Cardiovascular effects of edible oils: A comparison between four popular edible oils

Nutrition Research Reviews

Volumn 23, Issue 2, 2010, Pages 334-348

  Bester, D ^a   Esterhuyse, A J ^a   Truter, E J ^a   Van Rooyen, J ^a  

^a CAPE PENINSULA UNIVERSITY OF TECHNOLOGY   (South Africa)

Author keywords

Cardiovascular effects; Fish oil; Heart; Olive oil; Palm oil; Red palm oil; Sunflower seed oil

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; ANTIOXIDANT; CHOLESTEROL; CYANOCOBALAMIN; DOCOSAHEXAENOIC ACID; EDIBLE OIL; FISH OIL; HYDROXYTYROSOL; IODINE; LINOLEIC ACID; LONG CHAIN FATTY ACID; LOW DENSITY LIPOPROTEIN; OLEIC ACID; OLEUROPEIN; OLIVE OIL; PALM OIL; POLYPHENOL; POLYPHENOL DERIVATIVE; POLYUNSATURATED FATTY ACID; REACTIVE OXYGEN METABOLITE; RETINOL; SQUALENE; STEARIC ACID; SUNFLOWER OIL; TRACE ELEMENT; TYROSOL; UNINDEXED DRUG; VITAMIN D;

ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR EFFECT; CHOLESTEROL SYNTHESIS; DIET SUPPLEMENTATION; HEART ARRHYTHMIA; HEART DEATH; HEART PROTECTION; HUMAN; INFLAMMATION; ISCHEMIA; ISCHEMIC PRECONDITIONING; LIPID BLOOD LEVEL; LIPID COMPOSITION; LIPID OXIDATION; MORTALITY; NEOPLASM; NONHUMAN; OLIVE TREE; PH; REPERFUSION INJURY; RETINOL DEFICIENCY; RISK BENEFIT ANALYSIS; RISK REDUCTION; THROMBOCYTE AGGREGATION;

ARECACEAE; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; DIETARY FATS; DIETARY SUPPLEMENTS; FISH OILS; HELIANTHUS; HUMANS; OLEA; PLANT OILS;

HELIANTHUS;

EID: 78650544154     PISSN: 09544224     EISSN: 14752700     Source Type: Journal    
DOI: 10.1017/S0954422410000223     Document Type: Article

References (144)

1. Elson CE, Quereshi AA (1995) Coupling the cholesteroland tumour-suppresisve actions of palm oil to the impact of its minor constituents on 3-hydroxy-3-methylglutaryl coenzyme areductase activity. PLEFA 52, 205-208.
2. Schrauwen P, Westerterp KR (2000) The role of high-fat diets and physical activity in the regulation of body weight. Br J Nutr 84, 417-427.
3. Diniz YSA, Cicogna AC, Padovani CR, et al. (2004) Diets rich in saturated and polyunsaturated fatty acids: metabolic shifting and cardiac health. Nutrition 20, 230-234.
4. Puskas LG, Nagy ZB, Girics Z, et al. (2004) Cholesterol diet-induced hyperlipidaemia influences gene expression pattern of rat hearts: a DNA micoarray study. FEBS Lett 562, 99-104.
5. Horribon DF (1990) g Linoleic acid: an intermediate in fatty acid metabolism with potential as an ethical pharmaceutical and as a food. Rev Contemp Pharmacother 1, 1-45.
6. Das UN (1990) g-Linolenic acid, arachidonic acid and eicosapentaenoic acid as potential anti-cancer drugs. Nutrition 6, 429-434.
7. Das UN (2004) Long-chain polyunsaturated fatty acids interact with nitric oxide, superoxide anion, and transforming growth factor-b to prevent human essential hypertension. Eur J Clin Nutr 58, 195-203.
8. Das UN (2005) Essential fatty acids: biochemistry, physiology, and pathology. Biotech J 1, 420-439.
9. Suresh Y, Das UN (2006) Differential effect of saturated, monounsaturated, and polyunsaturated fatty acids on alloxan induced diabetes mellitus. PLEFA 74, 199-213. (Pubitemid 43363501)
10. Das UN (2007) A defect in the activity of D6 and D5 desaturases may be a factor in the initiation and progression of atherosclerosis. PLEFA 76, 251-268.
