메뉴 건너뛰기




Volumn 168, Issue 4, 2017, Pages 644-656

Endogenous DNA Damage as a Source of Genomic Instability in Cancer

Author keywords

cancer; DNA damage; DNA repair; DNA replication; Genome instability; mutagenesis; transcription

Indexed keywords

CYTOSINE DEAMINASE; DNA; DNA TOPOISOMERASE; SINGLE STRANDED DNA; CHROMATIN;

EID: 85011950306     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.01.002     Document Type: Review
Times cited : (962)

References (94)
  • 1
    • 0036469913 scopus 로고    scopus 로고
    • The connection between transcription and genomic instability
    • Aguilera, A., The connection between transcription and genomic instability. EMBO J. 21 (2002), 195–201.
    • (2002) EMBO J. , vol.21 , pp. 195-201
    • Aguilera, A.1
  • 2
    • 84891102589 scopus 로고    scopus 로고
    • Mutational signatures: the patterns of somatic mutations hidden in cancer genomes
    • Alexandrov, L.B., Stratton, M.R., Mutational signatures: the patterns of somatic mutations hidden in cancer genomes. Curr. Opin. Genet. Dev. 24 (2014), 52–60.
    • (2014) Curr. Opin. Genet. Dev. , vol.24 , pp. 52-60
    • Alexandrov, L.B.1    Stratton, M.R.2
  • 5
    • 33644511436 scopus 로고    scopus 로고
    • Structure of a DNA glycosylase searching for lesions
    • Banerjee, A., Santos, W.L., Verdine, G.L., Structure of a DNA glycosylase searching for lesions. Science 311 (2006), 1153–1157.
    • (2006) Science , vol.311 , pp. 1153-1157
    • Banerjee, A.1    Santos, W.L.2    Verdine, G.L.3
  • 10
    • 84975794132 scopus 로고    scopus 로고
    • A critical role for topoisomerase IIb and DNA double strand breaks in transcription
    • Calderwood, S.K., A critical role for topoisomerase IIb and DNA double strand breaks in transcription. Transcription 7 (2016), 75–83.
    • (2016) Transcription , vol.7 , pp. 75-83
    • Calderwood, S.K.1
  • 13
    • 79952314830 scopus 로고    scopus 로고
    • Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair
    • Chiolo, I., Minoda, A., Colmenares, S.U., Polyzos, A., Costes, S.V., Karpen, G.H., Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell 144 (2011), 732–744.
    • (2011) Cell , vol.144 , pp. 732-744
    • Chiolo, I.1    Minoda, A.2    Colmenares, S.U.3    Polyzos, A.4    Costes, S.V.5    Karpen, G.H.6
  • 14
    • 84938484731 scopus 로고    scopus 로고
    • Preventing replication fork collapse to maintain genome integrity
    • Cortez, D., Preventing replication fork collapse to maintain genome integrity. DNA Repair (Amst.) 32 (2015), 149–157.
    • (2015) DNA Repair (Amst.) , vol.32 , pp. 149-157
    • Cortez, D.1
  • 15
    • 0016402401 scopus 로고
    • The double helix: a personal view
    • Crick, F., The double helix: a personal view. Nature 248 (1974), 766–769.
    • (1974) Nature , vol.248 , pp. 766-769
    • Crick, F.1
  • 16
    • 0029065571 scopus 로고
    • Association of increased spontaneous mutation rates with high levels of transcription in yeast
    • Datta, A., Jinks-Robertson, S., Association of increased spontaneous mutation rates with high levels of transcription in yeast. Science 268 (1995), 1616–1619.
    • (1995) Science , vol.268 , pp. 1616-1619
    • Datta, A.1    Jinks-Robertson, S.2
  • 18
    • 34249790004 scopus 로고    scopus 로고
    • Molecular mechanisms of antibody somatic hypermutation
    • Di Noia, J.M., Neuberger, M.S., Molecular mechanisms of antibody somatic hypermutation. Annu. Rev. Biochem. 76 (2007), 1–22.
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 1-22
    • Di Noia, J.M.1    Neuberger, M.S.2
  • 19
    • 38049165631 scopus 로고    scopus 로고
    • A brief history of the DNA repair field
    • Friedberg, E.C., A brief history of the DNA repair field. Cell Res. 18 (2008), 3–7.
