Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 46, 2014, Pages E4946-E4953

  Yashiro Ohtani, Yumi ^a   Wang, Hongfang ^b   Zang, Chongzhi ^c   Arnett, Kelly L ^d   Bailis, Will ^a   Ho, Yugong ^e   Knoechel, Birgit ^f   Lanauze, Claudia ^a   Louis, Lumena ^a   Forsyth, Katherine S ^a   Chen, Sujun ^g   Chung, Yoonjie ^a   Schug, Jonathan ^e   Blobel, Gerd A ^e   Liebhaber, Stephen A ^e   Bernstein, Bradley E ^h   Blacklow, Stephen C ^c,d   Liu, Xiaole Shirley ^c   Aster, Jon C ^b   Pear, Warren S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f BOSTON CHILDREN S HOSPITAL   (United States)

^g TONGJI UNIVERSITY   (China)

^h MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Brd4; Chromatin; Enhancer; Gene regulation; Transcription

Indexed keywords

BROMODOMAIN CONTAINING 4; BROMODOMAIN INHIBITOR; GAMMA SECRETASE INHIBITOR; NOTCH1 RECEPTOR; TUMOR PROTEIN; UNCLASSIFIED DRUG; BRD4 PROTEIN, HUMAN; BRD4 PROTEIN, MOUSE; HISTONE; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; NOTCH1 PROTEIN, HUMAN; NOTCH1 PROTEIN, MOUSE; NUCLEAR PROTEIN; RBPJ PROTEIN, HUMAN; RBPJ PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; DRUG RESISTANCE; DRUG SENSITIVITY; ENHANCER REGION; GENE ACTIVATION; GENE EXPRESSION; GENE INTERACTION; GENE SILENCING; GENE TARGETING; HISTONE ACETYLATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MOUSE; NONHUMAN; ONCOGENE C MYC; PROMOTER REGION; REPORTER GENE; T CELL LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHROMATIN IMMUNOPRECIPITATION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; ONCOGENE MYC; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; TUMOR CELL LINE;

MURINAE;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION REGULATION, LEUKEMIC; GENES, MYC; GENES, REPORTER; GENOME-WIDE ASSOCIATION STUDY; HISTONES; HUMANS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROMOTER REGIONS, GENETIC; PROTEIN CONFORMATION; RECEPTOR, NOTCH1; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84911909070     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1407079111     Document Type: Article

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