11. Banegas JR, Rodriguez-Artalejo F, Graciani A, et al. (2003) Mortality attributable to cardiovascular risk factors in Spain. Eur J Clin Nutr 57, Suppl., S18-S21. (Pubitemid 37121022)
12. Jemal A, Ward E, Hao Y, et al. (2005) Trends in the leading causes of death in the United States, 1970-2002. JAMA 294, 1255-1259. (Pubitemid 41352114)
13. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285: 2486-2497.
14. Assman G, Schulte H, von Eckardstein A (1996) Hypertriglyceridemia and elevated lipoprotein(a) are risk factors for major coronary events in middle-aged men. Am J Cardiol 77, 1179-1184. (Pubitemid 26186958)
15. Jeppensen J, Hein HO, Suadicani P, et al. (1998) Triglyceride concentration and ischemic heart disease: an eight-year follow-up in the Copenhagen Male Study. Circulation 97, 1029-1036. (Pubitemid 28145372)
16. Austin MA, Hokanson JE, Edwards KL (1998) Hypertriglyceridemia as a cardiovascular risk factor. Am J Cardiol 81, 7B-12B.
17. Cullen P (2000) Evidence that triglycerides are an independent coronary heart disease risk factor. Am J Cardiol 86, 943-949.
18. Mullane KM, Read N, Salmon JA, et al. (1984) Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs. J Pharmacol Exp Ther 228, 510-522. (Pubitemid 14190764)
19. Braunwald E, Kloner RA (1985) Myocardial reperfusion: a double-edged sword? J Clin Invest 76, 1713-1719. (Pubitemid 16196036)
20. Jones SP, Lefer DJ (2000) Myocardial reperfusion injury: insights gained from gene-targeted mice. News Physiol Sci 15, 303-308.
21. Carnieto A, Dourado PMM, Da Luz PL, et al. (2009) Selective cyclooxygenase-2 inhibition protects against myocardial damage in experimental acute ischemia. Clinics 64, 245-252.
22. Palozza P, Krinsky NI (1992) b-Carotene and atocopherol are synergistic antioxidants. Arch Biochem Biophys 297, 184-187.
23. Böhm F, Edge R, McGarvey DJ, et al. (1998) b-Carotene with vitamins E and C offers synergistic cell protection against NOx. FEBS Lett 436, 387-389. (Pubitemid 28482967)
24. Stahl W, Junghans A, De Boer B, et al. (1998) Carotenoid mixtures protect multilamellar liposomes against oxidative damage: synergistic effects of lycopene and lutein. FEBS Lett 427, 305-308. (Pubitemid 28225080)
25. Age-Related Eye Disease Study Research Group (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, b carotene, and zinc for age-related macular degeneration and vision loss. AREDS report no. 8. Arch Ophthalmol 119, 1417-1436. (Pubitemid 32963246)
26. Stahl W, Sies H (2005) Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta 1740, 101-107. (Pubitemid 40798218)
27. Schroeder MT, Becker EM, Skibsted LH (2006) Molecular mechanism of antioxidant synergism of tocotrienols and carotenoids in palm oil. J Agric Food Chem 54, 3445-3453.
28. Owen RW, Mier W, Giacosa A, et al. (2000) Phenolic compounds and squalene in olive oils: the concentration and antioxidant potential of total phenols, simple phenols, secoiridoids, lignans and squalene. Food Chem Toxicol 38, 647-659. (Pubitemid 30447459)
29. Brenes M, Romero CN, Garciäa A, et al. (2004) Phenolic compounds in olive oils intended for refining: formation of 4-ethylphenol during olive paste storage. J Agric Food Chem 52, 8177-8181. (Pubitemid 40053711)
30. Giliani AH, Khan AU, Shah AJ, et al. (2005) Blood pressure lowering effect of olive is mediated through calcium channel blockade. Int J Food Sci Nutr 56, 613-620.
31. Newmark HL (1997) Squalene, olive oil, and cancer risk: a review and hypothesis. Cancer Epidemiol Biomarkers Prev 6, 1101-1103.
