Somatic mutation in single human neurons tracks developmental and transcriptional history

Science

Volumn 350, Issue 6256, 2015, Pages 94-98

  Lodato, Michael A ^a,b,c   Woodworth, Mollie B ^a,b,c   Lee, Semin ^b   Evrony, Gilad D ^a,b,c   Mehta, Bhaven K ^a,b,c   Karger, Amir ^b   Lee, Soohyun ^b   Chittenden, Thomas W ^b,d,f   D'Gama, Alissa M ^a,b,c   Cai, Xuyu ^a,b,c,g   Luquette, Lovelace J ^b   Lee, Eunjung ^b,e   Park, Peter J ^b,e   Walsh, Christopher A ^a,b,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d Complex Biological Systems Alliance ^*  (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f WuXi NextCODE   (United States)

^g ILLUMINA INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CANCER; DNA; GENE EXPRESSION; GENOME; MUTATION; NEUROLOGY;

ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; CYTOARCHITECTURE; DNA REPLICATION; GENETIC CODE; GENOTYPE; GERMLINE MUTATION; HUMAN; HUMAN CELL; LIFE HISTORY; NERVE CELL DIFFERENTIATION; PREFRONTAL CORTEX; PRIORITY JOURNAL; SOMATIC MUTATION; ADOLESCENT; CELL LINEAGE; CYTOLOGY; FEMALE; GENE LOCUS; GENETIC TRANSCRIPTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; MALE; MITOSIS; MUTATION; NERVE CELL; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; SINGLE CELL ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; CELL LINEAGE; CEREBRAL CORTEX; DNA MUTATIONAL ANALYSIS; DNA REPLICATION; FEMALE; GENETIC LOCI; HUMANS; MALE; MITOSIS; MUTATION; NEURONS; POLYMORPHISM, SINGLE NUCLEOTIDE; SINGLE-CELL ANALYSIS; TRANSCRIPTION, GENETIC;

EID: 84945278558     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aab1785     Document Type: Article

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