메뉴 건너뛰기




Volumn 33, Issue , 2016, Pages 67-73

The expanding scope and impact of epigenetic cytosine modifications

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLCYTOSINE; CYTIDINE DEAMINASE; CYTOSINE; ENZYME; TEN ELEVEN TRANSLOCATION ENZYME; UNCLASSIFIED DRUG;

EID: 84973926853     PISSN: 13675931     EISSN: 18790402     Source Type: Journal    
DOI: 10.1016/j.cbpa.2016.05.029     Document Type: Review
Times cited : (22)

References (62)
  • 1
    • 84874194072 scopus 로고    scopus 로고
    • DNA methylation: roles in mammalian development
    • Smith Z.D., Meissner A. DNA methylation: roles in mammalian development. Nat Rev Genet 2013, 14:204-220.
    • (2013) Nat Rev Genet , vol.14 , pp. 204-220
    • Smith, Z.D.1    Meissner, A.2
  • 2
    • 78751470921 scopus 로고    scopus 로고
    • Structure and function of mammalian DNA methyltransferases
    • Jurkowska R.Z., Jurkowski T.P., Jeltsch A. Structure and function of mammalian DNA methyltransferases. Chembiochem 2011, 12:206-222.
    • (2011) Chembiochem , vol.12 , pp. 206-222
    • Jurkowska, R.Z.1    Jurkowski, T.P.2    Jeltsch, A.3
  • 3
    • 84886860116 scopus 로고    scopus 로고
    • Tet, TDG and the dynamics of DNA demethylation
    • Kohli R.M., Zhang Y. Tet, TDG and the dynamics of DNA demethylation. Nature 2013, 502:472-479.
    • (2013) Nature , vol.502 , pp. 472-479
    • Kohli, R.M.1    Zhang, Y.2
  • 4
    • 84925762489 scopus 로고    scopus 로고
    • TET family proteins: oxidation activity, interacting molecules, and functions in diseases
    • Lu X., Zhao B.S., He C. TET family proteins: oxidation activity, interacting molecules, and functions in diseases. Chem Rev 2015, 115:2225-2239.
    • (2015) Chem Rev , vol.115 , pp. 2225-2239
    • Lu, X.1    Zhao, B.S.2    He, C.3
  • 6
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
    • Ito S., D'Alessio A.C., Taranova O.V., Hong K., Sowers L.C., Zhang Y. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 2010, 466:1129-1133.
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1    D'Alessio, A.C.2    Taranova, O.V.3    Hong, K.4    Sowers, L.C.5    Zhang, Y.6
  • 7
    • 80052495940 scopus 로고    scopus 로고
    • Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
    • He Y.F., Li B.Z., Li Z., Liu P., Wang Y., Tang Q., Ding J., Jia Y., Chen Z., Li L., et al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 2011, 333:1303-1307.
    • (2011) Science , vol.333 , pp. 1303-1307
    • He, Y.F.1    Li, B.Z.2    Li, Z.3    Liu, P.4    Wang, Y.5    Tang, Q.6    Ding, J.7    Jia, Y.8    Chen, Z.9    Li, L.10
  • 8
    • 80052461558 scopus 로고    scopus 로고
    • Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
    • Ito S., Shen L., Dai Q., Wu S.C., Collins L.B., Swenberg J.A., He C., Zhang Y. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 2011, 333:1300-1303.
    • (2011) Science , vol.333 , pp. 1300-1303
    • Ito, S.1    Shen, L.2    Dai, Q.3    Wu, S.C.4    Collins, L.B.5    Swenberg, J.A.6    He, C.7    Zhang, Y.8
  • 10
    • 84962428929 scopus 로고    scopus 로고
    • Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA
    • Hashimoto H., Pais J.E., Dai N., Correa I.R., Zhang X., Zheng Y., Cheng X. Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA. Nucleic Acids Res 2015, 43:10713-10721.
    • (2015) Nucleic Acids Res , vol.43 , pp. 10713-10721
    • Hashimoto, H.1    Pais, J.E.2    Dai, N.3    Correa, I.R.4    Zhang, X.5    Zheng, Y.6    Cheng, X.7
  • 11
    • 84946217906 scopus 로고    scopus 로고
    • Structural insight into substrate preference for TET-mediated oxidation
    • Hu L., Lu J., Cheng J., Rao Q., Li Z., Hou H., Lou Z., Zhang L., Li W., Gong W., et al. Structural insight into substrate preference for TET-mediated oxidation. Nature 2015, 527:118-122.