32. Quiles JL, Ochoa JJ, Ramirez-Tortosa C, et al. (2004) Dietary fat type (virgin olive vs. sunflower oils) affects agerelated changes in DNA double-strand-breaks, antioxidant capacity and blood lipids in rats. Exp Gerontol 39, 1189-1198. (Pubitemid 39024368)
33. OFarrell S, Jackson MJ (1997) Dietary polyunsaturated fatty acids, vitamin E and hypoxia/reoxygenation-induced damage to cardiac tissue. Clin Chim Acta 267, 197-211. (Pubitemid 28021730)
34. Turpeinen AM, Basu S, MutanenM(1998) A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans. PLEFA 59, 229-233. (Pubitemid 28505116)
35. Newaz MA, Yousefipour Z, Nawal N, et al. (2003) Nitric oxide synthase activity in blood vessels of spontaneously hypersensitive rats: antioxidant protection by g-tocotrienol. J Physiol Pharmacol 54, 319-327. (Pubitemid 37168997)
36. Wahle KW, Caruso D, Ochoa JJ, et al. (2004) Olive oil and modulation of cell signaling in disease prevention. Lipids 39, 1223-1231.
37. Eder E, Wacker M, Lutz U, et al. (2006) Oxidative stress related DNA adducts in the liver of female rats fed with sunflower-, rapeseed-, olive- or coconut oil supplemented diets. Chem Biol Interact 159, 81-89. (Pubitemid 43042616)
38. Lercker G, Rodríguez-Estrada MT (2000) Chromatographic analysis of unsaponifiable compounds of olive oils and fat-containing foods. J Chromatogr A 881, 105-129. (Pubitemid 30332197)
39. Caravaca AMG, Pancorbo AC, Diaz BC, et al. (2005) Electrophoretic identification and quantitation of compounds in the polyphenolic fraction of extra-virgin olive oil. Electrophoresis 26, 3538-3551.
40. Tuck KL, Hayball PJ (2002) Major phenolic compounds in olive oil: metabolism and health effects. J Nutr Biochem 13, 636-644. (Pubitemid 35341709)
41. Perona JS, Cabello-Moruno R, Ruiz-Gutierrez V (2006) The role of virgin olive oil components in the modulation of endothelial function. J Nutr Biochem 17, 429-445. (Pubitemid 43867255)
42. Romero C, Medina E, Vargas J, et al. (2007) In vitro activity of olive oil polyphenols against Helicobacter pylori. J Agric Food Chem 55, 680-686.
43. Montedoro G, Servilli M, Baldioli M, et al. (1993) Simple and hydro-lysable phenolic compounds in virgin olive oil 3. Spectroscopic characterisation of the secoiridoid derivatives. J Agric Food Chem 41, 2228-2234.
44. Visioli F, Poli A, Gall C (2002) Antioxidant and other biological activities of phenols from olives and olive oil. Med Res Rev 22, 65-75. (Pubitemid 34023573)
45. Relas H, Gylling H, Miettinen TA (2000) Dietary squalene increases cholesterol synthesis measured with serum noncholesterol sterols after a single oral dose in humans. Atherosclerosis 152, 377-383.
46. Heyden S (1994) Polyunsaturated and monounsaturated fatty acids in the diet to prevent coronary heart disease via cholesterol reduction. Ann Nutr Metab 38, 117-122. (Pubitemid 24241040)
47. Carrasco-Pancorbo L, Cerretani A, Bendini A, et al. (2005) Evaluation of the antioxidant capacity of individual phenolic compounds in virgin olive oil. J Agric Food Chem 53, 8918-8925. (Pubitemid 41735653)
48. Keys A, Menotti A, Karvonen MJ, et al. (1986) The diet and 15-year death rate in the Seven Countries Study. Am J Epidemiol 124, 903-915. (Pubitemid 17207259)
49. Vissers MN, Zock PL, Wiseman SA, et al. (2001) Effect of phenol-rich extra virgin olive oil on markers of oxidation in healthy volunteers. Eur J Clin Nutr 55, 334-341. (Pubitemid 32396742)
50. Briante R, Febbraio F, Nucci R (2004) Antioxidant/ prooxidant effects of dietary non-flavonoid phenols on the Cu2-induced oxidation of human low-density lipoprotein (LDL). Chem Biodivers 1, 1716-1729.
