BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements

Cell Reports

Volumn 15, Issue 3, 2016, Pages 519-530

  Bhagwat, Anand S ^a,b   Roe, Jae Seok ^a   Mok, Beverly Y L ^a   Hohmann, Anja F ^a   Shi, Junwei ^a,b   Vakoc, Christopher R ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRD4 PROTEIN; CIS ACTING ELEMENT; MED12 PROTEIN; MED13 PROTEIN; MED23 PROTEIN; MED24 PROTEIN; REGULATOR PROTEIN; TUMOR PROTEIN; UNCLASSIFIED DRUG; (+)-JQ1 COMPOUND; AZEPINE DERIVATIVE; BRD4 PROTEIN, MOUSE; MEDIATOR COMPLEX; NUCLEAR PROTEIN; PROTEIN SUBUNIT; RNA POLYMERASE II; TRANSCRIPTION FACTOR; TRIAZOLE DERIVATIVE;

ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL CELL; ARTICLE; BRD4 GENE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; EMBRYO; GENE REGULATORY NETWORK; GENE TARGETING; INHIBITION KINETICS; LEUKEMIA CELL; LEUKEMOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; REGULATOR GENE; TRANSCRIPTION INITIATION; TUMOR GENE; ACUTE MYELOID LEUKEMIA; ANIMAL; ANTAGONISTS AND INHIBITORS; BLAST CELL CRISIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; GENOME; METABOLISM; PATHOLOGY; PROTEIN SUBUNIT; REGULATORY SEQUENCE; TUMOR CELL LINE;

ANIMALS; AZEPINES; BLAST CRISIS; CELL DIFFERENTIATION; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, LEUKEMIC; GENE KNOCKDOWN TECHNIQUES; GENOME; LEUKEMIA, MYELOID, ACUTE; MEDIATOR COMPLEX; MICE; NUCLEAR PROTEINS; PROTEIN SUBUNITS; REGULATORY SEQUENCES, NUCLEIC ACID; RNA POLYMERASE II; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRIAZOLES;

EID: 84962683838     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.03.054     Document Type: Article

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