-
1
-
-
0034463957
-
Is estradiol a genotoxic mutagenic carcinogen?
-
Liehr, J.G. (2000) Is estradiol a genotoxic mutagenic carcinogen? Endocr. Rev., 21, 40-54.
-
(2000)
Endocr. Rev.
, vol.21
, pp. 40-54
-
-
Liehr, J.G.1
-
2
-
-
18444370889
-
Detection of DNA strand breaks and oxidized DNA bases at the single-cell level resulting from exposure to estradiol and hydroxylated metabolites
-
Rajapakse, N. et al. (2005) Detection of DNA strand breaks and oxidized DNA bases at the single-cell level resulting from exposure to estradiol and hydroxylated metabolites. Environ. Mol. Mutagen., 45, 397-404.
-
(2005)
Environ. Mol. Mutagen.
, vol.45
, pp. 397-404
-
-
Rajapakse, N.1
-
3
-
-
34547660173
-
In vitro short-term test evaluation of catecholestrogens genotoxicity
-
Rossi, D. et al. (2007) In vitro short-term test evaluation of catecholestrogens genotoxicity. J. Steroid Biochem. Mol. Biol., 105, 98-105.
-
(2007)
J. Steroid Biochem. Mol. Biol.
, vol.105
, pp. 98-105
-
-
Rossi, D.1
-
4
-
-
0033535424
-
Estrogen, DNA damage and mutations
-
Roy, D. et al. (1999) Estrogen, DNA damage and mutations. Mutat. Res., 424, 107-115.
-
(1999)
Mutat. Res.
, vol.424
, pp. 107-115
-
-
Roy, D.1
-
5
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
Jackson, S.P. et al. (2009) The DNA-damage response in human biology and disease. Nature, 461, 1071-1078.
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
-
6
-
-
33745255099
-
A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription
-
Ju, B.G. et al. (2006) A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science, 312, 1798-1802.
-
(2006)
Science
, vol.312
, pp. 1798-1802
-
-
Ju, B.G.1
-
7
-
-
64649105115
-
DNA topoisomerase II and its growing repertoire of biological functions
-
Nitiss, J.L. (2009) DNA topoisomerase II and its growing repertoire of biological functions. Nat. Rev. Cancer, 9, 327-337.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 327-337
-
-
Nitiss, J.L.1
-
8
-
-
77954187741
-
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
-
Pommier, Y. et al. (2010) DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem. Biol., 17, 421-433.
-
(2010)
Chem. Biol.
, vol.17
, pp. 421-433
-
-
Pommier, Y.1
-
9
-
-
0034034557
-
Topoisomerase II inhibitor-related acute myeloid leukaemia
-
Pui, C.H. et al. (2000) Topoisomerase II inhibitor-related acute myeloid leukaemia. Br. J. Haematol., 109, 13-23.
-
(2000)
Br. J. Haematol.
, vol.109
, pp. 13-23
-
-
Pui, C.H.1
-
10
-
-
34548391416
-
DNA topoisomerase II, genotoxicity, and cancer
-
McClendon, A.K. et al. (2007) DNA topoisomerase II, genotoxicity, and cancer. Mutat. Res., 623, 83-97.
-
(2007)
Mutat. Res.
, vol.623
, pp. 83-97
-
-
McClendon, A.K.1
-
11
-
-
77953166592
-
gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization
-
Lobrich, M. et al. (2010) gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle, 9, 662-669.
-
(2010)
Cell Cycle
, vol.9
, pp. 662-669
-
-
Lobrich, M.1
-
12
-
-
77749334700
-
Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX
-
Douglas, P. et al. (2010) Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. Mol. Cell Biol., 30, 1368-1381.
-
(2010)
Mol. Cell Biol.
, vol.30
, pp. 1368-1381
-
-
Douglas, P.1
-
13
-
-
43149118801
-
Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites
-
Berkovich, E. et al. (2008) Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites. Nat. Protoc., 3, 915-922.
-
(2008)
Nat. Protoc.
, vol.3
, pp. 915-922
-
-
Berkovich, E.1
-
14
-
-
1942538492
-
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
-
Stiff, T. et al. (2004) ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res., 64, 2390-2396.
