-
1
-
-
84905705842
-
Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma
-
Affer, M., Chesi, M., Chen, W.D., Keats, J.J., Demchenko, Y.N., Tamizhmani, K., Garbitt, V.M., Riggs, D.L., Brents, L.A., Roschke, A.V., et al. Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma. Leukemia 28 (2014), 1725–1735.
-
(2014)
Leukemia
, vol.28
, pp. 1725-1735
-
-
Affer, M.1
Chesi, M.2
Chen, W.D.3
Keats, J.J.4
Demchenko, Y.N.5
Tamizhmani, K.6
Garbitt, V.M.7
Riggs, D.L.8
Brents, L.A.9
Roschke, A.V.10
-
2
-
-
70350780570
-
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
-
Alarcón, C., Zaromytidou, A.I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A.N., Manova-Todorova, K., Macias, M.J., et al. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell 139 (2009), 757–769.
-
(2009)
Cell
, vol.139
, pp. 757-769
-
-
Alarcón, C.1
Zaromytidou, A.I.2
Xi, Q.3
Gao, S.4
Yu, J.5
Fujisawa, S.6
Barlas, A.7
Miller, A.N.8
Manova-Todorova, K.9
Macias, M.J.10
-
3
-
-
84923811117
-
The Mediator complex: a central integrator of transcription
-
Allen, B.L., Taatjes, D.J., The Mediator complex: a central integrator of transcription. Nat. Rev. Mol. Cell Biol. 16 (2015), 155–166.
-
(2015)
Nat. Rev. Mol. Cell Biol.
, vol.16
, pp. 155-166
-
-
Allen, B.L.1
Taatjes, D.J.2
-
4
-
-
84988592852
-
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing
-
Amabile, A., Migliara, A., Capasso, P., Biffi, M., Cittaro, D., Naldini, L., Lombardo, A., Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing. Cell 167 (2016), 219–232.
-
(2016)
Cell
, vol.167
, pp. 219-232
-
-
Amabile, A.1
Migliara, A.2
Capasso, P.3
Biffi, M.4
Cittaro, D.5
Naldini, L.6
Lombardo, A.7
-
5
-
-
84861581164
-
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
-
Barbieri, C.E., Baca, S.C., Lawrence, M.S., Demichelis, F., Blattner, M., Theurillat, J.P., White, T.A., Stojanov, P., Van Allen, E., Stransky, N., et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat. Genet. 44 (2012), 685–689.
-
(2012)
Nat. Genet.
, vol.44
, pp. 685-689
-
-
Barbieri, C.E.1
Baca, S.C.2
Lawrence, M.S.3
Demichelis, F.4
Blattner, M.5
Theurillat, J.P.6
White, T.A.7
Stojanov, P.8
Van Allen, E.9
Stransky, N.10
-
6
-
-
84876278080
-
Methylation-dependent and -independent genomic targeting principles of the MBD protein family
-
Baubec, T., Ivánek, R., Lienert, F., Schübeler, D., Methylation-dependent and -independent genomic targeting principles of the MBD protein family. Cell 153 (2013), 480–492.
-
(2013)
Cell
, vol.153
, pp. 480-492
-
-
Baubec, T.1
Ivánek, R.2
Lienert, F.3
Schübeler, D.4
-
7
-
-
77249119762
-
The landscape of somatic copy-number alteration across human cancers
-
Beroukhim, R., Mermel, C.H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J.S., Dobson, J., Urashima, M., et al. The landscape of somatic copy-number alteration across human cancers. Nature 463 (2010), 899–905.
-
(2010)
Nature
, vol.463
, pp. 899-905
-
-
Beroukhim, R.1
Mermel, C.H.2
Porter, D.3
Wei, G.4
Raychaudhuri, S.5
Donovan, J.6
Barretina, J.7
Boehm, J.S.8
Dobson, J.9
Urashima, M.10
-
8
-
-
84962683838
-
BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements
-
Bhagwat, A.S., Roe, J.S., Mok, B.Y., Hohmann, A.F., Shi, J., Vakoc, C.R., BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements. Cell Rep. 15 (2016), 519–530.
-
(2016)
Cell Rep.
, vol.15
, pp. 519-530
-
-
Bhagwat, A.S.1
Roe, J.S.2
Mok, B.Y.3
Hohmann, A.F.4
Shi, J.5
Vakoc, C.R.6
-
9
-
-
84957798869
-
Targeting Transcription Factors in Cancer
-
Bhagwat, A.S., Vakoc, C.R., Targeting Transcription Factors in Cancer. Trends Cancer 1 (2015), 53–65.
-
(2015)
Trends Cancer
, vol.1
, pp. 53-65
-
-
Bhagwat, A.S.1
Vakoc, C.R.2
-
10
-
-
35348816030
-
Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription
-
Bisgrove, D.A., Mahmoudi, T., Henklein, P., Verdin, E., Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. Proc. Natl. Acad. Sci. USA 104 (2007), 13690–13695.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 13690-13695
-
-
Bisgrove, D.A.1
Mahmoudi, T.2
Henklein, P.3
Verdin, E.4
-
11
-
-
84908602740
-
NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis
-
Brown, J.D., Lin, C.Y., Duan, Q., Griffin, G., Federation, A.J., Paranal, R.M., Bair, S., Newton, G., Lichtman, A.H., Kung, A.L., et al. NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis. Mol. Cell 56 (2014), 219–231.
-
(2014)
Mol. Cell
, vol.56
, pp. 219-231
-
-
Brown, J.D.1
Lin, C.Y.2
Duan, Q.3
Griffin, G.4
Federation, A.J.5
Paranal, R.M.6
Bair, S.7
Newton, G.8
Lichtman, A.H.9
Kung, A.L.10
-
12
-
-
84877978530
-
Mechanisms and models of somatic cell reprogramming
-
Buganim, Y., Faddah, D.A., Jaenisch, R., Mechanisms and models of somatic cell reprogramming. Nat. Rev. Genet. 14 (2013), 427–439.
-
(2013)
Nat. Rev. Genet.
, vol.14
, pp. 427-439
-
-
Buganim, Y.1
Faddah, D.A.2
Jaenisch, R.3
-
13
-
-
79551655285
-
Functional and mechanistic diversity of distal transcription enhancers
-
Bulger, M., Groudine, M., Functional and mechanistic diversity of distal transcription enhancers. Cell 144 (2011), 327–339.
-
(2011)
Cell
, vol.144
, pp. 327-339
-
-
Bulger, M.1
Groudine, M.2
-
14
-
-
84876884110
-
Dysregulation of the basal RNA polymerase transcription apparatus in cancer
-
Bywater, M.J., Pearson, R.B., McArthur, G.A., Hannan, R.D., Dysregulation of the basal RNA polymerase transcription apparatus in cancer. Nat. Rev. Cancer 13 (2013), 299–314.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 299-314
-
-
Bywater, M.J.1
Pearson, R.B.2
McArthur, G.A.3
Hannan, R.D.4
-
15
-
-
84947787152
-
Drugging Chromatin in Cancer: Recent Advances and Novel Approaches
-
Cai, S.F., Chen, C.W., Armstrong, S.A., Drugging Chromatin in Cancer: Recent Advances and Novel Approaches. Mol. Cell 60 (2015), 561–570.
-
(2015)
Mol. Cell
, vol.60
, pp. 561-570
-
-
Cai, S.F.1
Chen, C.W.2
Armstrong, S.A.3
-
16
-
-
73349092441
-
Histones: annotating chromatin
-
Campos, E.I., Reinberg, D., Histones: annotating chromatin. Annu. Rev. Genet. 43 (2009), 559–599.
-
(2009)
Annu. Rev. Genet.
, vol.43
, pp. 559-599
-
-
Campos, E.I.1
Reinberg, D.2
-
17
-
-
84891953718
-
Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma
-
Chapuy, B., McKeown, M.R., Lin, C.Y., Monti, S., Roemer, M.G., Qi, J., Rahl, P.B., Sun, H.H., Yeda, K.T., Doench, J.G., et al. Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma. Cancer Cell 24 (2013), 777–790.
-
(2013)
Cancer Cell
, vol.24
, pp. 777-790
-
-
Chapuy, B.1
McKeown, M.R.2
Lin, C.Y.3
Monti, S.4
Roemer, M.G.5
Qi, J.6
Rahl, P.B.7
Sun, H.H.8
Yeda, K.T.9
Doench, J.G.10
-
18
-
-
84939165694
-
Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond
-
Chen, C.W., Armstrong, S.A., Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond. Exp. Hematol. 43 (2015), 673–684.
-
(2015)
Exp. Hematol.
, vol.43
, pp. 673-684
-
-
Chen, C.W.1
Armstrong, S.A.2
-
19
-
-
0027411688
-
Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia
-
Chen, Z., Brand, N.J., Chen, A., Chen, S.J., Tong, J.H., Wang, Z.Y., Waxman, S., Zelent, A., Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J. 12 (1993), 1161–1167.
-
(1993)
EMBO J.
, vol.12
, pp. 1161-1167
-
-
Chen, Z.1
Brand, N.J.2
Chen, A.3
Chen, S.J.4
Tong, J.H.5
Wang, Z.Y.6
Waxman, S.7
Zelent, A.8
-
20
-
-
84911942289
-
CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer
-
Chipumuro, E., Marco, E., Christensen, C.L., Kwiatkowski, N., Zhang, T., Hatheway, C.M., Abraham, B.J., Sharma, B., Yeung, C., Altabef, A., et al. CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer. Cell 159 (2014), 1126–1139.