    • (2015) Nature , vol.527 , pp. 118-122
    • Hu, L.1    Lu, J.2    Cheng, J.3    Rao, Q.4    Li, Z.5    Hou, H.6    Lou, Z.7    Zhang, L.8    Li, W.9    Gong, W.10
  • 12
    • 84956811348 scopus 로고    scopus 로고
    • Tet2 catalyzes stepwise 5-methylcytosine oxidation by an iterative and de novo mechanism
    • Crawford D.J., Liu M.Y., Nabel C.S., Cao X.J., Garcia B.A., Kohli R.M. Tet2 catalyzes stepwise 5-methylcytosine oxidation by an iterative and de novo mechanism. J Am Chem Soc 2016, 138:730-733.
    • (2016) J Am Chem Soc , vol.138 , pp. 730-733
    • Crawford, D.J.1    Liu, M.Y.2    Nabel, C.S.3    Cao, X.J.4    Garcia, B.A.5    Kohli, R.M.6
  • 15
    • 84925780877 scopus 로고    scopus 로고
    • Chemical methods for decoding cytosine modifications in DNA
    • Booth M.J., Raiber E.A., Balasubramanian S. Chemical methods for decoding cytosine modifications in DNA. Chem Rev 2015, 115:2240-2254.
    • (2015) Chem Rev , vol.115 , pp. 2240-2254
    • Booth, M.J.1    Raiber, E.A.2    Balasubramanian, S.3
  • 16
    • 84964383428 scopus 로고    scopus 로고
    • Charting oxidized methylcytosines at base resolution
    • Yardimci H., Zhang Y. Charting oxidized methylcytosines at base resolution. Nat Struct Mol Biol 2015, 22:656-661.
    • (2015) Nat Struct Mol Biol , vol.22 , pp. 656-661
    • Yardimci, H.1    Zhang, Y.2
  • 17
    • 84889030206 scopus 로고    scopus 로고
    • CGmCGCG is a versatile substrate with which to evaluate Tet protein activity
    • Kizaki S., Sugiyama H. CGmCGCG is a versatile substrate with which to evaluate Tet protein activity. Org Biomol Chem 2014, 12:104-107.
    • (2014) Org Biomol Chem , vol.12 , pp. 104-107
    • Kizaki, S.1    Sugiyama, H.2
  • 22
    • 84927724481 scopus 로고    scopus 로고
    • Detection of mismatched 5-hydroxymethyluracil in DNA by selective chemical labeling
    • Yu M., Song C.X., He C. Detection of mismatched 5-hydroxymethyluracil in DNA by selective chemical labeling. Methods 2015, 72:16-20.
    • (2015) Methods , vol.72 , pp. 16-20
    • Yu, M.1    Song, C.X.2    He, C.3
  • 23
    • 63249106600 scopus 로고    scopus 로고
    • JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomes
    • Cliffe L.J., Kieft R., Southern T., Birkeland S.R., Marshall M., Sweeney K., Sabatini R. JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomes. Nucleic Acids Res 2009, 37:1452-1462.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1452-1462
    • Cliffe, L.J.1    Kieft, R.2    Southern, T.3    Birkeland, S.R.4    Marshall, M.5    Sweeney, K.6    Sabatini, R.7
  • 24
    • 84886810542 scopus 로고    scopus 로고
    • Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA
    • Iyer L.M., Zhang D., Burroughs A.M., Aravind L. Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA. Nucleic Acids Res 2013, 41:7635-7655.
    • (2013) Nucleic Acids Res , vol.41 , pp. 7635-7655
    • Iyer, L.M.1    Zhang, D.2    Burroughs, A.M.3    Aravind, L.4
  • 25
    • 84893431558 scopus 로고    scopus 로고
    • Lineage-specific expansions of TET/JBP genes and a new class of DNA transposons shape fungal genomic and epigenetic landscapes
    • Iyer L.M., Zhang D., de Souza R.F., Pukkila P.J., Rao A., Aravind L. Lineage-specific expansions of TET/JBP genes and a new class of DNA transposons shape fungal genomic and epigenetic landscapes. Proc Natl Acad Sci U S A 2014, 111:1676-1683.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 1676-1683
    • Iyer, L.M.1    Zhang, D.2    de Souza, R.F.3    Pukkila, P.J.4    Rao, A.5    Aravind, L.6
  • 26
    • 84897523964 scopus 로고    scopus 로고
    • A TET homologue protein from Coprinopsis cinerea (CcTET) that biochemically converts 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine
    • Zhang L., Chen W., Iyer L.M., Hu J., Wang G., Fu Y., Yu M., Dai Q., Aravind L., He C. A TET homologue protein from Coprinopsis cinerea (CcTET) that biochemically converts 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine. J Am Chem Soc 2014, 136:4801-4804.