51. Aguilera CM, Mesa MD, Ramirez-Tortosa MC, et al. (2004) Sunflower oil does not protect against LDL oxidation as virgin olive oil does in patients with peripheral vascular disease. Clin Nutr 23, 673-681.
52. Rietjens SJ, Bast A, Haenen GRMM (2007) New insights into controversies on the antioxidant potential of the olive oil antioxidant hydroxytyrosol. J Agric Food Chem 55, 7609-7614. (Pubitemid 47492322)
53. Fabiani R, De Bartolomeo A, Rosignoli P, et al. (2002) Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis. Eur J Cancer Prev 11, 351-358. (Pubitemid 34948203)
54. Theriault A, Chao J, Wang QI, et al. (1999) Tocotrienol: a review of its therapeutic potential. Clin Biochem 32, 309-319. (Pubitemid 29416720)
55. Kritchevsky D (2000) Impact of red palm oil on human nutrition and health. Food Nutr Bull 21, 182-188. (Pubitemid 30454467)
56. Fabiani R, Rosignoli P, De Bartolomeo A, et al. (2008) Oxidative DNA damage is prevented by extracts of olive oil, hydroxytyrosol, and other olive phenolic compounds in human blood mononuclear cells and HL60 cells. Am J Nutr 138, 1411-1416.
57. Baeza I, De Castro NM, Díaz LE, et al. (2008) Effect of oil (sunflower oil) consumption with added hydroxytyrosol (natural antioxidant) on antioxidant variables in leucocytes from healthy adults. Proc Nutr Soc 67, OCE, E26. (Pubitemid 351988236)
58. Díaz LE, Gómez S, Nova E, et al. (2008) Immunomodulation and antioxidant capacity of hydroxytyrosol present at oleic acid-rich sunflower oil. Proc Nutr Soc 67, OCE, E2.
59. Demonty I, Chan YM, Pelled D, et al. (2006) Fish-oil esters of plant sterols improve the lipid profile of dyslipidemic subjects more than do fish-oil or sunflower oil esters of plant sterols. Am J Clin Nutr 84, 1534-1542. (Pubitemid 44912841)
60. Metcalf RG, James MJ, Gibson RA, et al. (2007) Effects of fish-oil supplementation on myocardial fatty acids in humans. Am J Clin Nutr 85, 1222-1228.
61. Ferrara LA, Raimondi AS, dEpiscopo L, et al. (2000) Olive oil and reduced need for antihypertensive medications. Arch Intern Med 160, 837-842. (Pubitemid 30165245)
62. Ruiz-Gutierrez V, Muriana FJ, Guerrero A, et al. (1997) Role of dietary oleic acid from different sources on fatty acid composition of erythrocyte membrane and blood pressure in healthy subjects. J Nutr Biochem 8, 689-695. (Pubitemid 29267952)
63. Alonso A, Ruiz-Gutierrez V, Martinez-Gonzalez MA (2006) Monounsaturated fatty acids, olive oil and blood pressure: epidemiological, clinical and experimental evidence. Public Health Nutr 9, 251-257.
64. Manna C, Migliardi V, Golino P, et al. (2004) Oleuropein prevents oxidative myocardial injury induced by ischaemia and reperfusion. J Nutr Biochem 15, 461-466. (Pubitemid 39118492)
65. Patrick L, Uzick M (2001) Cardiovascular disease: C-reactive protein and the inflammatory disease paradigm: HMG-CoA reductase inhibitors, a-tocopherol, red yeast rice, and olive oil polyphenols. A review of the literature. Altern Med Rev 6, 248-271. (Pubitemid 32591863)
66. Zitouni N, Errahali Y, Metche M, et al. (2000) Influence of refining steps on trace allergenic protein content in sunflower oil. J Allergy Clin Immunol 106, 962-967.