-
(2014)
Cell
, vol.159
, pp. 1126-1139
-
-
Chipumuro, E.1
Marco, E.2
Christensen, C.L.3
Kwiatkowski, N.4
Zhang, T.5
Hatheway, C.M.6
Abraham, B.J.7
Sharma, B.8
Yeung, C.9
Altabef, A.10
-
21
-
-
84919495606
-
Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor
-
Christensen, C.L., Kwiatkowski, N., Abraham, B.J., Carretero, J., Al-Shahrour, F., Zhang, T., Chipumuro, E., Herter-Sprie, G.S., Akbay, E.A., Altabef, A., et al. Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor. Cancer Cell 26 (2014), 909–922.
-
(2014)
Cancer Cell
, vol.26
, pp. 909-922
-
-
Christensen, C.L.1
Kwiatkowski, N.2
Abraham, B.J.3
Carretero, J.4
Al-Shahrour, F.5
Zhang, T.6
Chipumuro, E.7
Herter-Sprie, G.S.8
Akbay, E.A.9
Altabef, A.10
-
22
-
-
84983479137
-
Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas
-
Clark, V.E., Harmancı, A.S., Bai, H., Youngblood, M.W., Lee, T.I., Baranoski, J.F., Ercan-Sencicek, A.G., Abraham, B.J., Weintraub, A.S., Hnisz, D., et al. Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas. Nat. Genet. 48 (2016), 1253–1259.
-
(2016)
Nat. Genet.
, vol.48
, pp. 1253-1259
-
-
Clark, V.E.1
Harmancı, A.S.2
Bai, H.3
Youngblood, M.W.4
Lee, T.I.5
Baranoski, J.F.6
Ercan-Sencicek, A.G.7
Abraham, B.J.8
Weintraub, A.S.9
Hnisz, D.10
-
23
-
-
84886864184
-
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
-
Daigle, S.R., Olhava, E.J., Therkelsen, C.A., Basavapathruni, A., Jin, L., Boriack-Sjodin, P.A., Allain, C.J., Klaus, C.R., Raimondi, A., Scott, M.P., et al. Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood 122 (2013), 1017–1025.
-
(2013)
Blood
, vol.122
, pp. 1017-1025
-
-
Daigle, S.R.1
Olhava, E.J.2
Therkelsen, C.A.3
Basavapathruni, A.4
Jin, L.5
Boriack-Sjodin, P.A.6
Allain, C.J.7
Klaus, C.R.8
Raimondi, A.9
Scott, M.P.10
-
24
-
-
0036782706
-
Transcription factors as targets for cancer therapy
-
Darnell, J.E. Jr., Transcription factors as targets for cancer therapy. Nat. Rev. Cancer 2 (2002), 740–749.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 740-749
-
-
Darnell, J.E.1
-
25
-
-
80054984945
-
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
-
Dawson, M.A., Prinjha, R.K., Dittmann, A., Giotopoulos, G., Bantscheff, M., Chan, W.I., Robson, S.C., Chung, C.W., Hopf, C., Savitski, M.M., et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 478 (2011), 529–533.
-
(2011)
Nature
, vol.478
, pp. 529-533
-
-
Dawson, M.A.1
Prinjha, R.K.2
Dittmann, A.3
Giotopoulos, G.4
Bantscheff, M.5
Chan, W.I.6
Robson, S.C.7
Chung, C.W.8
Hopf, C.9
Savitski, M.M.10
-
26
-
-
80052955256
-
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
-
Delmore, J.E., Issa, G.C., Lemieux, M.E., Rahl, P.B., Shi, J., Jacobs, H.M., Kastritis, E., Gilpatrick, T., Paranal, R.M., Qi, J., et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146 (2011), 904–917.
-
(2011)
Cell
, vol.146
, pp. 904-917
-
-
Delmore, J.E.1
Issa, G.C.2
Lemieux, M.E.3
Rahl, P.B.4
Shi, J.5
Jacobs, H.M.6
Kastritis, E.7
Gilpatrick, T.8
Paranal, R.M.9
Qi, J.10
-
27
-
-
84878383491
-
Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l
-
Deshpande, A.J., Chen, L., Fazio, M., Sinha, A.U., Bernt, K.M., Banka, D., Dias, S., Chang, J., Olhava, E.J., Daigle, S.R., et al. Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l. Blood 121 (2013), 2533–2541.
-
(2013)
Blood
, vol.121
, pp. 2533-2541
-
-
Deshpande, A.J.1
Chen, L.2
Fazio, M.3
Sinha, A.U.4
Bernt, K.M.5
Banka, D.6
Dias, S.7
Chang, J.8
Olhava, E.J.9
Daigle, S.R.10
-
28
-
-
84913594397
-
Genome editing. The new frontier of genome engineering with CRISPR-Cas9
-
Doudna, J.A., Charpentier, E., Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science, 346, 2014, 1258096.
-
(2014)
Science
, vol.346
, pp. 1258096
-
-
Doudna, J.A.1
Charpentier, E.2
-
29
-
-
84916880365
-
Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes
-
Dowen, J.M., Fan, Z.P., Hnisz, D., Ren, G., Abraham, B.J., Zhang, L.N., Weintraub, A.S., Schuijers, J., Lee, T.I., Zhao, K., Young, R.A., Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes. Cell 159 (2014), 374–387.
-
(2014)
Cell
, vol.159
, pp. 374-387
-
-
Dowen, J.M.1
Fan, Z.P.2
Hnisz, D.3
Ren, G.4
Abraham, B.J.5
Zhang, L.N.6
Weintraub, A.S.7
Schuijers, J.8
Lee, T.I.9
Zhao, K.10
Young, R.A.11
-
30
-
-
84959507957
-
An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma
-
Drier, Y., Cotton, M.J., Williamson, K.E., Gillespie, S.M., Ryan, R.J., Kluk, M.J., Carey, C.D., Rodig, S.J., Sholl, L.M., Afrogheh, A.H., et al. An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. Nat. Genet. 48 (2016), 265–272.
-
(2016)
Nat. Genet.
, vol.48
, pp. 265-272
-
-
Drier, Y.1
Cotton, M.J.2
Williamson, K.E.3
Gillespie, S.M.4
Ryan, R.J.5
Kluk, M.J.6
Carey, C.D.7
Rodig, S.J.8
Sholl, L.M.9
Afrogheh, A.H.10
-
31
-
-
84888991588
-
The RNA polymerase II carboxy-terminal domain (CTD) code
-
Eick, D., Geyer, M., The RNA polymerase II carboxy-terminal domain (CTD) code. Chem. Rev. 113 (2013), 8456–8490.
-
(2013)
Chem. Rev.
, vol.113
, pp. 8456-8490
-
-
Eick, D.1
Geyer, M.2
-
32
-
-
84865790047
-
An integrated encyclopedia of DNA elements in the human genome
-
ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489 (2012), 57–74.
-
(2012)
Nature
, vol.489
, pp. 57-74
-
-
-
33
-
-
0033180211
-
Reversible tumorigenesis by MYC in hematopoietic lineages
-
Felsher, D.W., Bishop, J.M., Reversible tumorigenesis by MYC in hematopoietic lineages. Mol. Cell 4 (1999), 199–207.
-
(1999)
Mol. Cell
, vol.4
, pp. 199-207
-
-
Felsher, D.W.1
Bishop, J.M.2
-
34
-
-
78650847770
-
Selective inhibition of BET bromodomains
-
Filippakopoulos, P., Qi, J., Picaud, S., Shen, Y., Smith, W.B., Fedorov, O., Morse, E.M., Keates, T., Hickman, T.T., Felletar, I., et al. Selective inhibition of BET bromodomains. Nature 468 (2010), 1067–1073.
-
(2010)
Nature
, vol.468
, pp. 1067-1073
-
-
Filippakopoulos, P.1
Qi, J.2
Picaud, S.3
Shen, Y.4
Smith, W.B.5
Fedorov, O.6
Morse, E.M.7
Keates, T.8
Hickman, T.T.9
Felletar, I.10
-
35
-
-
84953924597
-
Insulator dysfunction and oncogene activation in IDH mutant gliomas
-
Flavahan, W.A., Drier, Y., Liau, B.B., Gillespie, S.M., Venteicher, A.S., Stemmer-Rachamimov, A.O., Suvà, M.L., Bernstein, B.E., Insulator dysfunction and oncogene activation in IDH mutant gliomas. Nature 529 (2016), 110–114.
-
(2016)
Nature
, vol.529
, pp. 110-114
-
-
Flavahan, W.A.1
Drier, Y.2
Liau, B.B.3
Gillespie, S.M.4
Venteicher, A.S.5
Stemmer-Rachamimov, A.O.6
Suvà, M.L.7
Bernstein, B.E.8
-
36
-
-
84942531832
-
BET inhibitor resistance emerges from leukaemia stem cells
-
Fong, C.Y., Gilan, O., Lam, E.Y., Rubin, A.F., Ftouni, S., Tyler, D., Stanley, K., Sinha, D., Yeh, P., Morison, J., et al. BET inhibitor resistance emerges from leukaemia stem cells. Nature 525 (2015), 538–542.