    • (2008) Cell Res. , vol.18 , pp. 3-7
    • Friedberg, E.C.1
  • 20
    • 84923275611 scopus 로고    scopus 로고
    • Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
    • Frock, R.L., Hu, J., Meyers, R.M., Ho, Y.J., Kii, E., Alt, F.W., Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nat. Biotechnol. 33 (2015), 179–186.
    • (2015) Nat. Biotechnol. , vol.33 , pp. 179-186
    • Frock, R.L.1    Hu, J.2    Meyers, R.M.3    Ho, Y.J.4    Kii, E.5    Alt, F.W.6
  • 22
    • 47349107760 scopus 로고    scopus 로고
    • ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
    • Goodarzi, A.A., Noon, A.T., Deckbar, D., Ziv, Y., Shiloh, Y., Löbrich, M., Jeggo, P.A., ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol. Cell 31 (2008), 167–177.
    • (2008) Mol. Cell , vol.31 , pp. 167-177
    • Goodarzi, A.A.1    Noon, A.T.2    Deckbar, D.3    Ziv, Y.4    Shiloh, Y.5    Löbrich, M.6    Jeggo, P.A.7
  • 24
    • 84941364083 scopus 로고    scopus 로고
    • Deciphering the DNA Damage Response
    • Haber, J.E., Deciphering the DNA Damage Response. Cell 162 (2015), 1183–1185.
    • (2015) Cell , vol.162 , pp. 1183-1185
    • Haber, J.E.1
  • 26
    • 40449120350 scopus 로고    scopus 로고
    • An oncogene-induced DNA damage model for cancer development
    • Halazonetis, T.D., Gorgoulis, V.G., Bartek, J., An oncogene-induced DNA damage model for cancer development. Science 319 (2008), 1352–1355.
    • (2008) Science , vol.319 , pp. 1352-1355
    • Halazonetis, T.D.1    Gorgoulis, V.G.2    Bartek, J.3
  • 28
    • 77049308856 scopus 로고
    • Aging: a theory based on free radical and radiation chemistry
    • Harman, D., Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11 (1956), 298–300.
    • (1956) J. Gerontol. , vol.11 , pp. 298-300
    • Harman, D.1
  • 29
    • 84906303775 scopus 로고    scopus 로고
    • Mechanisms underlying mutational signatures in human cancers
    • Helleday, T., Eshtad, S., Nik-Zainal, S., Mechanisms underlying mutational signatures in human cancers. Nat. Rev. Genet. 15 (2014), 585–598.
    • (2014) Nat. Rev. Genet. , vol.15 , pp. 585-598
    • Helleday, T.1    Eshtad, S.2    Nik-Zainal, S.3
  • 33
    • 84884686924 scopus 로고    scopus 로고
    • Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage
    • Kennedy, S.R., Salk, J.J., Schmitt, M.W., Loeb, L.A., Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage. PLoS Genet., 9, 2013, e1003794.
    • (2013) PLoS Genet. , vol.9 , pp. e1003794
    • Kennedy, S.R.1    Salk, J.J.2    Schmitt, M.W.3    Loeb, L.A.4
  • 35
    • 84971006562 scopus 로고    scopus 로고
    • Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
    • Komor, A.C., Kim, Y.B., Packer, M.S., Zuris, J.A., Liu, D.R., Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature 533 (2016), 420–424.
    • (2016) Nature , vol.533 , pp. 420-424
    • Komor, A.C.1    Kim, Y.B.2    Packer, M.S.3    Zuris, J.A.4    Liu, D.R.5
  • 36
    • 84949256341 scopus 로고    scopus 로고
    • Celebrating DNA's Repair Crew
    • Kunkel, T.A., Celebrating DNA's Repair Crew. Cell 163 (2015), 1301–1303.
    • (2015) Cell , vol.163 , pp. 1301-1303
    • Kunkel, T.A.1
  • 42
    • 0027278557 scopus 로고
    • Instability and decay of the primary structure of DNA
    • Lindahl, T., Instability and decay of the primary structure of DNA. Nature 362 (1993), 709–715.