-
(2004)
Cancer Res.
, vol.64
, pp. 2390-2396
-
-
Stiff, T.1
-
15
-
-
33646090171
-
DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells
-
Mukherjee, B. et al. (2006) DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells. DNA Repair (Amst.), 5, 575-590.
-
(2006)
DNA Repair (Amst.)
, vol.5
, pp. 575-590
-
-
Mukherjee, B.1
-
16
-
-
9744271049
-
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
-
Hickson, I. et al. (2004) Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res., 64, 9152-9159.
-
(2004)
Cancer Res.
, vol.64
, pp. 9152-9159
-
-
Hickson, I.1
-
17
-
-
33744924482
-
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
-
Zhao, Y. et al. (2006) Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Res., 66, 5354-5362.
-
(2006)
Cancer Res.
, vol.66
, pp. 5354-5362
-
-
Zhao, Y.1
-
18
-
-
0035930537
-
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
-
Ward, I.M. et al. (2001) Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem., 276, 47759-47762.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47759-47762
-
-
Ward, I.M.1
-
19
-
-
24744454832
-
4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-kappaB and ERK/MAPK
-
Chen, Z.H. et al. (2005) 4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-kappaB and ERK/MAPK. Toxicol. Appl. Pharmacol., 208, 46-56.
-
(2005)
Toxicol. Appl. Pharmacol.
, vol.208
, pp. 46-56
-
-
Chen, Z.H.1
-
20
-
-
33947151051
-
Formation of depurinating N3Adenine and N7Guanine adducts by MCF-10F cells cultured in the presence of 4-hydroxyestradiol
-
Saeed, M. et al. (2007) Formation of depurinating N3Adenine and N7Guanine adducts by MCF-10F cells cultured in the presence of 4-hydroxyestradiol. Int. J. Cancer, 120, 1821-1824.
-
(2007)
Int. J. Cancer
, vol.120
, pp. 1821-1824
-
-
Saeed, M.1
-
21
-
-
0026701699
-
ICI 182, 780, a new antioestrogen with clinical potential
-
Wakeling, A.E. et al. (1992) ICI 182, 780, a new antioestrogen with clinical potential. J. Steroid Biochem. Mol. Biol., 43, 173-177.
-
(1992)
J. Steroid Biochem. Mol. Biol.
, vol.43
, pp. 173-177
-
-
Wakeling, A.E.1
-
22
-
-
62149105212
-
A role of DNA-PK for the metabolic gene regulation in response to insulin
-
Wong, R.H. et al. (2009) A role of DNA-PK for the metabolic gene regulation in response to insulin. Cell, 136, 1056-1072.
-
(2009)
Cell
, vol.136
, pp. 1056-1072
-
-
Wong, R.H.1
-
23
-
-
0024329909
-
In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone
-
Drake, F.H. et al. (1989) In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone. Cancer Res., 49, 2578-2583.
-
(1989)
Cancer Res.
, vol.49
, pp. 2578-2583
-
-
Drake, F.H.1
-
24
-
-
0038042087
-
2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic acid (XK469) inhibition of topoisomerase IIbeta is not sufficient for therapeutic response in human Waldenstrom's macroglobulinemia xenograft model
-
Mensah-Osman, E.J. et al. (2002) 2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic acid (XK469) inhibition of topoisomerase IIbeta is not sufficient for therapeutic response in human Waldenstrom's macroglobulinemia xenograft model. Mol. Cancer Ther., 1, 1315-1320.
-
(2002)
Mol. Cancer Ther.
, vol.1
, pp. 1315-1320
-
-
Mensah-Osman, E.J.1
-
25
-
-
0037981413
-
Cell cycle-dependent expression of phosphorylated histone H2AX: reduced expression in unirradiated but not X-irradiated G1-phase cells
-
MacPhail, S.H. et al. (2003) Cell cycle-dependent expression of phosphorylated histone H2AX: reduced expression in unirradiated but not X-irradiated G1-phase cells. Radiat. Res., 159, 759-767.
-
(2003)
Radiat. Res.