67. Navarro MD, Hortelano P, Periago JL, et al. (1992) Effect of dietary olive and sunflower oils on the lipid composition of the aorta and platelets and on blood eicosanoids in rats. Arteriosc Thromb 12, 830-835.
68. Larsen LF, Jespersen J, Marckmann P (1999) Are olive oil diets antithrombotic? Diets enriched with olive, rapeseed, or sunflower oil affect postprandial factor VII differently. Am J Clin Nutr 70, 976-982.
69. AbuGhazaleh AA, Felton DO, Ibrahim SA (2007) Milk conjugated linoleic acid response to fish oil and sunflower oil supplementation to dairy cows managed under two feeding systems. J Dairy Sci 90, 4763-4769. (Pubitemid 350045160)
70. Simopoulos AP (1991) Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 54, 438-463.
71. Das S, Lekli I, Das M, et al. (2008) Cardioprotection with palm oil tocotrienols: comparision of different isomers. Am J Physiol Heart Circ Physiol 294, 970-978. (Pubitemid 351253310)
72. Charnock JS, Sundram K, Abeywardena MYet al. (1991) Dietary fats and oils in cardiac arrhythmia in rats. Am J Clin Nutr 53, 1047S-1049S. (Pubitemid 21898872)
73. De Roos B, Geelen A, Ross K, et al. (2008) Identification of potential serum biomarkers of inflammation and lipid modulation that are altered by fish oil supplementation in healthy volunteers. Proteomics 8, 1965-1974. (Pubitemid 351775776)
74. Girardet M, Jacotot B, Mendy F, et al. (1977) Effects of edible oils on blood and arterial lipids in rats after one years balanced normolipidic diet. J Med 8, 261-278. (Pubitemid 8158436)
75. Nydahl M, Gustafsson IB, Ohrvall M, et al. (1994) Similar serum lipoprotein cholesterol concentrations in healthy subjects on diets enriched with rapeseed and with sunflower oil. Eur J Clin Nutr 48, 128-137. (Pubitemid 24063152)
76. Lambert EV, Goedecke JH, Bluett K, et al. (2007) Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals. Br J Nutr 97, 1001-1011. (Pubitemid 46554416)
77. Eder E, Wacker M, Wanek P (2008) Lipid peroxidationrelated 1,N2-propanodeoxyguanosine -DNA adducts induced by endogenously formed 4-hydroxy-2-nonenal in organs of female rats fed diets supplemented with sunflower, rapeseed, olive or coconut oil. Mut Res 654, 101-107.
78. Moghadasian MH (2008) Advances in dietary enrichment with n-3 fatty acids. Crit Rev Food Sci Nutr 48, 402-410. (Pubitemid 351890373)
79. De Caterina R, Endres S, Kristensen SD, et al. (1994) n-3 Fatty acids and renal diseases. Am J Kid Dis 24, 397-415. (Pubitemid 24277936)
80. Priyamvada S, Priyadarshini M, Arivarasu NA, et al. (2008) Studies on the protective effect of dietary fish oil on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney. PLEFA 78, 369-381.
81. Dahl L, Bjorkkjaer T, Graff IE, et al. (2006) Fish - more than just omega 3. Tidsskr Nor Laegeforen 126, 309-311.
82. Conde CMS, Cyrino FZGA, Bottino DA, et al. (2007) Longchain n-3 polyunsaturated fatty acids and microvascular reactivity: observation in the hamster cheek pouch. Microvasc Res 73, 237-247.
83. Mozaffarian D, Prineas RJ, Stein PK, et al. (2006) Dietary fish and n-3 fatty acid intake and cardiac electrocardiographic parameters in humans. J Am Coll Cardiol 48, 478-484. (Pubitemid 44093963)
84. Theobald HE, Goodall AH, Sattar N, et al. (2007) Low-dose docosahexaenoic acid lowers diastolic blood pressure in middle-aged men and women. J Nutr 137, 973-978. (Pubitemid 46596896)
85. McLennan P, Howe P, Abeywardena M, et al. (1996) The cardiovascular protective role of docosahexaenoic acid. Eur J Pharmacol 300, 83-89. (Pubitemid 26130477)
86. Plourde M, Cunnane SC (2007) Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. Appl Physiol Nutr Metab 32, 619-634.