    • (1993) Nature , vol.362 , pp. 709-715
    • Lindahl, T.1
  • 44
    • 0015504248 scopus 로고
    • Rate of depurination of native deoxyribonucleic acid
    • Lindahl, T., Nyberg, B., Rate of depurination of native deoxyribonucleic acid. Biochemistry 11 (1972), 3610–3618.
    • (1972) Biochemistry , vol.11 , pp. 3610-3618
    • Lindahl, T.1    Nyberg, B.2
  • 46
    • 63149179802 scopus 로고    scopus 로고
    • Balancing AID and DNA repair during somatic hypermutation
    • Liu, M., Schatz, D.G., Balancing AID and DNA repair during somatic hypermutation. Trends Immunol. 30 (2009), 173–181.
    • (2009) Trends Immunol. , vol.30 , pp. 173-181
    • Liu, M.1    Schatz, D.G.2
  • 49
    • 0016176530 scopus 로고
    • Errors in DNA replication as a basis of malignant changes
    • Loeb, L.A., Springgate, C.F., Battula, N., Errors in DNA replication as a basis of malignant changes. Cancer Res. 34 (1974), 2311–2321.
    • (1974) Cancer Res. , vol.34 , pp. 2311-2321
    • Loeb, L.A.1    Springgate, C.F.2    Battula, N.3
  • 50
    • 84921367731 scopus 로고    scopus 로고
    • Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors
    • Lord, C.J., Tutt, A.N., Ashworth, A., Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors. Annu. Rev. Med. 66 (2015), 455–470.
    • (2015) Annu. Rev. Med. , vol.66 , pp. 455-470
    • Lord, C.J.1    Tutt, A.N.2    Ashworth, A.3
  • 52
    • 84886867688 scopus 로고    scopus 로고
    • Maintaining genome stability in the nervous system
    • McKinnon, P.J., Maintaining genome stability in the nervous system. Nat. Neurosci. 16 (2013), 1523–1529.
    • (2013) Nat. Neurosci. , vol.16 , pp. 1523-1529
    • McKinnon, P.J.1
  • 60
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell, P.C., The clonal evolution of tumor cell populations. Science 194 (1976), 23–28.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 61
    • 77955363995 scopus 로고    scopus 로고
    • TP53 mutations in human cancers: origins, consequences, and clinical use
    • Olivier, M., Hollstein, M., Hainaut, P., TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb. Perspect. Biol., 2, 2010, a001008.
    • (2010) Cold Spring Harb. Perspect. Biol. , vol.2 , pp. a001008
    • Olivier, M.1    Hollstein, M.2    Hainaut, P.3
  • 63
    • 84964345447 scopus 로고    scopus 로고
    • Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes
    • Perera, D., Poulos, R.C., Shah, A., Beck, D., Pimanda, J.E., Wong, J.W., Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes. Nature 532 (2016), 259–263.
    • (2016) Nature , vol.532 , pp. 259-263
    • Perera, D.1    Poulos, R.C.2    Shah, A.3    Beck, D.4    Pimanda, J.E.5    Wong, J.W.6
  • 66
    • 84988556747 scopus 로고    scopus 로고
    • Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
    • Pommier, Y., Sun, Y., Huang, S.N., Nitiss, J.L., Roles of eukaryotic topoisomerases in transcription, replication and genomic stability. Nat. Rev. Mol. Cell Biol. 17 (2016), 703–721.
    • (2016) Nat. Rev. Mol. Cell Biol. , vol.17 , pp. 703-721
    • Pommier, Y.1    Sun, Y.2    Huang, S.N.3    Nitiss, J.L.4
  • 71
    • 84964403759 scopus 로고    scopus 로고
    • Nucleotide excision repair is impaired by binding of transcription factors to DNA
    • Sabarinathan, R., Mularoni, L., Deu-Pons, J., Gonzalez-Perez, A., López-Bigas, N., Nucleotide excision repair is impaired by binding of transcription factors to DNA. Nature 532 (2016), 264–267.
