Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing

Cell

Volumn 167, Issue 1, 2016, Pages 219-232.e14

  Amabile, Angelo ^a,b   Migliara, Alessandro ^a,b   Capasso, Paola ^a   Biffi, Mauro ^a   Cittaro, Davide ^c   Naldini, Luigi ^a,b   Lombardo, Angelo ^a,b  

^a SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

B2M null cells; CRISPR Cas9; DNA methylation; DNMT3L; epigenetic editing; gene therapy; KRAB ZFP KAP1; permanent gene silencing; TALE; TET1

Indexed keywords

CYTOKINE; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3L; GENOMIC DNA; HISTONE; KRAB PROTEIN; MESSENGER RNA; REPRESSOR PROTEIN; RNA; UNCLASSIFIED DRUG; DNA (CYTOSINE 5) METHYLTRANSFERASE; KRUPPEL LIKE FACTOR; ZNF10 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; DNA BINDING; DNA METHYLATION; DNA MODIFICATION; EMBRYONIC STEM CELL; EPIGENETICS; GENE ACTIVATION; GENE LOCUS; GENE REPRESSION; GENE SILENCING; GENE TARGETING; GENETIC ENGINEERING; GENETIC STABILITY; GENOME ANALYSIS; HUMAN; HUMAN CELL; INHERITANCE; LYMPHOBLASTOID CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REPRESSOR GENE; RETROVIRIDAE; RNA SEQUENCE; SOMATIC CELL; T LYMPHOCYTE; TRANSIENT EXPRESSION; ENZYME ACTIVE SITE; GENE EDITING; GENETICS; METABOLISM; PROCEDURES;

CATALYTIC DOMAIN; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EMBRYONIC STEM CELLS; GENE EDITING; GENE SILENCING; GENE TARGETING; GENETIC ENGINEERING; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; REPRESSOR PROTEINS; T-LYMPHOCYTES;

EID: 84988592852     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.09.006     Document Type: Article

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