87. Lee JH, OKeefe JH, Lavie CJ, et al. (2008) Omega-3 fatty acids for cardioprotection. Mayo Clin Proc 83, 324-332.
88. Chiu WC, Wang YC, Chien YW, et al. (2009) Effect of dietary fish oil supplementation on cellular adhesion molecule expression and tissue myeloperoxidase activity in hypercholesterolemic mice with sepsis. J Nutr Biochem 20, 254-260.
89. McLennan PL (1993) Relative effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on cardiac arrhythmias in rats. Am J Clin Nutr 57, 207-212.
90. Mclennan PL, Abeywardena MY (2005) Membrane basis for fish oil effects on the heart: linking natural hibernators to prevention of human sudden cardiac death. Membrane Biol 206, 85-102.
91. Nielsen KC, Owman C (1968) Difference in cardiac adrenergic innervation between hibernators and nonhibernating mammals. Acta Physiol Scand 316, 1-30.
92. Wolowyk MW, Hewlett S, Gordon T, et al. (1990) Smoothmuscle contractility and calcium-channel density in hibernating and nonhibernating animals. Can J Physiol Pharmacol 68, 68-70. (Pubitemid 20107598)
93. Wang W, Schulze C, Suarez-Pinzon W, et al. (2002) Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury. Circulation 106, 1543-1549.
94. Abdukeyum GG, Owen AJ, McLennan PL (2008) Dietary (n-3) long-chain polyunsaturated fatty acids inhibit ischemia and reperfusion arrhythmias and infarction in rat heart not enhanced by ischemic preconditioning. J Nutr 138, 1902-1909.
95. Hlavackova M, Neckar J, Jezkova J, et al. (2007) Dietary polyunsaturated fatty acids alter myocardial protein kinase-C expression and affect cardioprotection induced by chronic hypoxia. Exp Biol Med 232, 823-832. (Pubitemid 46827825)
96. Burr ML, Ashfield-Watt PA, Dunstan FD, et al. (2003) Lack of benefit of dietary advice to men with angina: results of a controlled trial. Eur J Clin Nutr 57, 193-200. (Pubitemid 36240469)
97. Leaf A, Albert CM, Josephson M, et al. (2005) Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake. Circulation 112, 2762-2768. (Pubitemid 41641669)
98. Brouwer IA, Zock PL, Camm AJ, et al. (2006) Effect of fish oil on ventricular tachyarrhythmia and death in patients with implantable cardioverter defibrillators: the study on omega- 3 fatty acids and ventricular arrhythmia (SOFA) randomized trial. JAMA 295, 2613-2619.
99. Den Ruijter HM, Berecki G, Opthof T, et al. (2007) Pro- and antiarrhythmic properties of a diet rich in fish oil. Cardiovasc Res 73, 316-325. (Pubitemid 44940880)
100. Wilhelm M, Asskali RTF, Kraehner R, et al. (2008) Red blood cell omega-3 fatty acids and the risk of ventricular arrhythmias in patients with heart failure. Am Heart J 155, 971-977.
101. Huikuri HV, Castellanos A, Meyerburg RJ (2001) Sudden death due to cardiac arrhythmias. N Engl J Med 345, 1473-1482.
102. DAllesandro ME, Chicco A, Lombardo YB (2008) Dietary fish oil reverses lipotoxicity, altered glucose metabolism, and nPKCe translocation in the heart of dyslipemic insulin-resistant rats. Metabol Clin Exp 57, 911-919. (Pubitemid 351814683)
103. He K, Liu K, Daviglus ML, et al. (2008) Intakes of longchain n-3 polyunsaturated fatty acids and fish in relation to measurements of subclinical atherosclerosis. Am J Clin Nutr 88, 1111-1118.
104. De Marco M, De Simone G, Roman MJ, et al. (2009) Cardiovascular and metabolic predictors of progression of prehypertension into hypertension. The Strong Heart Study. Hypertension 54, 974-980.
