메뉴 건너뛰기




Volumn 32, Issue 3, 2011, Pages 279-285

Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks

Author keywords

[No Author keywords available]

Indexed keywords

APHIDICOLIN; CYCLIN A; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE (ATP HYDROLYSING) B; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; HISTONE H2AX; RAD51 PROTEIN;

EID: 79952283912     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq255     Document Type: Article
Times cited : (83)

References (40)
  • 1
    • 0034463957 scopus 로고    scopus 로고
    • Is estradiol a genotoxic mutagenic carcinogen?
    • Liehr, J.G. (2000) Is estradiol a genotoxic mutagenic carcinogen? Endocr. Rev., 21, 40-54.
    • (2000) Endocr. Rev. , vol.21 , pp. 40-54
    • Liehr, J.G.1
  • 2
    • 18444370889 scopus 로고    scopus 로고
    • Detection of DNA strand breaks and oxidized DNA bases at the single-cell level resulting from exposure to estradiol and hydroxylated metabolites
    • Rajapakse, N. et al. (2005) Detection of DNA strand breaks and oxidized DNA bases at the single-cell level resulting from exposure to estradiol and hydroxylated metabolites. Environ. Mol. Mutagen., 45, 397-404.
    • (2005) Environ. Mol. Mutagen. , vol.45 , pp. 397-404
    • Rajapakse, N.1
  • 3
    • 34547660173 scopus 로고    scopus 로고
    • In vitro short-term test evaluation of catecholestrogens genotoxicity
    • Rossi, D. et al. (2007) In vitro short-term test evaluation of catecholestrogens genotoxicity. J. Steroid Biochem. Mol. Biol., 105, 98-105.
    • (2007) J. Steroid Biochem. Mol. Biol. , vol.105 , pp. 98-105
    • Rossi, D.1
  • 4
    • 0033535424 scopus 로고    scopus 로고
    • Estrogen, DNA damage and mutations
    • Roy, D. et al. (1999) Estrogen, DNA damage and mutations. Mutat. Res., 424, 107-115.
    • (1999) Mutat. Res. , vol.424 , pp. 107-115
    • Roy, D.1
  • 5
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson, S.P. et al. (2009) The DNA-damage response in human biology and disease. Nature, 461, 1071-1078.
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1
  • 6
    • 33745255099 scopus 로고    scopus 로고
    • A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription
    • Ju, B.G. et al. (2006) A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science, 312, 1798-1802.
    • (2006) Science , vol.312 , pp. 1798-1802
    • Ju, B.G.1
  • 7
    • 64649105115 scopus 로고    scopus 로고
    • DNA topoisomerase II and its growing repertoire of biological functions
    • Nitiss, J.L. (2009) DNA topoisomerase II and its growing repertoire of biological functions. Nat. Rev. Cancer, 9, 327-337.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 327-337
    • Nitiss, J.L.1
  • 8
    • 77954187741 scopus 로고    scopus 로고
    • DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
    • Pommier, Y. et al. (2010) DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem. Biol., 17, 421-433.
    • (2010) Chem. Biol. , vol.17 , pp. 421-433
    • Pommier, Y.1
  • 9
    • 0034034557 scopus 로고    scopus 로고
    • Topoisomerase II inhibitor-related acute myeloid leukaemia
    • Pui, C.H. et al. (2000) Topoisomerase II inhibitor-related acute myeloid leukaemia. Br. J. Haematol., 109, 13-23.
    • (2000) Br. J. Haematol. , vol.109 , pp. 13-23
    • Pui, C.H.1
  • 10
    • 34548391416 scopus 로고    scopus 로고
    • DNA topoisomerase II, genotoxicity, and cancer
    • McClendon, A.K. et al. (2007) DNA topoisomerase II, genotoxicity, and cancer. Mutat. Res., 623, 83-97.
    • (2007) Mutat. Res. , vol.623 , pp. 83-97
    • McClendon, A.K.1
  • 11
    • 77953166592 scopus 로고    scopus 로고
    • gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization
    • Lobrich, M. et al. (2010) gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle, 9, 662-669.
    • (2010) Cell Cycle , vol.9 , pp. 662-669
    • Lobrich, M.1
  • 12
    • 77749334700 scopus 로고    scopus 로고
    • Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX
    • Douglas, P. et al. (2010) Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. Mol. Cell Biol., 30, 1368-1381.
    • (2010) Mol. Cell Biol. , vol.30 , pp. 1368-1381
    • Douglas, P.1
  • 13
    • 43149118801 scopus 로고    scopus 로고
    • Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites
    • Berkovich, E. et al. (2008) Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites. Nat. Protoc., 3, 915-922.
    • (2008) Nat. Protoc. , vol.3 , pp. 915-922
    • Berkovich, E.1
  • 14
    • 1942538492 scopus 로고    scopus 로고
    • ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
    • Stiff, T. et al. (2004) ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res., 64, 2390-2396.
    • (2004) Cancer Res. , vol.64 , pp. 2390-2396
    • Stiff, T.1
  • 15
    • 33646090171 scopus 로고    scopus 로고
    • DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells
    • Mukherjee, B. et al. (2006) DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells. DNA Repair (Amst.), 5, 575-590.
    • (2006) DNA Repair (Amst.) , vol.5 , pp. 575-590
    • Mukherjee, B.1
  • 16
    • 9744271049 scopus 로고    scopus 로고
    • Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
    • Hickson, I. et al. (2004) Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res., 64, 9152-9159.
    • (2004) Cancer Res. , vol.64 , pp. 9152-9159
    • Hickson, I.1
  • 17
    • 33744924482 scopus 로고    scopus 로고
    • Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
    • Zhao, Y. et al. (2006) Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Res., 66, 5354-5362.
    • (2006) Cancer Res. , vol.66 , pp. 5354-5362
    • Zhao, Y.1
  • 18
    • 0035930537 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
    • Ward, I.M. et al. (2001) Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem., 276, 47759-47762.
    • (2001) J. Biol. Chem. , vol.276 , pp. 47759-47762
    • Ward, I.M.1
  • 19
    • 24744454832 scopus 로고    scopus 로고
    • 4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-kappaB and ERK/MAPK
    • Chen, Z.H. et al. (2005) 4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-kappaB and ERK/MAPK. Toxicol. Appl. Pharmacol., 208, 46-56.
    • (2005) Toxicol. Appl. Pharmacol. , vol.208 , pp. 46-56
    • Chen, Z.H.1
  • 20
    • 33947151051 scopus 로고    scopus 로고
    • Formation of depurinating N3Adenine and N7Guanine adducts by MCF-10F cells cultured in the presence of 4-hydroxyestradiol
    • Saeed, M. et al. (2007) Formation of depurinating N3Adenine and N7Guanine adducts by MCF-10F cells cultured in the presence of 4-hydroxyestradiol. Int. J. Cancer, 120, 1821-1824.
    • (2007) Int. J. Cancer , vol.120 , pp. 1821-1824
    • Saeed, M.1
  • 21
    • 0026701699 scopus 로고
    • ICI 182, 780, a new antioestrogen with clinical potential
    • Wakeling, A.E. et al. (1992) ICI 182, 780, a new antioestrogen with clinical potential. J. Steroid Biochem. Mol. Biol., 43, 173-177.
    • (1992) J. Steroid Biochem. Mol. Biol. , vol.43 , pp. 173-177
    • Wakeling, A.E.1
  • 22
    • 62149105212 scopus 로고    scopus 로고
    • A role of DNA-PK for the metabolic gene regulation in response to insulin
    • Wong, R.H. et al. (2009) A role of DNA-PK for the metabolic gene regulation in response to insulin. Cell, 136, 1056-1072.
    • (2009) Cell , vol.136 , pp. 1056-1072
    • Wong, R.H.1
  • 23
    • 0024329909 scopus 로고
    • In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone
    • Drake, F.H. et al. (1989) In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone. Cancer Res., 49, 2578-2583.
    • (1989) Cancer Res. , vol.49 , pp. 2578-2583
    • Drake, F.H.1
  • 24
    • 0038042087 scopus 로고    scopus 로고
    • 2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic acid (XK469) inhibition of topoisomerase IIbeta is not sufficient for therapeutic response in human Waldenstrom's macroglobulinemia xenograft model
    • Mensah-Osman, E.J. et al. (2002) 2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic acid (XK469) inhibition of topoisomerase IIbeta is not sufficient for therapeutic response in human Waldenstrom's macroglobulinemia xenograft model. Mol. Cancer Ther., 1, 1315-1320.
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 1315-1320
    • Mensah-Osman, E.J.1
  • 25
    • 0037981413 scopus 로고    scopus 로고
    • Cell cycle-dependent expression of phosphorylated histone H2AX: reduced expression in unirradiated but not X-irradiated G1-phase cells
    • MacPhail, S.H. et al. (2003) Cell cycle-dependent expression of phosphorylated histone H2AX: reduced expression in unirradiated but not X-irradiated G1-phase cells. Radiat. Res., 159, 759-767.
    • (2003) Radiat. Res. , vol.159 , pp. 759-767
    • MacPhail, S.H.1
  • 26
    • 0034710152 scopus 로고    scopus 로고
    • Rad51 accumulation at sites of DNA damage and in postreplicative chromatin
    • Tashiro, S. et al. (2000) Rad51 accumulation at sites of DNA damage and in postreplicative chromatin. J. Cell Biol., 150, 283-291.