-
(2015)
Nature
, vol.525
, pp. 538-542
-
-
Fong, C.Y.1
Gilan, O.2
Lam, E.Y.3
Rubin, A.F.4
Ftouni, S.5
Tyler, D.6
Stanley, K.7
Sinha, D.8
Yeh, P.9
Morison, J.10
-
37
-
-
84875758730
-
Lessons from the cancer genome
-
Garraway, L.A., Lander, E.S., Lessons from the cancer genome. Cell 153 (2013), 17–37.
-
(2013)
Cell
, vol.153
, pp. 17-37
-
-
Garraway, L.A.1
Lander, E.S.2
-
38
-
-
84861869979
-
Ubiquitin and proteasomes in transcription
-
Geng, F., Wenzel, S., Tansey, W.P., Ubiquitin and proteasomes in transcription. Annu. Rev. Biochem. 81 (2012), 177–201.
-
(2012)
Annu. Rev. Biochem.
, vol.81
, pp. 177-201
-
-
Geng, F.1
Wenzel, S.2
Tansey, W.P.3
-
39
-
-
84963805992
-
CTCF: making the right connections
-
Ghirlando, R., Felsenfeld, G., CTCF: making the right connections. Genes Dev. 30 (2016), 881–891.
-
(2016)
Genes Dev.
, vol.30
, pp. 881-891
-
-
Ghirlando, R.1
Felsenfeld, G.2
-
40
-
-
84876838711
-
The hierarchy of the 3D genome
-
Gibcus, J.H., Dekker, J., The hierarchy of the 3D genome. Mol. Cell 49 (2013), 773–782.
-
(2013)
Mol. Cell
, vol.49
, pp. 773-782
-
-
Gibcus, J.H.1
Dekker, J.2
-
41
-
-
84902212007
-
The 3D genome in transcriptional regulation and pluripotency
-
Gorkin, D.U., Leung, D., Ren, B., The 3D genome in transcriptional regulation and pluripotency. Cell Stem Cell 14 (2014), 762–775.
-
(2014)
Cell Stem Cell
, vol.14
, pp. 762-775
-
-
Gorkin, D.U.1
Leung, D.2
Ren, B.3
-
42
-
-
71449125977
-
Forcing cells to change lineages
-
Graf, T., Enver, T., Forcing cells to change lineages. Nature 462 (2009), 587–594.
-
(2009)
Nature
, vol.462
, pp. 587-594
-
-
Graf, T.1
Enver, T.2
-
43
-
-
84898494315
-
A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia
-
Gröschel, S., Sanders, M.A., Hoogenboezem, R., de Wit, E., Bouwman, B.A., Erpelinck, C., van der Velden, V.H., Havermans, M., Avellino, R., van Lom, K., et al. A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia. Cell 157 (2014), 369–381.
-
(2014)
Cell
, vol.157
, pp. 369-381
-
-
Gröschel, S.1
Sanders, M.A.2
Hoogenboezem, R.3
de Wit, E.4
Bouwman, B.A.5
Erpelinck, C.6
van der Velden, V.H.7
Havermans, M.8
Avellino, R.9
van Lom, K.10
-
44
-
-
58049220979
-
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia
-
Guenther, M.G., Lawton, L.N., Rozovskaia, T., Frampton, G.M., Levine, S.S., Volkert, T.L., Croce, C.M., Nakamura, T., Canaani, E., Young, R.A., Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia. Genes Dev. 22 (2008), 3403–3408.
-
(2008)
Genes Dev.
, vol.22
, pp. 3403-3408
-
-
Guenther, M.G.1
Lawton, L.N.2
Rozovskaia, T.3
Frampton, G.M.4
Levine, S.S.5
Volkert, T.L.6
Croce, C.M.7
Nakamura, T.8
Canaani, E.9
Young, R.A.10
-
45
-
-
84922435519
-
Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs
-
Hah, N., Benner, C., Chong, L.W., Yu, R.T., Downes, M., Evans, R.M., Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs. Proc. Natl. Acad. Sci. USA 112 (2015), E297–E302.
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. E297-E302
-
-
Hah, N.1
Benner, C.2
Chong, L.W.3
Yu, R.T.4
Downes, M.5
Evans, R.M.6
-
46
-
-
84976904754
-
Genetic dissection of the α-globin super-enhancer in vivo
-
Hay, D., Hughes, J.R., Babbs, C., Davies, J.O., Graham, B.J., Hanssen, L.L., Kassouf, M.T., Oudelaar, A.M., Sharpe, J.A., Suciu, M.C., et al. Genetic dissection of the α-globin super-enhancer in vivo. Nat. Genet. 48 (2016), 895–903.
-
(2016)
Nat. Genet.
, vol.48
, pp. 895-903
-
-
Hay, D.1
Hughes, J.R.2
Babbs, C.3
Davies, J.O.4
Graham, B.J.5
Hanssen, L.L.6
Kassouf, M.T.7
Oudelaar, A.M.8
Sharpe, J.A.9
Suciu, M.C.10
-
47
-
-
84888015137
-
Super-enhancers in the control of cell identity and disease
-
Hnisz, D., Abraham, B.J., Lee, T.I., Lau, A., Saint-André, V., Sigova, A.A., Hoke, H.A., Young, R.A., Super-enhancers in the control of cell identity and disease. Cell 155 (2013), 934–947.
-
(2013)
Cell
, vol.155
, pp. 934-947
-
-
Hnisz, D.1
Abraham, B.J.2
Lee, T.I.3
Lau, A.4
Saint-André, V.5
Sigova, A.A.6
Hoke, H.A.7
Young, R.A.8
-
48
-
-
84928207423
-
Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers
-
Hnisz, D., Schuijers, J., Lin, C.Y., Weintraub, A.S., Abraham, B.J., Lee, T.I., Bradner, J.E., Young, R.A., Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers. Mol. Cell 58 (2015), 362–370.
-
(2015)
Mol. Cell
, vol.58
, pp. 362-370
-
-
Hnisz, D.1
Schuijers, J.2
Lin, C.Y.3
Weintraub, A.S.4
Abraham, B.J.5
Lee, T.I.6
Bradner, J.E.7
Young, R.A.8
-
49
-
-
84995810181
-
Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control
-
Hnisz, D., Day, D.S., Young, R.A., Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control. Cell 167 (2016), 1188–1200.
-
(2016)
Cell
, vol.167
, pp. 1188-1200
-
-
Hnisz, D.1
Day, D.S.2
Young, R.A.3
-
50
-
-
84960171833
-
Activation of proto-oncogenes by disruption of chromosome neighborhoods
-
Hnisz, D., Weintraub, A.S., Day, D.S., Valton, A.L., Bak, R.O., Li, C.H., Goldmann, J., Lajoie, B.R., Fan, Z.P., Sigova, A.A., et al. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science 351 (2016), 1454–1458.
-
(2016)
Science
, vol.351
, pp. 1454-1458
-
-
Hnisz, D.1
Weintraub, A.S.2
Day, D.S.3
Valton, A.L.4
Bak, R.O.5
Li, C.H.6
Goldmann, J.7
Lajoie, B.R.8
Fan, Z.P.9
Sigova, A.A.10
-
51
-
-
0023752982
-
Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia
-
Huang, M.E., Ye, Y.C., Chen, S.R., Chai, J.R., Lu, J.X., Zhoa, L., Gu, L.J., Wang, Z.Y., Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72 (1988), 567–572.
-
(1988)
Blood
, vol.72
, pp. 567-572
-
-
Huang, M.E.1
Ye, Y.C.2
Chen, S.R.3
Chai, J.R.4
Lu, J.X.5
Zhoa, L.6
Gu, L.J.7
Wang, Z.Y.8
-
52
-
-
78049529488
-
Glucocorticoid use in acute lymphoblastic leukaemia
-
Inaba, H., Pui, C.H., Glucocorticoid use in acute lymphoblastic leukaemia. Lancet Oncol. 11 (2010), 1096–1106.
-
(2010)
Lancet Oncol.
, vol.11
, pp. 1096-1106
-
-
Inaba, H.1
Pui, C.H.2
-
53
-
-
0037025201
-
Sustained loss of a neoplastic phenotype by brief inactivation of MYC
-
Jain, M., Arvanitis, C., Chu, K., Dewey, W., Leonhardt, E., Trinh, M., Sundberg, C.D., Bishop, J.M., Felsher, D.W., Sustained loss of a neoplastic phenotype by brief inactivation of MYC. Science 297 (2002), 102–104.
-
(2002)
Science
, vol.297
, pp. 102-104
-
-
Jain, M.1
Arvanitis, C.2
Chu, K.3
Dewey, W.4
Leonhardt, E.5
Trinh, M.6
Sundberg, C.D.7
Bishop, J.M.8
Felsher, D.W.9
-
54
-
-
84957850407
-
3D Chromosome Regulatory Landscape of Human Pluripotent Cells
-
Ji, X., Dadon, D.B., Powell, B.E., Fan, Z.P., Borges-Rivera, D., Shachar, S., Weintraub, A.S., Hnisz, D., Pegoraro, G., Lee, T.I., et al. 3D Chromosome Regulatory Landscape of Human Pluripotent Cells. Cell Stem Cell 18 (2016), 262–275.