    • (2014) J Am Chem Soc , vol.136 , pp. 4801-4804
    • Zhang, L.1    Chen, W.2    Iyer, L.M.3    Hu, J.4    Wang, G.5    Fu, Y.6    Yu, M.7    Dai, Q.8    Aravind, L.9    He, C.10
  • 28
    • 84890087878 scopus 로고    scopus 로고
    • Crystal structures of B-DNA dodecamer containing the epigenetic modifications 5-hydroxymethylcytosine or 5-methylcytosine
    • Renciuk D., Blacque O., Vorlickova M., Spingler B. Crystal structures of B-DNA dodecamer containing the epigenetic modifications 5-hydroxymethylcytosine or 5-methylcytosine. Nucleic Acids Res 2013, 41:9891-9900.
    • (2013) Nucleic Acids Res , vol.41 , pp. 9891-9900
    • Renciuk, D.1    Blacque, O.2    Vorlickova, M.3    Spingler, B.4
  • 30
    • 84922663293 scopus 로고    scopus 로고
    • Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine
    • Szulik M.W., Pallan P.S., Nocek B., Voehler M., Banerjee S., Brooks S., Joachimiak A., Egli M., Eichman B.F., Stone M.P. Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine. Biochemistry 2015, 54:1294-1305.
    • (2015) Biochemistry , vol.54 , pp. 1294-1305
    • Szulik, M.W.1    Pallan, P.S.2    Nocek, B.3    Voehler, M.4    Banerjee, S.5    Brooks, S.6    Joachimiak, A.7    Egli, M.8    Eichman, B.F.9    Stone, M.P.10
  • 31
    • 84886468317 scopus 로고    scopus 로고
    • Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA
    • Maiti A., Michelson A.Z., Armwood C.J., Lee J.K., Drohat A.C. Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA. J Am Chem Soc 2013, 135:15813-15822.
    • (2013) J Am Chem Soc , vol.135 , pp. 15813-15822
    • Maiti, A.1    Michelson, A.Z.2    Armwood, C.J.3    Lee, J.K.4    Drohat, A.C.5
  • 32
    • 84959360038 scopus 로고    scopus 로고
    • Weakened N3 hydrogen bonding by 5-formylcytosine and 5-carboxylcytosine reduces their base-pairing stability
    • Dai Q., Sanstead P.J., Peng C.S., Han D., He C., Tokmakoff A. Weakened N3 hydrogen bonding by 5-formylcytosine and 5-carboxylcytosine reduces their base-pairing stability. ACS Chem Biol 2016, 11:470-477.
    • (2016) ACS Chem Biol , vol.11 , pp. 470-477
    • Dai, Q.1    Sanstead, P.J.2    Peng, C.S.3    Han, D.4    He, C.5    Tokmakoff, A.6
  • 34
    • 84959432574 scopus 로고    scopus 로고
    • Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability
    • Ngo T.T., Yoo J., Dai Q., Zhang Q., He C., Aksimentiev A., Ha T. Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability. Nat Commun 2016, 7:10813.
    • (2016) Nat Commun , vol.7 , pp. 10813
    • Ngo, T.T.1    Yoo, J.2    Dai, Q.3    Zhang, Q.4    He, C.5    Aksimentiev, A.6    Ha, T.7
  • 37
    • 84877313438 scopus 로고    scopus 로고
    • Selective chemical labelling of 5-formylcytosine in DNA by fluorescent dyes
    • Hu J., Xing X., Xu X., Wu F., Guo P., Yan S., Xu Z., Xu J., Weng X., Zhou X. Selective chemical labelling of 5-formylcytosine in DNA by fluorescent dyes. Chemistry 2013, 19:5836-5840.