    • (2000) J. Cell Biol. , vol.150 , pp. 283-291
    • Tashiro, S.1
  • 27
    • 70350763838 scopus 로고    scopus 로고
    • ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
    • Beucher, A. et al. (2009) ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. EMBO J., 28, 3413-3427.
    • (2009) EMBO J. , vol.28 , pp. 3413-3427
    • Beucher, A.1
  • 28
    • 77649131406 scopus 로고    scopus 로고
    • Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
    • Moynahan, M.E. et al. (2010) Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat. Rev. Mol. Cell Biol., 11, 196-207.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 196-207
    • Moynahan, M.E.1
  • 29
    • 71249101060 scopus 로고    scopus 로고
    • Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer
    • Lin, C. et al. (2009) Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell, 139, 1069-1083.
    • (2009) Cell , vol.139 , pp. 1069-1083
    • Lin, C.1
  • 30
    • 77955069195 scopus 로고    scopus 로고
    • Androgen-induced TOP2B-mediated doublestrand breaks and prostate cancer gene rearrangements
    • Haffner, M.C. et al. (2010) Androgen-induced TOP2B-mediated doublestrand breaks and prostate cancer gene rearrangements. Nat. Genet., 42, 668-675.
    • (2010) Nat. Genet. , vol.42 , pp. 668-675
    • Haffner, M.C.1
  • 31
    • 77951746652 scopus 로고    scopus 로고
    • Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alpha
    • Medunjanin, S. et al. (2010) Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alpha. Mol. Biol. Cell, 21, 1620-1628.
    • (2010) Mol. Biol. Cell , vol.21 , pp. 1620-1628
    • Medunjanin, S.1
  • 32
    • 67749137207 scopus 로고    scopus 로고
    • Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair
    • Pedram, A. et al. (2009) Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair. Mol Biol Cell, 20, 3374-3389.
    • (2009) Mol Biol Cell , vol.20 , pp. 3374-3389
    • Pedram, A.1
  • 33
    • 47749141560 scopus 로고    scopus 로고
    • ATR: an essential regulator of genome integrity
    • Cimprich, K.A. et al. (2008) ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol., 9, 616-627.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 616-627
    • Cimprich, K.A.1
  • 34
    • 65549088533 scopus 로고    scopus 로고
    • ATR and H2AX cooperate in maintaining genome stability under replication stress
    • Chanoux, R.A. et al. (2009) ATR and H2AX cooperate in maintaining genome stability under replication stress. J. Biol. Chem., 284, 5994-6003.
    • (2009) J. Biol. Chem. , vol.284 , pp. 5994-6003
    • Chanoux, R.A.1
  • 35
    • 66549085342 scopus 로고    scopus 로고
    • ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands
    • Welboren, W.J. et al. (2009) ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands. EMBO J., 28, 1418-1428.
    • (2009) EMBO J. , vol.28 , pp. 1418-1428
    • Welboren, W.J.1
  • 36
    • 77951498531 scopus 로고    scopus 로고
    • High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome
    • Iacovoni, J.S. et al. (2010) High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome. EMBO J., 29, 1446-1457.
    • (2010) EMBO J. , vol.29 , pp. 1446-1457
    • Iacovoni, J.S.1
  • 37
    • 33746491583 scopus 로고    scopus 로고
    • ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles
    • Renwick, A. et al. (2006) ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. Nat. Genet., 38, 873-875.
    • (2006) Nat. Genet. , vol.38 , pp. 873-875
    • Renwick, A.1
  • 38
    • 35448952908 scopus 로고    scopus 로고
    • Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex
    • Hsu, H.M. et al. (2007) Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex. Cancer Epidemiol. Biomarkers Prev., 16, 2024-2032.
    • (2007) Cancer Epidemiol. Biomarkers Prev. , vol.16 , pp. 2024-2032
    • Hsu, H.M.1
  • 39
    • 77953952646 scopus 로고    scopus 로고
    • BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double strand break repair
    • O'Donovan, P. et al. (2010) BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double strand break repair. Carcinogenesis, 31, 961-967.
    • (2010) Carcinogenesis , vol.31 , pp. 961-967
    • O'Donovan, P.1
  • 40
    • 59049101918 scopus 로고    scopus 로고
    • Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility
    • Ding, S.L. et al. (2009) Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility. Carcinogenesis, 30, 43-49.
    • (2009) Carcinogenesis , vol.30 , pp. 43-49
    • Ding, S.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.