-
(2016)
Cell Stem Cell
, vol.18
, pp. 262-275
-
-
Ji, X.1
Dadon, D.B.2
Powell, B.E.3
Fan, Z.P.4
Borges-Rivera, D.5
Shachar, S.6
Weintraub, A.S.7
Hnisz, D.8
Pegoraro, G.9
Lee, T.I.10
-
55
-
-
84992366141
-
Identification of multi-loci hubs from 4C-seq demonstrates the functional importance of simultaneous interactions
-
Jiang, T., Raviram, R., Snetkova, V., Rocha, P.P., Proudhon, C., Badri, S., Bonneau, R., Skok, J.A., Kluger, Y., Identification of multi-loci hubs from 4C-seq demonstrates the functional importance of simultaneous interactions. Nucleic Acids Res. 44 (2016), 8714–8725.
-
(2016)
Nucleic Acids Res.
, vol.44
, pp. 8714-8725
-
-
Jiang, T.1
Raviram, R.2
Snetkova, V.3
Rocha, P.P.4
Proudhon, C.5
Badri, S.6
Bonneau, R.7
Skok, J.A.8
Kluger, Y.9
-
56
-
-
84987781487
-
Targeting the cancer epigenome for therapy
-
Jones, P.A., Issa, J.P., Baylin, S., Targeting the cancer epigenome for therapy. Nat. Rev. Genet. 17 (2016), 630–641.
-
(2016)
Nat. Rev. Genet.
, vol.17
, pp. 630-641
-
-
Jones, P.A.1
Issa, J.P.2
Baylin, S.3
-
57
-
-
84923780299
-
Getting up to speed with transcription elongation by RNA polymerase II
-
Jonkers, I., Lis, J.T., Getting up to speed with transcription elongation by RNA polymerase II. Nat. Rev. Mol. Cell Biol. 16 (2015), 167–177.
-
(2015)
Nat. Rev. Mol. Cell Biol.
, vol.16
, pp. 167-177
-
-
Jonkers, I.1
Lis, J.T.2
-
58
-
-
84953840289
-
Stimulus-specific combinatorial functionality of neuronal c-fos enhancers
-
Joo, J.Y., Schaukowitch, K., Farbiak, L., Kilaru, G., Kim, T.K., Stimulus-specific combinatorial functionality of neuronal c-fos enhancers. Nat. Neurosci. 19 (2016), 75–83.
-
(2016)
Nat. Neurosci.
, vol.19
, pp. 75-83
-
-
Joo, J.Y.1
Schaukowitch, K.2
Farbiak, L.3
Kilaru, G.4
Kim, T.K.5
-
59
-
-
85041801996
-
Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics
-
Kadoch, C., Crabtree, G.R., Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics. Sci. Adv., 1, 2015, e1500447.
-
(2015)
Sci. Adv.
, vol.1
, pp. e1500447
-
-
Kadoch, C.1
Crabtree, G.R.2
-
60
-
-
77957139539
-
Mediator and cohesin connect gene expression and chromatin architecture
-
Kagey, M.H., Newman, J.J., Bilodeau, S., Zhan, Y., Orlando, D.A., van Berkum, N.L., Ebmeier, C.C., Goossens, J., Rahl, P.B., Levine, S.S., et al. Mediator and cohesin connect gene expression and chromatin architecture. Nature 467 (2010), 430–435.
-
(2010)
Nature
, vol.467
, pp. 430-435
-
-
Kagey, M.H.1
Newman, J.J.2
Bilodeau, S.3
Zhan, Y.4
Orlando, D.A.5
van Berkum, N.L.6
Ebmeier, C.C.7
Goossens, J.8
Rahl, P.B.9
Levine, S.S.10
-
61
-
-
84885735554
-
Mutational landscape and significance across 12 major cancer types
-
Kandoth, C., McLellan, M.D., Vandin, F., Ye, K., Niu, B., Lu, C., Xie, M., Zhang, Q., McMichael, J.F., Wyczalkowski, M.A., et al. Mutational landscape and significance across 12 major cancer types. Nature 502 (2013), 333–339.
-
(2013)
Nature
, vol.502
, pp. 333-339
-
-
Kandoth, C.1
McLellan, M.D.2
Vandin, F.3
Ye, K.4
Niu, B.5
Lu, C.6
Xie, M.7
Zhang, Q.8
McMichael, J.F.9
Wyczalkowski, M.A.10
-
62
-
-
84933278077
-
CTCF/cohesin-binding sites are frequently mutated in cancer
-
Katainen, R., Dave, K., Pitkänen, E., Palin, K., Kivioja, T., Välimäki, N., Gylfe, A.E., Ristolainen, H., Hänninen, U.A., Cajuso, T., et al. CTCF/cohesin-binding sites are frequently mutated in cancer. Nat. Genet. 47 (2015), 818–821.
-
(2015)
Nat. Genet.
, vol.47
, pp. 818-821
-
-
Katainen, R.1
Dave, K.2
Pitkänen, E.3
Palin, K.4
Kivioja, T.5
Välimäki, N.6
Gylfe, A.E.7
Ristolainen, H.8
Hänninen, U.A.9
Cajuso, T.10
-
63
-
-
84945157565
-
Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma
-
Kennedy, A.L., Vallurupalli, M., Chen, L., Crompton, B., Cowley, G., Vazquez, F., Weir, B.A., Tsherniak, A., Parasuraman, S., Kim, S., et al. Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma. Oncotarget 6 (2015), 30178–30193.
-
(2015)
Oncotarget
, vol.6
, pp. 30178-30193
-
-
Kennedy, A.L.1
Vallurupalli, M.2
Chen, L.3
Crompton, B.4
Cowley, G.5
Vazquez, F.6
Weir, B.A.7
Tsherniak, A.8
Parasuraman, S.9
Kim, S.10
-
64
-
-
84894589713
-
Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation
-
Kieffer-Kwon, K.R., Tang, Z., Mathe, E., Qian, J., Sung, M.H., Li, G., Resch, W., Baek, S., Pruett, N., Grøntved, L., et al. Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation. Cell 155 (2013), 1507–1520.
-
(2013)
Cell
, vol.155
, pp. 1507-1520
-
-
Kieffer-Kwon, K.R.1
Tang, Z.2
Mathe, E.3
Qian, J.4
Sung, M.H.5
Li, G.6
Resch, W.7
Baek, S.8
Pruett, N.9
Grøntved, L.10
-
65
-
-
33847076849
-
Chromatin modifications and their function
-
Kouzarides, T., Chromatin modifications and their function. Cell 128 (2007), 693–705.
-
(2007)
Cell
, vol.128
, pp. 693-705
-
-
Kouzarides, T.1
-
66
-
-
54549083228
-
H3K79 methylation profiles define murine and human MLL-AF4 leukemias
-
Krivtsov, A.V., Feng, Z., Lemieux, M.E., Faber, J., Vempati, S., Sinha, A.U., Xia, X., Jesneck, J., Bracken, A.P., Silverman, L.B., et al. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell 14 (2008), 355–368.
-
(2008)
Cancer Cell
, vol.14
, pp. 355-368
-
-
Krivtsov, A.V.1
Feng, Z.2
Lemieux, M.E.3
Faber, J.4
Vempati, S.5
Sinha, A.U.6
Xia, X.7
Jesneck, J.8
Bracken, A.P.9
Silverman, L.B.10
-
67
-
-
84923362619
-
Integrative analysis of 111 reference human epigenomes
-
Roadmap Epigenomics Consortium, Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., Ziller, M.J., et al. Integrative analysis of 111 reference human epigenomes. Nature 518 (2015), 317–330.
-
(2015)
Nature
, vol.518
, pp. 317-330
-
-
Kundaje, A.1
Meuleman, W.2
Ernst, J.3
Bilenky, M.4
Yen, A.5
Heravi-Moussavi, A.6
Kheradpour, P.7
Zhang, Z.8
Wang, J.9
Ziller, M.J.10
-
68
-
-
84904963991
-
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
-
Kwiatkowski, N., Zhang, T., Rahl, P.B., Abraham, B.J., Reddy, J., Ficarro, S.B., Dastur, A., Amzallag, A., Ramaswamy, S., Tesar, B., et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature 511 (2014), 616–620.
-
(2014)
Nature
, vol.511
, pp. 616-620
-
-
Kwiatkowski, N.1
Zhang, T.2
Rahl, P.B.3
Abraham, B.J.4
Reddy, J.5
Ficarro, S.B.6
Dastur, A.7
Amzallag, A.8
Ramaswamy, S.9
Tesar, B.10
-
69
-
-
84874368349
-
Activating RNAs associate with Mediator to enhance chromatin architecture and transcription
-
Lai, F., Orom, U.A., Cesaroni, M., Beringer, M., Taatjes, D.J., Blobel, G.A., Shiekhattar, R., Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature 494 (2013), 497–501.
-
(2013)
Nature
, vol.494
, pp. 497-501
-
-
Lai, F.1
Orom, U.A.2
Cesaroni, M.3
Beringer, M.4
Taatjes, D.J.5
Blobel, G.A.6
Shiekhattar, R.7
-
70
-
-
78650316134
-
p53 Research: the past thirty years and the next thirty years
-
Lane, D., Levine, A., p53 Research: the past thirty years and the next thirty years. Cold Spring Harb. Perspect. Biol., 2, 2010, a000893.
-
(2010)
Cold Spring Harb. Perspect. Biol.
, vol.2
, pp. a000893
-
-
Lane, D.1
Levine, A.2
-
71
-
-
84892833777
-
Discovery and saturation analysis of cancer genes across 21 tumour types
-
Lawrence, M.S., Stojanov, P., Mermel, C.H., Robinson, J.T., Garraway, L.A., Golub, T.R., Meyerson, M., Gabriel, S.B., Lander, E.S., Getz, G., Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 505 (2014), 495–501.