    • (2013) Chemistry , vol.19 , pp. 5836-5840
    • Hu, J.1    Xing, X.2    Xu, X.3    Wu, F.4    Guo, P.5    Yan, S.6    Xu, Z.7    Xu, J.8    Weng, X.9    Zhou, X.10
  • 39
    • 84907807685 scopus 로고    scopus 로고
    • Pyrene-based quantitative detection of the 5-formylcytosine loci symmetry in the CpG duplex content during TET-dependent demethylation
    • Xu L., Chen Y.C., Chong J., Fin A., McCoy L.S., Xu J., Zhang C., Wang D. Pyrene-based quantitative detection of the 5-formylcytosine loci symmetry in the CpG duplex content during TET-dependent demethylation. Angew Chem Int Ed Engl 2014, 53:11223-11227.
    • (2014) Angew Chem Int Ed Engl , vol.53 , pp. 11223-11227
    • Xu, L.1    Chen, Y.C.2    Chong, J.3    Fin, A.4    McCoy, L.S.5    Xu, J.6    Zhang, C.7    Wang, D.8
  • 40
    • 84879547408 scopus 로고    scopus 로고
    • Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA
    • Lu X., Song C.X., Szulwach K., Wang Z., Weidenbacher P., Jin P., He C. Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA. J Am Chem Soc 2013, 135:9315-9317.
    • (2013) J Am Chem Soc , vol.135 , pp. 9315-9317
    • Lu, X.1    Song, C.X.2    Szulwach, K.3    Wang, Z.4    Weidenbacher, P.5    Jin, P.6    He, C.7
  • 41
    • 84937116585 scopus 로고    scopus 로고
    • Deciphering epigenetic cytosine modifications by direct molecular recognition
    • Kubik G., Summerer D. Deciphering epigenetic cytosine modifications by direct molecular recognition. ACS Chem Biol 2015, 10:1580-1589.
    • (2015) ACS Chem Biol , vol.10 , pp. 1580-1589
    • Kubik, G.1    Summerer, D.2
  • 42
    • 84874267510 scopus 로고    scopus 로고
    • High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells
    • Sun Z., Terragni J., Borgaro J.G., Liu Y., Yu L., Guan S., Wang H., Sun D., Cheng X., Zhu Z., et al. High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells. Cell Rep 2013, 3:567-576.
    • (2013) Cell Rep , vol.3 , pp. 567-576
    • Sun, Z.1    Terragni, J.2    Borgaro, J.G.3    Liu, Y.4    Yu, L.5    Guan, S.6    Wang, H.7    Sun, D.8    Cheng, X.9    Zhu, Z.10
  • 43
    • 84921019170 scopus 로고    scopus 로고
    • Programmable sensors of 5-hydroxymethylcytosine
    • Kubik G., Batke S., Summerer D. Programmable sensors of 5-hydroxymethylcytosine. J Am Chem Soc 2015, 137:2-5.
    • (2015) J Am Chem Soc , vol.137 , pp. 2-5
    • Kubik, G.1    Batke, S.2    Summerer, D.3
  • 45
    • 84894248678 scopus 로고    scopus 로고
    • Induced DNA demethylation by targeting ten-eleven translocation 2 to the human ICAM-1 promoter
    • Chen H., Kazemier H.G., de Groote M.L., Ruiters M.H., Xu G.L., Rots M.G. Induced DNA demethylation by targeting ten-eleven translocation 2 to the human ICAM-1 promoter. Nucleic Acids Res 2014, 42:1563-1574.
    • (2014) Nucleic Acids Res , vol.42 , pp. 1563-1574
    • Chen, H.1    Kazemier, H.G.2    de Groote, M.L.3    Ruiters, M.H.4    Xu, G.L.5    Rots, M.G.6
  • 46
    • 80053917872 scopus 로고    scopus 로고
    • Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites
    • Maiti A., Drohat A.C. Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites. J Biol Chem 2011, 286:35334-35338.
    • (2011) J Biol Chem , vol.286 , pp. 35334-35338
    • Maiti, A.1    Drohat, A.C.2
  • 50
    • 84866940776 scopus 로고    scopus 로고
    • The mammalian de novo DNA methyltransferases DNMT3A and DNMT3B are also DNA 5-hydroxymethylcytosine dehydroxymethylases
    • Chen C.C., Wang K.Y., Shen C.K. The mammalian de novo DNA methyltransferases DNMT3A and DNMT3B are also DNA 5-hydroxymethylcytosine dehydroxymethylases. J Biol Chem 2012, 287:33116-33121.
