The effect of polyphenols in olive oil on heart disease risk factors: A randomized trial

Annals of Internal Medicine

Volumn 145, Issue 5, 2006, Pages 333-341

  Covas, María Isabel ^a   Nyyssönen, Kristiina ^b   Poulsen, Henrik E ^c   Kaikkonen, Jari ^d   Zunft, Hans Joachim F ^e   Kiesewetter, Holger ^f   Gaddi, Antonio ^g   De La Torre, Rafael ^a   Mursu, Jaakko ^b   Bäumler, Hans ^f   Nascetti, Simona ^g   Salonen, Jukka T ^d   Fitó, Montserrat ^a   Virtanen, Jyrki ^b   Marrugat, Jaume ^a  

^a INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c Rigshospitalet   (Denmark)

^d Oy Jurilab Ltd   (Finland)

^e GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^g UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; GLUCOSE; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYTYROSOL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LYCOPENE; MONOUNSATURATED FATTY ACID; OLIVE OIL; POLYPHENOL DERIVATIVE; TRIACYLGLYCEROL; TYROSOL; 3,4-DIHYDROXYPHENYLETHANOL; 4-HYDROXYPHENYLETHANOL; CHOLESTEROL; DRUG DERIVATIVE; EDIBLE OIL; FLAVONOID; PHENETHYL ALCOHOL; PHENOL DERIVATIVE; POLYPHENOLS; VEGETABLE OIL;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIETARY INTAKE; ENERGY CONSUMPTION; GLUCOSE BLOOD LEVEL; HEART DISEASE; HUMAN; HUMAN EXPERIMENT; ISCHEMIC HEART DISEASE; LIPID OXIDATION; MALE; MULTICENTER STUDY; NORMAL HUMAN; OXIDATIVE STRESS; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL; BLOOD; CHEMISTRY; DRUG EFFECT; METABOLISM; MIDDLE AGED; PATIENT; RISK FACTOR; URINE;

ADULT; ANTIOXIDANTS; CHOLESTEROL; CHOLESTEROL, HDL; CROSS-OVER STUDIES; DIETARY FATS, UNSATURATED; FLAVONOIDS; HEART DISEASES; HUMANS; MALE; MIDDLE AGED; PATIENT COMPLIANCE; PATIENT DROPOUTS; PHENOLS; PHENYLETHYL ALCOHOL; PLANT OILS; RISK FACTORS; TRIGLYCERIDES;

EID: 33749080532     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-145-5-200609050-00006     Document Type: Article

References (40)

1. Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F, et al. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med. 1995;155:381-6.
2. Zern TL, Fernandez ML. Cardioprotective effects of dietary polyphenols. J Nutr. 2005;135:2291-4.
3. Fortes C. Mediterranean diet health benefits may be due to a synergistic combination of phytochemicals and fatty-acids [Letter]. BMJ. 2005;331:E366.
4. Psaltopoulou T, Naska A, Orfanos P, Trichopoulos D, Mountokalakis T, Trichopoulou A. Olive oil, the Mediterranean diet, and arterial blood pressure: the Greek European Prospective Investigation into Cancer and Nutrition (EPIC) study. Am J Clin Nutr. 2004;80:1012-8.
5. FDA allows qualified health claim to decrease risk of coronary heart disease [Press release]. Press release P04-100. Rockville, MD: U.S. Food and Drug Administration; 1 November 2004. Accessed at www.fda.gov/bbs/topics/news/ 2004/NEW01129.html on 8 December 2005.
6. Gimeno E, Castellote AI, Lamuela-Raventós RM, de la Torre MC, López-Sabater MC. The effect of harvest and extraction methods on the antioxidant content (phenolics, α-tocopherol, and β-carotene) in virgin olive oil. Food Chemistry. 2002;78:207-11.
7. Owen RW, Mier W, Giacosa A, Hull WE, Spiegelhalder B, Bartsch H. Phenolic compounds and squalene in olive oils: the concentration and antioxidant potential of total phenols, simple phenols, secoiridoids, lignans and squalene. Food Chem Toxicol. 2000;38:647-59.
8. Visioli F, Galli C, Plasmati E, Viappiani S, Hernandez A, Colombo C, et al. Olive phenol hydroxytyrosol prevents passive smoking-induced oxidative stress. Circulation. 2000;102:2169-71.
9. Navab M, Berliner JA, Watson AD, Hama SY, Territo MC, Lusis AJ, et al. The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture. Arterioscler Thromb Vasc Biol. 1996;16:831-42.
10. Perez-Jimenez F. International conference on the healthy effect of virgin olive oil. Eur J Clin Invest. 2005;35:421-4.
11. Mangas-Cruz MA, Fernández-Moyano A, Albi T, Guinda A, Relimpio F, Lanzón A, et al. Effects of minor constituents (non-glyceride compounds) of virgin olive oil on plasma lipid concentrations in male Wistar rats. Clin Nutr. 2001;20:211-5.
12. Devaraj S, Vega-López S, Kaul N, Schönlau F, Rohdewald P, Jialal I. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids. 2002;37:931-4.
13. Mursu J, Voutilainen S, Nurmi T, Rissanen TH, Virtanen JK, Kaikkonen J, et al. Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans. Free Radic Biol Med. 2004;37:1351-9.
14. Yokozawa T, Nakagawa T, Kitani K. Antioxidative activity of green tea polyphenol in cholesterol-fed rats. J Agric Food Chem. 2002;50:3549-52.
15. Marrugat J, Covas MI, Fitó M, Schröder H, Miró-Casas E, Gimeno E, et al. Effects of differing phenolic content in dietary olive oils on lipids and LDL oxidation - a randomized controlled trial. Eur J Nutr. 2004;43:140-7.
16. Gardner CD, Coulston A, Chatterjee L, Rigby A, Spiller G, Farquhar JW. The effect of a plant-based diet on plasma lipids in hypercholesterolemic adults: a randomized trial. Ann Intern Med. 2005;142:725-33.
17. Badeau M, Adlercreutz H, Kaihovaara P, Tikkanen MJ. Estrogen A-ring structure and antioxidative effect on lipoproteins. J Steroid Biochem Mol Biol. 2005;96:271-8.
18. Fielding CJ, Havel RJ, Todd KM, Yeo KE, Schloetter MC, Weinberg V, et al. Effects of dietary cholesterol and fat saturation on plasma lipoproteins in an ethnically diverse population of healthy young men. J Clin Invest. 1995;95:611-8.
19. Taylor HL, Jacobs DR Jr, Schucker B, Knudsen J, Leon AS, Debacker G. A questionnaire for the assessment of leisure time physical activities. J Chronic Dis. 1978;31:741-55.
20. Peterson JI, Young DS. Evaluation of the hexokinase-glucose-6- phosphate dehydrogenase method of determination of glucose in urine. Anal Biochem. 1968;23:301-16.
21. Siedel J, Hägele EO, Ziegenhorn J, Wahlefeld AW. Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin Chem. 1983;29:1075-80.
22. Sugiuchi H, Uji Y, Okabe H, Irie T, Uekama K, Kayahara N, et al. Direct measurement of high-density lipoprotein cholesterol in serum with polyethylene glycol-modified enzymes and sulfated alpha-cyclodextrin. Clin Chem. 1995;41:717-23.
23. Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 1973;19:476-82.
24. Senn S. Cross-over Trials in Clinical Research. 2nd ed. Chichester, United Kingdom: J Wiley; 2002.
25. Connor WE, Connor SL. Should a low-fat, high-carbohydrate diet be recommended for everyone? The case for a low-fat, high-carbohydrate diet. N Engl J Med. 1997;337:562-3; discussion 566-7.
26. Brinton EA, Eisenberg S, Breslow JL. A low-fat diet decreases high density lipoprotein (HDL) cholesterol levels by decreasing HDL apolipoprotein transport rates. J Clin Invest. 1990;85:144-51.
27. Gordon DJ, Rifkind BM. High-density lipoprotein-the clinical implications of recent studies. N Engl J Med. 1989;321:1311-6.
28. Witztum JL. The oxidation hypothesis of atherosclerosis. Lancet. 1994;344:793-5.
29. Hazen SL, Heinecke JW. 3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. J Clin Invest. 1997;99:2075-81.
30. Meisinger C, Baumert J, Khuseyinova N, Loewel H, Koenig W. Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population. Circulation. 2005;112:651-7.
31. Toshima S, Hasegawa A, Kurabayashi M, Itabe H, Takano T, Sugano J, et al. Circulating oxidized low density lipoprotein levels. A biochemical risk marker for coronary heart disease. Arterioscler Thromb Vasc Biol. 2000;20:2243-7.
32. Parthasarathy S, Khoo JC, Miller E, Barnett J, Witztum JL, Steinberg D. Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis. Proc Natl Acad Sci U S A. 1990;87:3894-8.
33. Fuller CJ, Jialal I. Effects of antioxidants and fatty acids on low-density-lipoprotein oxidation. Am J Clin Nutr. 1994;60:1010S-1013S.
34. Covas MI, Fitó M, Lamuela-Raventós RM, Sebastiá N, de la Torre-Boronat C, Marrugat J. Virgin olive oil phenolic compounds: binding to human low density lipoprotein (LDL) and effect on LDL oxidation. Int J Clin Pharmacol Res. 2000;20:49-54.
35. Covas MI, de la Torre K, Farré-Albaladejo M, Kaikkonen J, Fitó M, López-Sabater C, et al. Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans. Free Radic Biol Med. 2006;40:608-16.
36. Hayes JD, McLellan LI. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res. 1999;31:273-300.
37. Biswas SK, Newby DE, Rahman I, Megson IL. Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E(-/-) mice. Biochem Biophys Res Commun. 2005;338:1368-73.
38. Nielsen SE, Young JF, Daneshvar B, Lauridsen ST, Knuthsen P, Sandström B, et al. Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects. Br J Nutr. 1999;81:447-55.
39. McGill CR, Green NR, Meadows MC, Gropper SS. Beta-carotene supplementation decreases leukocyte superoxide dismutase activity and serum glutathione peroxidase concentration in humans. J Nutr Biochem. 2003;14:656-62.
40. Meilhac O, Ramachandran S, Chiang K, Santanam N, Parthasarathy S. Role of arterial wall antioxidant defense in beneficial effects of exercise on atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2001;21:1681-8.