-
(2014)
Nature
, vol.505
, pp. 495-501
-
-
Lawrence, M.S.1
Stojanov, P.2
Mermel, C.H.3
Robinson, J.T.4
Garraway, L.A.5
Golub, T.R.6
Meyerson, M.7
Gabriel, S.B.8
Lander, E.S.9
Getz, G.10
-
72
-
-
84875198920
-
Transcriptional regulation and its misregulation in disease
-
Lee, T.I., Young, R.A., Transcriptional regulation and its misregulation in disease. Cell 152 (2013), 1237–1251.
-
(2013)
Cell
, vol.152
, pp. 1237-1251
-
-
Lee, T.I.1
Young, R.A.2
-
73
-
-
84897138228
-
Looping back to leap forward: transcription enters a new era
-
Levine, M., Cattoglio, C., Tjian, R., Looping back to leap forward: transcription enters a new era. Cell 157 (2014), 13–25.
-
(2014)
Cell
, vol.157
, pp. 13-25
-
-
Levine, M.1
Cattoglio, C.2
Tjian, R.3
-
74
-
-
84960146385
-
Enhancers as non-coding RNA transcription units: recent insights and future perspectives
-
Li, W., Notani, D., Rosenfeld, M.G., Enhancers as non-coding RNA transcription units: recent insights and future perspectives. Nat. Rev. Genet. 17 (2016), 207–223.
-
(2016)
Nat. Rev. Genet.
, vol.17
, pp. 207-223
-
-
Li, W.1
Notani, D.2
Rosenfeld, M.G.3
-
75
-
-
84867021989
-
Transcriptional amplification in tumor cells with elevated c-Myc
-
Lin, C.Y., Lovén, J., Rahl, P.B., Paranal, R.M., Burge, C.B., Bradner, J.E., Lee, T.I., Young, R.A., Transcriptional amplification in tumor cells with elevated c-Myc. Cell 151 (2012), 56–67.
-
(2012)
Cell
, vol.151
, pp. 56-67
-
-
Lin, C.Y.1
Lovén, J.2
Rahl, P.B.3
Paranal, R.M.4
Burge, C.B.5
Bradner, J.E.6
Lee, T.I.7
Young, R.A.8
-
76
-
-
84957573186
-
Active medulloblastoma enhancers reveal subgroup-specific cellular origins
-
Lin, C.Y., Erkek, S., Tong, Y., Yin, L., Federation, A.J., Zapatka, M., Haldipur, P., Kawauchi, D., Risch, T., Warnatz, H.J., et al. Active medulloblastoma enhancers reveal subgroup-specific cellular origins. Nature 530 (2016), 57–62.
-
(2016)
Nature
, vol.530
, pp. 57-62
-
-
Lin, C.Y.1
Erkek, S.2
Tong, Y.3
Yin, L.4
Federation, A.J.5
Zapatka, M.6
Haldipur, P.7
Kawauchi, D.8
Risch, T.9
Warnatz, H.J.10
-
77
-
-
84973926853
-
The expanding scope and impact of epigenetic cytosine modifications
-
Liu, M.Y., DeNizio, J.E., Schutsky, E.K., Kohli, R.M., The expanding scope and impact of epigenetic cytosine modifications. Curr. Opin. Chem. Biol. 33 (2016), 67–73.
-
(2016)
Curr. Opin. Chem. Biol.
, vol.33
, pp. 67-73
-
-
Liu, M.Y.1
DeNizio, J.E.2
Schutsky, E.K.3
Kohli, R.M.4
-
78
-
-
84988569121
-
Editing DNA Methylation in the Mammalian Genome
-
Liu, X.S., Wu, H., Ji, X., Stelzer, Y., Wu, X., Czauderna, S., Shu, J., Dadon, D., Young, R.A., Jaenisch, R., Editing DNA Methylation in the Mammalian Genome. Cell 167 (2016), 233–247.
-
(2016)
Cell
, vol.167
, pp. 233-247
-
-
Liu, X.S.1
Wu, H.2
Ji, X.3
Stelzer, Y.4
Wu, X.5
Czauderna, S.6
Shu, J.7
Dadon, D.8
Young, R.A.9
Jaenisch, R.10
-
79
-
-
84880287051
-
Retinoic acid and arsenic trioxide for acute promyelocytic leukemia
-
Lo-Coco, F., Avvisati, G., Vignetti, M., Thiede, C., Orlando, S.M., Iacobelli, S., Ferrara, F., Fazi, P., Cicconi, L., Di Bona, E., et al. Gruppo Italiano Malattie Ematologiche dell'Adulto German-Austrian Acute Myeloid Leukemia Study Group, Study Alliance Leukemia. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N. Engl. J. Med. 369 (2013), 111–121.
-
(2013)
N. Engl. J. Med.
, vol.369
, pp. 111-121
-
-
Lo-Coco, F.1
Avvisati, G.2
Vignetti, M.3
Thiede, C.4
Orlando, S.M.5
Iacobelli, S.6
Ferrara, F.7
Fazi, P.8
Cicconi, L.9
Di Bona, E.10
-
80
-
-
84995753074
-
Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution
-
Long, H.K., Prescott, S.L., Wysocka, J., Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution. Cell 167 (2016), 1170–1187.
-
(2016)
Cell
, vol.167
, pp. 1170-1187
-
-
Long, H.K.1
Prescott, S.L.2
Wysocka, J.3
-
81
-
-
84876222028
-
Selective inhibition of tumor oncogenes by disruption of super-enhancers
-
Lovén, J., Hoke, H.A., Lin, C.Y., Lau, A., Orlando, D.A., Vakoc, C.R., Bradner, J.E., Lee, T.I., Young, R.A., Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell 153 (2013), 320–334.
-
(2013)
Cell
, vol.153
, pp. 320-334
-
-
Lovén, J.1
Hoke, H.A.2
Lin, C.Y.3
Lau, A.4
Orlando, D.A.5
Vakoc, C.R.6
Bradner, J.E.7
Lee, T.I.8
Young, R.A.9
-
82
-
-
80054097980
-
MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas
-
Mäkinen, N., Mehine, M., Tolvanen, J., Kaasinen, E., Li, Y., Lehtonen, H.J., Gentile, M., Yan, J., Enge, M., Taipale, M., et al. MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas. Science 334 (2011), 252–255.
-
(2011)
Science
, vol.334
, pp. 252-255
-
-
Mäkinen, N.1
Mehine, M.2
Tolvanen, J.3
Kaasinen, E.4
Li, Y.5
Lehtonen, H.J.6
Gentile, M.7
Yan, J.8
Enge, M.9
Taipale, M.10
-
83
-
-
77958111633
-
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation
-
Malik, S., Roeder, R.G., The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat. Rev. Genet. 11 (2010), 761–772.
-
(2010)
Nat. Rev. Genet.
, vol.11
, pp. 761-772
-
-
Malik, S.1
Roeder, R.G.2
-
84
-
-
84917710235
-
Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element
-
Mansour, M.R., Abraham, B.J., Anders, L., Berezovskaya, A., Gutierrez, A., Durbin, A.D., Etchin, J., Lawton, L., Sallan, S.E., Silverman, L.B., et al. Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science 346 (2014), 1373–1377.
-
(2014)
Science
, vol.346
, pp. 1373-1377
-
-
Mansour, M.R.1
Abraham, B.J.2
Anders, L.3
Berezovskaya, A.4
Gutierrez, A.5
Durbin, A.D.6
Etchin, J.7
Lawton, L.8
Sallan, S.E.9
Silverman, L.B.10
-
85
-
-
84871563384
-
MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
-
Mellén, M., Ayata, P., Dewell, S., Kriaucionis, S., Heintz, N., MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell 151 (2012), 1417–1430.
-
(2012)
Cell
, vol.151
, pp. 1417-1430
-
-
Mellén, M.1
Ayata, P.2
Dewell, S.3
Kriaucionis, S.4
Heintz, N.5
-
86
-
-
70449671729
-
Direct inhibition of the NOTCH transcription factor complex
-
Moellering, R.E., Cornejo, M., Davis, T.N., Del Bianco, C., Aster, J.C., Blacklow, S.C., Kung, A.L., Gilliland, D.G., Verdine, G.L., Bradner, J.E., Direct inhibition of the NOTCH transcription factor complex. Nature 462 (2009), 182–188.
-
(2009)
Nature
, vol.462
, pp. 182-188
-
-
Moellering, R.E.1
Cornejo, M.2
Davis, T.N.3
Del Bianco, C.4
Aster, J.C.5
Blacklow, S.C.6
Kung, A.L.7
Gilliland, D.G.8
Verdine, G.L.9
Bradner, J.E.10
-
87
-
-
84872019812
-
A blueprint for engineering cell fate: current technologies to reprogram cell identity
-
Morris, S.A., Daley, G.Q., A blueprint for engineering cell fate: current technologies to reprogram cell identity. Cell Res. 23 (2013), 33–48.
-
(2013)
Cell Res.
, vol.23
, pp. 33-48
-
-
Morris, S.A.1
Daley, G.Q.2
-
88
-
-
80155137594
-
Master transcription factors determine cell-type-specific responses to TGF-β signaling
-
Mullen, A.C., Orlando, D.A., Newman, J.J., Lovén, J., Kumar, R.M., Bilodeau, S., Reddy, J., Guenther, M.G., DeKoter, R.P., Young, R.A., Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell 147 (2011), 565–576.
