eur J Clin Nutr 64 (2010), 1371–1372.
145. 145 Ebbeling, C.B., Swain, J.F., Feldman, H.A., et al. Effects of dietary composition on energy expenditure during weight-loss maintenance. JAMA 307 (2012), 2627–2634.
146. 146 Zanini, B., Mazzoncini, E., Lanzarotto, F., et al. Impact of gluten-free diet on cardiovascular risk factors. A retrospective analysis in a large cohort of coeliac patients. Dig Liver Dis 45 (2013), 810–815.