    • (2016) Nature , vol.532 , pp. 264-267
    • Sabarinathan, R.1    Mularoni, L.2    Deu-Pons, J.3    Gonzalez-Perez, A.4    López-Bigas, N.5
  • 72
    • 84978174580 scopus 로고    scopus 로고
    • The nature of mutations induced by replication–transcription collisions
    • Sankar, T.S., Wastuwidyaningtyas, B.D., Dong, Y., Lewis, S.A., Wang, J.D., The nature of mutations induced by replication–transcription collisions. Nature 535 (2016), 178–181.
    • (2016) Nature , vol.535 , pp. 178-181
    • Sankar, T.S.1    Wastuwidyaningtyas, B.D.2    Dong, Y.3    Lewis, S.A.4    Wang, J.D.5
  • 74
    • 84962385724 scopus 로고    scopus 로고
    • The complex nature of fragile site plasticity and its importance in cancer
    • Sarni, D., Kerem, B., The complex nature of fragile site plasticity and its importance in cancer. Curr. Opin. Cell Biol. 40 (2016), 131–136.
    • (2016) Curr. Opin. Cell Biol. , vol.40 , pp. 131-136
    • Sarni, D.1    Kerem, B.2
  • 75
    • 0014083515 scopus 로고
    • The heterogeneity of thymine methyl group origin in DNA pyrimidine isostichs of developing sea urchin embryos
    • Scarano, E., Iaccarino, M., Grippo, P., Parisi, E., The heterogeneity of thymine methyl group origin in DNA pyrimidine isostichs of developing sea urchin embryos. Proc. Natl. Acad. Sci. USA 57 (1967), 1394–1400.
    • (1967) Proc. Natl. Acad. Sci. USA , vol.57 , pp. 1394-1400
    • Scarano, E.1    Iaccarino, M.2    Grippo, P.3    Parisi, E.4
  • 76
    • 84928770388 scopus 로고    scopus 로고
    • Neoantigens in cancer immunotherapy
    • Schumacher, T.N., Schreiber, R.D., Neoantigens in cancer immunotherapy. Science 348 (2015), 69–74.
    • (2015) Science , vol.348 , pp. 69-74
    • Schumacher, T.N.1    Schreiber, R.D.2
  • 77
    • 84865248380 scopus 로고    scopus 로고
    • Chromatin organization is a major influence on regional mutation rates in human cancer cells
    • Schuster-Böckler, B., Lehner, B., Chromatin organization is a major influence on regional mutation rates in human cancer cells. Nature 488 (2012), 504–507.
    • (2012) Nature , vol.488 , pp. 504-507
    • Schuster-Böckler, B.1    Lehner, B.2
  • 78
    • 84923989372 scopus 로고    scopus 로고
    • Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers
    • Shlien, A., Campbell, B.B., de Borja, R., Alexandrov, L.B., Merico, D., Wedge, D., Van Loo, P., Tarpey, P.S., Coupland, P., Behjati, S., et al., Biallelic Mismatch Repair Deficiency Consortium. Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers. Nat. Genet. 47 (2015), 257–262.
    • (2015) Nat. Genet. , vol.47 , pp. 257-262
    • Shlien, A.1    Campbell, B.B.2    de Borja, R.3    Alexandrov, L.B.4    Merico, D.5    Wedge, D.6    Van Loo, P.7    Tarpey, P.S.8    Coupland, P.9    Behjati, S.10
  • 79
    • 84896845690 scopus 로고    scopus 로고
    • Complex correlations: replication timing and mutational landscapes during cancer and genome evolution
    • Sima, J., Gilbert, D.M., Complex correlations: replication timing and mutational landscapes during cancer and genome evolution. Curr. Opin. Genet. Dev. 25 (2014), 93–100.
    • (2014) Curr. Opin. Genet. Dev. , vol.25 , pp. 93-100
    • Sima, J.1    Gilbert, D.M.2
  • 81
    • 84925615834 scopus 로고    scopus 로고
    • Differential DNA mismatch repair underlies mutation rate variation across the human genome
    • Supek, F., Lehner, B., Differential DNA mismatch repair underlies mutation rate variation across the human genome. Nature 521 (2015), 81–84.
