Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Nature

Volumn 511, Issue 7511, 2014, Pages 616-620

  Kwiatkowski, Nicholas ^a,b,c   Zhang, Tinghu ^a,b   Rahl, Peter B ^c   Abraham, Brian J ^c   Reddy, Jessica ^c,d   Ficarro, Scott B ^a,b   Dastur, Anahita ^b   Amzallag, Arnaud ^b,e   Ramaswamy, Sridhar ^b,e   Tesar, Bethany ^b,f   Jenkins, Catherine E ^g   Hannett, Nancy M ^c   McMillin, Douglas ^b,f   Sanda, Takaomi ^b,h   Sim, Taebo ⁱ   Kim, Nam Doo ^j   Look, Thomas ^b,k   Mitsiades, Constantine S ^b,f   Weng, Andrew P ^g   Brown, Jennifer R ^b,f   Benes, Cyril H ^b   Marto, Jarrod A ^a,b   Young, Richard A ^c,d   Gray, Nathanael S ^a,b   more..

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g BRITISH COLUMBIA CANCER AGENCY   (Canada)

^h NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

ⁱ Korea Institute of Science and Technology   (South Korea)

^j Daegu Gyeongbuk Medical Innovation Foundation   (South Korea)

^k BOSTON CHILDREN S HOSPITAL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYSTEINE; PROTEIN SERINE THREONINE KINASE INHIBITOR; THZ 1; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL LINE; CONTROLLED STUDY; COVALENT BOND; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; JURKAT CELL LINE; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CORE BINDING FACTOR ALPHA 2 SUBUNIT; CYCLIN-DEPENDENT KINASES; CYSTEINE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; JURKAT CELLS; PHENYLENEDIAMINES; PHOSPHORYLATION; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PYRIMIDINES;

EID: 84904963991     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13393     Document Type: Article

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