-
(2011)
Cell
, vol.147
, pp. 565-576
-
-
Mullen, A.C.1
Orlando, D.A.2
Newman, J.J.3
Lovén, J.4
Kumar, R.M.5
Bilodeau, S.6
Reddy, J.7
Guenther, M.G.8
DeKoter, R.P.9
Young, R.A.10
-
89
-
-
84939780724
-
Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape
-
Nabet, B., Ó Broin, P., Reyes, J.M., Shieh, K., Lin, C.Y., Will, C.M., Popovic, R., Ezponda, T., Bradner, J.E., Golden, A.A., Licht, J.D., Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape. Cell Rep. 12 (2015), 1300–1313.
-
(2015)
Cell Rep.
, vol.12
, pp. 1300-1313
-
-
Nabet, B.1
Ó Broin, P.2
Reyes, J.M.3
Shieh, K.4
Lin, C.Y.5
Will, C.M.6
Popovic, R.7
Ezponda, T.8
Bradner, J.E.9
Golden, A.A.10
Licht, J.D.11
-
90
-
-
84867010006
-
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells
-
Nie, Z., Hu, G., Wei, G., Cui, K., Yamane, A., Resch, W., Wang, R., Green, D.R., Tessarollo, L., Casellas, R., et al. c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell 151 (2012), 68–79.
-
(2012)
Cell
, vol.151
, pp. 68-79
-
-
Nie, Z.1
Hu, G.2
Wei, G.3
Cui, K.4
Yamane, A.5
Resch, W.6
Wang, R.7
Green, D.R.8
Tessarollo, L.9
Casellas, R.10
-
91
-
-
84904816744
-
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma
-
Northcott, P.A., Lee, C., Zichner, T., Stütz, A.M., Erkek, S., Kawauchi, D., Shih, D.J., Hovestadt, V., Zapatka, M., Sturm, D., et al. Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. Nature 511 (2014), 428–434.
-
(2014)
Nature
, vol.511
, pp. 428-434
-
-
Northcott, P.A.1
Lee, C.2
Zichner, T.3
Stütz, A.M.4
Erkek, S.5
Kawauchi, D.6
Shih, D.J.7
Hovestadt, V.8
Zapatka, M.9
Sturm, D.10
-
92
-
-
79952901680
-
Enhancer function: new insights into the regulation of tissue-specific gene expression
-
Ong, C.T., Corces, V.G., Enhancer function: new insights into the regulation of tissue-specific gene expression. Nat. Rev. Genet. 12 (2011), 283–293.
-
(2011)
Nat. Rev. Genet.
, vol.12
, pp. 283-293
-
-
Ong, C.T.1
Corces, V.G.2
-
93
-
-
84924061466
-
Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure
-
Pagliarini, R., Shao, W., Sellers, W.R., Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure. EMBO Rep. 16 (2015), 280–296.
-
(2015)
EMBO Rep.
, vol.16
, pp. 280-296
-
-
Pagliarini, R.1
Shao, W.2
Sellers, W.R.3
-
94
-
-
84902668801
-
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
-
Patel, A.P., Tirosh, I., Trombetta, J.J., Shalek, A.K., Gillespie, S.M., Wakimoto, H., Cahill, D.P., Nahed, B.V., Curry, W.T., Martuza, R.L., et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science 344 (2014), 1396–1401.
-
(2014)
Science
, vol.344
, pp. 1396-1401
-
-
Patel, A.P.1
Tirosh, I.2
Trombetta, J.J.3
Shalek, A.K.4
Gillespie, S.M.5
Wakimoto, H.6
Cahill, D.P.7
Nahed, B.V.8
Curry, W.T.9
Martuza, R.L.10
-
95
-
-
84944257870
-
Mediator kinase inhibition further activates super-enhancer-associated genes in AML
-
Pelish, H.E., Liau, B.B., Nitulescu, I.I., Tangpeerachaikul, A., Poss, Z.C., Da Silva, D.H., Caruso, B.T., Arefolov, A., Fadeyi, O., Christie, A.L., et al. Mediator kinase inhibition further activates super-enhancer-associated genes in AML. Nature 526 (2015), 273–276.
-
(2015)
Nature
, vol.526
, pp. 273-276
-
-
Pelish, H.E.1
Liau, B.B.2
Nitulescu, I.I.3
Tangpeerachaikul, A.4
Poss, Z.C.5
Da Silva, D.H.6
Caruso, B.T.7
Arefolov, A.8
Fadeyi, O.9
Christie, A.L.10
-
96
-
-
84878188440
-
Chromatin insulators: linking genome organization to cellular function
-
Phillips-Cremins, J.E., Corces, V.G., Chromatin insulators: linking genome organization to cellular function. Mol. Cell 50 (2013), 461–474.
-
(2013)
Mol. Cell
, vol.50
, pp. 461-474
-
-
Phillips-Cremins, J.E.1
Corces, V.G.2
-
97
-
-
84974693469
-
Epigenetic balance of gene expression by Polycomb and COMPASS families
-
Piunti, A., Shilatifard, A., Epigenetic balance of gene expression by Polycomb and COMPASS families. Science, 352, 2016, aad9780.
-
(2016)
Science
, vol.352
, pp. aad9780
-
-
Piunti, A.1
Shilatifard, A.2
-
98
-
-
84876033650
-
Targeting MYCN in neuroblastoma by BET bromodomain inhibition
-
Puissant, A., Frumm, S.M., Alexe, G., Bassil, C.F., Qi, J., Chanthery, Y.H., Nekritz, E.A., Zeid, R., Gustafson, W.C., Greninger, P., et al. Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 3 (2013), 308–323.
-
(2013)
Cancer Discov.
, vol.3
, pp. 308-323
-
-
Puissant, A.1
Frumm, S.M.2
Alexe, G.3
Bassil, C.F.4
Qi, J.5
Chanthery, Y.H.6
Nekritz, E.A.7
Zeid, R.8
Gustafson, W.C.9
Greninger, P.10
-
99
-
-
77951920690
-
c-Myc regulates transcriptional pause release
-
Rahl, P.B., Lin, C.Y., Seila, A.C., Flynn, R.A., McCuine, S., Burge, C.B., Sharp, P.A., Young, R.A., c-Myc regulates transcriptional pause release. Cell 141 (2010), 432–445.
-
(2010)
Cell
, vol.141
, pp. 432-445
-
-
Rahl, P.B.1
Lin, C.Y.2
Seila, A.C.3
Flynn, R.A.4
McCuine, S.5
Burge, C.B.6
Sharp, P.A.7
Young, R.A.8
-
100
-
-
84942531799
-
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition
-
Rathert, P., Roth, M., Neumann, T., Muerdter, F., Roe, J.S., Muhar, M., Deswal, S., Cerny-Reiterer, S., Peter, B., Jude, J., et al. Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. Nature 525 (2015), 543–547.
-
(2015)
Nature
, vol.525
, pp. 543-547
-
-
Rathert, P.1
Roth, M.2
Neumann, T.3
Muerdter, F.4
Roe, J.S.5
Muhar, M.6
Deswal, S.7
Cerny-Reiterer, S.8
Peter, B.9
Jude, J.10
-
101
-
-
0017362792
-
15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia
-
Rowley, J.D., Golomb, H.M., Dougherty, C., 15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia. Lancet 1 (1977), 549–550.
-
(1977)
Lancet
, vol.1
, pp. 549-550
-
-
Rowley, J.D.1
Golomb, H.M.2
Dougherty, C.3
-
102
-
-
84865786819
-
Lineage conversion methodologies meet the reprogramming toolbox
-
Sancho-Martinez, I., Baek, S.H., Izpisua Belmonte, J.C., Lineage conversion methodologies meet the reprogramming toolbox. Nat. Cell Biol. 14 (2012), 892–899.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 892-899
-
-
Sancho-Martinez, I.1
Baek, S.H.2
Izpisua Belmonte, J.C.3
-
103
-
-
84865109759
-
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia
-
Sanda, T., Lawton, L.N., Barrasa, M.I., Fan, Z.P., Kohlhammer, H., Gutierrez, A., Ma, W., Tatarek, J., Ahn, Y., Kelliher, M.A., et al. Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell 22 (2012), 209–221.
-
(2012)
Cancer Cell
, vol.22
, pp. 209-221
-
-
Sanda, T.1
Lawton, L.N.2
Barrasa, M.I.3
Fan, Z.P.4
Kohlhammer, H.5
Gutierrez, A.6
Ma, W.7
Tatarek, J.8
Ahn, Y.9
Kelliher, M.A.10
-
104
-
-
77950809059
-
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
-
Sharma, S.V., Lee, D.Y., Li, B., Quinlan, M.P., Takahashi, F., Maheswaran, S., McDermott, U., Azizian, N., Zou, L., Fischbach, M.A., et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 141 (2010), 69–80.
-
(2010)
Cell
, vol.141
, pp. 69-80
-
-
Sharma, S.V.1
Lee, D.Y.2
Li, B.3
Quinlan, M.P.4
Takahashi, F.5
Maheswaran, S.6
McDermott, U.7
Azizian, N.8
Zou, L.9
Fischbach, M.A.10
-
105
-
-
84901821841
-
The mechanisms behind the therapeutic activity of BET bromodomain inhibition
-
Shi, J., Vakoc, C.R., The mechanisms behind the therapeutic activity of BET bromodomain inhibition. Mol. Cell 54 (2014), 728–736.