    • (2015) Nature , vol.521 , pp. 81-84
    • Supek, F.1    Lehner, B.2
  • 82
    • 84907588693 scopus 로고    scopus 로고
    • Hydroxymethylated cytosines are associated with elevated C to G transversion rates
    • Supek, F., Lehner, B., Hajkova, P., Warnecke, T., Hydroxymethylated cytosines are associated with elevated C to G transversion rates. PLoS Genet., 10, 2014, e1004585.
    • (2014) PLoS Genet. , vol.10 , pp. e1004585
    • Supek, F.1    Lehner, B.2    Hajkova, P.3    Warnecke, T.4
  • 83
    • 85018197468 scopus 로고    scopus 로고
    • APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity
    • Swanton, C., McGranahan, N., Starrett, G.J., Harris, R.S., APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity. Cancer Discov. 5 (2015), 704–712.
    • (2015) Cancer Discov. , vol.5 , pp. 704-712
    • Swanton, C.1    McGranahan, N.2    Starrett, G.J.3    Harris, R.S.4
  • 84
    • 79551661538 scopus 로고    scopus 로고
    • Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae
    • Takahashi, T., Burguiere-Slezak, G., Van der Kemp, P.A., Boiteux, S., Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 108 (2011), 692–697.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 692-697
    • Takahashi, T.1    Burguiere-Slezak, G.2    Van der Kemp, P.A.3    Boiteux, S.4
  • 85
    • 84921288028 scopus 로고    scopus 로고
    • Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions
    • Tomasetti, C., Vogelstein, B., Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 347 (2015), 78–81.
    • (2015) Science , vol.347 , pp. 78-81
    • Tomasetti, C.1    Vogelstein, B.2
  • 87
    • 33745141184 scopus 로고    scopus 로고
    • The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G(2)/M phase rather than S phase
    • Waters, L.S., Walker, G.C., The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G(2)/M phase rather than S phase. Proc. Natl. Acad. Sci. USA 103 (2006), 8971–8976.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 8971-8976
    • Waters, L.S.1    Walker, G.C.2
  • 88
    • 84958157371 scopus 로고    scopus 로고
    • Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells
    • Wei, P.C., Chang, A.N., Kao, J., Du, Z., Meyers, R.M., Alt, F.W., Schwer, B., Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells. Cell 164 (2016), 644–655.
    • (2016) Cell , vol.164 , pp. 644-655
    • Wei, P.C.1    Chang, A.N.2    Kao, J.3    Du, Z.4    Meyers, R.M.5    Alt, F.W.6    Schwer, B.7
  • 89
    • 79952283912 scopus 로고    scopus 로고
    • Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks
    • Williamson, L.M., Lees-Miller, S.P., Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks. Carcinogenesis 32 (2011), 279–285.
    • (2011) Carcinogenesis , vol.32 , pp. 279-285
    • Williamson, L.M.1    Lees-Miller, S.P.2
  • 90
    • 62149105212 scopus 로고    scopus 로고
    • A role of DNA-PK for the metabolic gene regulation in response to insulin
    • Wong, R.H., Chang, I., Hudak, C.S., Hyun, S., Kwan, H.Y., Sul, H.S., A role of DNA-PK for the metabolic gene regulation in response to insulin. Cell 136 (2009), 1056–1072.
    • (2009) Cell , vol.136 , pp. 1056-1072
    • Wong, R.H.1    Chang, I.2    Hudak, C.S.3    Hyun, S.4    Kwan, H.Y.5    Sul, H.S.6
  • 91
    • 84953858599 scopus 로고    scopus 로고
    • Substantial contribution of extrinsic risk factors to cancer development
    • Wu, S., Powers, S., Zhu, W., Hannun, Y.A., Substantial contribution of extrinsic risk factors to cancer development. Nature 529 (2016), 43–47.
    • (2016) Nature , vol.529 , pp. 43-47
    • Wu, S.1    Powers, S.2    Zhu, W.3    Hannun, Y.A.4
  • 92
    • 84888869068 scopus 로고    scopus 로고
    • Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements
    • Zhang, C.Z., Leibowitz, M.L., Pellman, D., Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements. Genes Dev. 27 (2013), 2513–2530.
    • (2013) Genes Dev. , vol.27 , pp. 2513-2530
    • Zhang, C.Z.1    Leibowitz, M.L.2    Pellman, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.