    • (2012) J Biol Chem , vol.287 , pp. 33116-33121
    • Chen, C.C.1    Wang, K.Y.2    Shen, C.K.3
  • 51
    • 84886035297 scopus 로고    scopus 로고
    • A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation
    • Iurlaro M., Ficz G., Oxley D., Raiber E.A., Bachman M., Booth M.J., Andrews S., Balasubramanian S., Reik W. A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation. Genome Biol 2013, 14:R119.
    • (2013) Genome Biol , vol.14 , pp. R119
    • Iurlaro, M.1    Ficz, G.2    Oxley, D.3    Raiber, E.A.4    Bachman, M.5    Booth, M.J.6    Andrews, S.7    Balasubramanian, S.8    Reik, W.9
  • 53
    • 84871563384 scopus 로고    scopus 로고
    • MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
    • Mellen M., Ayata P., Dewell S., Kriaucionis S., Heintz N. MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell 2012, 151:1417-1430.
    • (2012) Cell , vol.151 , pp. 1417-1430
    • Mellen, M.1    Ayata, P.2    Dewell, S.3    Kriaucionis, S.4    Heintz, N.5
  • 54
    • 84908093905 scopus 로고    scopus 로고
    • Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence
    • Hashimoto H., Olanrewaju Y.O., Zheng Y., Wilson G.G., Zhang X., Cheng X. Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. Genes Dev 2014, 28:2304-2313.
    • (2014) Genes Dev , vol.28 , pp. 2304-2313
    • Hashimoto, H.1    Olanrewaju, Y.O.2    Zheng, Y.3    Wilson, G.G.4    Zhang, X.5    Cheng, X.6
  • 55
    • 84938411464 scopus 로고    scopus 로고
    • Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex
    • Wang L., Zhou Y., Xu L., Xiao R., Lu X., Chen L., Chong J., Li H., He C., Fu X.D., Wang D. Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature 2015, 523:621-625.
    • (2015) Nature , vol.523 , pp. 621-625
    • Wang, L.1    Zhou, Y.2    Xu, L.3    Xiao, R.4    Lu, X.5    Chen, L.6    Chong, J.7    Li, H.8    He, C.9    Fu, X.D.10    Wang, D.11
  • 56
    • 84921989642 scopus 로고    scopus 로고
    • Connections between TET proteins and aberrant DNA modification in cancer
    • Huang Y., Rao A. Connections between TET proteins and aberrant DNA modification in cancer. Trends Genet 2014, 30:464-474.
    • (2014) Trends Genet , vol.30 , pp. 464-474
    • Huang, Y.1    Rao, A.2
  • 59
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • Ward P.S., Patel J., Wise D.R., Abdel-Wahab O., Bennett B.D., Coller H.A., Cross J.R., Fantin V.R., Hedvat C.V., Perl A.E., et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 2010, 17:225-234.
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3    Abdel-Wahab, O.4    Bennett, B.D.5    Coller, H.A.6    Cross, J.R.7    Fantin, V.R.8    Hedvat, C.V.9    Perl, A.E.10
  • 60
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
    • Xu W., Yang H., Liu Y., Yang Y., Wang P., Kim S., Ito S., Yang C., Wang P., Xiao M., et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell 2011, 19:17-30.
    • (2011) Cancer Cell , vol.19 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3    Yang, Y.4    Wang, P.5    Kim, S.6    Ito, S.7    Yang, C.8    Wang, P.9    Xiao, M.10
  • 61
    • 84961385300 scopus 로고    scopus 로고
    • Photoactivation of mutant isocitrate dehydrogenase 2 reveals rapid cancer-associated metabolic and epigenetic changes
    • Walker O.S., Elsasser S.J., Mahesh M., Bachman M., Balasubramanian S., Chin J.W. Photoactivation of mutant isocitrate dehydrogenase 2 reveals rapid cancer-associated metabolic and epigenetic changes. J Am Chem Soc 2016, 138:718-721.
    • (2016) J Am Chem Soc , vol.138 , pp. 718-721
    • Walker, O.S.1    Elsasser, S.J.2    Mahesh, M.3    Bachman, M.4    Balasubramanian, S.5    Chin, J.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.