-
(2014)
Mol. Cell
, vol.54
, pp. 728-736
-
-
Shi, J.1
Vakoc, C.R.2
-
106
-
-
84890717859
-
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation
-
Shi, J., Whyte, W.A., Zepeda-Mendoza, C.J., Milazzo, J.P., Shen, C., Roe, J.S., Minder, J.L., Mercan, F., Wang, E., Eckersley-Maslin, M.A., et al. Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes Dev. 27 (2013), 2648–2662.
-
(2013)
Genes Dev.
, vol.27
, pp. 2648-2662
-
-
Shi, J.1
Whyte, W.A.2
Zepeda-Mendoza, C.J.3
Milazzo, J.P.4
Shen, C.5
Roe, J.S.6
Minder, J.L.7
Mercan, F.8
Wang, E.9
Eckersley-Maslin, M.A.10
-
107
-
-
84976878643
-
Hierarchy within the mammary STAT5-driven Wap super-enhancer
-
Shin, H.Y., Willi, M., Yoo, K.H., Zeng, X., Wang, C., Metser, G., Hennighausen, L., Hierarchy within the mammary STAT5-driven Wap super-enhancer. Nat. Genet. 48 (2016), 904–911.
-
(2016)
Nat. Genet.
, vol.48
, pp. 904-911
-
-
Shin, H.Y.1
Willi, M.2
Yoo, K.H.3
Zeng, X.4
Wang, C.5
Metser, G.6
Hennighausen, L.7
-
108
-
-
84955472185
-
Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer
-
Shu, S., Lin, C.Y., He, H.H., Witwicki, R.M., Tabassum, D.P., Roberts, J.M., Janiszewska, M., Huh, S.J., Liang, Y., Ryan, J., et al. Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer. Nature 529 (2016), 413–417.
-
(2016)
Nature
, vol.529
, pp. 413-417
-
-
Shu, S.1
Lin, C.Y.2
He, H.H.3
Witwicki, R.M.4
Tabassum, D.P.5
Roberts, J.M.6
Janiszewska, M.7
Huh, S.J.8
Liang, Y.9
Ryan, J.10
-
109
-
-
84971383942
-
Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome
-
Soshnev, A.A., Josefowicz, S.Z., Allis, C.D., Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome. Mol. Cell 62 (2016), 681–694.
-
(2016)
Mol. Cell
, vol.62
, pp. 681-694
-
-
Soshnev, A.A.1
Josefowicz, S.Z.2
Allis, C.D.3
-
110
-
-
53349103292
-
Modelling Myc inhibition as a cancer therapy
-
Soucek, L., Whitfield, J., Martins, C.P., Finch, A.J., Murphy, D.J., Sodir, N.M., Karnezis, A.N., Swigart, L.B., Nasi, S., Evan, G.I., Modelling Myc inhibition as a cancer therapy. Nature 455 (2008), 679–683.
-
(2008)
Nature
, vol.455
, pp. 679-683
-
-
Soucek, L.1
Whitfield, J.2
Martins, C.P.3
Finch, A.J.4
Murphy, D.J.5
Sodir, N.M.6
Karnezis, A.N.7
Swigart, L.B.8
Nasi, S.9
Evan, G.I.10
-
111
-
-
84874835799
-
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice
-
Soucek, L., Whitfield, J.R., Sodir, N.M., Massó-Vallés, D., Serrano, E., Karnezis, A.N., Swigart, L.B., Evan, G.I., Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice. Genes Dev. 27 (2013), 504–513.
-
(2013)
Genes Dev.
, vol.27
, pp. 504-513
-
-
Soucek, L.1
Whitfield, J.R.2
Sodir, N.M.3
Massó-Vallés, D.4
Serrano, E.5
Karnezis, A.N.6
Swigart, L.B.7
Evan, G.I.8
-
112
-
-
84865249952
-
Transcription factors: from enhancer binding to developmental control
-
Spitz, F., Furlong, E.E., Transcription factors: from enhancer binding to developmental control. Nat. Rev. Genet. 13 (2012), 613–626.
-
(2012)
Nat. Rev. Genet.
, vol.13
, pp. 613-626
-
-
Spitz, F.1
Furlong, E.E.2
-
113
-
-
84964727676
-
Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628
-
Stathis, A., Zucca, E., Bekradda, M., Gomez-Roca, C., Delord, J.P., de La Motte Rouge, T., Uro-Coste, E., de Braud, F., Pelosi, G., French, C.A., Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628. Cancer Discov. 6 (2016), 492–500.
-
(2016)
Cancer Discov.
, vol.6
, pp. 492-500
-
-
Stathis, A.1
Zucca, E.2
Bekradda, M.3
Gomez-Roca, C.4
Delord, J.P.5
de La Motte Rouge, T.6
Uro-Coste, E.7
de Braud, F.8
Pelosi, G.9
French, C.A.10
-
114
-
-
64749094310
-
The cancer genome
-
Stratton, M.R., Campbell, P.J., Futreal, P.A., The cancer genome. Nature 458 (2009), 719–724.
-
(2009)
Nature
, vol.458
, pp. 719-724
-
-
Stratton, M.R.1
Campbell, P.J.2
Futreal, P.A.3
-
115
-
-
63749109364
-
Linking somatic genetic alterations in cancer to therapeutics
-
Stuart, D., Sellers, W.R., Linking somatic genetic alterations in cancer to therapeutics. Curr. Opin. Cell Biol. 21 (2009), 304–310.
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 304-310
-
-
Stuart, D.1
Sellers, W.R.2
-
116
-
-
84976526432
-
The role of enhancers in cancer
-
Sur, I., Taipale, J., The role of enhancers in cancer. Nat. Rev. Cancer 16 (2016), 483–493.
-
(2016)
Nat. Rev. Cancer
, vol.16
, pp. 483-493
-
-
Sur, I.1
Taipale, J.2
-
117
-
-
0001292985
-
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells
-
Taub, R., Kirsch, I., Morton, C., Lenoir, G., Swan, D., Tronick, S., Aaronson, S., Leder, P., Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc. Natl. Acad. Sci. USA 79 (1982), 7837–7841.
-
(1982)
Proc. Natl. Acad. Sci. USA
, vol.79
, pp. 7837-7841
-
-
Taub, R.1
Kirsch, I.2
Morton, C.3
Lenoir, G.4
Swan, D.5
Tronick, S.6
Aaronson, S.7
Leder, P.8
-
118
-
-
0018581647
-
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine
-
Taylor, S.M., Jones, P.A., Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. Cell 17 (1979), 771–779.
-
(1979)
Cell
, vol.17
, pp. 771-779
-
-
Taylor, S.M.1
Jones, P.A.2
-
119
-
-
84908151229
-
Histone core modifications regulating nucleosome structure and dynamics
-
Tessarz, P., Kouzarides, T., Histone core modifications regulating nucleosome structure and dynamics. Nat. Rev. Mol. Cell Biol. 15 (2014), 703–708.
-
(2014)
Nat. Rev. Mol. Cell Biol.
, vol.15
, pp. 703-708
-
-
Tessarz, P.1
Kouzarides, T.2
-
120
-
-
0034193442
-
Transcriptional regulation: Kamikaze activators
-
Thomas, D., Tyers, M., Transcriptional regulation: Kamikaze activators. Curr. Biol. 10 (2000), R341–R343.
-
(2000)
Curr. Biol.
, vol.10
, pp. R341-R343
-
-
Thomas, D.1
Tyers, M.2
-
121
-
-
84924614665
-
Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1
-
Tomazou, E.M., Sheffield, N.C., Schmidl, C., Schuster, M., Schönegger, A., Datlinger, P., Kubicek, S., Bock, C., Kovar, H., Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1. Cell Rep. 10 (2015), 1082–1095.
-
(2015)
Cell Rep.
, vol.10
, pp. 1082-1095
-
-
Tomazou, E.M.1
Sheffield, N.C.2
Schmidl, C.3
Schuster, M.4
Schönegger, A.5
Datlinger, P.6
Kubicek, S.7
Bock, C.8
Kovar, H.9
-
122
-
-
80155123782
-
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration
-
Trompouki, E., Bowman, T.V., Lawton, L.N., Fan, Z.P., Wu, D.C., DiBiase, A., Martin, C.S., Cech, J.N., Sessa, A.K., Leblanc, J.L., et al. Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell 147 (2011), 577–589.
-
(2011)
Cell
, vol.147
, pp. 577-589
-
-
Trompouki, E.1
Bowman, T.V.2
Lawton, L.N.3
Fan, Z.P.4
Wu, D.C.5
DiBiase, A.6
Martin, C.S.7
Cech, J.N.8
Sessa, A.K.9
Leblanc, J.L.10
-
123
-
-
62549128139
-
A census of human transcription factors: function, expression and evolution
-
Vaquerizas, J.M., Kummerfeld, S.K., Teichmann, S.A., Luscombe, N.M., A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 (2009), 252–263.
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 252-263
-
-
Vaquerizas, J.M.1
Kummerfeld, S.K.2
Teichmann, S.A.3
Luscombe, N.M.4
-
124
-
-
84866780162
-
Molecular roadblocks for cellular reprogramming
-
Vierbuchen, T., Wernig, M., Molecular roadblocks for cellular reprogramming. Mol. Cell 47 (2012), 827–838.
