DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer

Genome Biology

Volumn 17, Issue 1, 2016, Pages

  Kanu, Nnennaya ^a   Cerone, Maria Antonietta ^a   Goh, Gerald ^a   Zalmas, Lykourgos Panagiotis ^b   Bartkova, Jirina ^c,d   Dietzen, Michelle ^a   McGranahan, Nicholas ^b   Rogers, Rebecca ^e   Law, Emily K ^f   Gromova, Irina ^c   Kschischo, Maik ^g   Walton, Michael I ^e   Rossanese, Olivia W ^e   Bartek, Jiri ^c,d   Harris, Reuben S ^f   Venkatesan, Subramanian ^a,b   Swanton, Charles ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^c DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^d KAROLINSKA INSTITUTE   (Sweden)

^e INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^f UNIVERSITY OF MINNESOTA   (United States)

^g UNIVERSITY OF APPLIED SCIENCES KOBLENZ   (Germany)

Author keywords

APOBEC; Genomic instability; Replication stress; Somatic mutation

Indexed keywords

APHIDICOLIN; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3; ATR PROTEIN; CAMPTOTHECIN; CHECKPOINT KINASE 1; DNA; GEMCITABINE; HYDROLASE; HYDROXYUREA; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; APOBEC3 PROTEIN, HUMAN; ATM PROTEIN; ATR PROTEIN, HUMAN; CYTOSINE DEAMINASE; TUMOR MARKER;

APOBEC3B GENE; ARTICLE; BREAST CANCER; CONTROLLED STUDY; DNA DAMAGE CHECKPOINT; ENZYME ACTIVATION; ENZYME INHIBITION; GENE; GENE AMPLIFICATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MUTAGENESIS; ONCOGENE NEU; PROTEIN EXPRESSION; PTEN GENE; SIGNAL TRANSDUCTION; BREAST TUMOR; CELL TRANSFORMATION; DNA DAMAGE; DNA REPLICATION; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; MULTIGENE FAMILY; MUTATION; ONCOGENE; PHYSIOLOGICAL STRESS;

ANTINEOPLASTIC AGENTS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; BIOMARKERS, TUMOR; BREAST NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; CYTOSINE DEAMINASE; DNA DAMAGE; DNA REPLICATION; ENZYME ACTIVATION; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; MULTIGENE FAMILY; MUTAGENESIS; MUTATION; ONCOGENES; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL;

EID: 84988848343     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-016-1042-9     Document Type: Article

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