, vol.159
, pp. 759-767
-
-
MacPhail, S.H.1
-
26
-
-
0034710152
-
Rad51 accumulation at sites of DNA damage and in postreplicative chromatin
-
Tashiro, S. et al. (2000) Rad51 accumulation at sites of DNA damage and in postreplicative chromatin. J. Cell Biol., 150, 283-291.
-
(2000)
J. Cell Biol.
, vol.150
, pp. 283-291
-
-
Tashiro, S.1
-
27
-
-
70350763838
-
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
-
Beucher, A. et al. (2009) ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. EMBO J., 28, 3413-3427.
-
(2009)
EMBO J.
, vol.28
, pp. 3413-3427
-
-
Beucher, A.1
-
28
-
-
77649131406
-
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
-
Moynahan, M.E. et al. (2010) Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat. Rev. Mol. Cell Biol., 11, 196-207.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 196-207
-
-
Moynahan, M.E.1
-
29
-
-
71249101060
-
Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer
-
Lin, C. et al. (2009) Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell, 139, 1069-1083.
-
(2009)
Cell
, vol.139
, pp. 1069-1083
-
-
Lin, C.1
-
30
-
-
77955069195
-
Androgen-induced TOP2B-mediated doublestrand breaks and prostate cancer gene rearrangements
-
Haffner, M.C. et al. (2010) Androgen-induced TOP2B-mediated doublestrand breaks and prostate cancer gene rearrangements. Nat. Genet., 42, 668-675.
-
(2010)
Nat. Genet.
, vol.42
, pp. 668-675
-
-
Haffner, M.C.1
-
31
-
-
77951746652
-
Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alpha
-
Medunjanin, S. et al. (2010) Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alpha. Mol. Biol. Cell, 21, 1620-1628.
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 1620-1628
-
-
Medunjanin, S.1
-
32
-
-
67749137207
-
Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair
-
Pedram, A. et al. (2009) Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair. Mol Biol Cell, 20, 3374-3389.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 3374-3389
-
-
Pedram, A.1
-
33
-
-
47749141560
-
ATR: an essential regulator of genome integrity
-
Cimprich, K.A. et al. (2008) ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol., 9, 616-627.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 616-627
-
-
Cimprich, K.A.1
-
34
-
-
65549088533
-
ATR and H2AX cooperate in maintaining genome stability under replication stress
-
Chanoux, R.A. et al. (2009) ATR and H2AX cooperate in maintaining genome stability under replication stress. J. Biol. Chem., 284, 5994-6003.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 5994-6003
-
-
Chanoux, R.A.1
-
35
-
-
66549085342
-
ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands
-
Welboren, W.J. et al. (2009) ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands. EMBO J., 28, 1418-1428.
-
(2009)
EMBO J.
, vol.28
, pp. 1418-1428
-
-
Welboren, W.J.1
-
36
-
-
77951498531
-
High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome
-
Iacovoni, J.S. et al. (2010) High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome. EMBO J., 29, 1446-1457.
-
(2010)
EMBO J.
, vol.29
, pp. 1446-1457
-
-
Iacovoni, J.S.1
-
37
-
-
33746491583
-
ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles
-
Renwick, A. et al. (2006) ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. Nat. Genet., 38, 873-875.
-
(2006)
Nat. Genet.
, vol.38
, pp. 873-875
-
-
Renwick, A.1
-
38
-
-
35448952908
-
Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex
-
Hsu, H.M. et al. (2007) Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex. Cancer Epidemiol. Biomarkers Prev., 16, 2024-2032.
-
(2007)
Cancer Epidemiol. Biomarkers Prev.
, vol.16
, pp. 2024-2032
-
-
Hsu, H.M.1
-
39
-
-
77953952646
-
BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double strand break repair
-
O'Donovan, P. et al. (2010) BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double strand break repair. Carcinogenesis, 31, 961-967.
-
(2010)
Carcinogenesis
, vol.31
, pp. 961-967
-
-
O'Donovan, P.1
-
40
-
-
59049101918
-
Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility
-
Ding, S.L. et al. (2009) Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility. Carcinogenesis, 30, 43-49.
-
(2009)
Carcinogenesis
, vol.30
, pp. 43-49
-
-
Ding, S.L.1
|