105. Wilson TA, Nicolosi RJ, Kotyla T, et al. (2005) Different palm oil preparations reduce plasma cholesterol concentrations and aortic cholesterol accumulation compared to coconut oil in hypercholesterolaemic hamsters. J Nutr Biochem 16, 633-640. (Pubitemid 41338376)
106. Nagendran B, Unnithan UR, Choo YM, et al. (2000) Characteristics of red palm oil, a-carotene- and vitamin E-rich refined oil for food uses. Food Nutr Bull 2, 189-194. (Pubitemid 30454468)
107. Sundram K, Sambanthamurthi R, Tan YA (2003) Palm fruit chemistry. Asia Pac J Clin Nutr 12, 355-362.
108. Ong ASH, Goh SH (2002) Palm oil: a healthful and costeffective dietary component. Food Nutr Bull 23, 11-22.
109. Ooi CK (1999) Minor components of palm oil. PORIM Bull 38, 29-32.
110. Lehninger AL, Nelson DL, Cox MM (1993) In Principles of Biochemistry, 2nd ed., pp. 259-262. New York: Worth Publishers.
111. Ping BTY (2006) Palm carotenoids profile as a quality control tool for palm carotene producers: introducing an improvised method by HPLC-photodiode array and a C30 column. J Oil Palm Res 18, 253-259.
112. Steiner M, Anatasi J (1975) Vitamin E and platelet aggregation. J Clin Invest 57, 732-737.
113. Chan AC, Leith MK (1981) Decreased prostacyclin synthesis in vitamin E deficient rabbit aorta. Am J Clin Nutr 34, 2341-2347.
114. Helub BJ, Sicilia I, Mahadevappa VG (1989) Effect of tocotrienol derivatives on collagen and ADP-induced plasma platelet aggregation. Abstracts, PORUM International Palm Oil Development Conference, 5-9 September, Kuala Lumpur, N 9.
115. Qureshi AA, Qureshi N,Weight JJK, et al. (1991) Lowering of serum cholesterol in hypercholesterolaemic humans by tocotrienols (palmvitee). Am J Clin Nutr 53, 1021S-1026S.
116. Pearce BC, Parker RA, Deason ME, et al. (1992) Hypocholesterolaemic activity of synthetic and natural tocotrienols. J Med Chem 35, 3595-3606.
117. Serbinova E, Khavaja S, Catudioc J, et al. (1992) Palm oil vitamin E protects against ischaemia/reperfusion injury in the isolated perfused Langendorff heart. Nutr Res 12, 989S-1009S.
118. Goh SH, Choo YM, Ong ASH (1985) Minor constituents of palm oil. J Am Oil Chem Soc 62, 237-240.
119. Lietz G, Henry CJ, Mulokozi G, et al. (2001) Comparison of the effects of supplemental red palm oil and sunflower oil on maternal vitamin A status. Am J Clin Nutr 74, 501-509. (Pubitemid 32880261)
120. Van Stuijvenberg ME, Dhansay MA, Lombard CJ, et al. (2001) The effect of a biscuit with red palm oil as a source of b-carotene on the vitamin A status of primary school children: a comparison with b-carotene from a synthetic source in a randomized controlled trial. Eur J Clin Nutr 55, 657-662.
121. Radhika MS, Bhaskaram P, Balakrishna N, et al. (2003) Red palm oil supplementation: a feasible diet-based approach to improve the vitamin A status of pregnant woman and their infants. Food Nutr Bull 24, 208-217. (Pubitemid 37024533)
122. Hornstra G (1988) Dietary lipids and cardiovascular disease: effects of palm oil. Oleagineux 43, 75-81.
123. Ng TKW, Hassan K, Lim JB, et al. (1991) Non hypercholesterolemic effects of a palm-oil diet in Malaysian volunteers. Am J Clin Nutr 53, 1015S-1020S. (Pubitemid 21898865)
124. Qureshi AA, Bradlow BA, Brace L, et al. (1995) Response of hypercholesterolaemic subjects to administration of tocotrienols. Lipids 30, 1171-1177.