-
(2012)
Mol. Cell
, vol.47
, pp. 827-838
-
-
Vierbuchen, T.1
Wernig, M.2
-
125
-
-
84952038314
-
Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis
-
Viny, A.D., Ott, C.J., Spitzer, B., Rivas, M., Meydan, C., Papalexi, E., Yelin, D., Shank, K., Reyes, J., Chiu, A., et al. Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis. J. Exp. Med. 212 (2015), 1819–1832.
-
(2015)
J. Exp. Med.
, vol.212
, pp. 1819-1832
-
-
Viny, A.D.1
Ott, C.J.2
Spitzer, B.3
Rivas, M.4
Meydan, C.5
Papalexi, E.6
Yelin, D.7
Shank, K.8
Reyes, J.9
Chiu, A.10
-
126
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein, B., Papadopoulos, N., Velculescu, V.E., Zhou, S., Diaz, L.A. Jr., Kinzler, K.W., Cancer genome landscapes. Science 339 (2013), 1546–1558.
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
Papadopoulos, N.2
Velculescu, V.E.3
Zhou, S.4
Diaz, L.A.5
Kinzler, K.W.6
-
127
-
-
84901846972
-
Translocations at 8q24 juxtapose MYC with genes that harbor superenhancers resulting in overexpression and poor prognosis in myeloma patients
-
Walker, B.A., Wardell, C.P., Brioli, A., Boyle, E., Kaiser, M.F., Begum, D.B., Dahir, N.B., Johnson, D.C., Ross, F.M., Davies, F.E., Morgan, G.J., Translocations at 8q24 juxtapose MYC with genes that harbor superenhancers resulting in overexpression and poor prognosis in myeloma patients. Blood Cancer J., 4, 2014, e191.
-
(2014)
Blood Cancer J.
, vol.4
, pp. e191
-
-
Walker, B.A.1
Wardell, C.P.2
Brioli, A.3
Boyle, E.4
Kaiser, M.F.5
Begum, D.B.6
Dahir, N.B.7
Johnson, D.C.8
Ross, F.M.9
Davies, F.E.10
Morgan, G.J.11
-
128
-
-
41949111045
-
Acute promyelocytic leukemia: from highly fatal to highly curable
-
Wang, Z.Y., Chen, Z., Acute promyelocytic leukemia: from highly fatal to highly curable. Blood 111 (2008), 2505–2515.
-
(2008)
Blood
, vol.111
, pp. 2505-2515
-
-
Wang, Z.Y.1
Chen, Z.2
-
129
-
-
84943784340
-
CDK7-dependent transcriptional addiction in triple-negative breast cancer
-
Wang, Y., Zhang, T., Kwiatkowski, N., Abraham, B.J., Lee, T.I., Xie, S., Yuzugullu, H., Von, T., Li, H., Lin, Z., et al. CDK7-dependent transcriptional addiction in triple-negative breast cancer. Cell 163 (2015), 174–186.
-
(2015)
Cell
, vol.163
, pp. 174-186
-
-
Wang, Y.1
Zhang, T.2
Kwiatkowski, N.3
Abraham, B.J.4
Lee, T.I.5
Xie, S.6
Yuzugullu, H.7
Von, T.8
Li, H.9
Lin, Z.10
-
130
-
-
84884419292
-
Emerging patterns of somatic mutations in cancer
-
Watson, I.R., Takahashi, K., Futreal, P.A., Chin, L., Emerging patterns of somatic mutations in cancer. Nat. Rev. Genet. 14 (2013), 703–718.
-
(2013)
Nat. Rev. Genet.
, vol.14
, pp. 703-718
-
-
Watson, I.R.1
Takahashi, K.2
Futreal, P.A.3
Chin, L.4
-
131
-
-
33746961739
-
Mechanisms of disease: Oncogene addiction-a rationale for molecular targeting in cancer therapy
-
Weinstein, I.B., Joe, A.K., Mechanisms of disease: Oncogene addiction-a rationale for molecular targeting in cancer therapy. Nat. Clin. Pract. Oncol. 3 (2006), 448–457.
-
(2006)
Nat. Clin. Pract. Oncol.
, vol.3
, pp. 448-457
-
-
Weinstein, I.B.1
Joe, A.K.2
-
132
-
-
84876216563
-
Master transcription factors and mediator establish super-enhancers at key cell identity genes
-
Whyte, W.A., Orlando, D.A., Hnisz, D., Abraham, B.J., Lin, C.Y., Kagey, M.H., Rahl, P.B., Lee, T.I., Young, R.A., Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell 153 (2013), 307–319.
-
(2013)
Cell
, vol.153
, pp. 307-319
-
-
Whyte, W.A.1
Orlando, D.A.2
Hnisz, D.3
Abraham, B.J.4
Lin, C.Y.5
Kagey, M.H.6
Rahl, P.B.7
Lee, T.I.8
Young, R.A.9
-
133
-
-
84932634729
-
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation
-
Winter, G.E., Buckley, D.L., Paulk, J., Roberts, J.M., Souza, A., Dhe-Paganon, S., Bradner, J.E., DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science 348 (2015), 1376–1381.
-
(2015)
Science
, vol.348
, pp. 1376-1381
-
-
Winter, G.E.1
Buckley, D.L.2
Paulk, J.3
Roberts, J.M.4
Souza, A.5
Dhe-Paganon, S.6
Bradner, J.E.7
-
134
-
-
84862528505
-
Induced pluripotent stem cells: past, present, and future
-
Yamanaka, S., Induced pluripotent stem cells: past, present, and future. Cell Stem Cell 10 (2012), 678–684.
-
(2012)
Cell Stem Cell
, vol.10
, pp. 678-684
-
-
Yamanaka, S.1
-
135
-
-
84955279894
-
ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas
-
Yang, H., Schramek, D., Adam, R.C., Keyes, B.E., Wang, P., Zheng, D., Fuchs, E., ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas. eLife, 4, 2015, e10870.
-
(2015)
eLife
, vol.4
, pp. e10870
-
-
Yang, H.1
Schramek, D.2
Adam, R.C.3
Keyes, B.E.4
Wang, P.5
Zheng, D.6
Fuchs, E.7
-
136
-
-
84911909070
-
Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia
-
Yashiro-Ohtani, Y., Wang, H., Zang, C., Arnett, K.L., Bailis, W., Ho, Y., Knoechel, B., Lanauze, C., Louis, L., Forsyth, K.S., et al. Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia. Proc. Natl. Acad. Sci. USA 111 (2014), E4946–E4953.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. E4946-E4953
-
-
Yashiro-Ohtani, Y.1
Wang, H.2
Zang, C.3
Arnett, K.L.4
Bailis, W.5
Ho, Y.6
Knoechel, B.7
Lanauze, C.8
Louis, L.9
Forsyth, K.S.10
-
137
-
-
84984637726
-
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
-
Zhang, T., Kwiatkowski, N., Olson, C.M., Dixon-Clarke, S.E., Abraham, B.J., Greifenberg, A.K., Ficarro, S.B., Elkins, J.M., Liang, Y., Hannett, N.M., et al. Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. Nat. Chem. Biol. 12 (2016), 876–884.
-
(2016)
Nat. Chem. Biol.
, vol.12
, pp. 876-884
-
-
Zhang, T.1
Kwiatkowski, N.2
Olson, C.M.3
Dixon-Clarke, S.E.4
Abraham, B.J.5
Greifenberg, A.K.6
Ficarro, S.B.7
Elkins, J.M.8
Liang, Y.9
Hannett, N.M.10
-
138
-
-
84956634373
-
Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers
-
Zhang, X., Choi, P.S., Francis, J.M., Imielinski, M., Watanabe, H., Cherniack, A.D., Meyerson, M., Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers. Nat. Genet. 48 (2016), 176–182.
-
(2016)
Nat. Genet.
, vol.48
, pp. 176-182
-
-
Zhang, X.1
Choi, P.S.2
Francis, J.M.3
Imielinski, M.4
Watanabe, H.5
Cherniack, A.D.6
Meyerson, M.7
-
139
-
-
84882884517
-
Charting a dynamic DNA methylation landscape of the human genome
-
Ziller, M.J., Gu, H., Müller, F., Donaghey, J., Tsai, L.T., Kohlbacher, O., De Jager, P.L., Rosen, E.D., Bennett, D.A., Bernstein, B.E., et al. Charting a dynamic DNA methylation landscape of the human genome. Nature 500 (2013), 477–481.
-
(2013)
Nature
, vol.500
, pp. 477-481
-
-
Ziller, M.J.1
Gu, H.2
Müller, F.3
Donaghey, J.4
Tsai, L.T.5
Kohlbacher, O.6
De Jager, P.L.7
Rosen, E.D.8
Bennett, D.A.9
Bernstein, B.E.10
-
140
-
-
80055000824
-
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
-
Zuber, J., Shi, J., Wang, E., Rappaport, A.R., Herrmann, H., Sison, E.A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 478 (2011), 524–528.
-
(2011)
Nature
, vol.478
, pp. 524-528
-
-
Zuber, J.1
Shi, J.2
Wang, E.3
Rappaport, A.R.4
Herrmann, H.5
Sison, E.A.6
Magoon, D.7
Qi, J.8
Blatt, K.9
Wunderlich, M.10
|