125. Sundram K, Anisah I, Hayes KC, et al. (1997) Trans (elaidic) fatty acids adversely impact lipoprotein profiles relative to specific saturated fatty acids in humans. J Nutr 127, 514S-520S. (Pubitemid 27120008)
126. Chandrasekharan N (1999) Changing concepts in lipid nutrition in health and nutrition. Med J Malaysia 54, 408-428.
127. Kritchevsky D, Tepper SA, Kuksis A (1999) Effects of palm oil, randomized palm oil and red palm oil on experimental atherosclerosis. FASEB J 13, A213.
128. Khosla P, Sundram K (1997) Effects of dietary palmitic and oleic acids on lipoprotein cholesterol. Am J Clin Nutr 65, 170-171.
129. Renaud SC, Ruf JC, Petithory D (1995) The positional distribution of fatty acids in palm oil and lard influences their biologic effects in rats. J Nutr 125, 229-237.
130. Khor HT, Chieng DY, Ong KK (1995) Tocotrienols inhibit HMG-CoA reductase activity in the guinea pig. Nutr Res 15, 537-544.
131. Zhang J, Wang CR, Xue AN, et al. (2003) Effects of red palm oil on serum lipids and plasma carotenoids level in Chinese male adults. Biomed Environ Sci 16, 348-354. (Pubitemid 38073082)
132. Salinas N, Márquez M, Sutil R, et al. (2008) Effect of partially refined palm oil in lipid profile in rats. Invest Clin 49, 5-16.
133. Abeywardena MY, Charnock JS (1995) Dietary lipid modification of myocardial eicosanoids following ischaemia and reperfusion in the rat. Lipids 30, 1151-1156.
134. Narang D, Sood S, Thomas MK, et al. (2004) Effect of dietary palm oil on oxidative stress associated with ischaemic-reperfusion injury in isolated rat heart. BMC Pharmacol 4, 29. (Pubitemid 40177085)
135. Esterhuyse AJ, Du Toit EF, Van Rooyen J (2005) Dietary red palm oil supplementation protects against the consequences of global ischaemia in the isolated perfused rat heart. Asia Pac J Clin Nutr 14, 340-347. (Pubitemid 43219090)
136. Esterhuyse AJ, Du Toit EF, Benade AJS, et al. (2005) Dietary red palm oil improves reperfusion cardiac function in the isolated perfused rat heart of animals fed a high cholesterol diet. PLEFA 72, 153-161.
137. Bester DJ, Van Rooyen J, Du Toit EF, et al. (2006) Red palm oil protects against the consequences of oxidative stress when supplemented with dislipidaemic diets. Med Technol SA 20, 3-10.
138. Engelbrecht AM, Esterhuyse AJ, Du Toit EF, et al. (2006) p38-MAPK and PKB/Akt, possible role players in red palm oil-induced protection of the isolated perfused rat heart. J Nutr Biochem 17, 265-271.
139. Esterhuyse JS, Van Rooyen J, Strijdom H, et al. (2006) Proposed mechanisms for red palm oil induced cardioprotection in a model of hyperlipidaemia in the rat. PLEFA 75, 375-384. (Pubitemid 44648733)
140. Kruger MJ, Engelbrecht AM, Esterhuyse AJ, et al. (2007) Dietary red palm oil reduces ischaemia-reperfusion injury in rats fed a hypercholesterolaemic diet. Br J Nutr 97, 653-660.
141. Van Rooyen J, Esterhuyse AJ, Engelbrecht AM, et al. (2008) Health benefits of a natural carotenoid rich oil: a proposed mechanism of protection against ischaemia/ reperfusion injury. Asia Pac J Clin Nutr 17, Suppl. 1, 316-319.
142. Engelbrecht AM, Odendaal L, Du Toit EF, et al. (2009) The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused rat heart: the involvement of the PI3-kinase signalling pathway. Lipids Health Dis 8, 18.
143. Du Toit EF, Meiring J, Opie LH (2001) Relation of cyclic nucleotide ratios to ischaemic and reperfusion injury in nitric oxide-donor treated rat hearts. J Cardiovasc Pharmacol 38, 529-538. (Pubitemid 32868224)
144. Khairallah RJ, Khairallah M, Gélinas R, et al. (2008) Cyclic GMP signalling in cardiomyocytes modulates fatty acid trafficking and prevents triglyceride accumulation. J Mol Cell Cardiol 45, 230-239.